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Items: 26

1.

Application of 13C flux analysis to identify high-productivity CHO metabolic phenotypes.

Templeton N, Smith KD, McAtee-Pereira AG, Dorai H, Betenbaugh MJ, Lang SE, Young JD.

Metab Eng. 2017 Sep;43(Pt B):218-225. doi: 10.1016/j.ymben.2017.01.008. Epub 2017 Jan 23.

PMID:
28122259
2.

The contribution of cell surface FcRn in monoclonal antibody serum uptake from the intestine in suckling rat pups.

Cooper PR, Kliwinski CM, Perkinson RA, Ragwan E, Mabus JR, Powers GD, Dorai H, Giles-Komar J, Hornby PJ.

Front Pharmacol. 2014 Oct 7;5:225. doi: 10.3389/fphar.2014.00225. eCollection 2014.

3.

Mammalian cell-produced therapeutic proteins: heterogeneity derived from protein degradation.

Dorai H, Ganguly S.

Curr Opin Biotechnol. 2014 Dec;30:198-204. doi: 10.1016/j.copbio.2014.07.007. Epub 2014 Aug 12. Review.

PMID:
25118137
4.

The impact of anti-apoptotic gene Bcl-2∆ expression on CHO central metabolism.

Templeton N, Lewis A, Dorai H, Qian EA, Campbell MP, Smith KD, Lang SE, Betenbaugh MJ, Young JD.

Metab Eng. 2014 Sep;25:92-102. doi: 10.1016/j.ymben.2014.06.010. Epub 2014 Jul 8.

PMID:
25014175
5.

Human and non-human primate intestinal FcRn expression and immunoglobulin G transcytosis.

Hornby PJ, Cooper PR, Kliwinski C, Ragwan E, Mabus JR, Harman B, Thompson S, Kauffman AL, Yan Z, Tam SH, Dorai H, Powers GD, Giles-Komar J.

Pharm Res. 2014 Apr;31(4):908-22. doi: 10.1007/s11095-013-1212-3. Epub 2013 Sep 26.

6.

Early prediction of instability of Chinese hamster ovary cell lines expressing recombinant antibodies and antibody-fusion proteins.

Dorai H, Corisdeo S, Ellis D, Kinney C, Chomo M, Hawley-Nelson P, Moore G, Betenbaugh MJ, Ganguly S.

Biotechnol Bioeng. 2012 Apr;109(4):1016-30. doi: 10.1002/bit.24367. Epub 2011 Dec 1.

PMID:
22068683
7.

Controlling apoptosis to optimize yields of proteins from mammalian cells.

Zustiak MP, Dorai H, Betenbaugh MJ, Sauerwald TM.

Methods Mol Biol. 2012;801:111-23. doi: 10.1007/978-1-61779-352-3_8.

PMID:
21987250
8.

Characterization of the proteases involved in the N-terminal clipping of glucagon-like-peptide-1-antibody fusion proteins.

Dorai H, Santiago A, Campbell M, Tang QM, Lewis MJ, Wang Y, Lu QZ, Wu SL, Hancock W.

Biotechnol Prog. 2011 Jan-Feb;27(1):220-31. doi: 10.1002/btpr.537. Epub 2011 Jan 7.

PMID:
21312369
9.

Combining high-throughput screening of caspase activity with anti-apoptosis genes for development of robust CHO production cell lines.

Dorai H, Ellis D, Keung YS, Campbell M, Zhuang M, Lin C, Betenbaugh MJ.

Biotechnol Prog. 2010 Sep-Oct;26(5):1367-81. doi: 10.1002/btpr.426.

PMID:
20945491
10.

Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture.

Dorai H, Kyung YS, Ellis D, Kinney C, Lin C, Jan D, Moore G, Betenbaugh MJ.

Biotechnol Bioeng. 2009 Jun 15;103(3):592-608. doi: 10.1002/bit.22269.

PMID:
19241388
11.

Development of mammalian production cell lines expressing CNTO736, a glucagon like peptide-1-MIMETIBODY: factors that influence productivity and product quality.

Dorai H, Nemeth JF, Cammaart E, Wang Y, Tang QM, Magill A, Lewis MJ, Raju TS, Picha K, O'Neil K, Ganguly S, Moore G.

Biotechnol Bioeng. 2009 May 1;103(1):162-76. doi: 10.1002/bit.22217.

PMID:
19137588
12.

Genome-wide analysis of mouse myeloma cell lines expressing therapeutic antibodies.

Dorai H, Li K, Huang CC, Bittner A, Galindo J, Carmen A.

Biotechnol Prog. 2007 Jul-Aug;23(4):911-20. Epub 2007 Jun 26.

PMID:
17592857
13.

Correlation of heavy and light chain mRNA copy numbers to antibody productivity in mouse myeloma production cell lines.

Dorai H, Csirke B, Scallon B, Ganguly S.

Hybridoma (Larchmt). 2006 Feb;25(1):1-9.

PMID:
16475875
14.

BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells.

Gould SE, Day M, Jones SS, Dorai H.

Kidney Int. 2002 Jan;61(1):51-60.

15.

The 5' flanking region of the human bone morphogenetic protein-7 gene.

Dorai H, Shepard A, Ozkaynak E, Lin K, Jones S, Oppermann H, Sampath K.

Biochem Biophys Res Commun. 2001 Apr 6;282(3):823-31.

PMID:
11401538
16.

Bone morphogenetic protein-7 modulates genes that maintain the vascular smooth muscle cell phenotype in culture.

Dorai H, Sampath TK.

J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 1):S70-8. Review.

PMID:
11263669
18.

Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat.

Vukicevic S, Basic V, Rogic D, Basic N, Shih MS, Shepard A, Jin D, Dattatreyamurty B, Jones W, Dorai H, Ryan S, Griffiths D, Maliakal J, Jelic M, Pastorcic M, Stavljenic A, Sampath TK.

J Clin Invest. 1998 Jul 1;102(1):202-14.

19.

Mammalian cell expression of single-chain Fv (sFv) antibody proteins and their C-terminal fusions with interleukin-2 and other effector domains.

Dorai H, McCartney JE, Hudziak RM, Tai MS, Laminet AA, Houston LL, Huston JS, Oppermann H.

Biotechnology (N Y). 1994 Sep;12(9):890-7.

PMID:
7765352
20.

Role of inter-heavy and light chain disulfide bonds in the effector functions of human immunoglobulin IgG1.

Dorai H, Wesolowski JS, Gillies SD.

Mol Immunol. 1992 Dec;29(12):1487-91.

PMID:
1454066
21.

Cloning and reexpression of a functional human IgM anti-lipid A antibody.

Dorai H, Bubbers JE, Gillies SD.

Hybridoma. 1992 Oct;11(5):667-75.

PMID:
1459589
22.

Aglycosylated chimeric mouse/human IgG1 antibody retains some effector function.

Dorai H, Mueller BM, Reisfeld RA, Gillies SD.

Hybridoma. 1991 Apr;10(2):211-7.

PMID:
1874515
23.

The complete nucleotide sequence of a human immunoglobulin genomic C mu gene.

Dorai H, Gillies SD.

Nucleic Acids Res. 1989 Aug 11;17(15):6412. No abstract available.

24.
25.

A genetically engineered murine/human chimeric antibody retains specificity for human tumor-associated antigen.

Sahagan BG, Dorai H, Saltzgaber-Muller J, Toneguzzo F, Guindon CA, Lilly SP, McDonald KW, Morrissey DV, Stone BA, Davis GL, et al.

J Immunol. 1986 Aug 1;137(3):1066-74.

PMID:
3088107
26.

Polyoma virus middle T antigen: relationship to cell membranes and apparent lack of ATP-binding activity.

Schaffhausen BS, Dorai H, Arakere G, Benjamin TL.

Mol Cell Biol. 1982 Oct;2(10):1187-98.

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