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Items: 1 to 50 of 82

1.

Extra-endothelial TRPV1 channels participate in alcohol and caffeine actions on cerebral artery diameter.

North KC, Chang J, Bukiya AN, Dopico AM.

Alcohol. 2018 Apr 26;73:45-55. doi: 10.1016/j.alcohol.2018.04.002. [Epub ahead of print]

PMID:
30268908
2.

Large conductance voltage- and calcium-gated potassium channels (BK) in cerebral artery myocytes of perinatal fetal primates share several major characteristics with the adult phenotype.

Bisen S, Simakova MN, Dopico AM, Bukiya AN.

PLoS One. 2018 Sep 13;13(9):e0203199. doi: 10.1371/journal.pone.0203199. eCollection 2018.

3.
4.

Calcium- and voltage-gated BK channels in vascular smooth muscle.

Dopico AM, Bukiya AN, Jaggar JH.

Pflugers Arch. 2018 Sep;470(9):1271-1289. doi: 10.1007/s00424-018-2151-y. Epub 2018 May 11. Review.

PMID:
29748711
5.

Fetal Cerebral Circulation as Target of Maternal Alcohol Consumption.

Bukiya AN, Dopico AM.

Alcohol Clin Exp Res. 2018 Jun;42(6):1006-1018. doi: 10.1111/acer.13755. Epub 2018 May 9. Review.

PMID:
29672868
6.

Voltage-Sensitive Potassium Channels of the BK Type and Their Coding Genes Are Alcohol Targets in Neurons.

Dopico AM, Bukiya AN, Bettinger JC.

Handb Exp Pharmacol. 2017 Dec 5. doi: 10.1007/164_2017_78. [Epub ahead of print]

PMID:
29204711
7.

Activation of human smooth muscle BK channels by hydrochlorothiazide requires cell integrity and the presence of BK β1 subunit.

Martín P, Moncada M, Kuntamallappanavar G, Dopico AM, Milesi V.

Acta Pharmacol Sin. 2018 Mar;39(3):371-381. doi: 10.1038/aps.2017.133. Epub 2017 Nov 30.

PMID:
29188803
8.

The Effect of Prenatal Alcohol Exposure on Fetal Growth and Cardiovascular Parameters in a Baboon Model of Pregnancy.

Tobiasz AM, Duncan JR, Bursac Z, Sullivan RD, Tate DL, Dopico AM, Bukiya AN, Mari G.

Reprod Sci. 2018 Jul;25(7):1116-1123. doi: 10.1177/1933719117734317. Epub 2017 Oct 5.

PMID:
28982294
9.

BK β1 subunit-dependent facilitation of ethanol inhibition of BK current and cerebral artery constriction is mediated by the β1 transmembrane domain 2.

Kuntamallappanavar G, Dopico AM.

Br J Pharmacol. 2017 Dec;174(23):4430-4448. doi: 10.1111/bph.14046. Epub 2017 Oct 22.

PMID:
28940182
10.

Statin therapy exacerbates alcohol-induced constriction of cerebral arteries via modulation of ethanol-induced BK channel inhibition in vascular smooth muscle.

Simakova MN, Bisen S, Dopico AM, Bukiya AN.

Biochem Pharmacol. 2017 Dec 1;145:81-93. doi: 10.1016/j.bcp.2017.08.022. Epub 2017 Sep 1.

PMID:
28865873
11.

Regulation of Ca2+-Sensitive K+ Channels by Cholesterol and Bile Acids via Distinct Channel Subunits and Sites.

Dopico AM, Bukiya AN.

Curr Top Membr. 2017;80:53-93. doi: 10.1016/bs.ctm.2017.07.001. Epub 2017 Aug 23. Review.

PMID:
28863822
12.

Maternal alcohol exposure during mid-pregnancy dilates fetal cerebral arteries via endocannabinoid receptors.

Seleverstov O, Tobiasz A, Jackson JS, Sullivan R, Ma D, Sullivan JP, Davison S, Akkhawattanangkul Y, Tate DL, Costello T, Barnett S, Li W, Mari G, Dopico AM, Bukiya AN.

Alcohol. 2017 Jun;61:51-61. doi: 10.1016/j.alcohol.2017.01.014. Epub 2017 May 18.

13.

Common structural features of cholesterol binding sites in crystallized soluble proteins.

Bukiya AN, Dopico AM.

J Lipid Res. 2017 Jun;58(6):1044-1054. doi: 10.1194/jlr.R073452. Epub 2017 Apr 18. Review.

14.

Differential distribution and functional impact of BK channel beta1 subunits across mesenteric, coronary, and different cerebral arteries of the rat.

Kuntamallappanavar G, Bisen S, Bukiya AN, Dopico AM.

Pflugers Arch. 2017 Feb;469(2):263-277. doi: 10.1007/s00424-016-1929-z. Epub 2016 Dec 24.

15.

Alcohol modulation of BK channel gating depends on β subunit composition.

Kuntamallappanavar G, Dopico AM.

J Gen Physiol. 2016 Nov;148(5):419-440.

16.

Distinct mechanisms underlying cholesterol protection against alcohol-induced BK channel inhibition and resulting vasoconstriction.

Bisen S, Seleverstov O, Belani J, Rychnovsky S, Dopico AM, Bukiya AN.

Biochim Biophys Acta. 2016 Nov;1861(11):1756-1766. doi: 10.1016/j.bbalip.2016.08.013. Epub 2016 Aug 24.

17.

Modulation of BK Channels by Ethanol.

Dopico AM, Bukiya AN, Kuntamallappanavar G, Liu J.

Int Rev Neurobiol. 2016;128:239-79. doi: 10.1016/bs.irn.2016.03.019. Epub 2016 May 12. Review.

18.

Age-Dependent Susceptibility to Alcohol-Induced Cerebral Artery Constriction.

Bukiya AN, Seleverstov O, Bisen S, Dopico AM.

J Drug Alcohol Res. 2016;5. pii: 236002. doi: 10.4303/jdar/236002. Epub 2016 Nov 27.

19.

Endothelial Nitric Oxide Mediates Caffeine Antagonism of Alcohol-Induced Cerebral Artery Constriction.

Chang J, Fedinec AL, Kuntamallappanavar G, Leffler CW, Bukiya AN, Dopico AM.

J Pharmacol Exp Ther. 2016 Jan;356(1):106-15. doi: 10.1124/jpet.115.229054. Epub 2015 Nov 10.

20.

Cholesterol increases the open probability of cardiac KACh currents.

Bukiya AN, Osborn CV, Kuntamallappanavar G, Toth PT, Baki L, Kowalsky G, Oh MJ, Dopico AM, Levitan I, Rosenhouse-Dantsker A.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2406-13. doi: 10.1016/j.bbamem.2015.07.007. Epub 2015 Jul 18.

21.

Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment.

Tan XL, Xue YQ, Ma T, Wang X, Li JJ, Lan L, Malik KU, McDonald MP, Dopico AM, Liao FF.

Mol Neurodegener. 2015 Jun 24;10:24. doi: 10.1186/s13024-015-0020-0.

22.

Ethanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behavior.

Dopico AM, Bukiya AN, Martin GE.

Front Physiol. 2014 Dec 2;5:466. doi: 10.3389/fphys.2014.00466. eCollection 2014. Review.

23.

Multi-generational pharmacophore modeling for ligands to the cholane steroid-recognition site in the β₁ modulatory subunit of the BKCa channel.

McMillan JE, Bukiya AN, Terrell CL, Patil SA, Miller DD, Dopico AM, Parrill AL.

J Mol Graph Model. 2014 Nov;54:174-83. doi: 10.1016/j.jmgm.2014.10.008. Epub 2014 Oct 24. Erratum in: J Mol Graph Model. 2015 Feb;55:149.

24.

Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4.

Bukiya AN, McMillan J, Liu J, Shivakumar B, Parrill AL, Dopico AM.

J Biol Chem. 2014 Dec 19;289(51):35314-25. doi: 10.1074/jbc.M114.577825. Epub 2014 Nov 4.

25.

Both transmembrane domains of BK β1 subunits are essential to confer the normal phenotype of β1-containing BK channels.

Kuntamallappanavar G, Toro L, Dopico AM.

PLoS One. 2014 Oct 2;9(10):e109306. doi: 10.1371/journal.pone.0109306. eCollection 2014.

26.

Lipid regulation of BK channel function.

Dopico AM, Bukiya AN.

Front Physiol. 2014 Aug 22;5:312. doi: 10.3389/fphys.2014.00312. eCollection 2014. Review.

27.

An alcohol-sensing site in the calcium- and voltage-gated, large conductance potassium (BK) channel.

Bukiya AN, Kuntamallappanavar G, Edwards J, Singh AK, Shivakumar B, Dopico AM.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9313-8. doi: 10.1073/pnas.1317363111. Epub 2014 Jun 9.

28.

Type 2 ryanodine receptors are highly sensitive to alcohol.

Ye Y, Jian K, Jaggar JH, Bukiya AN, Dopico AM.

FEBS Lett. 2014 May 2;588(9):1659-65. doi: 10.1016/j.febslet.2014.03.005. Epub 2014 Mar 12.

29.

Dietary cholesterol protects against alcohol-induced cerebral artery constriction.

Bukiya A, Dopico AM, Leffler CW, Fedinec A.

Alcohol Clin Exp Res. 2014 May;38(5):1216-26. doi: 10.1111/acer.12373. Epub 2014 Mar 3.

30.

Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel β1-subunit by a novel nonsteroidal agent.

Bukiya AN, McMillan JE, Fedinec AL, Patil SA, Miller DD, Leffler CW, Parrill AL, Dopico AM.

Mol Pharmacol. 2013 May;83(5):1030-44. doi: 10.1124/mol.112.083519. Epub 2013 Mar 1.

31.

Distinct sensitivity of slo1 channel proteins to ethanol.

Liu J, Bukiya AN, Kuntamallappanavar G, Singh AK, Dopico AM.

Mol Pharmacol. 2013 Jan;83(1):235-44. doi: 10.1124/mol.112.081240. Epub 2012 Oct 23.

32.

Calcium- and voltage-gated potassium (BK) channel activators in the 5β-cholanic acid-3α-ol analogue series with modifications in the lateral chain.

Bukiya AN, Patil SA, Li W, Miller DD, Dopico AM.

ChemMedChem. 2012 Oct;7(10):1784-92. doi: 10.1002/cmdc.201200290. Epub 2012 Sep 4.

33.

Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol.

Dopico AM, Bukiya AN, Singh AK.

Pharmacol Ther. 2012 Aug;135(2):133-50. doi: 10.1016/j.pharmthera.2012.05.002. Epub 2012 May 11. Review.

34.

Multiple cholesterol recognition/interaction amino acid consensus (CRAC) motifs in cytosolic C tail of Slo1 subunit determine cholesterol sensitivity of Ca2+- and voltage-gated K+ (BK) channels.

Singh AK, McMillan J, Bukiya AN, Burton B, Parrill AL, Dopico AM.

J Biol Chem. 2012 Jun 8;287(24):20509-21. doi: 10.1074/jbc.M112.356261. Epub 2012 Apr 3.

35.

The steroid interaction site in transmembrane domain 2 of the large conductance, voltage- and calcium-gated potassium (BK) channel accessory β1 subunit.

Bukiya AN, Singh AK, Parrill AL, Dopico AM.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20207-12. doi: 10.1073/pnas.1112901108. Epub 2011 Nov 28.

36.

Smooth muscle cholesterol enables BK β1 subunit-mediated channel inhibition and subsequent vasoconstriction evoked by alcohol.

Bukiya AN, Vaithianathan T, Kuntamallappanavar G, Asuncion-Chin M, Dopico AM.

Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2410-23. doi: 10.1161/ATVBAHA.111.233965.

37.

Specificity of cholesterol and analogs to modulate BK channels points to direct sterol-channel protein interactions.

Bukiya AN, Belani JD, Rychnovsky S, Dopico AM.

J Gen Physiol. 2011 Jan;137(1):93-110. doi: 10.1085/jgp.201010519. Epub 2010 Dec 13. Erratum in: J Gen Physiol. 2011 Apr;137(4):391.

38.

Subtype identification and functional characterization of ryanodine receptors in rat cerebral artery myocytes.

Vaithianathan T, Narayanan D, Asuncion-Chin MT, Jeyakumar LH, Liu J, Fleischer S, Jaggar JH, Dopico AM.

Am J Physiol Cell Physiol. 2010 Aug;299(2):C264-78. doi: 10.1152/ajpcell.00318.2009. Epub 2010 May 5.

39.

Channel beta2-4 subunits fail to substitute for beta1 in sensitizing BK channels to lithocholate.

Bukiya AN, Vaithianathan T, Toro L, Dopico AM.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):995-1000. doi: 10.1016/j.bbrc.2009.10.091. Epub 2009 Oct 21.

PMID:
19852931
40.

The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constriction.

Bukiya AN, Liu J, Dopico AM.

FEBS Lett. 2009 Sep 3;583(17):2779-84. doi: 10.1016/j.febslet.2009.07.019. Epub 2009 Jul 17.

41.

Alternative splicing of Cav1.2 channel exons in smooth muscle cells of resistance-size arteries generates currents with unique electrophysiological properties.

Cheng X, Pachuau J, Blaskova E, Asuncion-Chin M, Liu J, Dopico AM, Jaggar JH.

Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H680-8. doi: 10.1152/ajpheart.00109.2009. Epub 2009 Jun 5.

42.

Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels.

Mulholland PJ, Hopf FW, Bukiya AN, Martin GE, Liu J, Dopico AM, Bonci A, Treistman SN, Chandler LJ.

Alcohol Clin Exp Res. 2009 Jul;33(7):1125-35. doi: 10.1111/j.1530-0277.2009.00936.x. Epub 2009 Apr 9. Review.

43.

Acute alcohol action and desensitization of ligand-gated ion channels.

Dopico AM, Lovinger DM.

Pharmacol Rev. 2009 Mar;61(1):98-114. doi: 10.1124/pr.108.000430. Epub 2009 Mar 6. Review.

44.

Structural determinants of monohydroxylated bile acids to activate beta 1 subunit-containing BK channels.

Bukiya AN, McMillan J, Parrill AL, Dopico AM.

J Lipid Res. 2008 Nov;49(11):2441-51. doi: 10.1194/jlr.M800286-JLR200. Epub 2008 Jul 23.

45.

Ethanol modulates BKCa channels by acting as an adjuvant of calcium.

Liu J, Vaithianathan T, Manivannan K, Parrill A, Dopico AM.

Mol Pharmacol. 2008 Sep;74(3):628-40. doi: 10.1124/mol.108.048694. Epub 2008 Jun 13.

46.

Design and synthesis of hydroxy-alkynoic acids and their methyl esters as novel activators of BK channels.

Patil S, Bukiya AN, Li W, Dopico AM, Miller D.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3427-30. doi: 10.1016/j.bmcl.2008.03.080. Epub 2008 Apr 8.

PMID:
18462939
47.

The second transmembrane domain of the large conductance, voltage- and calcium-gated potassium channel beta(1) subunit is a lithocholate sensor.

Bukiya AN, Vaithianathan T, Toro L, Dopico AM.

FEBS Lett. 2008 Mar 5;582(5):673-8. doi: 10.1016/j.febslet.2008.01.036. Epub 2008 Jan 31.

48.

A glance at the structural and functional diversity of membrane lipids.

Dopico AM, Tigyi GJ.

Methods Mol Biol. 2007;400:1-13. Review.

PMID:
17951723
49.

Ethanol interactions with calcium-dependent potassium channels.

Brodie MS, Scholz A, Weiger TM, Dopico AM.

Alcohol Clin Exp Res. 2007 Oct;31(10):1625-32. Review.

PMID:
17850640
50.

A novel Ca(V)1.2 N terminus expressed in smooth muscle cells of resistance size arteries modifies channel regulation by auxiliary subunits.

Cheng X, Liu J, Asuncion-Chin M, Blaskova E, Bannister JP, Dopico AM, Jaggar JH.

J Biol Chem. 2007 Oct 5;282(40):29211-21. Epub 2007 Aug 14.

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