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HIV Data to Care-Using Public Health Data to Improve HIV Care and Prevention.

Sweeney P, DiNenno EA, Flores SA, Dooley S, Shouse RL, Muckleroy S, Margolis AD.

J Acquir Immune Defic Syndr. 2019 Sep 1;82 Suppl 1:S1-S5. doi: 10.1097/QAI.0000000000002059.


Mechanism and theory of d-glucopyranose homogeneous acid catalysis in the aqueous solution phase.

Ghosh MK, Howard MS, Dussan K, Dooley S.

Phys Chem Chem Phys. 2019 Aug 15;21(32):17993-18011. doi: 10.1039/c8cp07224h.


ECM1 Prevents Activation of Transforming Growth Factor beta, Hepatic Stellate Cells, and Fibrogenesis in Mice.

Fan W, Liu T, Chen W, Hammad S, Longerich T, Fu Y, Li N, He Y, Liu C, Zhang Y, Lian Q, Zhao X, Yan C, Li L, Yi C, Ling Z, Ma L, Zhao X, Xu H, Wang P, Cong M, You H, Liu Z, Wang Y, Chen J, Li D, Hui L, Dooley S, Hou J, Jia J, Sun B.

Gastroenterology. 2019 Jul 27. pii: S0016-5085(19)41133-5. doi: 10.1053/j.gastro.2019.07.036. [Epub ahead of print]


Adenovirus‑mediated overexpression of bone morphogenetic protein‑9 promotes methionine choline deficiency‑induced non‑alcoholic steatohepatitis in non‑obese mice.

Li Q, Liu B, Breitkopf-Heinlein K, Weng H, Jiang Q, Dong P, Dooley S, Xu K, Ding H.

Mol Med Rep. 2019 Sep;20(3):2743-2753. doi: 10.3892/mmr.2019.10508. Epub 2019 Jul 19.


Assessing Cognitive Communication Skills in Dementia: A scoping review.

Dooley S, Walshe M.

Int J Lang Commun Disord. 2019 Jun 28. doi: 10.1111/1460-6984.12485. [Epub ahead of print] Review.


Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling.

Tao L, Ma W, Wu L, Xu M, Yang Y, Zhang W, Sha W, Li H, Xu J, Feng R, Xue D, Zhang J, Dooley S, Seki E, Liu P, Liu C.

Gut. 2019 Jun 6. pii: gutjnl-2018-317872. doi: 10.1136/gutjnl-2018-317872. [Epub ahead of print]


Hepatic Osteodystrophy-Molecular Mechanisms Proposed to Favor Its Development.

Ehnert S, Aspera-Werz RH, Ruoß M, Dooley S, Hengstler JG, Nadalin S, Relja B, Badke A, Nussler AK.

Int J Mol Sci. 2019 May 24;20(10). pii: E2555. doi: 10.3390/ijms20102555. Review.


Second exposure to acetaminophen overdose is associated with liver fibrosis in mice.

AlWahsh M, Othman A, Hamadneh L, Telfah A, Lambert J, Hikmat S, Alassi A, Mohamed FEZ, Hergenröder R, Al-Qirim T, Dooley S, Hammad S.

EXCLI J. 2019 Feb 6;18:51-62. eCollection 2019.


Signalling networks in cholangiocarcinoma: Molecular pathogenesis, targeted therapies and drug resistance.

Fouassier L, Marzioni M, Afonso MB, Dooley S, Gaston K, Giannelli G, Rodrigues CMP, Lozano E, Mancarella S, Segatto O, Vaquero J, Marin JJG, Coulouarn C.

Liver Int. 2019 May;39 Suppl 1:43-62. doi: 10.1111/liv.14102. Review.


Becoming the Standard: Expanding the Conventional Use of Interventional Embolization for Ruptured Pulmonary Artery Aneurysms.

Harmon TS, Kaleka G, Maciolek LM, Kathuria MK, Gill GS, Hussain A, Dooley S, Bagherpour AN.

Cureus. 2018 Nov 12;10(11):e3576. doi: 10.7759/cureus.3576.


Effect of alcohol on the interleukin 6-mediated inflammatory response in a new mouse model of acute-on-chronic liver injury.

Karatayli E, Hall RA, Weber SN, Dooley S, Lammert F.

Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):298-307. doi: 10.1016/j.bbadis.2018.11.008. Epub 2018 Nov 15.


SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance.

Yuan X, Li J, Coulouarn C, Lin T, Sulpice L, Bergeat D, De La Torre C, Liebe R, Gretz N, Ebert MPA, Dooley S, Weng HL.

Br J Cancer. 2018 Nov;119(11):1358-1366. doi: 10.1038/s41416-018-0338-9. Epub 2018 Nov 13.


Correction to: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.

Nwosu ZC, Battello N, Rothley M, Piorońska W, Sitek B, Ebert MP, Hofmann U, Sleeman J, Wölfl S, Meyer C, Megger DA, Dooley S.

J Exp Clin Cancer Res. 2018 Nov 2;37(1):267. doi: 10.1186/s13046-018-0939-4.


Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation.

Noh JR, Kim YH, Kim DK, Hwang JH, Kim KS, Choi DH, Lee SJ, Lee HG, Lee TG, Weng HL, Dooley S, Choi HS, Lee CH.

Sci Rep. 2018 Oct 15;8(1):15222. doi: 10.1038/s41598-018-33660-z.


The Role of Life Satisfaction in Predicting Youth Violence and Offending: A Prospective Examination.

Hanniball KB, Viljoen JL, Shaffer CS, Bhatt G, Tweed R, Aknin LB, Gagnon N, Douglas KS, Dooley S.

J Interpers Violence. 2018 Oct 13:886260518805103. doi: 10.1177/0886260518805103. [Epub ahead of print]


Focused scores enable reliable discrimination of small differences in steatosis.

Homeyer A, Hammad S, Schwen LO, Dahmen U, Höfener H, Gao Y, Dooley S, Schenk A.

Diagn Pathol. 2018 Sep 20;13(1):76. doi: 10.1186/s13000-018-0753-5.


Spliceosome-Mediated Pre-mRNA trans-Splicing Can Repair CEP290 mRNA.

Dooley SJ, McDougald DS, Fisher KJ, Bennicelli JL, Mitchell LG, Bennett J.

Mol Ther Nucleic Acids. 2018 Sep 7;12:294-308. doi: 10.1016/j.omtn.2018.05.014. Epub 2018 Jun 27.


Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.

Nwosu ZC, Battello N, Rothley M, Piorońska W, Sitek B, Ebert MP, Hofmann U, Sleeman J, Wölfl S, Meyer C, Megger DA, Dooley S.

J Exp Clin Cancer Res. 2018 Sep 3;37(1):211. doi: 10.1186/s13046-018-0872-6. Erratum in: J Exp Clin Cancer Res. 2018 Nov 2;37(1):267.


Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood.

Ghallab A, Hofmann U, Sezgin S, Vartak N, Hassan R, Zaza A, Godoy P, Schneider KM, Guenther G, Ahmed YA, Abbas AA, Keitel V, Kuepfer L, Dooley S, Lammert F, Trautwein C, Spiteller M, Drasdo D, Hofmann AF, Jansen PLM, Hengstler JG, Reif R.

Hepatology. 2019 Feb;69(2):666-683. doi: 10.1002/hep.30213. Epub 2018 Nov 19.


MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis.

Tao L, Xue D, Shen D, Ma W, Zhang J, Wang X, Zhang W, Wu L, Pan K, Yang Y, Nwosu ZC, Dooley S, Seki E, Liu C.

Arch Toxicol. 2018 Sep;92(9):2935-2946. doi: 10.1007/s00204-018-2278-9. Epub 2018 Aug 10.


Inverse agonist of ERRγ reduces cannabinoid receptor type 1-mediated induction of fibrinogen synthesis in mice with a high-fat diet-intoxicated liver.

Zhang Y, Kim DK, Jung YS, Kim YH, Lee YS, Kim J, Jeong WI, Lee IK, Cho SJ, Dooley S, Lee CH, Choi HS.

Arch Toxicol. 2018 Sep;92(9):2885-2896. doi: 10.1007/s00204-018-2270-4. Epub 2018 Jul 17.


Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation.

Hammad S, Othman A, Meyer C, Telfah A, Lambert J, Dewidar B, Werle J, Nwosu ZC, Mahli A, Dormann C, Gao Y, Gould K, Han M, Yuan X, Gogiashvili M, Hergenröder R, Hellerbrand C, Thomas M, Ebert MP, Amasheh S, Hengstler JG, Dooley S.

Arch Toxicol. 2018 Aug;92(8):2549-2561. doi: 10.1007/s00204-018-2254-4. Epub 2018 Jul 4.


Assessment of the hepatocytic differentiation ability of human skin-derived ABCB5+ stem cells.

Tietze L, Winkler S, Hempel M, Kluth MA, Tappenbeck N, Ganss C, Dooley S, Christ B.

Exp Cell Res. 2018 Aug 15;369(2):335-347. doi: 10.1016/j.yexcr.2018.05.040. Epub 2018 Jun 1.


Galunisertib modifies the liver fibrotic composition in the Abcb4Ko mouse model.

Hammad S, Cavalcanti E, Werle J, Caruso ML, Dropmann A, Ignazzi A, Ebert MP, Dooley S, Giannelli G.

Arch Toxicol. 2018 Jul;92(7):2297-2309. doi: 10.1007/s00204-018-2231-y. Epub 2018 May 28.


PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6 inhibitor therapy-induced senescence.

Klein ME, Dickson MA, Antonescu C, Qin LX, Dooley SJ, Barlas A, Manova K, Schwartz GK, Crago AM, Singer S, Koff A, Tap WD.

Oncogene. 2018 Sep;37(37):5066-5078. doi: 10.1038/s41388-018-0332-y. Epub 2018 May 23.


Bone morphogenetic protein 9 as a key regulator of liver progenitor cells in DDC-induced cholestatic liver injury.

Addante A, Roncero C, Almalé L, Lazcanoiturburu N, García-Álvaro M, Fernández M, Sanz J, Hammad S, Nwosu ZC, Lee SJ, Fabregat I, Dooley S, Ten Dijke P, Herrera B, Sánchez A.

Liver Int. 2018 Sep;38(9):1664-1675. doi: 10.1111/liv.13879. Epub 2018 May 25.


Corrigendum to "Small Heterodimer Partner Deficiency Increases Inflammatory Liver Injury Through C-X-C motif chemokine ligand 2-Driven Neutrophil Recruitment in Mice".

Noh JR, Kim YH, Kim DK, Hwang JH, Kim KS, Choi DH, Lee SJ, Lee HG, Lee TG, Weng HL, Dooley S, Choi HS, Lee CH.

Toxicol Sci. 2018 Jun 1;163(2):666. doi: 10.1093/toxsci/kfy092. No abstract available.


CD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma.

Cai X, Li J, Yuan X, Xiao J, Dooley S, Wan X, Weng H, Lu L.

J Transl Med. 2018 Mar 6;16(1):50. doi: 10.1186/s12967-018-1423-9.


A novel transforming growth factor beta-induced long noncoding RNA promotes an inflammatory microenvironment in human intrahepatic cholangiocarcinoma.

Merdrignac A, Angenard G, Allain C, Petitjean K, Bergeat D, Bellaud P, Fautrel A, Turlin B, Clément B, Dooley S, Sulpice L, Boudjema K, Coulouarn C.

Hepatol Commun. 2018 Jan 30;2(3):254-269. doi: 10.1002/hep4.1142. eCollection 2018 Mar.


Small Heterodimer Partner Deficiency Increases Inflammatory Liver Injury Through C-X-C motif chemokine ligand 2-Driven Neutrophil Recruitment in Mice.

Noh JR, Kim YH, Kim DK, Hwang JH, Kim KS, Choi DH, Lee SJ, Lee HG, Lee TG, Weng HL, Dooley S, Choi HS, Lee CH.

Toxicol Sci. 2018 May 1;163(1):254-264. doi: 10.1093/toxsci/kfy030. Erratum in: Toxicol Sci. 2018 Jun 1;163(2):666.


Ethanol sensitizes hepatocytes for TGF-β-triggered apoptosis.

Gaitantzi H, Meyer C, Rakoczy P, Thomas M, Wahl K, Wandrer F, Bantel H, Alborzinia H, Wölfl S, Ehnert S, Nüssler A, Bergheim I, Ciuclan L, Ebert M, Breitkopf-Heinlein K, Dooley S.

Cell Death Dis. 2018 Jan 19;9(2):51. doi: 10.1038/s41419-017-0071-y.


Effect of Intravenous Administration of Cobalt Chloride to Horses on Clinical and Hemodynamic Variables.

Burns TA, Dembek KA, Kamr A, Dooley SB, Dunbar LK, Aarnes TK, Bednarski LS, O'Brien C, Lakritz J, Byrum B, Wade A, Farmer R, Tan S, Toribio RE.

J Vet Intern Med. 2018 Jan;32(1):441-449. doi: 10.1111/jvim.15029. Epub 2017 Dec 29.


Hepatic Smad7 overexpression causes severe iron overload in mice.

Lai D, Teng F, Hammad S, Werle J, Maas T, Teufel A, Muckenthaler MU, Dooley S, Vujić Spasić M.

Blood. 2018 Feb 1;131(5):581-585. doi: 10.1182/blood-2017-07-796797. Epub 2017 Dec 13. No abstract available.


Monitoring cytochrome P450 activity in living hepatocytes by chromogenic substrates in response to drug treatment or during cell maturation.

Theobald J, Cheng X, Ghanem A, Gaitantzi H, Song G, Klipp E, Wodke J, Becker H, Mrowka R, Breitkopf-Heinlein K, Dooley S, Wölfl S.

Arch Toxicol. 2018 Mar;92(3):1133-1149. doi: 10.1007/s00204-017-2128-1. Epub 2017 Dec 5.


Adverse outcome pathways: opportunities, limitations and open questions.

Leist M, Ghallab A, Graepel R, Marchan R, Hassan R, Bennekou SH, Limonciel A, Vinken M, Schildknecht S, Waldmann T, Danen E, van Ravenzwaay B, Kamp H, Gardner I, Godoy P, Bois FY, Braeuning A, Reif R, Oesch F, Drasdo D, Höhme S, Schwarz M, Hartung T, Braunbeck T, Beltman J, Vrieling H, Sanz F, Forsby A, Gadaleta D, Fisher C, Kelm J, Fluri D, Ecker G, Zdrazil B, Terron A, Jennings P, van der Burg B, Dooley S, Meijer AH, Willighagen E, Martens M, Evelo C, Mombelli E, Taboureau O, Mantovani A, Hardy B, Koch B, Escher S, van Thriel C, Cadenas C, Kroese D, van de Water B, Hengstler JG.

Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19. Review.


The level of caveolin-1 expression determines response to TGF-β as a tumour suppressor in hepatocellular carcinoma cells.

Moreno-Càceres J, Caballero-Díaz D, Nwosu ZC, Meyer C, López-Luque J, Malfettone A, Lastra R, Serrano T, Ramos E, Dooley S, Fabregat I.

Cell Death Dis. 2017 Oct 12;8(10):e3098. doi: 10.1038/cddis.2017.469.


Transforming Growth Factor-β Drives the Transendothelial Migration of Hepatocellular Carcinoma Cells.

Koudelkova P, Costina V, Weber G, Dooley S, Findeisen P, Winter P, Agarwal R, Schlangen K, Mikulits W.

Int J Mol Sci. 2017 Oct 10;18(10). pii: E2119. doi: 10.3390/ijms18102119.


Identification of the Consistently Altered Metabolic Targets in Human Hepatocellular Carcinoma.

Nwosu ZC, Megger DA, Hammad S, Sitek B, Roessler S, Ebert MP, Meyer C, Dooley S.

Cell Mol Gastroenterol Hepatol. 2017 May 31;4(2):303-323.e1. doi: 10.1016/j.jcmgh.2017.05.004. eCollection 2017 Sep.


A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl4-induced pseudolobules is a portal vein.

Hammad S, Braeuning A, Meyer C, Mohamed FEZA, Hengstler JG, Dooley S.

Arch Toxicol. 2017 Nov;91(11):3689-3692. doi: 10.1007/s00204-017-2040-8. Epub 2017 Aug 19.


Orphan nuclear receptor ERRγ is a key regulator of human fibrinogen gene expression.

Zhang Y, Kim DK, Lu Y, Jung YS, Lee JM, Kim YH, Lee YS, Kim J, Dewidar B, Jeong WI, Lee IK, Cho SJ, Dooley S, Lee CH, Li X, Choi HS.

PLoS One. 2017 Jul 27;12(7):e0182141. doi: 10.1371/journal.pone.0182141. eCollection 2017.


GATA4 and LMO3 balance angiocrine signaling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells.

Olsavszky V, Ulbrich F, Singh S, Diett M, Sticht C, Schmid CD, Zierow J, Wohlfeil SA, Schledzewski K, Dooley S, Gaitantzi H, Breitkopf-Heinlein K, Géraud C, Goerdt S, Koch PS.

Gene. 2017 Sep 5;627:491-499. doi: 10.1016/j.gene.2017.06.051. Epub 2017 Jun 29.


Lessons learnt from implementation of a Lynch syndrome screening program for patients with gynaecological malignancy.

Najdawi F, Crook A, Maidens J, McEvoy C, Fellowes A, Pickett J, Ho M, Nevell D, McIlroy K, Sheen A, Sioson L, Ahadi M, Turchini J, Clarkson A, Hogg R, Valmadre S, Gard G, Dooley SJ, Scott RJ, Fox SB, Field M, Gill AJ.

Pathology. 2017 Aug;49(5):457-464. doi: 10.1016/j.pathol.2017.05.004. Epub 2017 Jun 30.


FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.

Xie F, Jin K, Shao L, Fan Y, Tu Y, Li Y, Yang B, van Dam H, Ten Dijke P, Weng H, Dooley S, Wang S, Jia J, Jin J, Zhou F, Zhang L.

Nat Commun. 2017 Apr 26;8:15021. doi: 10.1038/ncomms15021.


BMP-9 interferes with liver regeneration and promotes liver fibrosis.

Breitkopf-Heinlein K, Meyer C, König C, Gaitantzi H, Addante A, Thomas M, Wiercinska E, Cai C, Li Q, Wan F, Hellerbrand C, Valous NA, Hahnel M, Ehlting C, Bode JG, Müller-Bohl S, Klingmüller U, Altenöder J, Ilkavets I, Goumans MJ, Hawinkels LJ, Lee SJ, Wieland M, Mogler C, Ebert MP, Herrera B, Augustin H, Sánchez A, Dooley S, Ten Dijke P.

Gut. 2017 May;66(5):939-954. doi: 10.1136/gutjnl-2016-313314. Epub 2017 Mar 23.


Hydrogen sulfide promotes autophagy of hepatocellular carcinoma cells through the PI3K/Akt/mTOR signaling pathway.

Wang SS, Chen YH, Chen N, Wang LJ, Chen DX, Weng HL, Dooley S, Ding HG.

Cell Death Dis. 2017 Mar 23;8(3):e2688. doi: 10.1038/cddis.2017.18.


Robust detection and segmentation of cell nuclei in biomedical images based on a computational topology framework.

Rojas-Moraleda R, Xiong W, Halama N, Breitkopf-Heinlein K, Dooley S, Salinas L, Heermann DW, Valous NA.

Med Image Anal. 2017 May;38:90-103. doi: 10.1016/ Epub 2017 Mar 6.


Quantification of substrate and cellular strains in stretchable 3D cell cultures: an experimental and computational framework.

González-Avalos P, Mürnseer M, Deeg J, Bachmann A, Spatz J, Dooley S, Eils R, Gladilin E.

J Microsc. 2017 May;266(2):115-125. doi: 10.1111/jmi.12520. Epub 2017 Mar 7.


Pharmacokinetics and pharmacodynamics of buprenorphine and sustained-release buprenorphine after administration to adult alpacas.

Dooley SB, Aarnes TK, Lakritz J, Lerche P, Bednarski RM, Hubbell JA.

Am J Vet Res. 2017 Mar;78(3):321-329. doi: 10.2460/ajvr.78.3.321.


Global Transcriptional Response of Human Liver Cells to Ethanol Stress of Different Strength Reveals Hormetic Behavior.

Schmidt-Heck W, Wönne EC, Hiller T, Menzel U, Koczan D, Damm G, Seehofer D, Knöspel F, Freyer N, Guthke R, Dooley S, Zeilinger K.

Alcohol Clin Exp Res. 2017 May;41(5):883-894. doi: 10.1111/acer.13361. Epub 2017 Mar 27.


Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice.

Feng T, Dzieran J, Yuan X, Dropmann A, Maass T, Teufel A, Marhenke S, Gaiser T, Rückert F, Kleiter I, Kanzler S, Ebert MP, Vogel A, Ten Dijke P, Dooley S, Meindl-Beinker NM.

Oncogenesis. 2017 Jan 30;6(1):e294. doi: 10.1038/oncsis.2016.85.

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