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Items: 36

1.

Bridging immunogenetics and immunoproteomics: Model positional scanning library analysis for Major Histocompatibility Complex class II DQ in Tursiops truncatus.

Dooley CT, Ferrer T, Pagán H, O'Corry-Crowe GM.

PLoS One. 2018 Aug 2;13(8):e0201299. doi: 10.1371/journal.pone.0201299. eCollection 2018.

2.

A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation.

Shao J, Houghten RA, Dooley CT, Cazares M, McLaughlin JP, Eans SO, Ganno ML, Hoot MR, Giulianotti MA, Yu Y.

Org Biomol Chem. 2017 Sep 26;15(37):7796-7801. doi: 10.1039/c7ob01924f.

PMID:
28875208
3.

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.

Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L.

ACS Comb Sci. 2016 Jan 11;18(1):51-64. doi: 10.1021/acscombsci.5b00126. Epub 2016 Jan 5.

4.

Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors.

Eans SO, Ganno ML, Mizrachi E, Houghten RA, Dooley CT, McLaughlin JP, Nefzi A.

J Med Chem. 2015 Jun 25;58(12):4905-17. doi: 10.1021/jm501637c. Epub 2015 Jun 4.

PMID:
25996309
5.

Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin.

Hammami S, Mighri Z, Dooley CT, Nefzi A.

Bioorg Med Chem Lett. 2014 Sep 15;24(18):4482-4485. doi: 10.1016/j.bmcl.2014.07.090. Epub 2014 Aug 8.

PMID:
25168746
6.

Ligand/kappa-opioid receptor interactions: insights from the X-ray crystal structure.

Martinez-Mayorga K, Byler KG, Yongye AB, Giulianotti MA, Dooley CT, Houghten RA.

Eur J Med Chem. 2013 Aug;66:114-21. doi: 10.1016/j.ejmech.2013.05.021. Epub 2013 May 30.

7.

Fluorescent mu selective opioid ligands from a mixture based cyclic peptide library.

Li Y, Dooley CT, Misler JA, Debevec G, Giulianotti MA, Cazares ME, Maida L, Houghten RA.

ACS Comb Sci. 2012 Dec 10;14(12):673-9. doi: 10.1021/co300110t. Epub 2012 Nov 8.

8.

A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries.

Giulianotti MA, Debevec G, Santos RG, Maida LE, Chen W, Ou L, Yu Y, Dooley CT, Houghten RA.

ACS Comb Sci. 2012 Sep 10;14(9):503-12. doi: 10.1021/co300060s. Epub 2012 Aug 28.

9.

Toxicity of 6-hydroxydopamine: live cell imaging of cytoplasmic redox flux.

Dooley CT, Li L, Misler JA, Thompson JH.

Cell Biol Toxicol. 2012 Apr;28(2):89-101. doi: 10.1007/s10565-011-9209-3. Epub 2012 Jan 8.

PMID:
22228498
10.

Use and implications of the harmonic mean model on mixtures for basic research and drug discovery.

Santos RG, Giulianotti MA, Dooley CT, Pinilla C, Appel JR, Houghten RA.

ACS Comb Sci. 2011 May 9;13(3):337-44. doi: 10.1021/co100065a. Epub 2011 Mar 11. Erratum in: ACS Comb Sci.2011 May 9;13(3):344.

11.

Integrating computational and mixture-based screening of combinatorial libraries.

Yongye AB, Pinilla C, Medina-Franco JL, Giulianotti MA, Dooley CT, Appel JR, Nefzi A, Scior T, Houghten RA, Martínez-Mayorga K.

J Mol Model. 2011 Jun;17(6):1473-82. doi: 10.1007/s00894-010-0850-1. Epub 2010 Sep 21.

PMID:
20853183
12.

Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library.

Reilley KJ, Giulianotti M, Dooley CT, Nefzi A, McLaughlin JP, Houghten RA.

AAPS J. 2010 Sep;12(3):318-29. doi: 10.1208/s12248-010-9191-3. Epub 2010 Apr 27.

13.

Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.

Yongye AB, Appel JR, Giulianotti MA, Dooley CT, Medina-Franco JL, Nefzi A, Houghten RA, Martínez-Mayorga K.

Bioorg Med Chem. 2009 Aug 1;17(15):5583-97. doi: 10.1016/j.bmc.2009.06.026. Epub 2009 Jun 21.

14.

The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries.

Nagasaki H, Chung S, Dooley CT, Wang Z, Li C, Saito Y, Clark SD, Houghten RA, Civelli O.

Eur J Pharmacol. 2009 Jan 14;602(2-3):194-202. doi: 10.1016/j.ejphar.2008.10.068. Epub 2008 Nov 17.

15.

Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.

Martínez-Mayorga K, Medina-Franco JL, Giulianotti MA, Pinilla C, Dooley CT, Appel JR, Houghten RA.

Bioorg Med Chem. 2008 Jun 1;16(11):5932-8. doi: 10.1016/j.bmc.2008.04.061. Epub 2008 Apr 27.

16.

Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.

Houghten RA, Pinilla C, Giulianotti MA, Appel JR, Dooley CT, Nefzi A, Ostresh JM, Yu Y, Maggiora GM, Medina-Franco JL, Brunner D, Schneider J.

J Comb Chem. 2008 Jan-Feb;10(1):3-19. Epub 2007 Dec 8. No abstract available.

PMID:
18067268
18.

Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries.

Nefzi A, Ostresh JM, Appel JR, Bidlack J, Dooley CT, Houghten RA.

Bioorg Med Chem Lett. 2006 Aug 15;16(16):4331-8. Epub 2006 Jun 5.

PMID:
16750366
19.
20.

Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators.

Dooley CT, Dore TM, Hanson GT, Jackson WC, Remington SJ, Tsien RY.

J Biol Chem. 2004 May 21;279(21):22284-93. Epub 2004 Feb 25.

21.

Orphanin FQ/nociceptin receptor binding studies.

Dooley CT, Houghten RA.

Peptides. 2000 Jul;21(7):949-60. Review.

PMID:
10998528
22.

New opioid peptides, peptidomimetics, and heterocyclic compounds from combinatorial libraries.

Dooley CT, Houghten RA.

Biopolymers. 1999;51(6):379-90. Review.

PMID:
10797228
23.

Mixture-based synthetic combinatorial libraries.

Houghten RA, Pinilla C, Appel JR, Blondelle SE, Dooley CT, Eichler J, Nefzi A, Ostresh JM.

J Med Chem. 1999 Sep 23;42(19):3743-78. Review. No abstract available.

PMID:
10508425
25.

Synthesis and screening of positional scanning combinatorial libraries.

Dooley CT, Houghten RA.

Methods Mol Biol. 1998;87:13-24. No abstract available.

PMID:
9523255
26.

Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.

Dooley CT, Spaeth CG, Berzetei-Gurske IP, Craymer K, Adapa ID, Brandt SR, Houghten RA, Toll L.

J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.

PMID:
9353393
27.

Libraries from libraries: generation and comparison of screening profiles.

Houghten RA, Blondelle SE, Dooley CT, Dörner B, Eichler J, Ostresh JM.

Mol Divers. 1996 Oct;2(1-2):41-5.

PMID:
9238632
28.
29.

Peptide, peptidomimetic, and organic synthetic combinatorial libraries.

Eichler J, Appel JR, Blondelle SE, Dooley CT, Dörner B, Ostresh JM, Pérez-Payá E, Pinilla C, Houghten RA.

Med Res Rev. 1995 Nov;15(6):481-96. Review. No abstract available.

PMID:
8558988
30.

Six highly active mu-selective opioid peptides identified from two synthetic combinatorial libraries.

Dooley CT, Kaplan RA, Chung NN, Schiller PW, Bidlack JM, Houghten RA.

Pept Res. 1995 May-Jun;8(3):124-37.

PMID:
7670227
31.

An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library.

Dooley CT, Chung NN, Wilkes BC, Schiller PW, Bidlack JM, Pasternak GW, Houghten RA.

Science. 1994 Dec 23;266(5193):2019-22.

PMID:
7801131
32.

Acetalins: opioid receptor antagonists determined through the use of synthetic peptide combinatorial libraries.

Dooley CT, Chung NN, Schiller PW, Houghten RA.

Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10811-5.

34.

Synthetic peptide combinatorial libraries may be used to determine peptide ligands for opioid receptors.

Houghten RA, Dooley CT.

NIDA Res Monogr. 1993;134:66-74. No abstract available.

PMID:
8289887
35.

The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides.

Houghten RA, Appel JR, Blondelle SE, Cuervo JH, Dooley CT, Pinilla C.

Biotechniques. 1992 Sep;13(3):412-21.

PMID:
1382470
36.

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery.

Houghten RA, Pinilla C, Blondelle SE, Appel JR, Dooley CT, Cuervo JH.

Nature. 1991 Nov 7;354(6348):84-6.

PMID:
1719428

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