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Items: 1 to 50 of 155

1.

Protective Immunity against Severe Malaria in Children Is Associated with a Limited Repertoire of Antibodies to Conserved PfEMP1 Variants.

Tessema SK, Nakajima R, Jasinskas A, Monk SL, Lekieffre L, Lin E, Kiniboro B, Proietti C, Siba P, Felgner PL, Doolan DL, Mueller I, Barry AE.

Cell Host Microbe. 2019 Nov 13;26(5):579-590.e5. doi: 10.1016/j.chom.2019.10.012.

PMID:
31726028
2.

The Association between the Comprehensive Epstein-Barr Virus Serologic Profile and Endemic Burkitt Lymphoma.

Coghill AE, Proietti C, Liu Z, Krause L, Bethony J, Prokunina-Olsson L, Obajemu A, Nkrumah F, Biggar RJ, Bhatia K, Hildesheim A, Doolan DL, Mbulaiteye SM.

Cancer Epidemiol Biomarkers Prev. 2019 Oct 16. doi: 10.1158/1055-9965.EPI-19-0551. [Epub ahead of print]

PMID:
31619404
3.

Casting a Wide Net around Immunity to Malaria Catches p53.

Cooper MM, Loiseau C, Doolan DL.

Immunity. 2019 Oct 15;51(4):603-605. doi: 10.1016/j.immuni.2019.09.011.

PMID:
31618652
4.

Evaluation of the antibody response to the EBV proteome in EBV-associated classical Hodgkin lymphoma.

Liu Z, Jarrett RF, Hjalgrim H, Proietti C, Chang ET, Smedby KE, Yu KJ, Lake A, Troy S, McAulay KA, Pfeiffer RM, Adami HO, Glimelius B, Melbye M, Hildesheim A, Doolan DL, Coghill AE.

Int J Cancer. 2019 Oct 16. doi: 10.1002/ijc.32741. [Epub ahead of print]

PMID:
31618442
5.

Deciphering host immunity to malaria using systems immunology.

Loiseau C, Cooper MM, Doolan DL.

Immunol Rev. 2019 Oct 14. doi: 10.1111/imr.12814. [Epub ahead of print] Review.

PMID:
31608461
6.

IgM in human immunity to Plasmodium falciparum malaria.

Boyle MJ, Chan JA, Handayuni I, Reiling L, Feng G, Hilton A, Kurtovic L, Oyong D, Piera KA, Barber BE, William T, Eisen DP, Minigo G, Langer C, Drew DR, de Labastida Rivera F, Amante FH, Williams TN, Kinyanjui S, Marsh K, Doolan DL, Engwerda C, Fowkes FJI, Grigg MJ, Mueller I, McCarthy JS, Anstey NM, Beeson JG.

Sci Adv. 2019 Sep 25;5(9):eaax4489. doi: 10.1126/sciadv.aax4489. eCollection 2019 Sep.

7.

2018 ISV Congress: advances in the 100 years since the world's deadliest pandemic.

Doolan DL, Ross TM.

Hum Vaccin Immunother. 2019;15(9):2006-2008. doi: 10.1080/21645515.2019.1660544. No abstract available.

8.

Multilaboratory Assessment of Epstein-Barr Virus Serologic Assays: the Case for Standardization.

Liu Z, Yu KJ, Coghill AE, Brenner N, Cao SM, Chen CJ, Chen Y, Doolan DL, Hsu WL, Labo N, Middeldorp JM, Miley W, Simon J, Wang CP, Waterboer T, Whitby D, Xie SH, Ye W, Hildesheim A.

J Clin Microbiol. 2019 Oct 23;57(11). pii: e01107-19. doi: 10.1128/JCM.01107-19. Print 2019 Nov.

PMID:
31434722
9.

Chimeric Murine Polyomavirus Virus-Like Particles Induce Plasmodium Antigen-Specific CD8+ T Cell and Antibody Responses.

Pattinson DJ, Apte SH, Wibowo N, Chuan YP, Rivera-Hernandez T, Groves PL, Lua LH, Middelberg APJ, Doolan DL.

Front Cell Infect Microbiol. 2019 Jun 19;9:215. doi: 10.3389/fcimb.2019.00215. eCollection 2019.

10.

Human challenge models: tools to accelerate the development of malaria vaccines.

Cooper MM, Loiseau C, McCarthy JS, Doolan DL.

Expert Rev Vaccines. 2019 Mar;18(3):241-251. doi: 10.1080/14760584.2019.1580577. Epub 2019 Feb 27. Review.

PMID:
30732492
11.

Identification of Cytauxzoon felis antigens via protein microarray and assessment of expression library immunization against cytauxzoonosis.

Schreeg ME, Marr HS, Tarigo JL, Sherrill MK, Outi HK, Scholl EH, Bird DM, Vigil A, Hung C, Nakajima R, Liang L, Trieu A, Doolan DL, Thomas JE, Levy MG, Reichard MV, Felgner PL, Cohn LA, Birkenheuer AJ.

Clin Proteomics. 2018 Dec 29;15:44. doi: 10.1186/s12014-018-9218-9. eCollection 2018.

12.

Defined Small Molecules Produced by Himalayan Medicinal Plants Display Immunomodulatory Properties.

Wangchuk P, Apte SH, Smout MJ, Groves PL, Loukas A, Doolan DL.

Int J Mol Sci. 2018 Nov 6;19(11). pii: E3490. doi: 10.3390/ijms19113490.

13.

A Balanced Proinflammatory and Regulatory Cytokine Signature in Young African Children Is Associated With Lower Risk of Clinical Malaria.

Dobaño C, Nhabomba AJ, Manaca MN, Berthoud T, Aguilar R, Quintó L, Barbosa A, Rodríguez MH, Jiménez A, Groves PL, Santano R, Bassat Q, Aponte JJ, Guinovart C, Doolan DL, Alonso PL.

Clin Infect Dis. 2019 Aug 16;69(5):820-828. doi: 10.1093/cid/ciy934.

PMID:
30380038
14.

ISV Congress back to Europe.

Doolan DL, Lu S.

Hum Vaccin Immunother. 2018;14(9):2101-2104. doi: 10.1080/21645515.2018.1518065. No abstract available.

15.

Anomalies in T Cell Function Are Associated With Individuals at Risk of Mycobacterium abscessus Complex Infection.

Lutzky VP, Ratnatunga CN, Smith DJ, Kupz A, Doolan DL, Reid DW, Thomson RM, Bell SC, Miles JJ.

Front Immunol. 2018 Jun 11;9:1319. doi: 10.3389/fimmu.2018.01319. eCollection 2018.

16.

High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection.

Dobaño C, Berthoud T, Manaca MN, Nhabomba A, Guinovart C, Aguilar R, Barbosa A, Groves P, Rodríguez MH, Jimenez A, Quimice LM, Aponte JJ, Ordi J, Doolan DL, Mayor A, Alonso PL.

Malar J. 2018 May 10;17(1):177. doi: 10.1186/s12936-018-2317-2.

17.

Influence of Physicochemical Properties of Lipopeptide Adjuvants on the Immune Response: A Rationale for Engineering a Potent Vaccine.

Eskandari S, Pattinson DJ, Stephenson RJ, Groves PL, Apte SH, Sedaghat B, Chandurudu S, Doolan DL, Toth I.

Chemistry. 2018 Jul 11;24(39):9892-9902. doi: 10.1002/chem.201801378. Epub 2018 Jun 19.

PMID:
29707835
18.

Patterns of Interindividual Variability in the Antibody Repertoire Targeting Proteins Across the Epstein-Barr Virus Proteome.

Liu Z, Coghill AE, Pfeiffer RM, Proietti C, Hsu WL, Chien YC, Lekieffre L, Krause L, Yu KJ, Lou PJ, Wang CP, Mulvenna J, Middeldorp JM, Bethony J, Chen CJ, Doolan DL, Hildesheim A.

J Infect Dis. 2018 May 25;217(12):1923-1931. doi: 10.1093/infdis/jiy122.

19.

Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan.

Coghill AE, Pfeiffer RM, Proietti C, Hsu WL, Chien YC, Lekieffre L, Krause L, Teng A, Pablo J, Yu KJ, Lou PJ, Wang CP, Liu Z, Chen CJ, Middeldorp J, Mulvenna J, Bethony J, Hildesheim A, Doolan DL.

Clin Cancer Res. 2018 Mar 15;24(6):1305-1314. doi: 10.1158/1078-0432.CCR-17-1929. Epub 2018 Jan 4.

20.

Novel Plasmodium antigens identified via genome-based antibody screen induce protection associated with polyfunctional T cell responses.

Schussek S, Trieu A, Apte SH, Sidney J, Sette A, Doolan DL.

Sci Rep. 2017 Nov 8;7(1):15053. doi: 10.1038/s41598-017-15354-0.

21.

Profiling the Targets of Protective CD8+ T Cell Responses to Infection.

Bruder JT, Chen P, Ekberg G, Smith EC, Lazarski CA, Myers BA, Bolton J, Sedegah M, Villasante E, Richie TL, King CR, Aguiar JC, Doolan DL, Brough DE.

Mol Ther Methods Clin Dev. 2017 Aug 18;7:20-31. doi: 10.1016/j.omtm.2017.08.003. eCollection 2017 Dec 15.

22.

Dichotomous miR expression and immune responses following primary blood-stage malaria.

Burel JG, Apte SH, Groves PL, Boyle MJ, Langer C, Beeson JG, McCarthy JS, Doolan DL.

JCI Insight. 2017 Aug 3;2(15). pii: 93434. doi: 10.1172/jci.insight.93434. eCollection 2017 Aug 3.

23.

Plasmacytoid dendritic cells appear inactive during sub-microscopic Plasmodium falciparum blood-stage infection, yet retain their ability to respond to TLR stimulation.

Loughland JR, Minigo G, Sarovich DS, Field M, Tipping PE, Montes de Oca M, Piera KA, Amante FH, Barber BE, Grigg MJ, William T, Good MF, Doolan DL, Engwerda CR, Anstey NM, McCarthy JS, Woodberry T.

Sci Rep. 2017 Jun 1;7(1):2596. doi: 10.1038/s41598-017-02096-2.

24.

Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1c+ Myeloid Dendritic Cell Maturation Arrest, Induction of the Kynurenine Pathway, and Regulatory T Cell Activation.

Woodberry T, Loughland JR, Minigo G, Burel JG, Amante FH, Piera KA, McNeil Y, Yeo TW, Good MF, Doolan DL, Engwerda CR, McCarthy JS, Anstey NM.

Infect Immun. 2017 May 23;85(6). pii: e00986-16. doi: 10.1128/IAI.00986-16. Print 2017 Jun.

25.

Polyfunctional and IFN-γ monofunctional human CD4+ T cell populations are molecularly distinct.

Burel JG, Apte SH, Groves PL, McCarthy JS, Doolan DL.

JCI Insight. 2017 Feb 9;2(3):e87499. doi: 10.1172/jci.insight.87499.

26.

A Plasmodium vivax Plasmid DNA- and Adenovirus-Vectored Malaria Vaccine Encoding Blood-Stage Antigens AMA1 and MSP142 in a Prime/Boost Heterologous Immunization Regimen Partially Protects Aotus Monkeys against Blood-Stage Challenge.

Obaldia N 3rd, Stockelman MG, Otero W, Cockrill JA, Ganeshan H, Abot EN, Zhang J, Limbach K, Charoenvit Y, Doolan DL, Tang DC, Richie TL.

Clin Vaccine Immunol. 2017 Apr 5;24(4). pii: e00539-16. doi: 10.1128/CVI.00539-16. Print 2017 Apr.

27.

Plasmodium vivax but Not Plasmodium falciparum Blood-Stage Infection in Humans Is Associated with the Expansion of a CD8+ T Cell Population with Cytotoxic Potential.

Burel JG, Apte SH, McCarthy JS, Doolan DL.

PLoS Negl Trop Dis. 2016 Dec 8;10(12):e0005031. doi: 10.1371/journal.pntd.0005031. eCollection 2016 Dec.

28.

Mining, visualizing and comparing multidimensional biomolecular data using the Genomics Data Miner (GMine) Web-Server.

Proietti C, Zakrzewski M, Watkins TS, Berger B, Hasan S, Ratnatunga CN, Brion MJ, Crompton PD, Miles JJ, Doolan DL, Krause L.

Sci Rep. 2016 Dec 6;6:38178. doi: 10.1038/srep38178.

29.

Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection.

Montes de Oca M, Kumar R, Rivera FL, Amante FH, Sheel M, Faleiro RJ, Bunn PT, Best SE, Beattie L, Ng SS, Edwards CL, Boyle GM, Price RN, Anstey NM, Loughland JR, Burel J, Doolan DL, Haque A, McCarthy JS, Engwerda CR.

Cell Rep. 2016 Oct 4;17(2):399-412. doi: 10.1016/j.celrep.2016.09.015.

30.

Reduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ Production.

Burel JG, Apte SH, Groves PL, Klein K, McCarthy JS, Doolan DL.

PLoS Pathog. 2016 Sep 23;12(9):e1005839. doi: 10.1371/journal.ppat.1005839. eCollection 2016 Sep.

31.

Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity.

Hickey BW, Lumsden JM, Reyes S, Sedegah M, Hollingdale MR, Freilich DA, Luke TC, Charoenvit Y, Goh LM, Berzins MP, Bebris L, Sacci JB Jr, De La Vega P, Wang R, Ganeshan H, Abot EN, Carucci DJ, Doolan DL, Brice GT, Kumar A, Aguiar J, Nutman TB, Leitman SF, Hoffman SL, Epstein JE, Richie TL.

Malar J. 2016 Jul 22;15(1):377. doi: 10.1186/s12936-016-1435-y.

32.

Chemically Attenuated Blood-Stage Plasmodium yoelii Parasites Induce Long-Lived and Strain-Transcending Protection.

Raja AI, Cai Y, Reiman JM, Groves P, Chakravarty S, McPhun V, Doolan DL, Cockburn I, Hoffman SL, Stanisic DI, Good MF.

Infect Immun. 2016 Jul 21;84(8):2274-2288. doi: 10.1128/IAI.00157-16. Print 2016 Aug.

33.

Development of a cytokine-secreting-based assay for the identification, sorting and transcriptomic analysis of polyfunctional human T cells.

Burel JG, Apte SH, Doolan DL.

Eur Cytokine Netw. 2015 Oct-Dec;26(4):67-72. doi: 10.1684/ecn.2015.0369.

34.

Profoundly Reduced CD1c+ Myeloid Dendritic Cell HLA-DR and CD86 Expression and Increased Tumor Necrosis Factor Production in Experimental Human Blood-Stage Malaria Infection.

Loughland JR, Minigo G, Burel J, Tipping PE, Piera KA, Amante FH, Engwerda CR, Good MF, Doolan DL, Anstey NM, McCarthy JS, Woodberry T.

Infect Immun. 2016 Apr 22;84(5):1403-1412. doi: 10.1128/IAI.01522-15. Print 2016 May.

35.

Immunomics: a 21st century approach to vaccine development for complex pathogens.

De Sousa KP, Doolan DL.

Parasitology. 2016 Feb;143(2):236-44. doi: 10.1017/S0031182015001079. Review.

PMID:
26864136
36.

Defining the targets of antiparasitic compounds.

Skinner-Adams TS, Sumanadasa SD, Fisher GM, Davis RA, Doolan DL, Andrews KT.

Drug Discov Today. 2016 May;21(5):725-39. doi: 10.1016/j.drudis.2016.01.002. Epub 2016 Jan 16. Review.

PMID:
26784142
37.

Synthesis of Mannosylated Lipopeptides with Receptor Targeting Properties.

Sedaghat B, Stephenson RJ, Giddam AK, Eskandari S, Apte SH, Pattinson DJ, Doolan DL, Toth I.

Bioconjug Chem. 2016 Mar 16;27(3):533-48. doi: 10.1021/acs.bioconjchem.5b00547. Epub 2016 Jan 25.

PMID:
26735314
38.

Systems Approaches towards Molecular Profiling of Human Immunity.

Burel JG, Apte SH, Doolan DL.

Trends Immunol. 2016 Jan;37(1):53-67. doi: 10.1016/j.it.2015.11.006. Epub 2015 Dec 5. Review.

PMID:
26669258
39.

Systematic evaluation of self-adjuvanting lipopeptide nano-vaccine platforms for the induction of potent CD8(+) T-cell responses.

Apte SH, Stephenson RJ, Simerska P, Groves PL, Aljohani S, Eskandari S, Toth I, Doolan DL.

Nanomedicine (Lond). 2016 Jan;11(2):137-52. doi: 10.2217/nnm.15.184. Epub 2015 Dec 11.

PMID:
26653407
40.

Large screen approaches to identify novel malaria vaccine candidates.

Davies DH, Duffy P, Bodmer JL, Felgner PL, Doolan DL.

Vaccine. 2015 Dec 22;33(52):7496-505. doi: 10.1016/j.vaccine.2015.09.059. Epub 2015 Oct 1. Review.

41.

Antibody Signatures Reflect Different Disease Pathologies in Patients With Schistosomiasis Due to Schistosoma japonicum.

Driguez P, Li Y, Gaze S, Pearson MS, Nakajima R, Trieu A, Doolan DL, Felgner PL, Hou X, Cardoso FC, Jasinskas A, Gobert GN, Loukas A, McManus DP.

J Infect Dis. 2016 Jan 1;213(1):122-30. doi: 10.1093/infdis/jiv356. Epub 2015 Jul 6.

PMID:
26150545
42.

Specific humoral response of hosts with variable schistosomiasis susceptibility.

Driguez P, McWilliam HE, Gaze S, Piedrafita D, Pearson MS, Nakajima R, Duke M, Trieu A, Doolan DL, Cardoso FC, Jasinskas A, Gobert GN, Felgner PL, Loukas A, Meeusen E, McManus DP.

Immunol Cell Biol. 2016 Jan;94(1):52-65. doi: 10.1038/icb.2015.61. Epub 2015 Jun 5.

PMID:
26044065
43.

Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates.

Pearson MS, Becker L, Driguez P, Young ND, Gaze S, Mendes T, Li XH, Doolan DL, Midzi N, Mduluza T, McManus DP, Wilson RA, Bethony JM, Nausch N, Mutapi F, Felgner PL, Loukas A.

Front Immunol. 2015 May 5;6:213. doi: 10.3389/fimmu.2015.00213. eCollection 2015.

44.

The case for a rational genome-based vaccine against malaria.

Proietti C, Doolan DL.

Front Microbiol. 2015 Jan 22;5:741. doi: 10.3389/fmicb.2014.00741. eCollection 2014. Review.

45.

Synthesis and characterisation of self-assembled and self-adjuvanting asymmetric multi-epitope lipopeptides of ovalbumin.

Eskandari S, Stephenson RJ, Fuaad AA, Apte SH, Doolan DL, Toth I.

Chemistry. 2015 Jan 12;21(3):1251-61. doi: 10.1002/chem.201404997. Epub 2014 Nov 14.

PMID:
25399845
46.

Protein microarrays for parasite antigen discovery.

Driguez P, Doolan DL, Molina DM, Loukas A, Trieu A, Felgner PL, McManus DP.

Methods Mol Biol. 2015;1201:221-33. doi: 10.1007/978-1-4939-1438-8_13.

PMID:
25388117
47.

Genome-based vaccine design: the promise for malaria and other infectious diseases.

Doolan DL, Apte SH, Proietti C.

Int J Parasitol. 2014 Oct 15;44(12):901-13. doi: 10.1016/j.ijpara.2014.07.010. Epub 2014 Sep 6. Review.

48.

Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling.

Tribolet L, Cantacessi C, Pickering DA, Navarro S, Doolan DL, Trieu A, Fei H, Chao Y, Hofmann A, Gasser RB, Giacomin PR, Loukas A.

J Infect Dis. 2015 Feb 1;211(3):416-25. doi: 10.1093/infdis/jiu451. Epub 2014 Aug 19.

PMID:
25139017
49.

An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas.

Gaze S, Driguez P, Pearson MS, Mendes T, Doolan DL, Trieu A, McManus DP, Gobert GN, Periago MV, Correa Oliveira R, Cardoso FC, Oliveira G, Nakajima R, Jasinskas A, Hung C, Liang L, Pablo J, Bethony JM, Felgner PL, Loukas A.

PLoS Pathog. 2014 Mar 27;10(3):e1004033. doi: 10.1371/journal.ppat.1004033. eCollection 2014 Mar.

50.

Genome- and proteome-wide screening strategies for antigen discovery and immunogen design.

Schussek S, Trieu A, Doolan DL.

Biotechnol Adv. 2014 Mar-Apr;32(2):403-14. doi: 10.1016/j.biotechadv.2013.12.006. Epub 2014 Jan 2. Review.

PMID:
24389084

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