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Items: 30


Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.

Stephenson S, Care MA, Fan I, Zougman A, Westhead DR, Doody GM, Tooze RM.

J Immunol. 2019 Feb 15;202(4):1287-1300. doi: 10.4049/jimmunol.1801407. Epub 2019 Jan 14.


Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity.

Al-Maskari M, Care MA, Robinson E, Cocco M, Tooze RM, Doody GM.

Sci Rep. 2018 Sep 25;8(1):14338. doi: 10.1038/s41598-018-32705-7.


Transforming Growth Factor ╬▓ Activation Primes Canonical Wnt Signaling Through Down-Regulation of Axin-2.

Gillespie J, Ross RL, Corinaldesi C, Esteves F, Derrett-Smith E, McDermott MF, Doody GM, Denton CP, Emery P, Del Galdo F.

Arthritis Rheumatol. 2018 Jun;70(6):932-942. doi: 10.1002/art.40437. Epub 2018 Apr 23.


Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia.

Varghese AM, Rawstron A, Newton D, Tooze RM, Munir T, Dickson M, Doody GM, Hillmen P.

Br J Haematol. 2018 Sep;182(6):927-930. doi: 10.1111/bjh.14884. Epub 2017 Aug 2. No abstract available.


Early Emergence of CD19-Negative Human Antibody-Secreting Cells at the Plasmablast to Plasma Cell Transition.

Arumugakani G, Stephenson SJ, Newton DJ, Rawstron A, Emery P, Doody GM, McGonagle D, Tooze RM.

J Immunol. 2017 Jun 15;198(12):4618-4628. doi: 10.4049/jimmunol.1501761. Epub 2017 May 10.


Biallelic mutations in IRF8 impair human NK cell maturation and function.

Mace EM, Bigley V, Gunesch JT, Chinn IK, Angelo LS, Care MA, Maisuria S, Keller MD, Togi S, Watkin LB, LaRosa DF, Jhangiani SN, Muzny DM, Stray-Pedersen A, Coban Akdemir Z, Smith JB, Hernández-Sanabria M, Le DT, Hogg GD, Cao TN, Freud AG, Szymanski EP, Savic S, Collin M, Cant AJ, Gibbs RA, Holland SM, Caligiuri MA, Ozato K, Paust S, Doody GM, Lupski JR, Orange JS.

J Clin Invest. 2017 Jan 3;127(1):306-320. doi: 10.1172/JCI86276. Epub 2016 Nov 28.


Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity.

Care MA, Stephenson SJ, Barnes NA, Fan I, Zougman A, El-Sherbiny YM, Vital EM, Westhead DR, Tooze RM, Doody GM.

J Immunol. 2016 Aug 15;197(4):1447-59. doi: 10.4049/jimmunol.1600624. Epub 2016 Jun 29.


Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans.

Vieira Braga FA, Hertoghs KM, Kragten NA, Doody GM, Barnes NA, Remmerswaal EB, Hsiao CC, Moerland PD, Wouters D, Derks IA, van Stijn A, Demkes M, Hamann J, Eldering E, Nolte MA, Tooze RM, ten Berge IJ, van Gisbergen KP, van Lier RA.

Eur J Immunol. 2015 Oct;45(10):2945-58. doi: 10.1002/eji.201545650. Epub 2015 Sep 7.


Natural killer (NK) cell function in paroxysmal nocturnal hemoglobinuria: a deficiency of NK cells, but not an NK cell deficiency.

El-Sherbiny YM, Doody GM, Kelly RJ, Hill A, Hillmen P, Cook GP.

Blood. 2015 Feb 19;125(8):1351-2. doi: 10.1182/blood-2014-07-591255. No abstract available.


SPIB and BATF provide alternate determinants of IRF4 occupancy in diffuse large B-cell lymphoma linked to disease heterogeneity.

Care MA, Cocco M, Laye JP, Barnes N, Huang Y, Wang M, Barrans S, Du M, Jack A, Westhead DR, Doody GM, Tooze RM.

Nucleic Acids Res. 2014 Jul;42(12):7591-610. doi: 10.1093/nar/gku451. Epub 2014 May 29.


TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes.

Savic S, Ouboussad L, Dickie LJ, Geiler J, Wong C, Doody GM, Churchman SM, Ponchel F, Emery P, Cook GP, Buch MH, Tooze RM, McDermott MF.

J Autoimmun. 2014 May;50:59-66. doi: 10.1016/j.jaut.2013.11.002. Epub 2013 Dec 31.


Altered natural killer cell subset homeostasis and defective chemotactic responses in paroxysmal nocturnal hemoglobinuria.

El-Sherbiny YM, Kelly RJ, Hill A, Doody GM, Hillmen P, Cook GP.

Blood. 2013 Sep 12;122(11):1887-90. doi: 10.1182/blood-2013-06-507574. Epub 2013 Jul 23.


In vitro generation of long-lived human plasma cells.

Cocco M, Stephenson S, Care MA, Newton D, Barnes NA, Davison A, Rawstron A, Westhead DR, Doody GM, Tooze RM.

J Immunol. 2012 Dec 15;189(12):5773-85. doi: 10.4049/jimmunol.1103720. Epub 2012 Nov 16.


BLIMP-1 and STAT3 counterregulate microRNA-21 during plasma cell differentiation.

Barnes NA, Stephenson S, Cocco M, Tooze RM, Doody GM.

J Immunol. 2012 Jul 1;189(1):253-60. doi: 10.4049/jimmunol.1101563. Epub 2012 May 25.


An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression.

Doody GM, Care MA, Burgoyne NJ, Bradford JR, Bota M, Bonifer C, Westhead DR, Tooze RM.

Nucleic Acids Res. 2010 Sep;38(16):5336-50. doi: 10.1093/nar/gkq268. Epub 2010 Apr 26.


Amino acid deprivation links BLIMP-1 to the immunomodulatory enzyme indoleamine 2,3-dioxygenase.

Barnes NA, Stephenson SJ, Tooze RM, Doody GM.

J Immunol. 2009 Nov 1;183(9):5768-77. doi: 10.4049/jimmunol.0803480. Epub 2009 Oct 14.


PRDM1/BLIMP-1 modulates IFN-gamma-dependent control of the MHC class I antigen-processing and peptide-loading pathway.

Doody GM, Stephenson S, McManamy C, Tooze RM.

J Immunol. 2007 Dec 1;179(11):7614-23.


BLIMP-1 is a target of cellular stress and downstream of the unfolded protein response.

Doody GM, Stephenson S, Tooze RM.

Eur J Immunol. 2006 Jun;36(6):1572-82.


Marker gene transfer into human haemopoietic cells using a herpesvirus saimiri-based vector.

Doody GM, Leek JP, Bali AK, Ensser A, Markham AF, de Wynter EA.

Gene Ther. 2005 Feb;12(4):373-9.


Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C.

Pearce AC, Wilde JI, Doody GM, Best D, Inoue O, Vigorito E, Tybulewicz VL, Turner M, Watson SP.

Blood. 2002 Nov 15;100(10):3561-9.


Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation.

Doody GM, Bell SE, Vigorito E, Clayton E, McAdam S, Tooze R, Fernandez C, Lee IJ, Turner M.

Nat Immunol. 2001 Jun;2(6):542-7.


Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes.

Doody GM, Billadeau DD, Clayton E, Hutchings A, Berland R, McAdam S, Leibson PJ, Turner M.

EMBO J. 2000 Nov 15;19(22):6173-84.


Inhibition of the B cell by CD22: a requirement for Lyn.

Smith KG, Tarlinton DM, Doody GM, Hibbs ML, Fearon DT.

J Exp Med. 1998 Mar 2;187(5):807-11.


Avermectin toxicity in the dog.

Doody GM.

Vet Rec. 1997 Jun 7;140(23):611-2. No abstract available.


Activation of B lymphocytes: integrating signals from CD19, CD22 and Fc gamma RIIb1.

Doody GM, Dempsey PW, Fearon DT.

Curr Opin Immunol. 1996 Jun;8(3):378-82. Review.


A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP.

Doody GM, Justement LB, Delibrias CC, Matthews RJ, Lin J, Thomas ML, Fearon DT.

Science. 1995 Jul 14;269(5221):242-4.


Non-specific pruritus in dogs.

Doody GM.

Vet Rec. 1990 Mar 17;126(11):273-4. No abstract available.


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