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Items: 1 to 50 of 91

1.

TGFβ, Fibronectin and Integrin α5β1 Promote Invasion in Basal Cell Carcinoma.

Kuonen F, Surbeck I, Sarin KY, Dontenwill M, Rüegg C, Gilliet M, Oro AE, Gaide O.

J Invest Dermatol. 2018 Jul 14. pii: S0022-202X(18)31966-3. doi: 10.1016/j.jid.2018.04.029. [Epub ahead of print]

PMID:
29758283
2.

Selection of Nucleic Acid Aptamers Targeting Tumor Cell-Surface Protein Biomarkers.

Mercier MC, Dontenwill M, Choulier L.

Cancers (Basel). 2017 Jun 21;9(6). pii: E69. doi: 10.3390/cancers9060069. Review.

3.

Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells.

Renner G, Noulet F, Mercier MC, Choulier L, Etienne-Selloum N, Gies JP, Lehmann M, Lelong-Rebel I, Martin S, Dontenwill M.

Oncotarget. 2016 Sep 20;7(38):62194-62207. doi: 10.18632/oncotarget.11552.

4.

Formation of multicellular tumor spheroids induced by cyclic RGD-peptides and use for anticancer drug testing in vitro.

Akasov R, Zaytseva-Zotova D, Burov S, Leko M, Dontenwill M, Chiper M, Vandamme T, Markvicheva E.

Int J Pharm. 2016 Jun 15;506(1-2):148-57. doi: 10.1016/j.ijpharm.2016.04.005. Epub 2016 Apr 20.

PMID:
27107900
5.

Glioma cell dispersion is driven by α5 integrin-mediated cell-matrix and cell-cell interactions.

Blandin AF, Noulet F, Renner G, Mercier MC, Choulier L, Vauchelles R, Ronde P, Carreiras F, Etienne-Selloum N, Vereb G, Lelong-Rebel I, Martin S, Dontenwill M, Lehmann M.

Cancer Lett. 2016 Jul 1;376(2):328-38. doi: 10.1016/j.canlet.2016.04.007. Epub 2016 Apr 8.

PMID:
27063097
6.

β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer.

Blandin AF, Renner G, Lehmann M, Lelong-Rebel I, Martin S, Dontenwill M.

Front Pharmacol. 2015 Nov 24;6:279. doi: 10.3389/fphar.2015.00279. eCollection 2015. Review.

7.

Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties.

Jung AC, Ray AM, Ramolu L, Macabre C, Simon F, Noulet F, Blandin AF, Renner G, Lehmann M, Choulier L, Kessler H, Abecassis J, Dontenwill M, Martin S.

Oncotarget. 2015 Dec 8;6(39):41884-901. doi: 10.18632/oncotarget.6099.

8.

Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma.

Renner G, Janouskova H, Noulet F, Koenig V, Guerin E, Bär S, Nuesch J, Rechenmacher F, Neubauer S, Kessler H, Blandin AF, Choulier L, Etienne-Selloum N, Lehmann M, Lelong-Rebel I, Martin S, Dontenwill M.

Cell Death Differ. 2016 Apr;23(4):640-53. doi: 10.1038/cdd.2015.131. Epub 2015 Oct 16.

9.

Single cell tracking assay reveals an opposite effect of selective small non-peptidic α5β1 or αvβ3/β5 integrin antagonists in U87MG glioma cells.

Ray AM, Schaffner F, Janouskova H, Noulet F, Rognan D, Lelong-Rebel I, Choulier L, Blandin AF, Lehmann M, Martin S, Kapp T, Neubauer S, Rechenmacher F, Kessler H, Dontenwill M.

Biochim Biophys Acta. 2014 Sep;1840(9):2978-87. doi: 10.1016/j.bbagen.2014.04.024. Epub 2014 May 5.

PMID:
24810979
10.

Quantitative measurement of delivery and gene silencing activities of siRNA polyplexes containing pyridylthiourea-grafted polyethylenimines.

Pinel S, Aman E, Erblang F, Dietrich J, Frisch B, Sirman J, Kichler A, Sibler AP, Dontenwill M, Schaffner F, Zuber G.

J Control Release. 2014 May 28;182:1-12. doi: 10.1016/j.jconrel.2014.03.001. Epub 2014 Mar 11.

PMID:
24631860
11.

Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors.

Schaffner F, Ray AM, Dontenwill M.

Cancers (Basel). 2013 Jan 15;5(1):27-47. doi: 10.3390/cancers5010027.

12.

Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target α5 integrin in colon cancer cells.

Janouskova H, Ray AM, Noulet F, Lelong-Rebel I, Choulier L, Schaffner F, Lehmann M, Martin S, Teisinger J, Dontenwill M.

Cancer Lett. 2013 Aug 19;336(2):307-18. doi: 10.1016/j.canlet.2013.03.018. Epub 2013 Mar 21.

PMID:
23523610
13.

Integrins and p53 pathways in glioblastoma resistance to temozolomide.

Martin S, Janouskova H, Dontenwill M.

Front Oncol. 2012 Oct 31;2:157. doi: 10.3389/fonc.2012.00157. eCollection 2012.

14.

Methylation of imidazoline related compounds leads to loss of α₂-adrenoceptor affinity. Synthesis and biological evaluation of selective I₁ imidazoline receptor ligands.

Schann S, Greney H, Gasparik V, Dontenwill M, Rascente C, Lacroix G, Monassier L, Bruban V, Feldman J, Ehrhardt JD, Bousquet P.

Bioorg Med Chem. 2012 Aug 1;20(15):4710-5. doi: 10.1016/j.bmc.2012.06.008. Epub 2012 Jun 9.

PMID:
22750139
15.

Integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma.

Janouskova H, Maglott A, Leger DY, Bossert C, Noulet F, Guerin E, Guenot D, Pinel S, Chastagner P, Plenat F, Entz-Werle N, Lehmann-Che J, Godet J, Martin S, Teisinger J, Dontenwill M.

Cancer Res. 2012 Jul 15;72(14):3463-70. doi: 10.1158/0008-5472.CAN-11-4199. Epub 2012 May 16.

16.

Pyridylthiourea-grafted polyethylenimine offers an effective assistance to siRNA-mediated gene silencing in vitro and in vivo.

Creusat G, Thomann JS, Maglott A, Pons B, Dontenwill M, Guérin E, Frisch B, Zuber G.

J Control Release. 2012 Feb 10;157(3):418-26. doi: 10.1016/j.jconrel.2011.10.007. Epub 2011 Oct 12.

PMID:
22019558
17.

Involvement of the TGFβ pathway in the regulation of α5 β1 integrins by caveolin-1 in human glioblastoma.

Cosset EC, Godet J, Entz-Werlé N, Guérin E, Guenot D, Froelich S, Bonnet D, Pinel S, Plenat F, Chastagner P, Dontenwill M, Martin S.

Int J Cancer. 2012 Aug 1;131(3):601-11. doi: 10.1002/ijc.26415. Epub 2011 Oct 5.

18.

Liquid ordered phase in cell membranes evidenced by a hydration-sensitive probe: effects of cholesterol depletion and apoptosis.

Oncul S, Klymchenko AS, Kucherak OA, Demchenko AP, Martin S, Dontenwill M, Arntz Y, Didier P, Duportail G, Mély Y.

Biochim Biophys Acta. 2010 Jul;1798(7):1436-43. doi: 10.1016/j.bbamem.2010.01.013. Epub 2010 Jan 25.

19.

alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells.

Martinkova E, Maglott A, Leger DY, Bonnet D, Stiborova M, Takeda K, Martin S, Dontenwill M.

Int J Cancer. 2010 Sep 1;127(5):1240-8. doi: 10.1002/ijc.25187.

20.

Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells.

Martinkova E, Dontenwill M, Frei E, Stiborova M.

Neuro Endocrinol Lett. 2009;30 Suppl 1:60-6.

PMID:
20027146
21.

Synthetic viruslike particles for targeted gene delivery to alphavbeta3 integrin-presenting endothelial cells.

Zuber G, Dontenwill M, Behr JP.

Mol Pharm. 2009 Sep-Oct;6(5):1544-52. doi: 10.1021/mp900105q.

PMID:
19685893
22.

Caveolin-1 regulates glioblastoma aggressiveness through the control of alpha(5)beta(1) integrin expression and modulates glioblastoma responsiveness to SJ749, an alpha(5)beta(1) integrin antagonist.

Martin S, Cosset EC, Terrand J, Maglott A, Takeda K, Dontenwill M.

Biochim Biophys Acta. 2009 Feb;1793(2):354-67. doi: 10.1016/j.bbamcr.2008.09.019. Epub 2008 Oct 17.

23.

Detection of a hypersialylated beta1 integrin endogenously expressed in the human astrocytoma cell line A172.

Bartik P, Maglott A, Entlicher G, Vestweber D, Takeda K, Martin S, Dontenwill M.

Int J Oncol. 2008 May;32(5):1021-31.

PMID:
18425328
24.

The small alpha5beta1 integrin antagonist, SJ749, reduces proliferation and clonogenicity of human astrocytoma cells.

Maglott A, Bartik P, Cosgun S, Klotz P, Rondé P, Fuhrmann G, Takeda K, Martin S, Dontenwill M.

Cancer Res. 2006 Jun 15;66(12):6002-7.

25.

Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397.

Hamadi A, Bouali M, Dontenwill M, Stoeckel H, Takeda K, Rondé P.

J Cell Sci. 2005 Oct 1;118(Pt 19):4415-25. Epub 2005 Sep 13.

26.

I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells.

Dupuy L, Urosevic D, Greney H, Quaglia W, Pigini M, Brasili L, Dontenwill M, Bousquet P.

Cell Death Differ. 2004 Sep;11(9):1049-52. No abstract available.

27.

IRAS is an anti-apoptotic protein.

Dontenwill M, Piletz JE, Chen M, Baldwin J, Pascal G, Ronde P, Dupuy L, Greney H, Takeda K, Bousquetd P.

Ann N Y Acad Sci. 2003 Dec;1009:400-12.

PMID:
15028619
28.

IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells.

Dontenwill M, Pascal G, Piletz JE, Chen M, Baldwin J, Rondé P, Dupuy L, Urosevic D, Greney H, Takeda K, Bousquet P.

Cell Death Differ. 2003 Aug;10(8):933-5. No abstract available.

29.

Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues.

Gentili F, Bousquet P, Brasili L, Dontenwill M, Feldman J, Ghelfi F, Giannella M, Piergentili A, Quaglia W, Pigini M.

J Med Chem. 2003 May 22;46(11):2169-76.

PMID:
12747788
30.

[125I]2-(2-chloro-4-iodo-phenylamino)-5-methyl-pyrroline (LNP 911), a high-affinity radioligand selective for I1 imidazoline receptors.

Greney H, Urosevic D, Schann S, Dupuy L, Bruban V, Ehrhardt JD, Bousquet P, Dontenwill M.

Mol Pharmacol. 2002 Jul;62(1):181-91.

31.

Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole.

Gentili F, Bousquet P, Brasili L, Caretto M, Carrieri A, Dontenwill M, Giannella M, Marucci G, Perfumi M, Piergentili A, Quaglia W, Rascente C, Pigini M.

J Med Chem. 2002 Jan 3;45(1):32-40.

PMID:
11754577
32.

Differential sensitivity to inverse agonists of GABA(A)/benzodiazepine receptors in rats with genetic absence-epilepsy.

Vergnes M, Boehrer A, He X, Greney H, Dontenwill M, Cook J, Marescaux C.

Epilepsy Res. 2001 Nov;47(1-2):43-53.

PMID:
11673020
33.

Respective contributions of alpha-adrenergic and non-adrenergic mechanisms in the hypotensive effect of imidazoline-like drugs.

Bruban V, Feldman J, Greney H, Dontenwill M, Schann S, Jarry C, Payard M, Boutin J, Scalbert E, Pfeiffer B, Renard P, Vanhoutte P, Bousquet P.

Br J Pharmacol. 2001 May;133(2):261-6.

34.

Imidazoline receptors in cardiovascular and metabolic diseases.

Bousquet P, Dontenwill M, Greney H, Feldman J.

J Cardiovasc Pharmacol. 2000;35(7 Suppl 4):S21-5. Review.

PMID:
11346216
35.

Coupling of I(1) imidazoline receptors to the cAMP pathway: studies with a highly selective ligand, benazoline.

Greney H, Ronde P, Magnier C, Maranca F, Rascente C, Quaglia W, Giannella M, Pigini M, Brasili L, Lugnier C, Bousquet P, Dontenwill M.

Mol Pharmacol. 2000 Jun;57(6):1142-51.

36.

2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors.

Quaglia W, Bousquet P, Pigini M, Carotti A, Carrieri A, Dontenwill M, Gentili F, Giannella M, Maranca F, Piergentili A, Brasili L.

J Med Chem. 1999 Jul 29;42(15):2737-40. No abstract available.

PMID:
10425083
37.

Participation of imidazoline receptors and alpha(2-)-adrenoceptors in the central hypotensive effects of imidazoline-like drugs.

Bousquet P, Bruban V, Schann S, Greney H, Ehrhardt JD, Dontenwill M, Feldman J.

Ann N Y Acad Sci. 1999 Jun 21;881:272-8. Review.

PMID:
10415925
38.

Evidence for presynaptic high affinity imidazoline-specific binding sites in the bovine brainstem.

Heemskerk FM, Dontenwill M, Greney H, Vonthron C, Bousquet P.

Ann N Y Acad Sci. 1999 Jun 21;881:185-8. No abstract available.

PMID:
10415913
39.

Identification of human I1 receptors and their relationship to alpha 2-adrenoceptors.

Dontenwill M, Vonthron C, Greney H, Magnier C, Heemskerk F, Bousquet P.

Ann N Y Acad Sci. 1999 Jun 21;881:123-34.

PMID:
10415908
40.

Binding of tracizolines to the imidazoline receptor. Role of lipophilicity in quantitative structure-activity relationship models.

Pigini M, Bousquet P, Brasili L, Carrieri A, Dontenwill M, Gentili F, Giannella M, Leonetti F, Piergentili A, Quaglia W, Carotti A.

Ann N Y Acad Sci. 1999 Jun 21;881:118-22. No abstract available.

PMID:
10415907
41.

An unexpected central hypertensive effect of the new imidazoline compound benazoline.

Bruban V, Feldman J, Dontenwill M, Greney H, Brasili L, Giannella M, Pigini M, Bousquet P.

Ann N Y Acad Sci. 1999 Jun 21;881:102-5. No abstract available.

PMID:
10415903
42.

Transfected cells expressing the three subtypes of alpha 2-adrenergic receptors lack I1-imidazoline binding sites.

Ordener C, Greney H, Devedjian J, Dontenwill M, Bousquet P, Parini A.

Ann N Y Acad Sci. 1999 Jun 21;881:59-60. No abstract available.

PMID:
10415897
43.

Coexpression of imidazoline receptors and alpha 2-adrenoceptors in neuroglial cell line NG 108,15.

Greney H, Heemskerk F, Vonthron C, Magnier C, Bousquet P, Dontenwill M.

Ann N Y Acad Sci. 1999 Jun 21;881:54-8. No abstract available.

PMID:
10415896
44.

Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models.

Pigini M, Bousquet P, Brasili L, Carrieri A, Cavagna R, Dontenwill M, Gentili F, Giannella M, Leonetti F, Piergentili A, Quaglia W, Carotti A.

Bioorg Med Chem. 1998 Dec;6(12):2245-60.

PMID:
9925287
45.

Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera.

Ivanov TR, Jones JC, Dontenwill M, Bousquet P, Piletz JE.

J Auton Nerv Syst. 1998 Oct 15;72(2-3):98-110.

PMID:
9851558
46.

Does a second generation of centrally acting antihypertensive drugs really exist?

Feldman J, Greney H, Monassier L, Vonthron C, Bruban V, Dontenwill M, Bousquet P.

J Auton Nerv Syst. 1998 Oct 15;72(2-3):94-7. Review.

PMID:
9851557
47.

Evidence for the existence of imidazoline-specific binding sites in synaptosomal plasma membranes of the bovine brainstem.

Heemskerk FM, Dontenwill M, Greney H, Vonthron C, Bousquet P.

J Neurochem. 1998 Nov;71(5):2193-202.

48.

I1-imidazoline receptors: an update.

Bousquet P, Dontenwill M, Greney H, Feldman J.

J Hypertens Suppl. 1998 Aug;16(3):S1-5. Review.

PMID:
9747903
49.

Co-detection by two imidazoline receptor protein antisera of a novel 85 kilodalton protein.

Ivanov TR, Zhu H, Regunathan S, Reis DJ, Dontenwill M, Vonthron C, Bousquet P, Piletz JE.

Biochem Pharmacol. 1998 Mar 1;55(5):649-55.

PMID:
9515575
50.

Imidazoline receptors: qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity.

Pigini M, Bousquet P, Carotti A, Dontenwill M, Giannella M, Moriconi R, Piergentili A, Quaglia W, Tayebati SK, Brasili L.

Bioorg Med Chem. 1997 May;5(5):833-41.

PMID:
9208095

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