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Items: 1 to 50 of 280

1.

Enterotoxigenic Escherichia coli blood group A interactions intensify diarrheal severity.

Kumar P, Kuhlmann FM, Chakroborty S, Bourgeois AL, Foulke-Abel J, Tumala B, Vickers TJ, Sack DA, DeNearing B, Harro CD, Wright WS, Gildersleeve JC, Ciorba MA, Santhanam S, Porter CK, Gutierrez RL, Prouty MG, Riddle MS, Polino A, Sheikh A, Donowitz M, Fleckenstein JM.

J Clin Invest. 2018 May 17. pii: 97659. doi: 10.1172/JCI97659. [Epub ahead of print]

2.

Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation.

Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK.

Cell Rep. 2018 Jan 23;22(4):1003-1015. doi: 10.1016/j.celrep.2017.12.093. Epub 2018 Jan 28.

3.

Identifying the localization and exploring a functional role for Gprc5c in the kidney.

Rajkumar P, Cha B, Yin J, Arend LJ, Păunescu TG, Hirabayashi Y, Donowitz M, Pluznick JL.

FASEB J. 2018 Apr;32(4):2046-2059. doi: 10.1096/fj.201700610RR. Epub 2018 Jan 5.

PMID:
29196502
4.

New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut.

Qiang X, Liotta AS, Shiloach J, Gutierrez JC, Wang H, Ochani M, Ochani K, Yang H, Rabin A, LeRoith D, Lesniak MA, Böhm M, Maaser C, Kannengiesser K, Donowitz M, Rabizadeh S, Czura CJ, Tracey KJ, Westlake M, Zarfeshani A, Mehdi SF, Danoff A, Ge X, Sanyal S, Schwartz GJ, Roth J.

NPJ Biofilms Microbiomes. 2017 Nov 13;3:31. doi: 10.1038/s41522-017-0039-9. eCollection 2017.

5.

Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca2+, cGMP, and lysophosphatidic acid.

Avula LR, Chen T, Kovbasnjuk O, Donowitz M.

Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G81-G90. doi: 10.1152/ajpgi.00140.2017. Epub 2017 Sep 7.

PMID:
28882822
6.

Catching the Zebra: Clinical Pearls and Pitfalls for the Successful Diagnosis of Zollinger-Ellison Syndrome.

Mendelson AH, Donowitz M.

Dig Dis Sci. 2017 Sep;62(9):2258-2265. doi: 10.1007/s10620-017-4695-7. Epub 2017 Aug 3. Review.

PMID:
28776139
7.

Gastrointestinal microphysiological systems.

Blutt SE, Broughman JR, Zou W, Zeng XL, Karandikar UC, In J, Zachos NC, Kovbasnjuk O, Donowitz M, Estes MK.

Exp Biol Med (Maywood). 2017 Oct;242(16):1633-1642. doi: 10.1177/1535370217710638. Epub 2017 May 23. Review.

8.

A common NHE3 single-nucleotide polymorphism has normal function and sensitivity to regulatory ligands.

Yin J, Tse CM, Cha B, Sarker R, Zhu XC, Walentinsson A, Greasley PJ, Donowitz M.

Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1;313(2):G129-G137. doi: 10.1152/ajpgi.00044.2017. Epub 2017 May 11.

PMID:
28495802
9.

Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes.

Sarker R, Cha B, Kovbasnjuk O, Cole R, Gabelli S, Tse CM, Donowitz M.

Mol Biol Cell. 2017 Jul 1;28(13):1754-1767. doi: 10.1091/mbc.E16-12-0862. Epub 2017 May 11.

10.

Erratum: A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.

Noel G, Baetz NW, Staab JF, Donowitz M, Kovbasnjuk O, Pasetti MF, Zachos NC.

Sci Rep. 2017 May 3;7:46790. doi: 10.1038/srep46790. No abstract available.

11.

A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.

Noel G, Baetz NW, Staab JF, Donowitz M, Kovbasnjuk O, Pasetti MF, Zachos NC.

Sci Rep. 2017 Mar 27;7:45270. doi: 10.1038/srep45270. Erratum in: Sci Rep. 2017 May 03;7:46790.

12.

Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle.

Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL.

Sci Rep. 2017 Mar 16;7:44517. doi: 10.1038/srep44517. No abstract available.

13.

PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs.

Cha B, Yang J, Singh V, Zachos NC, Sarker RI, Chen TE, Chakraborty M, Tse CM, Donowitz M.

J Biol Chem. 2017 May 19;292(20):8279-8290. doi: 10.1074/jbc.M116.774489. Epub 2017 Mar 10.

14.

The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology.

Yu H, Hasan NM, In JG, Estes MK, Kovbasnjuk O, Zachos NC, Donowitz M.

Annu Rev Physiol. 2017 Feb 10;79:291-312. doi: 10.1146/annurev-physiol-021115-105211. Review.

15.

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle.

Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL.

Sci Rep. 2017 Feb 8;7:42296. doi: 10.1038/srep42296.

16.

Practical Advice From a Basic and Translational Researcher at a Major Medical School.

Donowitz M.

Cell Mol Gastroenterol Hepatol. 2016 Sep 6;2(6):707-709. doi: 10.1016/j.jcmgh.2016.08.002. eCollection 2016 Nov. No abstract available.

17.

The Zn2+-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl- absorption, via basolateral KCC1, and reduces fluid loss.

Sunuwar L, Asraf H, Donowitz M, Sekler I, Hershfinkel M.

Biochim Biophys Acta. 2017 Apr;1863(4):947-960. doi: 10.1016/j.bbadis.2017.01.009. Epub 2017 Jan 16.

18.

A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection.

Saxena K, Simon LM, Zeng XL, Blutt SE, Crawford SE, Sastri NP, Karandikar UC, Ajami NJ, Zachos NC, Kovbasnjuk O, Donowitz M, Conner ME, Shaw CA, Estes MK.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E570-E579. doi: 10.1073/pnas.1615422114. Epub 2017 Jan 9.

19.

Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.

Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS.

FASEB J. 2017 Feb;31(2):751-760. doi: 10.1096/fj.201600891R. Epub 2016 Nov 8.

20.

Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.

Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS.

Transl Res. 2017 Apr;182:14-26.e4. doi: 10.1016/j.trsl.2016.10.003. Epub 2016 Oct 15.

21.

Human mini-guts: new insights into intestinal physiology and host-pathogen interactions.

In JG, Foulke-Abel J, Estes MK, Zachos NC, Kovbasnjuk O, Donowitz M.

Nat Rev Gastroenterol Hepatol. 2016 Nov;13(11):633-642. doi: 10.1038/nrgastro.2016.142. Epub 2016 Sep 28. Review.

22.

Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids.

In J, Foulke-Abel J, Zachos NC, Hansen AM, Kaper JB, Bernstein HD, Halushka M, Blutt S, Estes MK, Donowitz M, Kovbasnjuk O.

Cell Mol Gastroenterol Hepatol. 2016 Jan 1;2(1):48-62.e3.

23.

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology.

Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M.

Gastroenterology. 2016 Mar;150(3):638-649.e8. doi: 10.1053/j.gastro.2015.11.047. Epub 2015 Dec 8.

24.

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology.

Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz M.

J Biol Chem. 2016 Feb 19;291(8):3759-66. doi: 10.1074/jbc.R114.635995. Epub 2015 Dec 16. Review.

25.

Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology.

Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK.

J Virol. 2015 Oct 7;90(1):43-56. doi: 10.1128/JVI.01930-15. Print 2016 Jan 1.

26.

Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea.

Janecke AR, Heinz-Erian P, Yin J, Petersen BS, Franke A, Lechner S, Fuchs I, Melancon S, Uhlig HH, Travis S, Marinier E, Perisic V, Ristic N, Gerner P, Booth IW, Wedenoja S, Baumgartner N, Vodopiutz J, Frechette-Duval MC, De Lafollie J, Persad R, Warner N, Tse CM, Sud K, Zachos NC, Sarker R, Zhu X, Muise AM, Zimmer KP, Witt H, Zoller H, Donowitz M, Müller T.

Hum Mol Genet. 2015 Dec 1;24(23):6614-23. doi: 10.1093/hmg/ddv367. Epub 2015 Sep 10.

27.

The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity.

Yang J, Sarker R, Singh V, Sarker P, Yin J, Chen TE, Chaerkady R, Li X, Tse CM, Donowitz M.

Biochem J. 2015 Aug 15;470(1):77-90. doi: 10.1042/BJ20150238. Epub 2015 Jun 16.

28.

Secretory diarrhoea: mechanisms and emerging therapies.

Thiagarajah JR, Donowitz M, Verkman AS.

Nat Rev Gastroenterol Hepatol. 2015 Aug;12(8):446-57. doi: 10.1038/nrgastro.2015.111. Epub 2015 Jun 30. Review.

29.

Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3.

Singh V, Yang J, Cha B, Chen TE, Sarker R, Yin J, Avula LR, Tse M, Donowitz M.

Mol Biol Cell. 2015 Jun 1;26(11):2030-43. doi: 10.1091/mbc.E14-12-1597. Epub 2015 Apr 7.

30.

Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activity.

Zhu XC, Sarker R, Horton JR, Chakraborty M, Chen TE, Tse CM, Cha B, Donowitz M.

Am J Physiol Cell Physiol. 2015 May 1;308(9):C758-66. doi: 10.1152/ajpcell.00421.2014. Epub 2015 Feb 25.

31.

Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site.

Chen T, Kocinsky HS, Cha B, Murtazina R, Yang J, Tse CM, Singh V, Cole R, Aronson PS, de Jonge H, Sarker R, Donowitz M.

J Biol Chem. 2015 Jan 23;290(4):1952-65. doi: 10.1074/jbc.M114.590174. Epub 2014 Dec 5.

32.
33.

Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells.

Chen T, Hubbard A, Murtazina R, Price J, Yang J, Cha B, Sarker R, Donowitz M.

J Cell Sci. 2014 Aug 15;127(Pt 16):3535-45. doi: 10.1242/jcs.149930. Epub 2014 Jun 13.

34.

NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol.

Yang J, Singh V, Chen TE, Sarker R, Xiong L, Cha B, Jin S, Li X, Tse CM, Zachos NC, Donowitz M.

J Biol Chem. 2014 Jul 18;289(29):20039-53. doi: 10.1074/jbc.M114.562413. Epub 2014 May 27.

35.

Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling.

Cha B, Chen T, Sarker R, Yang J, Raben D, Tse CM, Kovbasnjuk O, Donowitz M.

Am J Physiol Cell Physiol. 2014 Jul 1;307(1):C55-65. doi: 10.1152/ajpcell.00045.2014. Epub 2014 Apr 23.

36.

Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids.

Jin BJ, Battula S, Zachos N, Kovbasnjuk O, Fawlke-Abel J, In J, Donowitz M, Verkman AS.

Biomicrofluidics. 2014 Apr 1;8(2):024106. doi: 10.1063/1.4870400. eCollection 2014 Mar.

37.

Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract.

Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M.

Exp Biol Med (Maywood). 2014 Sep;239(9):1124-34. doi: 10.1177/1535370214529398. Epub 2014 Apr 9. Review.

38.

Human enteroids: preclinical models of non-inflammatory diarrhea.

Kovbasnjuk O, Zachos NC, In J, Foulke-Abel J, Ettayebi K, Hyser JM, Broughman JR, Zeng XL, Middendorp S, de Jonge HR, Estes MK, Donowitz M.

Stem Cell Res Ther. 2013;4 Suppl 1:S3. doi: 10.1186/scrt364. Epub 2013 Dec 20. Review.

39.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

40.

AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking.

Singh V, Lin R, Yang J, Cha B, Sarker R, Tse CM, Donowitz M.

J Biol Chem. 2014 Feb 28;289(9):5449-61. doi: 10.1074/jbc.M113.521336. Epub 2014 Jan 7.

41.

Discovery and development of antisecretory drugs for treating diarrheal diseases.

Thiagarajah JR, Ko EA, Tradtrantip L, Donowitz M, Verkman AS.

Clin Gastroenterol Hepatol. 2014 Feb;12(2):204-9. doi: 10.1016/j.cgh.2013.12.001. Epub 2013 Dec 4. Review.

42.

Differential association of the Na+/H+ Exchanger Regulatory Factor (NHERF) family of adaptor proteins with the raft- and the non-raft brush border membrane fractions of NHE3.

Sultan A, Luo M, Yu Q, Riederer B, Xia W, Chen M, Lissner S, Gessner JE, Donowitz M, Yun CC, deJonge H, Lamprecht G, Seidler U.

Cell Physiol Biochem. 2013;32(5):1386-402.

43.

Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption.

Singh V, Yang J, Chen TE, Zachos NC, Kovbasnjuk O, Verkman AS, Donowitz M.

Clin Gastroenterol Hepatol. 2014 Jan;12(1):27-31. doi: 10.1016/j.cgh.2013.10.020. Epub 2013 Oct 31. Review.

44.

Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo.

Mroz MS, Keating N, Ward JB, Sarker R, Amu S, Aviello G, Donowitz M, Fallon PG, Keely SJ.

Gut. 2014 May;63(5):808-17. doi: 10.1136/gutjnl-2013-305088. Epub 2013 Aug 5.

PMID:
23916961
45.

PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells.

Zachos NC, Lee LJ, Kovbasnjuk O, Li X, Donowitz M.

Am J Physiol Cell Physiol. 2013 Aug 1;305(3):C266-75. doi: 10.1152/ajpcell.00277.2012. Epub 2013 May 22.

46.

NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.

Yang J, Singh V, Cha B, Chen TE, Sarker R, Murtazina R, Jin S, Zachos NC, Patterson GH, Tse CM, Kovbasnjuk O, Li X, Donowitz M.

J Biol Chem. 2013 Jun 7;288(23):16960-74. doi: 10.1074/jbc.M113.470799. Epub 2013 Apr 23.

47.

Insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR.

Lee HW, Cheng J, Kovbasnjuk O, Donowitz M, Guggino WB.

PLoS One. 2013;8(3):e59992. doi: 10.1371/journal.pone.0059992. Epub 2013 Mar 28.

48.

SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers.

Donowitz M, Ming Tse C, Fuster D.

Mol Aspects Med. 2013 Apr-Jun;34(2-3):236-51. doi: 10.1016/j.mam.2012.05.001. Review.

49.

Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.

Zizak M, Chen T, Bartonicek D, Sarker R, Zachos NC, Cha B, Kovbasnjuk O, Korac J, Mohan S, Cole R, Chen Y, Tse CM, Donowitz M.

J Biol Chem. 2012 Apr 13;287(16):13442-56. doi: 10.1074/jbc.M111.307256. Epub 2012 Feb 27.

50.

Translational approaches for pharmacotherapy development for acute diarrhea.

Donowitz M, Alpers DH, Binder HJ, Brewer T, Carrington J, Grey MJ.

Gastroenterology. 2012 Mar;142(3):e1-9. doi: 10.1053/j.gastro.2012.01.014. Epub 2012 Jan 20. No abstract available.

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