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C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.

Le Bihan YV, Lanigan RM, Atrash B, McLaughlin MG, Velupillai S, Malcolm AG, England KS, Ruda GF, Mok NY, Tumber A, Tomlin K, Saville H, Shehu E, McAndrew C, Carmichael L, Bennett JM, Jeganathan F, Eve P, Donovan A, Hayes A, Wood F, Raynaud FI, Fedorov O, Brennan PE, Burke R, van Montfort RLM, Rossanese OW, Blagg J, Bavetsias V.

Eur J Med Chem. 2019 Sep 1;177:316-337. doi: 10.1016/j.ejmech.2019.05.041. Epub 2019 May 17.


Effects of environmentally relevant concentrations of mixtures of TiO2, ZnO and Ag ENPs on a river bacterial community.

Londono N, Donovan AR, Shi H, Geisler M, Liang Y.

Chemosphere. 2019 Sep;230:567-577. doi: 10.1016/j.chemosphere.2019.05.110. Epub 2019 May 16.


Life-threatening gastrointestinal bleeding from a giant ileal lipoma.

Donovan A, Abeyasundara S, Nabi H.

ANZ J Surg. 2019 May 13. doi: 10.1111/ans.15297. [Epub ahead of print] No abstract available.


Traumatic Ventral Cervical Spinal Cord Herniation: A Case Report.

Khattar NK, Donovan AM, Oxford BG, Adams SWC, Altstadt TJ.

Cureus. 2019 Feb 13;11(2):e4070. doi: 10.7759/cureus.4070.


Update in Hospital Medicine: Practical Lessons from Current Literature.

Cooper CM, Donovan AK, Sharpe BA, Slawski B, Burger A.

J Hosp Med. 2019 Apr 8;14:E1-E5. doi: 10.12788/jhm.3206. [Epub ahead of print] Review.


Colonoscopic resection of giant colonic lipoma causing subacute large bowel obstruction.

Donovan A, Abeyasundara S, Nabi H.

ANZ J Surg. 2019 Apr 11. doi: 10.1111/ans.15082. [Epub ahead of print] No abstract available.


Molecular interactions of phospholipid monolayers with a model phospholipase.

Zhang P, Villanueva V, Kalkowski J, Liu C, Donovan AJ, Bu W, Schlossman ML, Lin B, Liu Y.

Soft Matter. 2019 May 22;15(20):4068-4077. doi: 10.1039/c8sm01154k.


Traumatic coronary artery dissection leading to ventricular tachycardia.

Donovan AE, Bridwell RE, Carius B, Kot C, Oliver JJ.

Am J Emerg Med. 2019 May;37(5):1007.e5-1007.e7. doi: 10.1016/j.ajem.2019.02.018. Epub 2019 Feb 13.


Diminution of pharyngeal segmentation and the evolution of the amniotes.

Poopalasundaram S, Richardson J, Scott A, Donovan A, Liu K, Graham A.

Zoological Lett. 2019 Feb 11;5:6. doi: 10.1186/s40851-019-0123-5. eCollection 2019.


Intraoperative dexmedetomidine to prevent postoperative delirium: in search of the magic bullet.

Donovan AL, Whitlock EL.

Can J Anaesth. 2019 Apr;66(4):365-370. doi: 10.1007/s12630-019-01300-3. Epub 2019 Jan 28. No abstract available.


Case 1-2019: A 34-Year-Old Veteran with Multiple Somatic Symptoms.

Donovan AL, Petersen TJ, Nadal-Vicens MF, Kamenker-Orlov YS.

N Engl J Med. 2019 Jan 10;380(2):178-185. doi: 10.1056/NEJMcpc1802833. No abstract available.


Survival Outcomes of Younger Patients With Mantle Cell Lymphoma Treated in the Rituximab Era.

Gerson JN, Handorf E, Villa D, Gerrie AS, Chapani P, Li S, Medeiros LJ, Wang MI, Cohen JB, Calzada O, Churnetski MC, Hill BT, Sawalha Y, Hernandez-Ilizaliturri FJ, Kothari S, Vose JM, Bast MA, Fenske TS, Narayana Rao Gari S, Maddocks KJ, Bond D, Bachanova V, Kolla B, Chavez J, Shah B, Lansigan F, Burns TF, Donovan AM, Wagner-Johnston N, Messmer M, Mehta A, Anderson JK, Reddy N, Kovach AE, Landsburg DJ, Glenn M, Inwards DJ, Karmali R, Kaplan JB, Caimi PF, Rajguru S, Evens A, Klein A, Umyarova E, Pulluri B, Amengual JE, Lue JK, Diefenbach C, Fisher RI, Barta SK.

J Clin Oncol. 2019 Feb 20;37(6):471-480. doi: 10.1200/JCO.18.00690. Epub 2019 Jan 7.


Teaching to Teach: An Effective and Feasible Teaching Curriculum for Internal Medicine Interns.

Donovan AK, Linz DR, Rubio DM, McNeil MA, Spagnoletti CL.

South Med J. 2018 Dec;111(12):733-738. doi: 10.14423/SMJ.0000000000000908.


Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy.

Long KK, O'Shea KM, Khairallah RJ, Howell K, Paushkin S, Chen KS, Cote SM, Webster MT, Stains JP, Treece E, Buckler A, Donovan A.

Hum Mol Genet. 2019 Apr 1;28(7):1076-1089. doi: 10.1093/hmg/ddy382.


Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.

Vazquez-Rodriguez S, Wright M, Rogers CM, Cribbs AP, Velupillai S, Philpott M, Lee H, Dunford JE, Huber KVM, Robers MB, Vasta JD, Thezenas ML, Bonham S, Kessler B, Bennett J, Fedorov O, Raynaud F, Donovan A, Blagg J, Bavetsias V, Oppermann U, Bountra C, Kawamura A, Brennan PE.

Angew Chem Int Ed Engl. 2019 Jan 8;58(2):515-519. doi: 10.1002/anie.201810179. Epub 2018 Dec 7.


Author Correction: Insights into the functionality of endophytic actinobacteria with a focus on their biosynthetic potential and secondary metabolites production.

Passari AK, Mishra VK, Singh G, Singh P, Kumar B, Gupta VK, Sarma RK, Saikia R, Donovan AO, Singh BP.

Sci Rep. 2018 Mar 12;8(1):4650. doi: 10.1038/s41598-018-22947-w.


Interprofessional Care and Teamwork in the ICU.

Donovan AL, Aldrich JM, Gross AK, Barchas DM, Thornton KC, Schell-Chaple HM, Gropper MA, Lipshutz AKM; University of California, San Francisco Critical Care Innovations Group.

Crit Care Med. 2018 Jun;46(6):980-990. doi: 10.1097/CCM.0000000000003067.


Simultaneous removal of ammonia and N-nitrosamine precursors from high ammonia water by zeolite and powdered activated carbon.

Xue R, Donovan A, Zhang H, Ma Y, Adams C, Yang J, Hua B, Inniss E, Eichholz T, Shi H.

J Environ Sci (China). 2018 Feb;64:82-91. doi: 10.1016/j.jes.2017.02.010. Epub 2017 Feb 24.


Blocking extracellular activation of myostatin as a strategy for treating muscle wasting.

Pirruccello-Straub M, Jackson J, Wawersik S, Webster MT, Salta L, Long K, McConaughy W, Capili A, Boston C, Carven GJ, Mahanthappa NK, Turner KJ, Donovan A.

Sci Rep. 2018 Feb 2;8(1):2292. doi: 10.1038/s41598-018-20524-9.


Core-shell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering.

Szymusiak M, Kalkowski J, Luo H, Donovan AJ, Zhang P, Liu C, Shang W, Irving T, Herrera-Alonso M, Liu Y.

ACS Macro Lett. 2017 Sep 19;6(9):1005-1012. doi: 10.1021/acsmacrolett.7b00490. Epub 2017 Aug 31.


Fate of nanoparticles during alum and ferric coagulation monitored using single particle ICP-MS.

Donovan AR, Adams CD, Ma Y, Stephan C, Eichholz T, Shi H.

Chemosphere. 2018 Mar;195:531-541. doi: 10.1016/j.chemosphere.2017.12.116. Epub 2017 Dec 19.


Distinct cerebellar foliation anomalies in a CHD7 haploinsufficient mouse model of CHARGE syndrome.

Whittaker DE, Kasah S, Donovan APA, Ellegood J, Riegman KLH, Volk HA, McGonnell I, Lerch JP, Basson MA.

Am J Med Genet C Semin Med Genet. 2017 Dec;175(4). doi: 10.1002/ajmg.c.31595. Epub 2017 Nov 23.


Impact of TiO2 and ZnO nanoparticles on an aquatic microbial community: effect at environmentally relevant concentrations.

Londono N, Donovan AR, Shi H, Geisler M, Liang Y.

Nanotoxicology. 2017 Nov - Dec;11(9-10):1140-1156. doi: 10.1080/17435390.2017.1401141. Epub 2017 Nov 10.


Evidence-Based Reporting: A Method to Optimize Prostate MRI Communications With Referring Physicians.

Magnetta MJ, Donovan AL, Jacobs BL, Davies BJ, Furlan A.

AJR Am J Roentgenol. 2018 Jan;210(1):108-112. doi: 10.2214/AJR.17.18260. Epub 2017 Nov 1.


Nature Elements and Fundamental Motor Skill Development Opportunities at Five Elementary School Districts in British Columbia.

Lim C, Donovan AM, Harper NJ, Naylor PJ.

Int J Environ Res Public Health. 2017 Oct 24;14(10). pii: E1279. doi: 10.3390/ijerph14101279.


Cerebellar Vermis and Midbrain Hypoplasia Upon Conditional Deletion of Chd7 from the Embryonic Mid-Hindbrain Region.

Donovan APA, Yu T, Ellegood J, Riegman KLH, de Geus C, van Ravenswaaij-Arts C, Fernandes C, Lerch JP, Basson MA.

Front Neuroanat. 2017 Oct 4;11:86. doi: 10.3389/fnana.2017.00086. eCollection 2017.


Insights into the functionality of endophytic actinobacteria with a focus on their biosynthetic potential and secondary metabolites production.

Passari AK, Mishra VK, Singh G, Singh P, Kumar B, Gupta VK, Sarma RK, Saikia R, Donovan AO, Singh BP.

Sci Rep. 2017 Sep 18;7(1):11809. doi: 10.1038/s41598-017-12235-4. Erratum in: Sci Rep. 2018 Mar 12;8(1):4650.


Radiology Online Patient Education Materials Provided by Major University Hospitals: Do They Conform to NIH and AMA Guidelines?

Prabhu AV, Donovan AL, Crihalmeanu T, Hansberry DR, Agarwal N, Beriwal S, Kale H, Heller M.

Curr Probl Diagn Radiol. 2018 Mar - Apr;47(2):75-79. doi: 10.1067/j.cpradiol.2017.05.007. Epub 2017 May 22.


Enhancing the Radiologist-Patient Relationship through Improved Communication: A Quantitative Readability Analysis in Spine Radiology.

Hansberry DR, Donovan AL, Prabhu AV, Agarwal N, Cox M, Flanders AE.

AJNR Am J Neuroradiol. 2017 Jun;38(6):1252-1256. doi: 10.3174/ajnr.A5151. Epub 2017 Apr 6.


Linking Incidents in Long-Term Care Facilities to Worker Activities.

McCloskey R, Donovan C, Donovan A.

Workplace Health Saf. 2017 Oct;65(10):457-466. doi: 10.1177/2165079916680366. Epub 2017 Apr 3.


Localization of Short-Chain Polyphosphate Enhances its Ability to Clot Flowing Blood Plasma.

Yeon JH, Mazinani N, Schlappi TS, Chan KY, Baylis JR, Smith SA, Donovan AJ, Kudela D, Stucky GD, Liu Y, Morrissey JH, Kastrup CJ.

Sci Rep. 2017 Feb 10;7:42119. doi: 10.1038/srep42119.


Quantifying gas emissions from the "Millennium Eruption" of Paektu volcano, Democratic People's Republic of Korea/China.

Iacovino K, Ju-Song K, Sisson T, Lowenstern J, Kuk-Hun R, Jong-Nam J, Kun-Ho S, Song-Hwan H, Oppenheimer C, Hammond JO, Donovan A, Liu KW, Kum-Ran R.

Sci Adv. 2016 Nov 30;2(11):e1600913. doi: 10.1126/sciadv.1600913. eCollection 2016 Nov.


Low abundance of colonic butyrate-producing bacteria in HIV infection is associated with microbial translocation and immune activation.

Dillon SM, Kibbie J, Lee EJ, Guo K, Santiago ML, Austin GL, Gianella S, Landay AL, Donovan AM, Frank DN, McCARTER MD, Wilson CC.

AIDS. 2017 Feb 20;31(4):511-521. doi: 10.1097/QAD.0000000000001366.


A Phase IV Study of Thromboembolic and Bleeding Events Following Hip and Knee Arthroplasty Using Oral Factor Xa Inhibitor.

Gomez D, Razmjou H, Donovan A, Bansal VB, Gollish JD, Murnaghan JJ.

J Arthroplasty. 2017 Mar;32(3):958-964. doi: 10.1016/j.arth.2016.09.021. Epub 2016 Oct 4.


Corrigendum: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

Planas-Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, Xie Y, Roma G, Donovan A, Marti P, Beckmann N, Dill MT, Carbone W, Bergling S, Isken A, Mueller M, Kinzel B, Yang Y, Mao X, Nicholson TB, Zamponi R, Capodieci P, Valdez R, Rivera D, Loew A, Ukomadu C, Terracciano LM, Bouwmeester T, Cong F, Heim MH, Forbes SJ, Ruffner H, Tchorz JS.

Nat Cell Biol. 2016 Oct 27;18(11):1260. doi: 10.1038/ncb3428. No abstract available.


Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages.

Davis PR, Giannini G, Rudolph K, Calloway N, Royer CM, Beckett TL, Murphy MP, Bresch F, Pagani D, Platt T, Wang X, Donovan AS, Sudduth TL, Lou W, Abner E, Kryscio R, Wilcock DM, Barrett EG, Head E.

Neurobiol Aging. 2017 Jan;49:86-99. doi: 10.1016/j.neurobiolaging.2016.09.007. Epub 2016 Sep 26.


Peripartal rumination dynamics and health status in cows calving in hot and cool seasons.

Paudyal S, Maunsell F, Richeson J, Risco C, Donovan A, Pinedo P.

J Dairy Sci. 2016 Nov;99(11):9057-9068. doi: 10.3168/jds.2016-11203. Epub 2016 Sep 7.


Appendicitis in Diabetics: Predictors of Complications and Their Incidence.

Bach L, Donovan A, Loggins W, Thompson S, Richmond B.

Am Surg. 2016 Aug;82(8):753-8.


The neuroanatomy of autism - a developmental perspective.

Donovan AP, Basson MA.

J Anat. 2017 Jan;230(1):4-15. doi: 10.1111/joa.12542. Epub 2016 Sep 12. Review.


Rapid simultaneous analysis of 17 haloacetic acids and related halogenated water contaminants by high-performance ion chromatography-tandem mass spectrometry.

Xue R, Donovan A, Shi H, Yang J, Hua B, Inniss E, Eichholz T.

Anal Bioanal Chem. 2016 Sep;408(24):6613-22. doi: 10.1007/s00216-016-9773-8. Epub 2016 Jul 15.


Gradual caldera collapse at Bárdarbunga volcano, Iceland, regulated by lateral magma outflow.

Gudmundsson MT, Jónsdóttir K, Hooper A, Holohan EP, Halldórsson SA, Ófeigsson BG, Cesca S, Vogfjörd KS, Sigmundsson F, Högnadóttir T, Einarsson P, Sigmarsson O, Jarosch AH, Jónasson K, Magnússon E, Hreinsdóttir S, Bagnardi M, Parks MM, Hjörleifsdóttir V, Pálsson F, Walter TR, Schöpfer MP, Heimann S, Reynolds HI, Dumont S, Bali E, Gudfinnsson GH, Dahm T, Roberts MJ, Hensch M, Belart JM, Spaans K, Jakobsson S, Gudmundsson GB, Fridriksdóttir HM, Drouin V, Dürig T, Aðalgeirsdóttir G, Riishuus MS, Pedersen GB, van Boeckel T, Oddsson B, Pfeffer MA, Barsotti S, Bergsson B, Donovan A, Burton MR, Aiuppa A.

Science. 2016 Jul 15;353(6296):aaf8988. doi: 10.1126/science.aaf8988.


Artificial Dense Granules: A Procoagulant Liposomal Formulation Modeled after Platelet Polyphosphate Storage Pools.

Donovan AJ, Kalkowski J, Szymusiak M, Wang C, Smith SA, Klie RF, Morrissey JH, Liu Y.

Biomacromolecules. 2016 Aug 8;17(8):2572-81. doi: 10.1021/acs.biomac.6b00577. Epub 2016 Jul 27.


The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

Planas-Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, Xie Y, Roma G, Donovan A, Marti P, Beckmann N, Dill MT, Carbone W, Bergling S, Isken A, Mueller M, Kinzel B, Yang Y, Mao X, Nicholson TB, Zamponi R, Capodieci P, Valdez R, Rivera D, Loew A, Ukomadu C, Terracciano LM, Bouwmeester T, Cong F, Heim MH, Forbes SJ, Ruffner H, Tchorz JS.

Nat Cell Biol. 2016 May;18(5):467-79. doi: 10.1038/ncb3337. Epub 2016 Apr 18. Erratum in: Nat Cell Biol. 2016 Oct 27;18(11):1260.


Review of cardiometabolic risk factors in a cohort of paediatric type 1 diabetes mellitus patients.

Donovan A, Finner N, O'Connor C, Quinn A, O'Gorman CS.

Ir J Med Sci. 2017 May;186(2):427-432. doi: 10.1007/s11845-016-1440-8. Epub 2016 Mar 17.


N-nitrosamine formation by monochloramine, free chlorine, and peracetic acid disinfection with presence of amine precursors in drinking water system.

West DM, Wu Q, Donovan A, Shi H, Ma Y, Jiang H, Wang J.

Chemosphere. 2016 Jun;153:521-7. doi: 10.1016/j.chemosphere.2016.03.035. Epub 2016 Mar 31.


Faculty Communication Knowledge, Attitudes, and Skills Around Chronic Non-Malignant Pain Improve with Online Training.

Donovan AK, Wood GJ, Rubio DM, Day HD, Spagnoletti CL.

Pain Med. 2016 Nov;17(11):1985-1992. Epub 2016 Apr 1.


Detection of zinc oxide and cerium dioxide nanoparticles during drinking water treatment by rapid single particle ICP-MS methods.

Donovan AR, Adams CD, Ma Y, Stephan C, Eichholz T, Shi H.

Anal Bioanal Chem. 2016 Jul;408(19):5137-45. doi: 10.1007/s00216-016-9432-0. Epub 2016 Mar 9.


Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection.

Dillon SM, Lee EJ, Donovan AM, Guo K, Harper MS, Frank DN, McCarter MD, Santiago ML, Wilson CC.

Retrovirology. 2016 Jan 14;13:5. doi: 10.1186/s12977-016-0237-1.


8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

Bavetsias V, Lanigan RM, Ruda GF, Atrash B, McLaughlin MG, Tumber A, Mok NY, Le Bihan YV, Dempster S, Boxall KJ, Jeganathan F, Hatch SB, Savitsky P, Velupillai S, Krojer T, England KS, Sejberg J, Thai C, Donovan A, Pal A, Scozzafava G, Bennett JM, Kawamura A, Johansson C, Szykowska A, Gileadi C, Burgess-Brown NA, von Delft F, Oppermann U, Walters Z, Shipley J, Raynaud FI, Westaway SM, Prinjha RK, Fedorov O, Burke R, Schofield CJ, Westwood IM, Bountra C, Müller S, van Montfort RL, Brennan PE, Blagg J.

J Med Chem. 2016 Feb 25;59(4):1388-409. doi: 10.1021/acs.jmedchem.5b01635. Epub 2016 Jan 7.


Knowledge of carbohydrate counting and insulin dose calculations in paediatric patients with type 1 diabetes mellitus.

Finner N, Quinn A, Donovan A, O'Leary O, O'Gorman CS.

BBA Clin. 2015 Sep 15;4:99-101. doi: 10.1016/j.bbacli.2015.09.002. eCollection 2015 Dec.

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