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Items: 1 to 50 of 136

1.

The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation.

Grozavu A, Hepburn HB, Smith PJ, Potukuchi HK, Lindsay-Scott PJ, Donohoe TJ.

Nat Chem. 2019 Mar;11(3):242-247. doi: 10.1038/s41557-018-0178-5. Epub 2018 Dec 17.

PMID:
30559370
2.

Stereoselective Synthesis of Cyclohexanes via an Iridium Catalyzed (5 + 1) Annulation Strategy.

Akhtar WM, Armstrong RJ, Frost JR, Stevenson NG, Donohoe TJ.

J Am Chem Soc. 2018 Sep 26;140(38):11916-11920. doi: 10.1021/jacs.8b07776. Epub 2018 Sep 13.

PMID:
30212192
3.

Persistent stigmatizing and negative perceptions of pre-exposure prophylaxis (PrEP) users: implications for PrEP adoption among Latino men who have sex with men.

Brooks RA, Nieto O, Landrian A, Donohoe TJ.

AIDS Care. 2019 Apr;31(4):427-435. doi: 10.1080/09540121.2018.1499864. Epub 2018 Jul 18.

PMID:
30021456
4.

OBO-Protected Pyruvates as Reagents for the Synthesis of Functionalized Heteroaromatic Compounds.

Alves Esteves CH, Koyioni M, Christensen KE, Smith PD, Donohoe TJ.

Org Lett. 2018 Jul 6;20(13):4048-4051. doi: 10.1021/acs.orglett.8b01614. Epub 2018 Jun 15.

PMID:
29906124
5.

Asymmetric Total Synthesis of (-)-(3 R)-Inthomycin C.

Balcells S, Haughey MB, Walker JCL, Josa-Culleré L, Towers C, Donohoe TJ.

Org Lett. 2018 Jun 15;20(12):3583-3586. doi: 10.1021/acs.orglett.8b01370. Epub 2018 Jun 4.

PMID:
29863350
6.

Cobalt versus Osmium: Control of Both trans and cis Selectivity in Construction of the EFG Rings of Pectenotoxin 4.

Roushanbakhti A, Liu Y, Winship PCM, Tucker MJ, Akhtar WM, Walter DS, Wrigley G, Donohoe TJ.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14883-14887. doi: 10.1002/anie.201708278. Epub 2017 Oct 19.

PMID:
28926175
7.

Pyruvate Enolate Arylation and Alkylation: OBO Ester Protected Pyruvates as Useful Reagents in Organic Synthesis.

Alves Esteves CH, Hall CJJ, Smith PD, Donohoe TJ.

Org Lett. 2017 Oct 6;19(19):5248-5251. doi: 10.1021/acs.orglett.7b02524. Epub 2017 Sep 18.

PMID:
28920691
8.

Catalytic Enolate Arylation with 3-Bromoindoles Allows the Formation of β-Carbolines.

Alves Esteves CH, Smith PD, Donohoe TJ.

J Org Chem. 2017 Apr 21;82(8):4435-4443. doi: 10.1021/acs.joc.7b00299. Epub 2017 Mar 31.

PMID:
28362489
9.

Hydrogen Borrowing Catalysis with Secondary Alcohols: A New Route for the Generation of β-Branched Carbonyl Compounds.

Akhtar WM, Cheong CB, Frost JR, Christensen KE, Stevenson NG, Donohoe TJ.

J Am Chem Soc. 2017 Feb 22;139(7):2577-2580. doi: 10.1021/jacs.6b12840. Epub 2017 Feb 8.

10.

Orthogonally Protected 1,2-Diols from Electron-Rich Alkenes Using Metal-Free Olefin syn-Dihydroxylation.

Colomer I, Barcelos RC, Christensen KE, Donohoe TJ.

Org Lett. 2016 Nov 18;18(22):5880-5883. Epub 2016 Nov 9.

PMID:
27934501
11.

Dehydromicrosclerodermin B and Microsclerodermin J: Total Synthesis and Structural Revision.

Melikhova EY, Pullin RD, Winter C, Donohoe TJ.

Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9753-7. doi: 10.1002/anie.201604764. Epub 2016 Jul 15.

12.

Hydrogen Bonding to Hexafluoroisopropanol Controls the Oxidative Strength of Hypervalent Iodine Reagents.

Colomer I, Batchelor-McAuley C, Odell B, Donohoe TJ, Compton RG.

J Am Chem Soc. 2016 Jul 20;138(28):8855-61. doi: 10.1021/jacs.6b04057. Epub 2016 Jul 5.

PMID:
27380523
13.

Catalytic Hypervalent Iodine Promoters Lead to Styrene Dimerization and the Formation of Tri- and Tetrasubstituted Cyclobutanes.

Colomer I, Coura Barcelos R, Donohoe TJ.

Angew Chem Int Ed Engl. 2016 Apr 4;55(15):4748-52. doi: 10.1002/anie.201511683. Epub 2016 Mar 7.

PMID:
26948413
14.

Strategic Application and Transformation of ortho-Disubstituted Phenyl and Cyclopropyl Ketones To Expand the Scope of Hydrogen Borrowing Catalysis.

Frost JR, Cheong CB, Akhtar WM, Caputo DF, Stevenson NG, Donohoe TJ.

J Am Chem Soc. 2015 Dec 23;137(50):15664-7. doi: 10.1021/jacs.5b11196. Epub 2015 Dec 11.

PMID:
26654947
15.

Palladium-catalyzed enolate arylation as a key C-C bond-forming reaction for the synthesis of isoquinolines.

Pilgrim BS, Gatland AE, Esteves CH, McTernan CT, Jones GR, Tatton MR, Procopiou PA, Donohoe TJ.

Org Biomol Chem. 2016 Jan 21;14(3):1065-90. doi: 10.1039/c5ob02320c. Epub 2015 Dec 3.

PMID:
26632484
16.

Aziridine electrophiles in the functionalisation of peptide chains with amine nucleophiles.

Spork AP, Donohoe TJ.

Org Biomol Chem. 2015 Aug 21;13(31):8545-9. doi: 10.1039/c5ob00856e.

PMID:
26166551
17.

Modular Synthesis of Highly Substituted Pyridines via Enolate α-Alkenylation.

Hardegger LA, Habegger J, Donohoe TJ.

Org Lett. 2015 Jul 2;17(13):3222-5. doi: 10.1021/acs.orglett.5b01312. Epub 2015 Jun 18.

PMID:
26087079
18.

Palladium-catalyzed α-arylation of carbonyls in the de novo synthesis of aromatic heterocycles.

Potukuchi HK, Spork AP, Donohoe TJ.

Org Biomol Chem. 2015 Apr 21;13(15):4367-73. doi: 10.1039/c5ob00055f.

19.

Hydrogen-borrowing and interrupted-hydrogen-borrowing reactions of ketones and methanol catalyzed by iridium.

Shen D, Poole DL, Shotton CC, Kornahrens AF, Healy MP, Donohoe TJ.

Angew Chem Int Ed Engl. 2015 Jan 26;54(5):1642-5. doi: 10.1002/anie.201410391. Epub 2014 Dec 9.

20.

Short and efficient syntheses of protoberberine alkaloids using palladium-catalyzed enolate arylation.

Gatland AE, Pilgrim BS, Procopiou PA, Donohoe TJ.

Angew Chem Int Ed Engl. 2014 Dec 22;53(52):14555-8. doi: 10.1002/anie.201409164. Epub 2014 Oct 27.

21.

Love-Hate ligands for high resolution analysis of strain in ultra-stable protein/small molecule interaction.

Fairhead M, Shen D, Chan LK, Lowe ED, Donohoe TJ, Howarth M.

Bioorg Med Chem. 2014 Oct 1;22(19):5476-86. doi: 10.1016/j.bmc.2014.07.029. Epub 2014 Jul 24.

PMID:
25128469
22.

New methods for the synthesis of naphthyl amines; application to the synthesis of dihydrosanguinarine, sanguinarine, oxysanguinarine and (±)-maclekarpines B and C.

Tatton MR, Simpson I, Donohoe TJ.

Chem Commun (Camb). 2014 Oct 7;50(77):11314-6. doi: 10.1039/c4cc05209a.

PMID:
25116797
23.

De novo synthesis of multisubstituted aryl amines using alkene cross metathesis.

Tatton MR, Simpson I, Donohoe TJ.

Org Lett. 2014 Apr 4;16(7):1920-3. doi: 10.1021/ol500441q. Epub 2014 Mar 19.

24.

Total synthesis of the antitumor antibiotic (±)-streptonigrin: first- and second-generation routes for de novo pyridine formation using ring-closing metathesis.

Donohoe TJ, Jones CR, Kornahrens AF, Barbosa LC, Walport LJ, Tatton MR, O'Hagan M, Rathi AH, Baker DB.

J Org Chem. 2013 Dec 20;78(24):12338-50. doi: 10.1021/jo402388f. Epub 2013 Dec 12.

25.

Rhodium-catalyzed ketone methylation using methanol under mild conditions: formation of α-branched products.

Chan LK, Poole DL, Shen D, Healy MP, Donohoe TJ.

Angew Chem Int Ed Engl. 2014 Jan 13;53(3):761-5. doi: 10.1002/anie.201307950. Epub 2013 Nov 29.

26.

Modular isoquinoline synthesis using catalytic enolate arylation and in situ functionalization.

Pilgrim BS, Gatland AE, McTernan CT, Procopiou PA, Donohoe TJ.

Org Lett. 2013 Dec 20;15(24):6190-3. doi: 10.1021/ol4030309. Epub 2013 Nov 19.

27.

Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B.

Pullin RD, Rathi AH, Melikhova EY, Winter C, Thompson AL, Donohoe TJ.

Org Lett. 2013 Nov 1;15(21):5492-5. doi: 10.1021/ol402638n. Epub 2013 Oct 16.

28.

Osmium-catalyzed oxidative cyclization of dienes and their derivatives.

Pilgrim BS, Donohoe TJ.

J Org Chem. 2013 Mar 15;78(6):2149-67. doi: 10.1021/jo302719y. Epub 2013 Jan 31.

PMID:
23369062
29.

Interplay of cascade oxidative cyclization and hydride shifts in the synthesis of the ABC spiroketal ring system of pectenotoxin-4.

Donohoe TJ, Lipiński RM.

Angew Chem Int Ed Engl. 2013 Feb 25;52(9):2491-4. doi: 10.1002/anie.201208919. Epub 2013 Jan 30.

PMID:
23362216
30.

Natural product synthesis as a challenging test of newly developed methodology.

Donohoe TJ, Pullin RD.

Chem Commun (Camb). 2012 Dec 21;48(98):11924-38. doi: 10.1039/c2cc36040c. Review.

PMID:
23086503
31.

Asymmetric synthesis of the fully elaborated pyrrolidinone core of oxazolomycin A.

Donohoe TJ, O'Riordan TJ, Peifer M, Jones CR, Miles TJ.

Org Lett. 2012 Nov 2;14(21):5460-3. doi: 10.1021/ol302541j. Epub 2012 Oct 12.

PMID:
23061613
32.

Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones.

Donohoe TJ, Pilgrim BS, Jones GR, Bassuto JA.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11605-8. doi: 10.1073/pnas.1206532109. Epub 2012 Jul 2.

33.

Olefin cross-metathesis for the synthesis of heteroaromatic compounds.

Donohoe TJ, Bower JF, Chan LK.

Org Biomol Chem. 2012 Feb 21;10(7):1322-8. doi: 10.1039/c2ob06659a. Epub 2012 Jan 4.

PMID:
22215025
34.

Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes.

Donohoe TJ, Kabeshov MA, Rathi AH, Smith IE.

Org Biomol Chem. 2012 Feb 7;10(5):1093-101. doi: 10.1039/c1ob06587d. Epub 2011 Dec 12.

PMID:
22159268
35.

Amino acid-based reoxidants for aminohydroxylation: application to the construction of amino acid-amino alcohol conjugates.

Donohoe TJ, Callens CK, Flores A, Mesch S, Poole DL, Roslan IA.

Angew Chem Int Ed Engl. 2011 Nov 11;50(46):10957-60. doi: 10.1002/anie.201103293. Epub 2011 Sep 23. No abstract available.

PMID:
21953892
36.

Total synthesis of (±)-streptonigrin: de novo construction of a pentasubstituted pyridine using ring-closing metathesis.

Donohoe TJ, Jones CR, Barbosa LC.

J Am Chem Soc. 2011 Oct 19;133(41):16418-21. doi: 10.1021/ja207835w. Epub 2011 Sep 23.

PMID:
21942896
37.

The influence of exocyclic stereochemistry on the tethered aminohydroxylation reaction.

Donohoe TJ, Lacy AR, Rathi AH, Walter DS.

Chem Asian J. 2011 Dec 2;6(12):3214-22. doi: 10.1002/asia.201100497. Epub 2011 Sep 14.

PMID:
21919211
38.

Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence.

Donohoe TJ, Bower JF, Baker DB, Basutto JA, Chan LK, Gallagher P.

Chem Commun (Camb). 2011 Oct 14;47(38):10611-3. doi: 10.1039/c1cc14257g. Epub 2011 Aug 25.

PMID:
21870019
39.

A short and efficient synthesis of neodysiherbaine A by using catalytic oxidative cyclization.

Donohoe TJ, Winship PC, Tatton MR, Szeto P.

Angew Chem Int Ed Engl. 2011 Aug 8;50(33):7604-6. doi: 10.1002/anie.201102525. Epub 2011 Jun 27. No abstract available.

PMID:
21710669
40.

Dehydrogenation of cyclic thioethers bound to a [Rh(diphosphine)]+ fragment.

Dallanegra R, Pilgrim BS, Chaplin AB, Donohoe TJ, Weller AS.

Dalton Trans. 2011 Jul 7;40(25):6626-8. doi: 10.1039/c1dt10503e. Epub 2011 May 25.

PMID:
21611674
41.

Exerting control over the acyloin reaction.

Donohoe TJ, Jahanshahi A, Tucker MJ, Bhatti FL, Roslan IA, Kabeshov M, Wrigley G.

Chem Commun (Camb). 2011 May 28;47(20):5849-51. doi: 10.1039/c1cc11654a. Epub 2011 Apr 18.

PMID:
21503291
42.

Intramolecular hydride addition to pyridinium salts: new routes to enantiopure dihydropyridones.

Donohoe TJ, Connolly MJ, Rathi AH, Walton L.

Org Lett. 2011 Apr 15;13(8):2074-7. doi: 10.1021/ol200478p. Epub 2011 Mar 18.

PMID:
21417360
43.

Heteroaromatic synthesis via olefin cross-metathesis: entry to polysubstituted pyridines.

Donohoe TJ, Basutto JA, Bower JF, Rathi A.

Org Lett. 2011 Mar 4;13(5):1036-9. doi: 10.1021/ol103088r. Epub 2011 Jan 26.

PMID:
21268598
44.

Recent developments in methodology for the direct oxyamination of olefins.

Donohoe TJ, Callens CK, Flores A, Lacy AR, Rathi AH.

Chemistry. 2011 Jan 3;17(1):58-76. doi: 10.1002/chem.201002323. Epub 2010 Dec 16. Review.

PMID:
21207600
45.

Olefin cross-metathesis-based approaches to furans: procedures for the preparation of di- and trisubstituted variants.

Donohoe TJ, Bower JF, Basutto JA.

Nat Protoc. 2010 Dec;5(12):2005-10. doi: 10.1038/nprot.2010.147. Epub 2010 Dec 2.

PMID:
21127493
46.

Osmium-free direct syn-dihydroxylation of alkenes.

Bataille CJ, Donohoe TJ.

Chem Soc Rev. 2011 Jan;40(1):114-28. doi: 10.1039/b923880h. Epub 2010 Nov 3. Review.

PMID:
21049111
47.

Identification of epigenetic DNA modifications with a protein nanopore.

Wallace EV, Stoddart D, Heron AJ, Mikhailova E, Maglia G, Donohoe TJ, Bayley H.

Chem Commun (Camb). 2010 Nov 21;46(43):8195-7. doi: 10.1039/c0cc02864a. Epub 2010 Oct 6.

48.

A novel oxidative cyclisation onto vinyl silanes.

Donohoe TJ, Winship PC, Pilgrim BS, Walter DS, Callens CK.

Chem Commun (Camb). 2010 Oct 21;46(39):7310-2. doi: 10.1039/c0cc01342k. Epub 2010 Sep 6.

PMID:
20830333
49.

Substituted pyrroles via olefin cross-metathesis.

Donohoe TJ, Race NJ, Bower JF, Callens CK.

Org Lett. 2010 Sep 17;12(18):4094-7. doi: 10.1021/ol101681r.

PMID:
20712303
50.

A Lewis acid promoted oxidative cyclization.

Donohoe TJ, Winship PC, Walter DS.

J Org Chem. 2009 Aug 21;74(16):6394-7. doi: 10.1021/jo901243y.

PMID:
20560576

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