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Items: 42


RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis.

Schmidt ML, Hobbing KR, Donninger H, Clark GJ.

Cancer Res. 2018 May 15;78(10):2614-2623. doi: 10.1158/0008-5472.CAN-17-2466. Epub 2018 May 7.


The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.

Barnoud T, Schmidt ML, Donninger H, Clark GJ.

Cancer Lett. 2017 Aug 1;400:30-36. doi: 10.1016/j.canlet.2017.04.030. Epub 2017 Apr 26. Review.


Nonstructural protein 5B promotes degradation of the NORE1A tumor suppressor to facilitate hepatitis C virus replication.

Arora P, Basu A, Schmidt ML, Clark GJ, Donninger H, Nichols DB, Calvisi DF, Kaushik-Basu N.

Hepatology. 2017 May;65(5):1462-1477. doi: 10.1002/hep.29049. Epub 2017 Mar 30.


Nore1a drives Ras to flick the P53 senescence switch.

Donninger H, Clark GJ.

Mol Cell Oncol. 2015 Jun 10;3(3):e1055050. doi: 10.1080/23723556.2015.1055050. eCollection 2016 May.


Ras signaling through RASSF proteins.

Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ.

Semin Cell Dev Biol. 2016 Oct;58:86-95. doi: 10.1016/j.semcdb.2016.06.007. Epub 2016 Jun 8. Review.


Proteomics Analysis Reveals Novel RASSF2 Interaction Partners.

Barnoud T, Wilkey DW, Merchant ML, Clark JA, Donninger H.

Cancers (Basel). 2016 Mar 16;8(3). pii: E37. doi: 10.3390/cancers8030037.


NORE1A is a double barreled Ras senescence effector that activates p53 and Rb.

Donninger H, Barnoud T, Clark GJ.

Cell Cycle. 2016 Sep;15(17):2263-4. doi: 10.1080/15384101.2016.1152431. Epub 2016 Feb 26.


Ras Regulates Rb via NORE1A.

Barnoud T, Donninger H, Clark GJ.

J Biol Chem. 2016 Feb 5;291(6):3114-23. doi: 10.1074/jbc.M115.697557. Epub 2015 Dec 16.


A porcine model system of BRCA1 driven breast cancer.

Donninger H, Hobbing K, Schmidt ML, Walters E, Rund L, Schook L, Clark GJ.

Front Genet. 2015 Aug 25;6:269. doi: 10.3389/fgene.2015.00269. eCollection 2015.


Fibroblast-Derived Extracellular Matrices: An Alternative Cell Culture System That Increases Metastatic Cellular Properties.

Scherzer MT, Waigel S, Donninger H, Arumugam V, Zacharias W, Clark G, Siskind LJ, Soucy P, Beverly L.

PLoS One. 2015 Sep 15;10(9):e0138065. doi: 10.1371/journal.pone.0138065. eCollection 2015.


NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2.

Donninger H, Calvisi DF, Barnoud T, Clark J, Schmidt ML, Vos MD, Clark GJ.

J Cell Biol. 2015 Mar 16;208(6):777-89. doi: 10.1083/jcb.201408087.


Human polymorphonuclear neutrophils specifically recognize and kill cancerous cells.

Yan J, Kloecker G, Fleming C, Bousamra M 2nd, Hansen R, Hu X, Ding C, Cai Y, Xiang D, Donninger H, Eaton JW, Clark GJ.

Oncoimmunology. 2014 Jul 3;3(7):e950163. eCollection 2014.


The RASSF1A tumor suppressor regulates XPA-mediated DNA repair.

Donninger H, Clark J, Rinaldo F, Nelson N, Barnoud T, Schmidt ML, Hobbing KR, Vos MD, Sils B, Clark GJ.

Mol Cell Biol. 2015 Jan;35(1):277-87. doi: 10.1128/MCB.00202-14. Epub 2014 Nov 3.


Cell cycle restriction is more important than apoptosis induction for RASSF1A protein tumor suppression.

Donninger H, Clark JA, Monaghan MK, Schmidt ML, Vos M, Clark GJ.

J Biol Chem. 2014 Nov 7;289(45):31287-95. doi: 10.1074/jbc.M114.609537. Epub 2014 Sep 15.


Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A.

Schmidt ML, Donninger H, Clark GJ.

J Biol Chem. 2014 Nov 7;289(45):31102-10. doi: 10.1074/jbc.M114.594283. Epub 2014 Sep 12.


p21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts.

Holderness Parker N, Donninger H, Birrer MJ, Leaner VD.

PLoS One. 2013 Jun 20;8(6):e66892. doi: 10.1371/journal.pone.0066892. Print 2013.


Loss of RASSF2 Enhances Tumorigencity of Lung Cancer Cells and Confers Resistance to Chemotherapy.

Clark J, Freeman J, Donninger H.

Mol Biol Int. 2012;2012:705948. doi: 10.1155/2012/705948. Epub 2012 May 24.


RASSF1A and the Taxol Response in Ovarian Cancer.

Kassler S, Donninger H, Birrer MJ, Clark GJ.

Mol Biol Int. 2012;2012:263267. doi: 10.1155/2012/263267. Epub 2012 Apr 3.


Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions.

Donninger H, Allen N, Henson A, Pogue J, Williams A, Gordon L, Kassler S, Dunwell T, Latif F, Clark GJ.

J Biol Chem. 2011 May 27;286(21):18483-91. doi: 10.1074/jbc.M110.214874. Epub 2011 Apr 13.


RASSF1A and the rs2073498 Cancer Associated SNP.

Donninger H, Barnoud T, Nelson N, Kassler S, Clark J, Cummins TD, Powell DW, Nyante S, Millikan RC, Clark GJ.

Front Oncol. 2011 Dec 28;1:54. doi: 10.3389/fonc.2011.00054. eCollection 2011.


The Ras effector RASSF2 controls the PAR-4 tumor suppressor.

Donninger H, Hesson L, Vos M, Beebe K, Gordon L, Sidransky D, Liu JW, Schlegel T, Payne S, Hartmann A, Latif F, Clark GJ.

Mol Cell Biol. 2010 Jun;30(11):2608-20. doi: 10.1128/MCB.00208-09. Epub 2010 Apr 5.


A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2.

Mok SC, Bonome T, Vathipadiekal V, Bell A, Johnson ME, Wong KK, Park DC, Hao K, Yip DK, Donninger H, Ozbun L, Samimi G, Brady J, Randonovich M, Pise-Masison CA, Barrett JC, Wong WH, Welch WR, Berkowitz RS, Birrer MJ.

Cancer Cell. 2009 Dec 8;16(6):521-32. doi: 10.1016/j.ccr.2009.10.018.


NORE1A tumor suppressor candidate modulates p21CIP1 via p53.

Calvisi DF, Donninger H, Vos MD, Birrer MJ, Gordon L, Leaner V, Clark GJ.

Cancer Res. 2009 Jun 1;69(11):4629-37. doi: 10.1158/0008-5472.CAN-08-3672. Epub 2009 May 12.


Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma.

Leaner VD, Chick JF, Donninger H, Linniola I, Mendoza A, Khanna C, Birrer MJ.

Am J Pathol. 2009 Jan;174(1):265-75. doi: 10.2353/ajpath.2009.071006. Epub 2008 Dec 12.


Differential effects of novel tumour-derived p53 mutations on the transformation of NIH-3T3 cells.

Donninger H, Binder A, Bohm L, Parker MI.

Biol Chem. 2008 Jan;389(1):57-67.


The RASSF1A tumor suppressor.

Donninger H, Vos MD, Clark GJ.

J Cell Sci. 2007 Sep 15;120(Pt 18):3163-72. Review.


Expression of p53 and its homolog, p73, in HPV DNA positive oesophageal squamous cell carcinomas.

Matsha T, Donninger H, Erasmus RT, Hendricks D, Stepien A, Parker MI.

Virology. 2007 Dec 5;369(1):182-90. Epub 2007 Aug 29.


RASSF6 is a novel member of the RASSF family of tumor suppressors.

Allen NP, Donninger H, Vos MD, Eckfeld K, Hesson L, Gordon L, Birrer MJ, Latif F, Clark GJ.

Oncogene. 2007 Sep 13;26(42):6203-11. Epub 2007 Apr 2.


Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth.

Wu K, Liu M, Li A, Donninger H, Rao M, Jiao X, Lisanti MP, Cvekl A, Birrer M, Pestell RG.

Mol Biol Cell. 2007 Mar;18(3):755-67. Epub 2006 Dec 20.


Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancer.

Sunde JS, Donninger H, Wu K, Johnson ME, Pestell RG, Rose GS, Mok SC, Brady J, Bonome T, Birrer MJ.

Cancer Res. 2006 Sep 1;66(17):8404-12.


The RASSF1A tumor suppressor activates Bax via MOAP-1.

Vos MD, Dallol A, Eckfeld K, Allen NP, Donninger H, Hesson LB, Calvisi D, Latif F, Clark GJ.

J Biol Chem. 2006 Feb 24;281(8):4557-63. Epub 2005 Dec 12.


Persistence of rhinovirus RNA after asthma exacerbation in children.

Kling S, Donninger H, Williams Z, Vermeulen J, Weinberg E, Latiff K, Ghildyal R, Bardin P.

Clin Exp Allergy. 2005 May;35(5):672-8.


Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells.

Katabami M, Donninger H, Hommura F, Leaner VD, Kinoshita I, Chick JF, Birrer MJ.

J Biol Chem. 2005 Apr 29;280(17):16728-38. Epub 2005 Feb 28.


Rhinovirus infects primary human airway fibroblasts and induces a neutrophil chemokine and a permeability factor.

Ghildyal R, Dagher H, Donninger H, de Silva D, Li X, Freezer NJ, Wilson JW, Bardin PG.

J Med Virol. 2005 Apr;75(4):608-15.


Whole genome expression profiling of advance stage papillary serous ovarian cancer reveals activated pathways.

Donninger H, Bonome T, Radonovich M, Pise-Masison CA, Brady J, Shih JH, Barrett JC, Birrer MJ.

Oncogene. 2004 Oct 21;23(49):8065-77.


HMG-I/Y is a c-Jun/activator protein-1 target gene and is necessary for c-Jun-induced anchorage-independent growth in Rat1a cells.

Hommura F, Katabami M, Leaner VD, Donninger H, Sumter TF, Resar LM, Birrer MJ.

Mol Cancer Res. 2004 May;2(5):305-14.


Functional analysis of novel SLC11A1 (NRAMP1) promoter variants in susceptibility to HIV-1.

Donninger H, Cashmore TJ, Scriba T, Petersen DC, Janse van Rensburg E, Hayes VM.

J Med Genet. 2004 Apr;41(4):e49. No abstract available.


Rhinovirus detection: comparison of real-time and conventional PCR.

Dagher H, Donninger H, Hutchinson P, Ghildyal R, Bardin P.

J Virol Methods. 2004 May;117(2):113-21.


Rhinovirus induction of the CXC chemokine epithelial-neutrophil activating peptide-78 in bronchial epithelium.

Donninger H, Glashoff R, Haitchi HM, Syce JA, Ghildyal R, van Rensburg E, Bardin PG.

J Infect Dis. 2003 Jun 1;187(11):1809-17.


Radiosensitization and DNA repair inhibition by pentoxifylline in NIH3T3 p53 transfectants.

Binder A, Theron T, Donninger H, Parker M, Bohm L.

Int J Radiat Biol. 2002 Nov;78(11):991-1000.


Rhinovirus is associated with severe asthma exacerbations and raised nasal interleukin-12.

Ferreira A, Williams Z, Donninger H, van Schalkwyk EM, Bardin PG.

Respiration. 2002;69(2):136-42.


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