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Items: 1 to 50 of 73

1.

Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.

Jakob CG, Upadhyay AK, Donner PL, Nicholl E, Addo SN, Qiu W, Ling C, Gopalakrishnan SM, Torrent M, Cepa SP, Shanley J, Shoemaker AR, Sun CC, Vasudevan A, Woller KR, Shotwell JB, Shaw B, Bian Z, Hutti JE.

J Med Chem. 2018 Aug 9;61(15):6647-6657. doi: 10.1021/acs.jmedchem.8b00305. Epub 2018 Jul 30.

PMID:
30004704
2.

Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).

Wagner R, Randolph JT, Patel SV, Nelson L, Matulenko MA, Keddy R, Pratt JK, Liu D, Krueger AC, Donner PL, Hutchinson DK, Flentge C, Betebenner D, Rockway T, Maring CJ, Ng TI, Krishnan P, Pilot-Matias T, Collins C, Panchal N, Reisch T, Dekhtyar T, Mondal R, Stolarik DF, Gao Y, Gao W, Beno DA, Kati WM.

J Med Chem. 2018 May 10;61(9):4052-4066. doi: 10.1021/acs.jmedchem.8b00082. Epub 2018 Apr 23.

PMID:
29653491
3.

Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability.

Randolph JT, Krueger AC, Donner PL, Pratt JK, Liu D, Motter CE, Rockway TW, Tufano MD, Wagner R, Lim HB, Beyer JM, Mondal R, Panchal NS, Colletti L, Liu Y, Koev G, Kati WM, Hernandez LE, Beno DWA, Longenecker KL, Stewart KD, Dumas EO, Molla A, Maring CJ.

J Med Chem. 2018 Feb 8;61(3):1153-1163. doi: 10.1021/acs.jmedchem.7b01630. Epub 2018 Jan 25.

PMID:
29342358
4.

Discovery of fluorobenzimidazole HCV NS5A inhibitors.

Randolph JT, Flentge CA, Donner P, Rockway TW, Patel SV, Nelson L, Hutchinson DK, Mondal R, Mistry N, Reisch T, Dekhtyar T, Krishnan P, Pilot-Matias T, Stolarik DF, Beno DWA, Wagner R, Maring C, Kati WM.

Bioorg Med Chem Lett. 2016 Nov 15;26(22):5462-5467. doi: 10.1016/j.bmcl.2016.10.030. Epub 2016 Oct 13.

PMID:
27780635
5.

Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.

DeGoey DA, Randolph JT, Liu D, Pratt J, Hutchins C, Donner P, Krueger AC, Matulenko M, Patel S, Motter CE, Nelson L, Keddy R, Tufano M, Caspi DD, Krishnan P, Mistry N, Koev G, Reisch TJ, Mondal R, Pilot-Matias T, Gao Y, Beno DW, Maring CJ, Molla A, Dumas E, Campbell A, Williams L, Collins C, Wagner R, Kati WM.

J Med Chem. 2014 Mar 13;57(5):2047-57. doi: 10.1021/jm401398x. Epub 2014 Jan 15.

PMID:
24400777
6.

High potency improvements to weak aryl uracil HCV polymerase inhibitor leads.

Donner P, Randolph JT, Huang P, Wagner R, Maring C, Lim BH, Colletti L, Liu Y, Mondal R, Beyer J, Koev G, Marsh K, Beno D, Longenecker K, Pilot-Matias T, Kati W, Molla A, Kempf D.

Bioorg Med Chem Lett. 2013 Aug 1;23(15):4367-9. doi: 10.1016/j.bmcl.2013.05.078. Epub 2013 Jun 4.

PMID:
23791079
7.

Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif.

Krueger AC, Randolph JT, DeGoey DA, Donner PL, Flentge CA, Hutchinson DK, Liu D, Motter CE, Rockway TW, Wagner R, Beno DW, Koev G, Lim HB, Beyer JM, Mondal R, Liu Y, Kati WM, Longenecker KL, Molla A, Stewart KD, Maring CJ.

Bioorg Med Chem Lett. 2013 Jun 15;23(12):3487-90. doi: 10.1016/j.bmcl.2013.04.057. Epub 2013 May 1.

PMID:
23664214
8.

Structural and functional insights into a dodecameric molecular machine - the RuvBL1/RuvBL2 complex.

Gorynia S, Bandeiras TM, Pinho FG, McVey CE, Vonrhein C, Round A, Svergun DI, Donner P, Matias PM, Carrondo MA.

J Struct Biol. 2011 Dec;176(3):279-91. doi: 10.1016/j.jsb.2011.09.001. Epub 2011 Sep 10.

PMID:
21933716
9.

Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety.

Hutchinson DK, Flentge CA, Donner PL, Wagner R, Maring CJ, Kati WM, Liu Y, Masse SV, Middleton T, Mo H, Montgomery D, Jiang WW, Koev G, Beno DW, Stewart KD, Stoll VS, Molla A, Kempf DJ.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1876-9. doi: 10.1016/j.bmcl.2010.12.067. Epub 2011 Jan 13.

PMID:
21316235
10.

Off-target decoding of a multitarget kinase inhibitor by chemical proteomics.

Missner E, Bahr I, Badock V, Lücking U, Siemeister G, Donner P.

Chembiochem. 2009 May 4;10(7):1163-74. doi: 10.1002/cbic.200800796.

PMID:
19350611
11.

Cloning, expression, purification, crystallization and preliminary X-ray analysis of the human RuvBL1-RuvBL2 complex.

Gorynia S, Matias PM, Bandeiras TM, Donner P, Carrondo MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Sep 1;64(Pt 9):840-6. doi: 10.1107/S174430910802558X. Epub 2008 Aug 20.

12.

[Persistent diarrhea and loss of weight during therapy with leflunomide].

Gugenberger C, Donner P, Naami A, Berges W.

Dtsch Med Wochenschr. 2008 Aug;133(34-35):1730-2. doi: 10.1055/s-0028-1082795. German.

PMID:
18696405
13.

Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase.

Liu Y, Donner PL, Pratt JK, Jiang WW, Ng T, Gracias V, Baumeister S, Wiedeman PE, Traphagen L, Warrior U, Maring C, Kati WM, Djuric SW, Molla A.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3173-7. doi: 10.1016/j.bmcl.2008.04.068. Epub 2008 May 1.

PMID:
18479921
14.

Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin.

Bandeiras TM, Hillig RC, Matias PM, Eberspaecher U, Fanghänel J, Thomaz M, Miranda S, Crusius K, Pütter V, Amstutz P, Gulotti-Georgieva M, Binz HK, Holz C, Schmitz AA, Lang C, Donner P, Egner U, Carrondo MA, Müller-Tiemann B.

Acta Crystallogr D Biol Crystallogr. 2008 Apr;64(Pt 4):339-53. doi: 10.1107/S0907444907068217. Epub 2008 Mar 19.

PMID:
18391401
15.

Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase.

Donner PL, Xie Q, Pratt JK, Maring CJ, Kati W, Jiang W, Liu Y, Koev G, Masse S, Montgomery D, Molla A, Kempf DJ.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2735-8. doi: 10.1016/j.bmcl.2008.02.064. Epub 2008 Mar 4.

PMID:
18362072
16.

Identifying protein construct variants with increased crystallization propensity--a case study.

Malawski GA, Hillig RC, Monteclaro F, Eberspaecher U, Schmitz AA, Crusius K, Huber M, Egner U, Donner P, Müller-Tiemann B.

Protein Sci. 2006 Dec;15(12):2718-28.

17.

Crystal structure of the human AAA+ protein RuvBL1.

Matias PM, Gorynia S, Donner P, Carrondo MA.

J Biol Chem. 2006 Dec 15;281(50):38918-29. Epub 2006 Oct 23.

18.

Expression, purification, crystallization and preliminary X-ray analysis of the human RuvB-like protein RuvBL1.

Gorynia S, Matias PM, Gonçalves S, Coelho R, Lopes G, Thomaz M, Huber M, Haendler B, Donner P, Carrondo MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jan 1;62(Pt 1):61-6. Epub 2005 Dec 16.

19.

LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain.

Korr D, Toschi L, Donner P, Pohlenz HD, Kreft B, Weiss B.

Cell Signal. 2006 Jun;18(6):910-20. Epub 2005 Oct 21.

PMID:
16243488
20.

Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.

Mo H, Lu L, Pilot-Matias T, Pithawalla R, Mondal R, Masse S, Dekhtyar T, Ng T, Koev G, Stoll V, Stewart KD, Pratt J, Donner P, Rockway T, Maring C, Molla A.

Antimicrob Agents Chemother. 2005 Oct;49(10):4305-14.

21.

Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines.

Pratt JK, Donner P, McDaniel KF, Maring CJ, Kati WM, Mo H, Middleton T, Liu Y, Ng T, Xie Q, Zhang R, Montgomery D, Molla A, Kempf DJ, Kohlbrenner W.

Bioorg Med Chem Lett. 2005 Mar 15;15(6):1577-82.

PMID:
15745800
22.

Domain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.

Blume A, Weidemann W, Stelzl U, Wanker EE, Lucka L, Donner P, Reutter W, Horstkorte R, Hinderlich S.

Biochem J. 2004 Dec 15;384(Pt 3):599-607.

23.

UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, functionally expressed in and purified from Escherichia coli, yeast, and insect cells.

Blume A, Ghaderi D, Liebich V, Hinderlich S, Donner P, Reutter W, Lucka L.

Protein Expr Purif. 2004 Jun;35(2):387-96.

PMID:
15135418
24.

Methanol induction optimization for scFv antibody fragment production in Pichia pastoris.

Cunha AE, Clemente JJ, Gomes R, Pinto F, Thomaz M, Miranda S, Pinto R, Moosmayer D, Donner P, Carrondo MJ.

Biotechnol Bioeng. 2004 May 20;86(4):458-67.

PMID:
15112298
25.

Comparison of proteomic and genomic analyses of the human breast cancer cell line T47D and the antiestrogen-resistant derivative T47D-r.

Huber M, Bahr I, Krätzschmar JR, Becker A, Müller EC, Donner P, Pohlenz HD, Schneider MR, Sommer A.

Mol Cell Proteomics. 2004 Jan;3(1):43-55. Epub 2003 Oct 13.

26.

Keratinocyte unresponsiveness towards interleukin-10: lack of specific binding due to deficient IL-10 receptor 1 expression.

Seifert M, Gruenberg BH, Sabat R, Donner P, Gruetz G, Volk HD, Wolk K, Asadullah K.

Exp Dermatol. 2003 Apr;12(2):137-44.

PMID:
12702141
27.

A tumor-specific kinase activity regulates the viral death protein Apoptin.

Rohn JL, Zhang YH, Aalbers RI, Otto N, Den Hertog J, Henriquez NV, Van De Velde CJ, Kuppen PJ, Mumberg D, Donner P, Noteborn MH.

J Biol Chem. 2002 Dec 27;277(52):50820-7. Epub 2002 Oct 21.

28.

Structural basis for the glucocorticoid response in a mutant human androgen receptor (AR(ccr)) derived from an androgen-independent prostate cancer.

Matias PM, Carrondo MA, Coelho R, Thomaz M, Zhao XY, Wegg A, Crusius K, Egner U, Donner P.

J Med Chem. 2002 Mar 28;45(7):1439-46.

PMID:
11906285
29.

Immunohistochemical localization of zona pellucida proteins ZPA, ZPB and ZPC in human, cynomolgus monkey and mouse ovaries.

Eberspaecher U, Becker A, Bringmann P, van der Merwe L, Donner P.

Cell Tissue Res. 2001 Feb;303(2):277-87.

PMID:
11291774
30.

Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations.

Matias PM, Donner P, Coelho R, Thomaz M, Peixoto C, Macedo S, Otto N, Joschko S, Scholz P, Wegg A, Bäsler S, Schäfer M, Egner U, Carrondo MA.

J Biol Chem. 2000 Aug 25;275(34):26164-71.

31.

Characterization of human zona pellucida glycoproteins.

Bauskin AR, Franken DR, Eberspaecher U, Donner P.

Mol Hum Reprod. 1999 Jun;5(6):534-40.

PMID:
10341000
32.

Identification of the autoantigen of celiac disease.

Schuppan D, Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO.

Ann N Y Acad Sci. 1998 Nov 17;859:121-6. Review.

PMID:
9928375
33.

Fibrin selectivity of the isolated protease domains of tissue-type and vampire bat salivary gland plasminogen activators.

Toschi L, Bringmann P, Petri T, Donner P, Schleuning WD.

Eur J Biochem. 1998 Feb 15;252(1):108-12.

34.

Catalytic domain structure of vampire bat plasminogen activator: a molecular paradigm for proteolysis without activation cleavage.

Renatus M, Stubbs MT, Huber R, Bringmann P, Donner P, Schleuning WD, Bode W.

Biochemistry. 1997 Nov 4;36(44):13483-93.

PMID:
9354616
35.

Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug.

Fuentes-Prior P, Noeske-Jungblut C, Donner P, Schleuning WD, Huber R, Bode W.

Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11845-50.

36.

Identification of tissue transglutaminase as the autoantigen of celiac disease.

Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D.

Nat Med. 1997 Jul;3(7):797-801.

PMID:
9212111
38.

Analysis of site-specific N-glycosylation of recombinant Desmodus rotundus salivary plasminogen activator rDSPA alpha 1 expressed in Chinese hamster ovary cells.

Gohlke M, Nuck R, Kannicht C, Grunow D, Baude G, Donner P, Reutter W.

Glycobiology. 1997 Feb;7(1):67-77.

PMID:
9061366
39.

Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.

Li Q, Chu DT, Claiborne A, Cooper CS, Lee CM, Raye K, Berst KB, Donner P, Wang W, Hasvold L, Fung A, Ma Z, Tufano M, Flamm R, Shen LL, Baranowski J, Nilius A, Alder J, Meulbroek J, Marsh K, Crowell D, Hui Y, Seif L, Melcher LM, Plattner JJ, et al.

J Med Chem. 1996 Aug 2;39(16):3070-88.

PMID:
8759628
40.

The synthesis and in vitro antibacterial activity of conformationally restricted quinolone antibacterial agents.

Cooper CS, Tufano MD, Donner PK, Chu DT.

Bioorg Med Chem. 1996 Aug;4(8):1307-15.

PMID:
8879552
41.

O-linked L-fucose is present in Desmodus rotundus salivary plasminogen activator.

Gohlke M, Baude G, Nuck R, Grunow D, Kannicht C, Bringmann P, Donner P, Reutter W.

J Biol Chem. 1996 Mar 29;271(13):7381-6.

42.

The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3.

Krätzschmar J, Haendler B, Eberspaecher U, Roosterman D, Donner P, Schleuning WD.

Eur J Biochem. 1996 Mar 15;236(3):827-36.

43.

Expression, purification and characterisation of recombinant pallidipin, a novel platelet aggregation inhibitor from the haematophageous triatomine bug Triatoma pallidipennis.

Haendler B, Becker A, Noeske-Jungblut C, Krätzschmar J, Donner P, Schleuning WD.

Blood Coagul Fibrinolysis. 1996 Mar;7(2):183-6.

PMID:
8735814
44.

Triabin, a highly potent exosite inhibitor of thrombin.

Noeske-Jungblut C, Haendler B, Donner P, Alagon A, Possani L, Schleuning WD.

J Biol Chem. 1995 Dec 1;270(48):28629-34.

45.

Structural features mediating fibrin selectivity of vampire bat plasminogen activators.

Bringmann P, Gruber D, Liese A, Toschi L, Krätzchmar J, Schleuning WD, Donner P.

J Biol Chem. 1995 Oct 27;270(43):25596-603.

46.

Mouse androgen-dependent epididymal glycoprotein CRISP-1 (DE/AEG): isolation, biochemical characterization, and expression in recombinant form.

Eberspaecher U, Roosterman D, Krätzschmar J, Haendler B, Habenicht UF, Becker A, Quensel C, Petri T, Schleuning WD, Donner P.

Mol Reprod Dev. 1995 Oct;42(2):157-72.

PMID:
8562061
47.

[New thrombolytic and anticoagulant drugs from the saliva of blood-sucking animals].

Donner P, Noeske-Jungblut C, Schleuning WD.

Pharm Unserer Zeit. 1995 Jun;24(3):125-9. Review. German. No abstract available.

PMID:
7610107
48.

Expression of active recombinant pallidipin, a novel platelet aggregation inhibitor, in the periplasm of Escherichia coli.

Haendler B, Becker A, Noeske-Jungblut C, Krätzschmar J, Donner P, Schleuning WD.

Biochem J. 1995 Apr 15;307 ( Pt 2):465-70.

49.

Production of vampire bat plasminogen activator DSPA alpha 1 in CHO and insect cells.

Petri T, Langer G, Bringmann P, Cashion L, Shallow S, Schleuning WD, Donner P.

J Biotechnol. 1995 Feb 21;39(1):75-83.

PMID:
7766013
50.

Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa.

Zheng X, Geiger M, Ecke S, Bielek E, Donner P, Eberspächer U, Schleuning WD, Binder BR.

Am J Physiol. 1994 Aug;267(2 Pt 1):C466-72.

PMID:
7521127

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