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Items: 17


Characterization of the Activity and Distribution of a 2'-O-Methoxyethyl-Modified Antisense Oligonucleotide in Models of Acute and Chronic Kidney Disease.

Donner AJ, Bell TA, Greenlee S, Graham MJ, Crooke RM.

Nucleic Acid Ther. 2018 Oct;28(5):297-306. doi: 10.1089/nat.2018.0723. Epub 2018 Aug 22.


Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver.

Miller CM, Tanowitz M, Donner AJ, Prakash TP, Swayze EE, Harris EN, Seth PP.

Nucleic Acid Ther. 2018 Jun;28(3):119-127. doi: 10.1089/nat.2017.0709. Epub 2018 Feb 9. Review.


Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver.

Donner AJ, Wancewicz EV, Murray HM, Greenlee S, Post N, Bell M, Lima WF, Swayze EE, Seth PP.

Nucleic Acid Ther. 2017 Aug;27(4):209-220. doi: 10.1089/nat.2017.0662. Epub 2017 Apr 27.


Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor.

Schmidt K, Prakash TP, Donner AJ, Kinberger GA, Gaus HJ, Low A, Østergaard ME, Bell M, Swayze EE, Seth PP.

Nucleic Acids Res. 2017 Mar 17;45(5):2294-2306. doi: 10.1093/nar/gkx060.


Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver.

Miller CM, Donner AJ, Blank EE, Egger AW, Kellar BM, Østergaard ME, Seth PP, Harris EN.

Nucleic Acids Res. 2016 Apr 7;44(6):2782-94. doi: 10.1093/nar/gkw112. Epub 2016 Feb 22.


CD40 Generation 2.5 Antisense Oligonucleotide Treatment Attenuates Doxorubicin-induced Nephropathy and Kidney Inflammation.

Donner AJ, Yeh ST, Hung G, Graham MJ, Crooke RM, Mullick AE.

Mol Ther Nucleic Acids. 2015 Dec 1;4:e265. doi: 10.1038/mtna.2015.40.


Trends in mild, moderate, and severe stunting and underweight, and progress towards MDG 1 in 141 developing countries: a systematic analysis of population representative data.

Stevens GA, Finucane MM, Paciorek CJ, Flaxman SR, White RA, Donner AJ, Ezzati M; Nutrition Impact Model Study Group (Child Growth).

Lancet. 2012 Sep 1;380(9844):824-34. doi: 10.1016/S0140-6736(12)60647-3. Epub 2012 Jul 5.


CDK8: a positive regulator of transcription.

Galbraith MD, Donner AJ, Espinosa JM.

Transcription. 2010 Jul-Aug;1(1):4-12. doi: 10.4161/trns.1.1.12373. Review.


CDK8 is a positive regulator of transcriptional elongation within the serum response network.

Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM.

Nat Struct Mol Biol. 2010 Feb;17(2):194-201. doi: 10.1038/nsmb.1752. Epub 2010 Jan 24.


A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.

Beckerman R, Donner AJ, Mattia M, Peart MJ, Manley JL, Espinosa JM, Prives C.

Genes Dev. 2009 Jun 1;23(11):1364-77. doi: 10.1101/gad.1795709.


The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator.

Knuesel MT, Meyer KD, Donner AJ, Espinosa JM, Taatjes DJ.

Mol Cell Biol. 2009 Feb;29(3):650-61. doi: 10.1128/MCB.00993-08. Epub 2008 Dec 1.


Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.

Meyer KD, Donner AJ, Knuesel MT, York AG, Espinosa JM, Taatjes DJ.

EMBO J. 2008 May 21;27(10):1447-57. doi: 10.1038/emboj.2008.78. Epub 2008 Apr 17.


Stimulus-specific transcriptional regulation within the p53 network.

Donner AJ, Hoover JM, Szostek SA, Espinosa JM.

Cell Cycle. 2007 Nov 1;6(21):2594-8. Epub 2007 Aug 13.


CDK8 is a stimulus-specific positive coregulator of p53 target genes.

Donner AJ, Szostek S, Hoover JM, Espinosa JM.

Mol Cell. 2007 Jul 6;27(1):121-33.


[Kasabach-Merritt syndrome in giant hemangioma of the liver. A case report].

Vogel T, Lammers B, von Herbay A, Kunz BM, Donner AJ, Fürst G, Goretzki PE.

Chirurg. 2002 Jul;73(7):729-32. German.


Legionella pneumophila in a human trophoblast cell line.

Schmid EN, Müller KD, Nalik HP, Donner AJ.

In Vitro Cell Dev Biol. 1991 Nov;27A(11):829-30. No abstract available.


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