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The ELISA Detectability and Potency of Pegfilgrastim Decrease in Physiological Conditions: Key Roles for Aggregation and Individual Variability.

Xie T, Fang H, Ouyang W, Angart P, Chiang MJ, Bhirde AA, Sheikh F, Lynch P, Shah AB, Patil SM, Chen K, Shen M, Agarabi C, Donnelly RP, Brorson K, Schrieber SJ, Howard KE, Rogstad SM, Frucht DM.

Sci Rep. 2020 Feb 12;10(1):2476. doi: 10.1038/s41598-020-59346-z.


Development of a Biodegradable Subcutaneous Implant for Prolonged Drug Delivery Using 3D Printing.

Stewart SA, Domínguez-Robles J, McIlorum VJ, Mancuso E, Lamprou DA, Donnelly RF, Larrañeta E.

Pharmaceutics. 2020 Jan 28;12(2). pii: E105. doi: 10.3390/pharmaceutics12020105.


Readiness to prescribe: Using educational design to untie the Gordian Knot.

Lee C, McCrory R, Tully MP, Carrington A, Donnelly R, Dornan T.

PLoS One. 2020 Jan 24;15(1):e0227865. doi: 10.1371/journal.pone.0227865. eCollection 2020.


Enhancement in site-specific delivery of carvacrol for potential treatment of infected wounds using infection responsive nanoparticles loaded into dissolving microneedles: A proof of concept study.

Mir M, Permana AD, Ahmed N, Khan GM, Rehman AU, Donnelly RF.

Eur J Pharm Biopharm. 2020 Feb;147:57-68. doi: 10.1016/j.ejpb.2019.12.008. Epub 2019 Dec 27.


Pullulan-based dissolving microneedle arrays for enhanced transdermal delivery of small and large biomolecules.

Vora LK, Courtenay AJ, Tekko IA, Larrañeta E, Donnelly RF.

Int J Biol Macromol. 2020 Mar 1;146:290-298. doi: 10.1016/j.ijbiomac.2019.12.184. Epub 2019 Dec 26.


Modelling and manipulation of aphid-mediated spread of non-persistently transmitted viruses.

Carr JP, Tungadi T, Donnelly R, Bravo-Cazar A, Rhee SJ, Watt LG, Mutuku JM, Wamonje FO, Murphy AM, Arinaitwe W, Pate AE, Cunniffe NJ, Gilligan CA.

Virus Res. 2019 Dec 23;277:197845. doi: 10.1016/j.virusres.2019.197845. [Epub ahead of print] Review.


Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies.

Ilyushina NA, Komatsu TE, Ince WL, Donaldson EF, Lee N, O'Rear JJ, Donnelly RP.

Virol J. 2019 Nov 29;16(1):149. doi: 10.1186/s12985-019-1258-x.


Cucumber mosaic virus 2b proteins inhibit virus-induced aphid resistance in tobacco.

Tungadi T, Donnelly R, Qing L, Iqbal J, Murphy AM, Pate AE, Cunniffe NJ, Carr JP.

Mol Plant Pathol. 2020 Feb;21(2):250-257. doi: 10.1111/mpp.12892. Epub 2019 Nov 27.


Enhancement in Site-Specific Delivery of Carvacrol against Methicillin Resistant Staphylococcus aureus Induced Skin Infections Using Enzyme Responsive Nanoparticles: A Proof of Concept Study.

Mir M, Ahmed N, Permana AD, Rodgers AM, Donnelly RF, Rehman AU.

Pharmaceutics. 2019 Nov 13;11(11). pii: E606. doi: 10.3390/pharmaceutics11110606.


Design and Development of Liquid Drug Reservoirs for Microneedle Delivery of Poorly Soluble Drug Molecules.

Kearney MC, McKenna PE, Quinn HL, Courtenay AJ, Larrañeta E, Donnelly RF.

Pharmaceutics. 2019 Nov 13;11(11). pii: E605. doi: 10.3390/pharmaceutics11110605.


3D printed microneedles for anticancer therapy of skin tumours.

Uddin MJ, Scoutaris N, Economidou SN, Giraud C, Chowdhry BZ, Donnelly RF, Douroumis D.

Mater Sci Eng C Mater Biol Appl. 2020 Feb;107:110248. doi: 10.1016/j.msec.2019.110248. Epub 2019 Oct 12.


Death of a Child Prior to Midlife, Dementia Risk, and Racial Disparities.

Umberson D, Donnelly R, Xu M, Farina M, Garcia MA.

J Gerontol B Psychol Sci Soc Sci. 2019 Nov 24. pii: gbz154. doi: 10.1093/geronb/gbz154. [Epub ahead of print]


Gut Check Time: Antibiotic Delivery Strategies to Reduce Antimicrobial Resistance.

Kelly SA, Rodgers AM, O'Brien SC, Donnelly RF, Gilmore BF.

Trends Biotechnol. 2019 Nov 19. pii: S0167-7799(19)30249-5. doi: 10.1016/j.tibtech.2019.10.008. [Epub ahead of print] Review.


How innovative drug delivery devices can help realize clinical utility of new effective therapies.

Lamprou DA, Singh TRR, Larrañeta E, Donnelly RF.

Expert Opin Drug Deliv. 2019 Dec;16(12):1277-1281. doi: 10.1080/17425247.2019.1689956. Epub 2019 Nov 13. No abstract available.


Solid lipid nanoparticle-based dissolving microneedles: A promising intradermal lymph targeting drug delivery system with potential for enhanced treatment of lymphatic filariasis.

Permana AD, Tekko IA, McCrudden MTC, Anjani QK, Ramadon D, McCarthy HO, Donnelly RF.

J Control Release. 2019 Dec 28;316:34-52. doi: 10.1016/j.jconrel.2019.10.004. Epub 2019 Oct 23.


Dissolving Microneedles for Intradermal Vaccination against Shigellosis.

Pastor Y, Larrañeta E, Erhard Á, Quincooces G, Peñuelas I, Irache JM, Donnelly R, Gamazo C.

Vaccines (Basel). 2019 Oct 24;7(4). pii: E159. doi: 10.3390/vaccines7040159.


Cross disciplinary collaboration in the current market place.

Donnelly R.

Sci Justice. 2019 Nov;59(6):678-679. doi: 10.1016/j.scijus.2019.07.002. Epub 2019 Jul 8. No abstract available.


Technology update: dissolvable microneedle patches for vaccine delivery.

Rodgers AM, Cordeiro AS, Donnelly RF.

Med Devices (Auckl). 2019 Sep 19;12:379-398. doi: 10.2147/MDER.S198220. eCollection 2019.


Modelling the intradermal delivery of microneedle array patches for long-acting antiretrovirals using PBPK.

Rajoli RKR, Flexner C, Chiong J, Owen A, Donnelly RF, Larrañeta E, Siccardi M.

Eur J Pharm Biopharm. 2019 Nov;144:101-109. doi: 10.1016/j.ejpb.2019.09.011. Epub 2019 Sep 13.


Lignin and Cellulose Blends as Pharmaceutical Excipient for Tablet Manufacturing via Direct Compression.

Domínguez-Robles J, Stewart SA, Rendl A, González Z, Donnelly RF, Larrañeta E.

Biomolecules. 2019 Aug 28;9(9). pii: E423. doi: 10.3390/biom9090423.


Effect of Bariatric Surgery on Cardiovascular Events and Metabolic Outcomes in Obese Patients with Insulin-Treated Type 2 Diabetes: a Retrospective Cohort Study.

Alkharaiji M, Anyanwagu U, Donnelly R, Idris I.

Obes Surg. 2019 Oct;29(10):3154-3164. doi: 10.1007/s11695-019-03809-4.


Enhanced Intradermal Delivery of Nanosuspensions of Antifilariasis Drugs Using Dissolving Microneedles: A Proof of Concept Study.

Permana AD, McCrudden MTC, Donnelly RF.

Pharmaceutics. 2019 Jul 17;11(7). pii: E346. doi: 10.3390/pharmaceutics11070346.


DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen.

Cole G, Ali AA, McErlean E, Mulholland EJ, Short A, McCrudden CM, McCaffrey J, Robson T, Kett VL, Coulter JA, Dunne NJ, Donnelly RF, McCarthy HO.

Acta Biomater. 2019 Sep 15;96:480-490. doi: 10.1016/j.actbio.2019.07.003. Epub 2019 Jul 9.


Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin.

Abdelghany S, Tekko IA, Vora L, Larrañeta E, Permana AD, Donnelly RF.

Pharmaceutics. 2019 Jul 2;11(7). pii: E308. doi: 10.3390/pharmaceutics11070308.


Effect of influenza H1N1 neuraminidase V116A and I117V mutations on NA activity and sensitivity to NA inhibitors.

Adams SE, Lee N, Lugovtsev VY, Kan A, Donnelly RP, Ilyushina NA.

Antiviral Res. 2019 Sep;169:104539. doi: 10.1016/j.antiviral.2019.104539. Epub 2019 Jun 19.


Can Spouses Buffer the Impact of Discrimination on Depressive Symptoms? An Examination of Same-sex and Different-sex Marriages.

Donnelly R, Robinson BA, Umberson D.

Soc Ment Health. 2019;9(2):192-210. doi: 10.1177/2156869318800157. Epub 2018 Sep 21.


Rapidly dissolving bilayer microneedle arrays - A minimally invasive transdermal drug delivery system for vitamin B12.

Ramöller IK, Tekko IA, McCarthy HO, Donnelly RF.

Int J Pharm. 2019 Jul 20;566:299-306. doi: 10.1016/j.ijpharm.2019.05.066. Epub 2019 May 28.


Identification and quantification of defective virus genomes in high throughput sequencing data using DVG-profiler, a novel post-sequence alignment processing algorithm.

Bosma TJ, Karagiannis K, Santana-Quintero L, Ilyushina N, Zagorodnyaya T, Petrovskaya S, Laassri M, Donnelly RP, Rubin S, Simonyan V, Sauder CJ.

PLoS One. 2019 May 17;14(5):e0216944. doi: 10.1371/journal.pone.0216944. eCollection 2019.


Meeting Overview: Interferon Lambda-Disease Impact and Therapeutic Potential.

O'Brien TR, Young HA, Donnelly RP, Prokunina-Olsson L.

J Interferon Cytokine Res. 2019 Oct;39(10):586-591. doi: 10.1089/jir.2019.0018. Epub 2019 Apr 17.


Antioxidant PLA Composites Containing Lignin for 3D Printing Applications: A Potential Material for Healthcare Applications.

Domínguez-Robles J, Martin NK, Fong ML, Stewart SA, Irwin NJ, Rial-Hermida MI, Donnelly RF, Larrañeta E.

Pharmaceutics. 2019 Apr 4;11(4). pii: E165. doi: 10.3390/pharmaceutics11040165.


Pathogenic modification of plants enhances long-distance dispersal of nonpersistently transmitted viruses to new hosts.

Donnelly R, Cunniffe NJ, Carr JP, Gilligan CA.

Ecology. 2019 Jul;100(7):e02725. doi: 10.1002/ecy.2725. Epub 2019 May 21.


Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications.

Stewart SA, Domínguez-Robles J, Donnelly RF, Larrañeta E.

Polymers (Basel). 2018 Dec 12;10(12). pii: E1379. doi: 10.3390/polym10121379. Review.


Slowly dissolving intradermal microneedles.

Donnelly RF, Larraňeta E.

Nat Biomed Eng. 2019 Mar;3(3):169-170. doi: 10.1038/s41551-019-0369-4. No abstract available.


New HPLC-MS method for rapid and simultaneous quantification of doxycycline, diethylcarbamazine and albendazole metabolites in rat plasma and organs after concomitant oral administration.

Permana AD, Tekko IA, McCarthy HO, Donnelly RF.

J Pharm Biomed Anal. 2019 Jun 5;170:243-253. doi: 10.1016/j.jpba.2019.03.047. Epub 2019 Mar 26.


Efficacy and Safety of Pioglitazone Monotherapy in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Alam F, Islam MA, Mohamed M, Ahmad I, Kamal MA, Donnelly R, Idris I, Gan SH.

Sci Rep. 2019 Mar 29;9(1):5389. doi: 10.1038/s41598-019-41854-2.


Klebsiella pneumoniae ST307 with blaOXA-181, South Africa, 2014-2016.

Lowe M, Kock MM, Coetzee J, Hoosien E, Peirano G, Strydom KA, Ehlers MM, Mbelle NM, Shashkina E, Haslam DB, Dhawan P, Donnelly RJ, Chen L, Kreiswirth BN, Pitout JDD.

Emerg Infect Dis. 2019 Apr;25(4):739-747. doi: 10.3201/eid2504.181482.


Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin.

Rodgers AM, McCrudden MTC, Courtenay AJ, Kearney MC, Edwards KL, Ingram RJ, Bengoechea J, Donnelly RF.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02612-18. doi: 10.1128/AAC.02612-18. Print 2019 May.


Design, Formulation, and Evaluation of Novel Dissolving Microarray Patches Containing Rilpivirine for Intravaginal Delivery.

Mc Crudden MTC, Larrañeta E, Clark A, Jarrahian C, Rein-Weston A, Creelman B, Moyo Y, Lachau-Durand S, Niemeijer N, Williams P, McCarthy HO, Zehrung D, Donnelly RF.

Adv Healthc Mater. 2019 May;8(9):e1801510. doi: 10.1002/adhm.201801510. Epub 2019 Mar 6.


Tier 3 specialist weight management service and pre-bariatric multicomponent weight management programmes for adults with obesity living in the UK: A systematic review.

Alkharaiji M, Anyanwagu U, Donnelly R, Idris I.

Endocrinol Diabetes Metab. 2018 Oct 25;2(1):e00042. doi: 10.1002/edm2.42. eCollection 2019 Jan.


A comparison of interferon gene expression induced by influenza A virus infection of human airway epithelial cells from two different donors.

Ilyushina NA, Dickensheets H, Donnelly RP.

Virus Res. 2019 Apr 15;264:1-7. doi: 10.1016/j.virusres.2019.02.002. Epub 2019 Feb 16.


Understanding the basis of transcutaneous vaccine delivery.

Gamazo C, Pastor Y, Larrañeta E, Berzosa M, Irache JM, Donnelly RF.

Ther Deliv. 2019 Jan;10(1):63-80. doi: 10.4155/tde-2018-0054. Review.


Physical Compatibility and Chemical Stability of Injectable and Oral Ranitidine Solutions.

Fleming K, Donnelly RF.

Hosp Pharm. 2019 Feb;54(1):32-36. doi: 10.1177/0018578718763085. Epub 2018 Mar 7.


Albuminuria Regression and All-Cause Mortality among Insulin-Treated Patients with Type 2 Diabetes: Analysis of a Large UK Primary Care Cohort.

Anyanwagu U, Donnelly R, Idris I.

Am J Nephrol. 2019;49(2):146-155. doi: 10.1159/000496276. Epub 2019 Jan 24.


Evaluation of microneedles-assisted in situ depot forming poloxamer gels for sustained transdermal drug delivery.

Khan S, Minhas MU, Tekko IA, Donnelly RF, Thakur RRS.

Drug Deliv Transl Res. 2019 Aug;9(4):764-782. doi: 10.1007/s13346-019-00617-2.


Editorial. Neurodevelopmental outcome and sagittal synostosis.

Kulkarni AV, Donnelly R.

J Neurosurg Pediatr. 2019 Jan 18:1-2. doi: 10.3171/2018.9.PEDS18531. [Epub ahead of print] No abstract available.


Relationship between HbA1c and all-cause mortality in older patients with insulin-treated type 2 diabetes: results of a large UK Cohort Study.

Anyanwagu U, Mamza J, Donnelly R, Idris I.

Age Ageing. 2019 Mar 1;48(2):235-240. doi: 10.1093/ageing/afy178.


Gender, Socioeconomic Status, and Diet Behaviors within Brazilian Families.

Donnelly R, Marteleto LJ.

Socius. 2018 Jan-Dec;4. doi: 10.1177/2378023118804688. Epub 2018 Oct 24.


MtrA Response Regulator Controls Cell Division and Cell Wall Metabolism and Affects Susceptibility of Mycobacteria to the First Line Antituberculosis Drugs.

Gorla P, Plocinska R, Sarva K, Satsangi AT, Pandeeti E, Donnelly R, Dziadek J, Rajagopalan M, Madiraju MV.

Front Microbiol. 2018 Nov 23;9:2839. doi: 10.3389/fmicb.2018.02839. eCollection 2018.


Psychological Distress Transmission in Same-sex and Different-sex Marriages.

Behler R, Donnelly R, Umberson D.

J Health Soc Behav. 2019 Mar;60(1):18-35. doi: 10.1177/0022146518813097. Epub 2018 Nov 21.


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