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Targeting defective pulmonary innate immunity - A new therapeutic option?

Belchamber KBR, Donnelly LE.

Pharmacol Ther. 2020 Feb 12:107500. doi: 10.1016/j.pharmthera.2020.107500. [Epub ahead of print] Review.


Senotherapy: a new horizon for COPD therapy.

Baker JR, Donnelly LE, Barnes PJ.

Chest. 2020 Feb 10. pii: S0012-3692(20)30252-X. doi: 10.1016/j.chest.2020.01.027. [Epub ahead of print] Review.


Phenotypic comparison between smoking and non-smoking chronic obstructive pulmonary disease.

Salvi SS, Brashier BB, Londhe J, Pyasi K, Vincent V, Kajale SS, Tambe S, Mandani K, Nair A, Mak SM, Madas S, Juvekar S, Donnelly LE, Barnes PJ.

Respir Res. 2020 Feb 12;21(1):50. doi: 10.1186/s12931-020-1310-9.


The ERS fellowship portfolio: fostering excellence and diversity.

Morty RE, Donnelly LE, Stolz D, Roche N, Welte T, Forrest KA, Brightling CE, Brusselle GG.

Eur Respir J. 2019 Sep 5;54(3). pii: 1901503. doi: 10.1183/13993003.01503-2019. Print 2019 Sep. No abstract available.


Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages.

Belchamber KBR, Singh R, Batista CM, Whyte MK, Dockrell DH, Kilty I, Robinson MJ, Wedzicha JA, Barnes PJ, Donnelly LE; COPD-MAP consortium.

Eur Respir J. 2019 Oct 10;54(4). pii: 1802244. doi: 10.1183/13993003.02244-2018. Print 2019 Oct.


Update in Asthma and Airway Inflammation 2018.

Menzies-Gow A, McBrien CN, Baker JR, Donnelly LE, Cohen RT.

Am J Respir Crit Care Med. 2019 Jul 1;200(1):14-19. doi: 10.1164/rccm.201902-0321UP. No abstract available.


Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases.

Barnes PJ, Baker J, Donnelly LE.

Am J Respir Crit Care Med. 2019 Sep 1;200(5):556-564. doi: 10.1164/rccm.201810-1975TR.


Galectin-3 enhances monocyte-derived macrophage efferocytosis of apoptotic granulocytes in asthma.

Erriah M, Pabreja K, Fricker M, Baines KJ, Donnelly LE, Bylund J, Karlsson A, Simpson JL.

Respir Res. 2019 Jan 3;20(1):1. doi: 10.1186/s12931-018-0967-9.


Bacterial load and defective monocyte-derived macrophage bacterial phagocytosis in biomass smoke-related COPD.

Ghosh B, Gaike AH, Pyasi K, Brashier B, Das VV, Londhe JD, Juvekar S, Shouche YS, Donnelly LE, Salvi SS, Barnes PJ.

Eur Respir J. 2019 Feb 28;53(2). pii: 1702273. doi: 10.1183/13993003.02273-2017. Print 2019 Feb.


Human Rhinovirus Impairs the Innate Immune Response to Bacteria in Alveolar Macrophages in Chronic Obstructive Pulmonary Disease.

Finney LJ, Belchamber KBR, Fenwick PS, Kemp SV, Edwards MR, Mallia P, Donaldson G, Johnston SL, Donnelly LE, Wedzicha JA.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1496-1507. doi: 10.1164/rccm.201806-1095OC.


Direct Inhibitory Effect of the PDE4 Inhibitor Roflumilast on Neutrophil Migration in Chronic Obstructive Pulmonary Disease.

Dunne AE, Kawamatawong T, Fenwick PS, Davies CM, Tullett H, Barnes PJ, Donnelly LE.

Am J Respir Cell Mol Biol. 2019 Apr;60(4):445-453. doi: 10.1165/rcmb.2018-0065OC.


Comparison of fluticasone propionate and budesonide on COPD macrophage and neutrophil function.

Belchamber KB, Thomas CM, Dunne AE, Barnes PJ, Donnelly LE.

Int J Chron Obstruct Pulmon Dis. 2018 Sep 17;13:2883-2897. doi: 10.2147/COPD.S169337. eCollection 2018.


MicroRNA-570 is a novel regulator of cellular senescence and inflammaging.

Baker JR, Vuppusetty C, Colley T, Hassibi S, Fenwick PS, Donnelly LE, Ito K, Barnes PJ.

FASEB J. 2019 Feb;33(2):1605-1616. doi: 10.1096/fj.201800965R. Epub 2018 Aug 29.


Pre-clinical Pharmacokinetic and Metabolomic Analyses of Isorhapontigenin, a Dietary Resveratrol Derivative.

Dai Y, Yeo SCM, Barnes PJ, Donnelly LE, Loo LC, Lin HS.

Front Pharmacol. 2018 Jul 11;9:753. doi: 10.3389/fphar.2018.00753. eCollection 2018.


Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists.

Bewley MA, Budd RC, Ryan E, Cole J, Collini P, Marshall J, Kolsum U, Beech G, Emes RD, Tcherniaeva I, Berbers GAM, Walmsley SR, Donaldson G, Wedzicha JA, Kilty I, Rumsey W, Sanchez Y, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Whyte MKB, Dockrell DH; COPDMAP.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):739-750. doi: 10.1164/rccm.201705-0903OC.


The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure.

Yanagisawa S, Baker JR, Vuppusetty C, Koga T, Colley T, Fenwick P, Donnelly LE, Barnes PJ, Ito K.

PLoS One. 2018 Mar 6;13(3):e0193921. doi: 10.1371/journal.pone.0193921. eCollection 2018.


Reduced Clearance of Fungal Spores by Chronic Obstructive Pulmonary Disease GM-CSF- and M-CSF-derived Macrophages.

Wrench C, Belchamber KBR, Bercusson A, Shah A, Barnes PJ, Armstrong-James D, Donnelly LE.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):271-273. doi: 10.1165/rcmb.2017-0351LE. No abstract available.


Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study.

Wang Z, Singh R, Miller BE, Tal-Singer R, Van Horn S, Tomsho L, Mackay A, Allinson JP, Webb AJ, Brookes AJ, George LM, Barker B, Kolsum U, Donnelly LE, Belchamber K, Barnes PJ, Singh D, Brightling CE, Donaldson GC, Wedzicha JA, Brown JR; COPDMAP.

Thorax. 2018 Apr;73(4):331-338. doi: 10.1136/thoraxjnl-2017-210741. Epub 2017 Dec 21.


Catalog of Differentially Expressed Long Non-Coding RNA following Activation of Human and Mouse Innate Immune Response.

Roux BT, Heward JA, Donnelly LE, Jones SW, Lindsay MA.

Front Immunol. 2017 Aug 29;8:1038. doi: 10.3389/fimmu.2017.01038. eCollection 2017.


Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and Patients with Chronic Obstructive Pulmonary Disease.

Paschalaki KE, Zampetaki A, Baker JR, Birrell MA, Starke RD, Belvisi MG, Donnelly LE, Mayr M, Randi AM, Barnes PJ.

Am J Respir Crit Care Med. 2018 Mar 1;197(5):665-668. doi: 10.1164/rccm.201706-1304LE. No abstract available.


Correcting the "Wandering" Neutrophil with Statins. A Novel Antiaging Strategy?

Belchamber KBR, Donnelly LE.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1243-1244. doi: 10.1164/rccm.201707-1410ED. No abstract available.


Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages.

Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH.

Am J Respir Crit Care Med. 2017 Oct 1;196(7):845-855. doi: 10.1164/rccm.201608-1714OC.


Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD.

Yanagisawa S, Baker JR, Vuppusetty C, Fenwick P, Donnelly LE, Ito K, Barnes PJ.

Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L230-L239. doi: 10.1152/ajplung.00382.2016. Epub 2017 May 18.


Macrophage Dysfunction in Respiratory Disease.

Belchamber KBR, Donnelly LE.

Results Probl Cell Differ. 2017;62:299-313. doi: 10.1007/978-3-319-54090-0_12. Review.


Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid-independent mechanism.

Yeo SCM, Fenwick PS, Barnes PJ, Lin HS, Donnelly LE.

Br J Pharmacol. 2017 Jul;174(13):2043-2059. doi: 10.1111/bph.13803. Epub 2017 May 16.


Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

Bewley MA, Belchamber KB, Chana KK, Budd RC, Donaldson G, Wedzicha JA, Brightling CE, Kilty I, Donnelly LE, Barnes PJ, Singh D, Whyte MK, Dockrell DH; COPDMAP.

PLoS One. 2016 Sep 28;11(9):e0163139. doi: 10.1371/journal.pone.0163139. eCollection 2016.


A novel flow cytometric-based method to measure kinase inhibition in sputum from COPD subjects.

Nicholson GC, Holloway RA, Leaker BR, Kilty I, Salganik M, Tan L, Barnes PJ, Donnelly LE.

BMJ Open Respir Res. 2016 Jun 22;3(1):e000140. doi: 10.1136/bmjresp-2016-000140. eCollection 2016.


Could Protecting the Immunoproteasome Reduce Exacerbations in Chronic Obstructive Pulmonary Disease?

Donnelly LE.

Am J Respir Crit Care Med. 2016 Jun 1;193(11):1188-90. doi: 10.1164/rccm.201601-0060ED. No abstract available.


Now We Know Who You Are: A Clear Description of Mononuclear Phagocyte Subsets in the Human Lung.

Singh D, Donnelly LE.

Am J Respir Crit Care Med. 2016 Mar 15;193(6):594-6. doi: 10.1164/rccm.201511-2212ED. No abstract available.


Enhanced monocyte migration to CXCR3 and CCR5 chemokines in COPD.

Costa C, Traves SL, Tudhope SJ, Fenwick PS, Belchamber KB, Russell RE, Barnes PJ, Donnelly LE.

Eur Respir J. 2016 Apr;47(4):1093-102.


Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells.

Fenwick PS, Macedo P, Kilty IC, Barnes PJ, Donnelly LE.

PLoS One. 2015 Jun 19;10(6):e0128757. doi: 10.1371/journal.pone.0128757. eCollection 2015.


Corrigendum: Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes.

Ilott NE, Heward JA, Roux B, Tsitsiou E, Fenwick PS, Lenzi L, Goodhead I, Hertz-Fowler C, Heger A, Hall N, Donnelly LE, Sims D, Lindsay MA.

Nat Commun. 2015 Apr 9;6:6814. doi: 10.1038/ncomms7814. No abstract available.


Inflammatory thresholds and the species-specific effects of colonising bacteria in stable chronic obstructive pulmonary disease.

Singh R, Mackay AJ, Patel AR, Garcha DS, Kowlessar BS, Brill SE, Donnelly LE, Barnes PJ, Donaldson GC, Wedzicha JA.

Respir Res. 2014 Sep 14;15:114. doi: 10.1186/s12931-014-0114-1.


The lipidome: a new player in chronic obstructive pulmonary disease pathophysiology?

Donnelly LE.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):124-5. doi: 10.1164/rccm.201406-1061ED. No abstract available.


Impaired macrophage phagocytosis of bacteria in severe asthma.

Liang Z, Zhang Q, Thomas CM, Chana KK, Gibeon D, Barnes PJ, Chung KF, Bhavsar PK, Donnelly LE.

Respir Res. 2014 Jun 27;15:72. doi: 10.1186/1465-9921-15-72.


Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes.

IIott NE, Heward JA, Roux B, Tsitsiou E, Fenwick PS, Lenzi L, Goodhead I, Hertz-Fowler C, Heger A, Hall N, Donnelly LE, Sims D, Lindsay MA.

Nat Commun. 2014 Jun 9;5:3979. doi: 10.1038/ncomms4979. Erratum in: Nat Commun. 2015;6:6814.


Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses.

Forbes B, O'Lone R, Allen PP, Cahn A, Clarke C, Collinge M, Dailey LA, Donnelly LE, Dybowski J, Hassall D, Hildebrand D, Jones R, Kilgour J, Klapwijk J, Maier CC, McGovern T, Nikula K, Parry JD, Reed MD, Robinson I, Tomlinson L, Wolfreys A.

Adv Drug Deliv Rev. 2014 May;71:15-33. doi: 10.1016/j.addr.2014.02.001. Epub 2014 Feb 13.


Identification of a distinct glucocorticosteroid-insensitive pulmonary macrophage phenotype in patients with chronic obstructive pulmonary disease.

Chana KK, Fenwick PS, Nicholson AG, Barnes PJ, Donnelly LE.

J Allergy Clin Immunol. 2014 Jan;133(1):207-16.e1-11. doi: 10.1016/j.jaci.2013.08.044. Epub 2013 Oct 28.


A role for M(2) and M(3) muscarinic receptors in the contraction of rat and human small airways.

Brown SM, Koarai A, Sturton RG, Nicholson AG, Barnes PJ, Donnelly LE.

Eur J Pharmacol. 2013 Feb 28;702(1-3):109-15. doi: 10.1016/j.ejphar.2013.01.054. Epub 2013 Feb 8.


Immunopathogenesis of chronic obstructive pulmonary disease.

Holloway RA, Donnelly LE.

Curr Opin Pulm Med. 2013 Mar;19(2):95-102. doi: 10.1097/MCP.0b013e32835cfff5. Review.


Defective phagocytosis in airways disease.

Donnelly LE, Barnes PJ.

Chest. 2012 Apr;141(4):1055-1062. doi: 10.1378/chest.11-2348. Review.


Expression of muscarinic receptors by human macrophages.

Koarai A, Traves SL, Fenwick PS, Brown SM, Chana KK, Russell RE, Nicholson AG, Barnes PJ, Donnelly LE.

Eur Respir J. 2012 Mar;39(3):698-704. doi: 10.1183/09031936.00136710. Epub 2011 Sep 1.


Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.

Mercado N, Thimmulappa R, Thomas CM, Fenwick PS, Chana KK, Donnelly LE, Biswal S, Ito K, Barnes PJ.

Biochem Biophys Res Commun. 2011 Mar 11;406(2):292-8. doi: 10.1016/j.bbrc.2011.02.035. Epub 2011 Feb 12.


Effects of formoterol and salmeterol on cytokine release from monocyte-derived macrophages.

Donnelly LE, Tudhope SJ, Fenwick PS, Barnes PJ.

Eur Respir J. 2010 Jul;36(1):178-86. doi: 10.1183/09031936.00158008. Epub 2009 Nov 19.


Defective macrophage phagocytosis of bacteria in COPD.

Taylor AE, Finney-Hayward TK, Quint JK, Thomas CM, Tudhope SJ, Wedzicha JA, Barnes PJ, Donnelly LE.

Eur Respir J. 2010 May;35(5):1039-47. doi: 10.1183/09031936.00036709. Epub 2009 Nov 6.


Expression of transient receptor potential C6 channels in human lung macrophages.

Finney-Hayward TK, Popa MO, Bahra P, Li S, Poll CT, Gosling M, Nicholson AG, Russell RE, Kon OM, Jarai G, Westwick J, Barnes PJ, Donnelly LE.

Am J Respir Cell Mol Biol. 2010 Sep;43(3):296-304. doi: 10.1165/rcmb.2008-0373OC. Epub 2009 Oct 20.


Leukotriene B4 release by human lung macrophages via receptor- not voltage-operated Ca2+ channels.

Finney-Hayward TK, Bahra P, Li S, Poll CT, Nicholson AG, Russell RE, Ford PA, Westwick J, Fenwick PS, Barnes PJ, Donnelly LE.

Eur Respir J. 2009 May;33(5):1105-12. doi: 10.1183/09031936.00062708. Epub 2009 Jan 22.


Th17 cells in airway diseases.

Traves SL, Donnelly LE.

Curr Mol Med. 2008 Aug;8(5):416-26. Review.


Novel targets and drugs in inflammatory lung disease.

Donnelly LE, Rogers DF.

Curr Opin Pharmacol. 2008 Jun;8(3):219-21. doi: 10.1016/j.coph.2008.04.007. Epub 2008 May 22. No abstract available.


The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells.

Tudhope SJ, Catley MC, Fenwick PS, Russell RE, Rumsey WL, Newton R, Barnes PJ, Donnelly LE.

J Immunol. 2007 Nov 1;179(9):6237-45.

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