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Items: 15


DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes.

Maul RW, MacCarthy T, Frank EG, Donigan KA, McLenigan MP, Yang W, Saribasak H, Huston DE, Lange SS, Woodgate R, Gearhart PJ.

J Exp Med. 2016 Aug 22;213(9):1675-83. doi: 10.1084/jem.20151227. Epub 2016 Jul 25.


A research roadmap for next-generation sequencing informatics.

Altman RB, Prabhu S, Sidow A, Zook JM, Goldfeder R, Litwack D, Ashley E, Asimenos G, Bustamante CD, Donigan K, Giacomini KM, Johansen E, Khuri N, Lee E, Liang XS, Salit M, Serang O, Tezak Z, Wall DP, Mansfield E, Kass-Hout T.

Sci Transl Med. 2016 Apr 20;8(335):335ps10. doi: 10.1126/scitranslmed.aaf7314. Review.


Unlocking the steric gate of DNA polymerase η leads to increased genomic instability in Saccharomyces cerevisiae.

Donigan KA, Cerritelli SM, McDonald JP, Vaisman A, Crouch RJ, Woodgate R.

DNA Repair (Amst). 2015 Nov;35:1-12. doi: 10.1016/j.dnarep.2015.07.002. Epub 2015 Aug 7.


FDA oversight of laboratory-developed tests will facilitate adoption of pharmacogenetic testing into routine clinical care.

Hillebrenner E, Litwack E, Bradley P, Donigan K, Lowe T, Serrano K, Kelm K, Mansfield E, Gutierrez A.

J Clin Pharmacol. 2015 Jul;55(7):728-30. doi: 10.1002/jcph.521. No abstract available.


Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.

Chen J, Morrical MD, Donigan KA, Weidhaas JB, Sweasy JB, Averill AM, Tomczak JA, Morrical SW.

Nucleic Acids Res. 2015 Jan;43(2):1098-111. doi: 10.1093/nar/gku1337. Epub 2014 Dec 24.


The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.

Nemec AA, Murphy DL, Donigan KA, Sweasy JB.

J Biol Chem. 2014 May 16;289(20):13708-16. doi: 10.1074/jbc.M114.550400. Epub 2014 Mar 25.


The steric gate of DNA polymerase ι regulates ribonucleotide incorporation and deoxyribonucleotide fidelity.

Donigan KA, McLenigan MP, Yang W, Goodman MF, Woodgate R.

J Biol Chem. 2014 Mar 28;289(13):9136-45. doi: 10.1074/jbc.M113.545442. Epub 2014 Feb 14.


DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation.

Donigan KA, Tuck D, Schulz V, Sweasy JB.

Mutagenesis. 2012 Nov;27(6):683-91. doi: 10.1093/mutage/ges034. Epub 2012 Aug 21.


The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator.

Murphy DL, Donigan KA, Jaeger J, Sweasy JB.

Biochemistry. 2012 Jul 3;51(26):5269-75. Epub 2012 Jun 19.


Human POLB gene is mutated in high percentage of colorectal tumors.

Donigan KA, Sun KW, Nemec AA, Murphy DL, Cong X, Northrup V, Zelterman D, Sweasy JB.

J Biol Chem. 2012 Jul 6;287(28):23830-9. doi: 10.1074/jbc.M111.324947. Epub 2012 May 10.


Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.

Nemec AA, Donigan KA, Murphy DL, Jaeger J, Sweasy JB.

J Biol Chem. 2012 Jul 6;287(28):23840-9. doi: 10.1074/jbc.M112.362111. Epub 2012 May 9.


The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation.

Donigan KA, Hile SE, Eckert KA, Sweasy JB.

DNA Repair (Amst). 2012 Apr 1;11(4):381-90. doi: 10.1016/j.dnarep.2012.01.004. Epub 2012 Feb 15.


Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation.

Stachelek GC, Dalal S, Donigan KA, Campisi Hegan D, Sweasy JB, Glazer PM.

Cancer Res. 2010 Jan 1;70(1):409-17. doi: 10.1158/0008-5472.CAN-09-1353. Epub 2009 Dec 22.


Sequence context-specific mutagenesis and base excision repair.

Donigan KA, Sweasy JB.

Mol Carcinog. 2009 Apr;48(4):362-8. doi: 10.1002/mc.20497. Review.


Crypticity and functional distribution of the membrane associated alpha-L-fucosidase of human sperm.

Venditti JJ, Donigan KA, Bean BS.

Mol Reprod Dev. 2007 Jun;74(6):758-66.


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