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Items: 1 to 50 of 181

1.

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.

Hsu JI, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, Zhang J, Heffernan TP, Gera S, Kovacs JJ, Marszalek JR, Bristow C, Yan Y, Garcia-Manero G, Kantarjian H, Vassiliou G, Futreal PA, Donehower LA, Takahashi K, Goodell MA.

Cell Stem Cell. 2018 Nov 1;23(5):700-713.e6. doi: 10.1016/j.stem.2018.10.004.

2.

Transglutaminase-2 promotes metastatic and stem-like phenotypes in osteosarcoma.

Fuja DG, Rainusso NC, Shuck RL, Kurenbekova L, Donehower LA, Yustein JT.

Am J Cancer Res. 2018 Sep 1;8(9):1752-1763. eCollection 2018.

3.

Literature-based automated discovery of tumor suppressor p53 phosphorylation and inhibition by NEK2.

Choi BK, Dayaram T, Parikh N, Wilkins AD, Nagarajan M, Novikov IB, Bachman BJ, Jung SY, Haas PJ, Labrie JL, Pickering CR, Adikesavan AK, Regenbogen S, Kato L, Lelescu A, Buchovecky CM, Zhang H, Bao SH, Boyer S, Weber G, Scott KL, Chen Y, Spangler S, Donehower LA, Lichtarge O.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10666-10671. doi: 10.1073/pnas.1806643115. Epub 2018 Sep 28.

4.

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.

Knijnenburg TA, Wang L, Zimmermann MT, Chambwe N, Gao GF, Cherniack AD, Fan H, Shen H, Way GP, Greene CS, Liu Y, Akbani R, Feng B, Donehower LA, Miller C, Shen Y, Karimi M, Chen H, Kim P, Jia P, Shinbrot E, Zhang S, Liu J, Hu H, Bailey MH, Yau C, Wolf D, Zhao Z, Weinstein JN, Li L, Ding L, Mills GB, Laird PW, Wheeler DA, Shmulevich I; Cancer Genome Atlas Research Network, Monnat RJ Jr, Xiao Y, Wang C.

Cell Rep. 2018 Apr 3;23(1):239-254.e6. doi: 10.1016/j.celrep.2018.03.076.

5.

Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene-induced lung tumors in aged mice.

Parikh N, Shuck RL, Gagea M, Shen L, Donehower LA.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12691. Epub 2017 Oct 18.

6.

miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma.

Satterfield L, Shuck R, Kurenbekova L, Allen-Rhoades W, Edwards D, Huang S, Rajapakshe K, Coarfa C, Donehower LA, Yustein JT.

Int J Cancer. 2017 Nov 15;141(10):2062-2075. doi: 10.1002/ijc.30909. Epub 2017 Aug 8.

7.

Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice.

Leroy B, Ballinger ML, Baran-Marszak F, Bond GL, Braithwaite A, Concin N, Donehower LA, El-Deiry WS, Fenaux P, Gaidano G, Langerød A, Hellstrom-Lindberg E, Iggo R, Lehmann-Che J, Mai PL, Malkin D, Moll UM, Myers JN, Nichols KE, Pospisilova S, Ashton-Prolla P, Rossi D, Savage SA, Strong LC, Tonin PN, Zeillinger R, Zenz T, Fraumeni JF Jr, Taschner PE, Hainaut P, Soussi T.

Cancer Res. 2017 Mar 15;77(6):1250-1260. doi: 10.1158/0008-5472.CAN-16-2179. Review.

8.

LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro.

Wamsley JJ, Issaeva N, An H, Lu X, Donehower LA, Yarbrough WG.

Cell Cycle. 2017 Jan 17;16(2):213-223. doi: 10.1080/15384101.2016.1261767. Epub 2016 Dec 27.

9.

Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential.

Techavichit P, Gao Y, Kurenbekova L, Shuck R, Donehower LA, Yustein JT.

BMC Cancer. 2016 Nov 8;16(1):869.

10.

Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation.

Gingras MC, Covington KR, Chang DK, Donehower LA, Gill AJ, Ittmann MM, Creighton CJ, Johns AL, Shinbrot E, Dewal N, Fisher WE; Australian Pancreatic Cancer Genome Initiative, Pilarsky C, Grützmann R, Overman MJ, Jamieson NB, Van Buren G 2nd, Drummond J, Walker K, Hampton OA, Xi L, Muzny DM, Doddapaneni H, Lee SL, Bellair M, Hu J, Han Y, Dinh HH, Dahdouli M, Samra JS, Bailey P, Waddell N, Pearson JV, Harliwong I, Wang H, Aust D, Oien KA, Hruban RH, Hodges SE, McElhany A, Saengboonmee C, Duthie FR, Grimmond SM, Biankin AV, Wheeler DA, Gibbs RA.

Cell Rep. 2016 Feb 2;14(4):907-919. doi: 10.1016/j.celrep.2015.12.005. Epub 2016 Jan 21.

11.

Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes.

Wang L, Ni X, Covington KR, Yang BY, Shiu J, Zhang X, Xi L, Meng Q, Langridge T, Drummond J, Donehower LA, Doddapaneni H, Muzny DM, Gibbs RA, Wheeler DA, Duvic M.

Nat Genet. 2015 Dec;47(12):1426-34. doi: 10.1038/ng.3444. Epub 2015 Nov 9.

12.

Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis.

Roos A, Satterfield L, Zhao S, Fuja D, Shuck R, Hicks MJ, Donehower LA, Yustein JT.

Br J Cancer. 2015 Nov 3;113(9):1289-97. doi: 10.1038/bjc.2015.305. Epub 2015 Oct 15.

13.

Coamplification of Myc/Pvt1 and homozygous deletion of Nlrp1 locus are frequent genetics changes in mouse osteosarcoma.

Rao PH, Zhao S, Zhao YJ, Yu A, Rainusso N, Trucco M, Allen-Rhoades W, Satterfield L, Fuja D, Borra VJ, Man TK, Donehower LA, Yustein JT.

Genes Chromosomes Cancer. 2015 Dec;54(12):796-808. doi: 10.1002/gcc.22291. Epub 2015 Sep 10.

PMID:
26355645
14.

Ghrelin Prevents Cisplatin-Induced Testicular Damage by Facilitating Repair of DNA Double Strand Breaks Through Activation of p53 in Mice.

Garcia JM, Chen JA, Guillory B, Donehower LA, Smith RG, Lamb DJ.

Biol Reprod. 2015 Jul;93(1):24. doi: 10.1095/biolreprod.115.129759. Epub 2015 May 27.

15.

Cross-species identification of a plasma microRNA signature for detection, therapeutic monitoring, and prognosis in osteosarcoma.

Allen-Rhoades W, Kurenbekova L, Satterfield L, Parikh N, Fuja D, Shuck RL, Rainusso N, Trucco M, Barkauskas DA, Jo E, Ahern C, Hilsenbeck S, Donehower LA, Yustein JT.

Cancer Med. 2015 Jul;4(7):977-88. doi: 10.1002/cam4.438. Epub 2015 Mar 17.

16.

WIP1 phosphatase as a potential therapeutic target in neuroblastoma.

Richter M, Dayaram T, Gilmartin AG, Ganji G, Pemmasani SK, Van Der Key H, Shohet JM, Donehower LA, Kumar R.

PLoS One. 2015 Feb 6;10(2):e0115635. doi: 10.1371/journal.pone.0115635. eCollection 2015.

17.

NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma.

Zhao S, Kurenbekova L, Gao Y, Roos A, Creighton CJ, Rao P, Hicks J, Man TK, Lau C, Brown AM, Jones SN, Lazar AJ, Ingram D, Lev D, Donehower LA, Yustein JT.

Oncogene. 2015 Sep 24;34(39):5069-79. doi: 10.1038/onc.2014.429. Epub 2015 Jan 12.

18.

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types.

Xia Z, Donehower LA, Cooper TA, Neilson JR, Wheeler DA, Wagner EJ, Li W.

Nat Commun. 2014 Nov 20;5:5274. doi: 10.1038/ncomms6274.

19.

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.

Totoki Y, Tatsuno K, Covington KR, Ueda H, Creighton CJ, Kato M, Tsuji S, Donehower LA, Slagle BL, Nakamura H, Yamamoto S, Shinbrot E, Hama N, Lehmkuhl M, Hosoda F, Arai Y, Walker K, Dahdouli M, Gotoh K, Nagae G, Gingras MC, Muzny DM, Ojima H, Shimada K, Midorikawa Y, Goss JA, Cotton R, Hayashi A, Shibahara J, Ishikawa S, Guiteau J, Tanaka M, Urushidate T, Ohashi S, Okada N, Doddapaneni H, Wang M, Zhu Y, Dinh H, Okusaka T, Kokudo N, Kosuge T, Takayama T, Fukayama M, Gibbs RA, Wheeler DA, Aburatani H, Shibata T.

Nat Genet. 2014 Dec;46(12):1267-73. doi: 10.1038/ng.3126. Epub 2014 Nov 2.

PMID:
25362482
20.

Notch activation as a driver of osteogenic sarcoma.

Tao J, Jiang MM, Jiang L, Salvo JS, Zeng HC, Dawson B, Bertin TK, Rao PH, Chen R, Donehower LA, Gannon F, Lee BH.

Cancer Cell. 2014 Sep 8;26(3):390-401. doi: 10.1016/j.ccr.2014.07.023.

21.

The somatic genomic landscape of chromophobe renal cell carcinoma.

Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, Buhay C, Kang H, Kim SC, Fahey CC, Hacker KE, Bhanot G, Gordenin DA, Chu A, Gunaratne PH, Biehl M, Seth S, Kaipparettu BA, Bristow CA, Donehower LA, Wallen EM, Smith AB, Tickoo SK, Tamboli P, Reuter V, Schmidt LS, Hsieh JJ, Choueiri TK, Hakimi AA; The Cancer Genome Atlas Research Network, Chin L, Meyerson M, Kucherlapati R, Park WY, Robertson AG, Laird PW, Henske EP, Kwiatkowski DJ, Park PJ, Morgan M, Shuch B, Muzny D, Wheeler DA, Linehan WM, Gibbs RA, Rathmell WK, Creighton CJ.

Cancer Cell. 2014 Sep 8;26(3):319-330. doi: 10.1016/j.ccr.2014.07.014. Epub 2014 Aug 21.

22.

Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.

Xiong S, Tu H, Kollareddy M, Pant V, Li Q, Zhang Y, Jackson JG, Suh YA, Elizondo-Fraire AC, Yang P, Chau G, Tashakori M, Wasylishen AR, Ju Z, Solomon H, Rotter V, Liu B, El-Naggar AK, Donehower LA, Martinez LA, Lozano G.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11145-50. doi: 10.1073/pnas.1404139111. Epub 2014 Jul 14.

23.

Phosphatases reverse p53-mediated cell cycle checkpoints.

Donehower LA.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7172-3. doi: 10.1073/pnas.1405663111. Epub 2014 May 7. No abstract available.

24.

Combinatorial therapy discovery using mixed integer linear programming.

Pang K, Wan YW, Choi WT, Donehower LA, Sun J, Pant D, Liu Z.

Bioinformatics. 2014 May 15;30(10):1456-63. doi: 10.1093/bioinformatics/btu046. Epub 2014 Jan 24.

25.

Insights into wild-type and mutant p53 functions provided by genetically engineered mice.

Donehower LA.

Hum Mutat. 2014 Jun;35(6):715-27. doi: 10.1002/humu.22507. Epub 2014 Feb 5.

PMID:
24415648
26.

Effects of TP53 mutational status on gene expression patterns across 10 human cancer types.

Parikh N, Hilsenbeck S, Creighton CJ, Dayaram T, Shuck R, Shinbrot E, Xi L, Gibbs RA, Wheeler DA, Donehower LA.

J Pathol. 2014 Apr;232(5):522-33. doi: 10.1002/path.4321. Epub 2014 Jan 29.

27.

REGγ deficiency promotes premature aging via the casein kinase 1 pathway.

Li L, Zhao D, Wei H, Yao L, Dang Y, Amjad A, Xu J, Liu J, Guo L, Li D, Li Z, Zuo D, Zhang Y, Liu J, Huang S, Jia C, Wang L, Wang Y, Xie Y, Luo J, Zhang B, Luo H, Donehower LA, Moses RE, Xiao J, O'Malley BW, Li X.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11005-10. doi: 10.1073/pnas.1308497110. Epub 2013 Jun 13.

28.

Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage.

Dayaram T, Lemoine FJ, Donehower LA, Marriott SJ.

PLoS One. 2013;8(2):e55989. doi: 10.1371/journal.pone.0055989. Epub 2013 Feb 6.

29.
30.

MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes.

Donehower LA, Creighton CJ, Schultz N, Shinbrot E, Chang K, Gunaratne PH, Muzny D, Sander C, Hamilton SR, Gibbs RA, Wheeler D.

J Pathol. 2013 Jan;229(1):99-110. doi: 10.1002/path.4087.

31.

Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.

Parikh N, Shuck RL, Nguyen TA, Herron A, Donehower LA.

Mol Cancer Res. 2012 Jun;10(6):845-55. doi: 10.1158/1541-7786.MCR-12-0089. Epub 2012 Apr 24.

32.

Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.

Darlington Y, Nguyen TA, Moon SH, Herron A, Rao P, Zhu C, Lu X, Donehower LA.

Oncogene. 2012 Mar 1;31(9):1155-65. doi: 10.1038/onc.2011.303. Epub 2011 Jul 18.

33.

Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models.

Terzian T, Dumble M, Arbab F, Thaller C, Donehower LA, Lozano G, Justice MJ, Roop DR, Box NF.

J Pathol. 2011 Aug;224(4):540-52. doi: 10.1002/path.2891. Epub 2011 Jun 14.

34.

Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin.

Gannon HS, Donehower LA, Lyle S, Jones SN.

Dev Biol. 2011 May 1;353(1):1-9. doi: 10.1016/j.ydbio.2011.02.007. Epub 2011 Feb 17.

35.

P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis.

Fuchs-Young R, Shirley SH, Lambertz I, Colby JK, Tian J, Johnston D, Gimenez-Conti IB, Donehower LA, Conti CJ, Hursting SD.

Breast Cancer Res Treat. 2011 Nov;130(2):399-408. doi: 10.1007/s10549-010-1308-y. Epub 2010 Dec 30.

36.

Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma.

Shang X, Vasudevan SA, Yu Y, Ge N, Ludwig AD, Wesson CL, Wang K, Burlingame SM, Zhao YJ, Rao PH, Lu X, Russell HV, Okcu MF, Hicks MJ, Shohet JM, Donehower LA, Nuchtern JG, Yang J.

Oncogene. 2010 Sep 2;29(35):4938-46. doi: 10.1038/onc.2010.244. Epub 2010 Jun 21.

PMID:
20562916
37.

Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice.

Lee S, Donehower LA, Herron AJ, Moore DD, Fu L.

PLoS One. 2010 Jun 7;5(6):e10995. doi: 10.1371/journal.pone.0010995.

38.

Dephosphorylation of γ-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control.

Moon SH, Nguyen TA, Darlington Y, Lu X, Donehower LA.

Cell Cycle. 2010 Jun 1;9(11):2092-6. Epub 2010 Jun 1.

39.

55K isoform of CDK9 associates with Ku70 and is involved in DNA repair.

Liu H, Herrmann CH, Chiang K, Sung TL, Moon SH, Donehower LA, Rice AP.

Biochem Biophys Res Commun. 2010 Jun 25;397(2):245-50. doi: 10.1016/j.bbrc.2010.05.092. Epub 2010 May 20.

40.

Using mice to examine p53 functions in cancer, aging, and longevity.

Donehower LA.

Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001081. doi: 10.1101/cshperspect.a001081. Epub 2009 Nov 4. Review.

41.

The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.

Nguyen TA, Slattery SD, Moon SH, Darlington YF, Lu X, Donehower LA.

DNA Repair (Amst). 2010 Jul 1;9(7):813-23. doi: 10.1016/j.dnarep.2010.04.005. Epub 2010 May 6.

42.

Impact papers on aging in 2009.

Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM Jr, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J.

Aging (Albany NY). 2010 Mar;2(3):111-21. Epub 2010 Mar 23. Review.

43.

Longevity regulation in flies: a role for p53.

Donehower LA.

Aging (Albany NY). 2009 Jan 10;1(1):6-8. No abstract available.

44.

Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation.

Reddy JP, Peddibhotla S, Bu W, Zhao J, Haricharan S, Du YC, Podsypanina K, Rosen JM, Donehower LA, Li Y.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3728-33. doi: 10.1073/pnas.0910665107. Epub 2010 Feb 3.

45.

Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.

Moon SH, Lin L, Zhang X, Nguyen TA, Darlington Y, Waldman AS, Lu X, Donehower LA.

J Biol Chem. 2010 Apr 23;285(17):12935-47. doi: 10.1074/jbc.M109.071696. Epub 2010 Jan 29.

46.

Widespread and tissue specific age-related DNA methylation changes in mice.

Maegawa S, Hinkal G, Kim HS, Shen L, Zhang L, Zhang J, Zhang N, Liang S, Donehower LA, Issa JP.

Genome Res. 2010 Mar;20(3):332-40. doi: 10.1101/gr.096826.109. Epub 2010 Jan 27.

47.

20 years studying p53 functions in genetically engineered mice.

Donehower LA, Lozano G.

Nat Rev Cancer. 2009 Nov;9(11):831-41. doi: 10.1038/nrc2731. Epub 2009 Sep 24. Review.

PMID:
19776746
48.

Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression.

Hinkal G, Parikh N, Donehower LA.

PLoS One. 2009 Aug 14;4(8):e6654. doi: 10.1371/journal.pone.0006654.

49.

Exercise effects on tumorigenesis in a p53-deficient mouse model of breast cancer.

Colbert LH, Westerlind KC, Perkins SN, Haines DC, Berrigan D, Donehower LA, Fuchs-Young R, Hursting SD.

Med Sci Sports Exerc. 2009 Aug;41(8):1597-605. doi: 10.1249/MSS.0b013e31819f1f05.

50.

Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging.

Hinkal GW, Gatza CE, Parikh N, Donehower LA.

Mech Ageing Dev. 2009 Apr;130(4):262-71.

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