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Items: 1 to 50 of 113

1.

Stem-cell derived hepatocyte-like cells for the assessment of drug-induced liver injury.

Donato MT, Tolosa L.

Differentiation. 2019 Mar - Apr;106:15-22. doi: 10.1016/j.diff.2019.02.004. Epub 2019 Feb 19. Review.

PMID:
30844688
2.

Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes.

Tolosa L, Jiménez N, Pelechá M, Castell JV, Gómez-Lechón MJ, Donato MT.

Arch Toxicol. 2019 Feb;93(2):519-532. doi: 10.1007/s00204-018-2349-y. Epub 2018 Nov 13.

PMID:
30426164
3.

Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea.

Rodeiro I, Hernández I, Herrera JA, Riera M, Donato MT, Tolosa L, González K, Ansoar Y, Gómez-Lechón MJ, Vanden Berghe W, Lopes M.

J Pharm Pharmacol. 2018 Nov;70(11):1553-1560. doi: 10.1111/jphp.13001. Epub 2018 Aug 30.

PMID:
30159909
4.

In vitro modulation of the cytochrome P450 and ABCB1/P-glycoprotein activities of the aqueous extract of Allophylus cominia (L) Sw. leaves.

Pérez CL, Donato MT, Hernández I, Paz Lopes MT, Marrero E, Herrera JA, Gómez-Lechón MJ, Rodeiro I.

Drug Metab Pers Ther. 2017 Dec 20;32(4):201-208. doi: 10.1515/dmpt-2017-0020.

PMID:
29176019
5.

Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.

Tolosa L, Jiménez N, Pérez G, Castell JV, Gómez-Lechón MJ, Donato MT.

Arch Toxicol. 2018 Jan;92(1):383-399. doi: 10.1007/s00204-017-2036-4. Epub 2017 Jul 31.

6.

A lipidomic cell-based assay for studying drug-induced phospholipidosis and steatosis.

García-Cañaveras JC, Peris-Díaz MD, Alcoriza-Balaguer MI, Cerdán-Calero M, Donato MT, Lahoz A.

Electrophoresis. 2017 Sep;38(18):2331-2340. doi: 10.1002/elps.201700079. Epub 2017 Jun 8.

PMID:
28512733
7.

A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture.

Tolosa L, Gómez-Lechón MJ, Donato MT.

Curr Protoc Toxicol. 2017 May 2;72:14.15.1-14.15.11. doi: 10.1002/cptx.20.

PMID:
28463417
8.

Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies.

Donato MT, Gómez-Lechón MJ, Tolosa L.

Expert Opin Drug Discov. 2017 Feb;12(2):201-211. doi: 10.1080/17460441.2017.1271784. Epub 2016 Dec 21. Review.

PMID:
27936962
9.

Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development.

Donato MT, López-Riera M, Castell JV, Gómez-Lechón MJ, Jover R.

Toxicol Lett. 2016 Nov 30;263:58-67. doi: 10.1016/j.toxlet.2016.10.008. Epub 2016 Oct 17.

PMID:
27765674
10.

Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing.

Gómez-Lechón MJ, Tolosa L, Donato MT.

Expert Opin Drug Metab Toxicol. 2017 Feb;13(2):137-148. doi: 10.1080/17425255.2017.1238459. Epub 2016 Sep 27. Review.

PMID:
27671376
11.

A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury.

García-Cañaveras JC, Castell JV, Donato MT, Lahoz A.

Sci Rep. 2016 Jun 6;6:27239. doi: 10.1038/srep27239.

12.

Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.

Tolosa L, Gómez-Lechón MJ, López S, Guzmán C, Castell JV, Donato MT, Jover R.

Toxicol Sci. 2016 Jul;152(1):214-29. doi: 10.1093/toxsci/kfw078. Epub 2016 May 4.

PMID:
27208088
13.

Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis.

Tolosa L, Gómez-Lechón MJ, Jiménez N, Hervás D, Jover R, Donato MT.

Toxicol Appl Pharmacol. 2016 Jul 1;302:1-9. doi: 10.1016/j.taap.2016.04.007. Epub 2016 Apr 16.

PMID:
27089845
14.

Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells.

García-Cañaveras JC, López S, Castell JV, Donato MT, Lahoz A.

Anal Bioanal Chem. 2016 Feb;408(4):1217-30. doi: 10.1007/s00216-015-9227-8. Epub 2016 Jan 14.

PMID:
26769129
15.

Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.

Gómez-Lechón MJ, Tolosa L, Donato MT.

J Appl Toxicol. 2016 Jun;36(6):752-68. doi: 10.1002/jat.3277. Epub 2015 Dec 22. Review.

PMID:
26691983
16.

General Cytotoxicity Assessment by Means of the MTT Assay.

Tolosa L, Donato MT, Gómez-Lechón MJ.

Methods Mol Biol. 2015;1250:333-48. doi: 10.1007/978-1-4939-2074-7_26.

PMID:
26272156
17.

Culture and Functional Characterization of Human Hepatoma HepG2 Cells.

Donato MT, Tolosa L, Gómez-Lechón MJ.

Methods Mol Biol. 2015;1250:77-93. doi: 10.1007/978-1-4939-2074-7_5.

PMID:
26272135
18.

LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells.

García-Cañaveras JC, Jiménez N, Gómez-Lechón MJ, Castell JV, Donato MT, Lahoz A.

Electrophoresis. 2015 Sep;36(18):2294-2302. doi: 10.1002/elps.201500095. Epub 2015 Jul 22.

PMID:
26031481
19.

Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat.

Tolosa L, López S, Pareja E, Donato MT, Myara A, Nguyen TH, Castell JV, Gómez-Lechón MJ.

Liver Transpl. 2015 Jun;21(6):801-11. doi: 10.1002/lt.24121.

20.

High-content screening technology for studying drug-induced hepatotoxicity in cell models.

Tolosa L, Gómez-Lechón MJ, Donato MT.

Arch Toxicol. 2015 Jul;89(7):1007-22. doi: 10.1007/s00204-015-1503-z. Epub 2015 Mar 19. Review.

PMID:
25787152
21.

Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease.

Benet M, Guzmán C, Pisonero-Vaquero S, García-Mediavilla MV, Sánchez-Campos S, Martínez-Chantar ML, Donato MT, Castell JV, Jover R.

Mol Pharmacol. 2015 Apr;87(4):582-94. doi: 10.1124/mol.114.096313. Epub 2015 Jan 9.

PMID:
25576488
22.

Competency of different cell models to predict human hepatotoxic drugs.

Gómez-Lechón MJ, Tolosa L, Conde I, Donato MT.

Expert Opin Drug Metab Toxicol. 2014 Nov;10(11):1553-68. doi: 10.1517/17425255.2014.967680. Epub 2014 Oct 9. Review.

PMID:
25297626
23.

Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids: application to serum, liver tissue, and cultured cells of different species.

García-Cañaveras JC, Donato MT, Lahoz A.

Methods Mol Biol. 2014;1198:233-47. doi: 10.1007/978-1-4939-1258-2_15.

PMID:
25270933
24.

High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins.

Tolosa L, Carmona A, Castell JV, Gómez-Lechón MJ, Donato MT.

Arch Toxicol. 2015 Oct;89(10):1847-60. doi: 10.1007/s00204-014-1334-3. Epub 2014 Aug 27.

PMID:
25160661
25.

In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS.

Carretero A, León Z, García-Cañaveras JC, Zaragoza A, Gómez-Lechón MJ, Donato MT, Lahoz A.

Anal Bioanal Chem. 2014 Sep;406(22):5465-76. doi: 10.1007/s00216-014-7983-5. Epub 2014 Jun 27.

PMID:
24969468
26.

The thromboembolic risk in giant cell arteritis: a critical review of the literature.

Guida A, Tufano A, Perna P, Moscato P, De Donato MT, Finelli R, Caputo D, Di Minno MN.

Int J Rheumatol. 2014;2014:806402. doi: 10.1155/2014/806402. Epub 2014 May 20. Review.

27.

Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction.

Cortes M, Pareja E, García-Cañaveras JC, Donato MT, Montero S, Mir J, Castell JV, Lahoz A.

J Hepatol. 2014 Sep;61(3):564-74. doi: 10.1016/j.jhep.2014.04.023. Epub 2014 May 2.

PMID:
24798621
28.

A simple transcriptomic signature able to predict drug-induced hepatic steatosis.

Benet M, Moya M, Donato MT, Lahoz A, Hervás D, Guzmán C, Gómez-Lechón MJ, Castell JV, Jover R.

Arch Toxicol. 2014 Apr;88(4):967-82. doi: 10.1007/s00204-014-1197-7. Epub 2014 Jan 28.

PMID:
24469900
29.
30.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG.

Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Review.

31.

Neonatal livers: a source for the isolation of good-performing hepatocytes for cell transplantation.

Tolosa L, Pareja-Ibars E, Donato MT, Cortés M, López S, Jiménez N, Mir J, Castell JV, Gómez-Lechón MJ.

Cell Transplant. 2014;23(10):1229-42. doi: 10.3727/096368913X669743. Epub 2013 Jun 25.

PMID:
23803290
32.

Multiparametric evaluation of the cytoprotective effect of the Mangifera indica L. stem bark extract and mangiferin in HepG2 cells.

Tolosa L, Rodeiro I, Donato MT, Herrera JA, Delgado R, Castell JV, Gómez-Lechón MJ.

J Pharm Pharmacol. 2013 Jul;65(7):1073-82. doi: 10.1111/jphp.12071. Epub 2013 Apr 26.

PMID:
23738735
33.

Fluorescence-based screening of cytochrome P450 activities in intact cells.

Donato MT, Gómez-Lechón MJ.

Methods Mol Biol. 2013;987:135-48. doi: 10.1007/978-1-62703-321-3_12.

PMID:
23475674
34.

Mammalian cell metabolomics: experimental design and sample preparation.

León Z, García-Cañaveras JC, Donato MT, Lahoz A.

Electrophoresis. 2013 Oct;34(19):2762-75. doi: 10.1002/elps.201200605. Epub 2013 May 13. Review.

PMID:
23436493
35.

HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.

Tolosa L, Gómez-Lechón MJ, Pérez-Cataldo G, Castell JV, Donato MT.

Arch Toxicol. 2013 Jun;87(6):1115-27. doi: 10.1007/s00204-013-1012-x. Epub 2013 Feb 9.

PMID:
23397584
36.

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method.

García-Cañaveras JC, Donato MT, Castell JV, Lahoz A.

J Lipid Res. 2012 Oct;53(10):2231-41. doi: 10.1194/jlr.D028803. Epub 2012 Jul 19.

37.

Drug-induced liver steatosis and phospholipidosis: cell-based assays for early screening of drug candidates.

Donato MT, Gómez-Lechón MJ.

Curr Drug Metab. 2012 Oct;13(8):1160-73. Review.

PMID:
22746303
38.

Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.

Tolosa L, Pinto S, Donato MT, Lahoz A, Castell JV, O'Connor JE, Gómez-Lechón MJ.

Toxicol Sci. 2012 May;127(1):187-98. doi: 10.1093/toxsci/kfs083. Epub 2012 Feb 13.

PMID:
22331495
39.

Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment.

Tolosa L, Donato MT, Pérez-Cataldo G, Castell JV, Gómez-Lechón MJ.

Toxicol In Vitro. 2012 Dec;26(8):1272-7. doi: 10.1016/j.tiv.2011.11.008. Epub 2011 Nov 25.

PMID:
22138474
40.

High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay.

Donato MT, Tolosa L, Jiménez N, Castell JV, Gómez-Lechón MJ.

J Biomol Screen. 2012 Mar;17(3):394-400. doi: 10.1177/1087057111427586. Epub 2011 Nov 23.

PMID:
22116976
41.

Evaluation of cytochrome P450 activities in human hepatocytes in vitro.

Gómez-Lechón MJ, Lahoz A, Castell JV, Donato MT.

Methods Mol Biol. 2012;806:87-97. doi: 10.1007/978-1-61779-367-7_7.

PMID:
22057447
42.

A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals important metabolic alterations.

García-Cañaveras JC, Donato MT, Castell JV, Lahoz A.

J Proteome Res. 2011 Oct 7;10(10):4825-34. doi: 10.1021/pr200629p. Epub 2011 Sep 6.

PMID:
21830829
43.

Influence of platelet lysate on the recovery and metabolic performance of cryopreserved human hepatocytes upon thawing.

Tolosa L, Bonora-Centelles A, Donato MT, Mirabet V, Pareja E, Negro A, López S, Castell JV, Gómez-Lechón MJ.

Transplantation. 2011 Jun 27;91(12):1340-6. doi: 10.1097/TP.0b013e31821aba37.

PMID:
21516066
44.

Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project.

Gómez-Lechón MJ, Tolosa L, Castell JV, Donato MT.

Toxicol In Vitro. 2010 Oct;24(7):1879-89. doi: 10.1016/j.tiv.2010.07.018. Epub 2010 Jul 23. Review.

PMID:
20656008
45.

The use of hepatocytes to investigate drug toxicity.

Gómez-Lechón MJ, Castell JV, Donato MT.

Methods Mol Biol. 2010;640:389-415. doi: 10.1007/978-1-60761-688-7_21.

PMID:
20645064
46.

Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo.

Donato MT, Hallifax D, Picazo L, Castell JV, Houston JB, Gomez-Lechón MJ, Lahoz A.

Drug Metab Dispos. 2010 Sep;38(9):1449-55. doi: 10.1124/dmd.110.033605. Epub 2010 May 25.

PMID:
20501911
47.

In vitro evaluation of potential hepatotoxicity induced by drugs.

Gómez-Lechón MJ, Lahoz A, Gombau L, Castell JV, Donato MT.

Curr Pharm Des. 2010 Jun;16(17):1963-77. Review.

PMID:
20236064
48.

Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies.

Donato MT, Montero S, Castell JV, Gómez-Lechón MJ, Lahoz A.

Anal Bioanal Chem. 2010 Mar;396(6):2251-63. doi: 10.1007/s00216-009-3441-1. Epub 2010 Feb 10.

PMID:
20145913
49.

Synthesis of new, UV-photoactive dansyl derivatives for flow cytometric studies on bile acid uptake.

Rohacova J, Marin ML, Martínez-Romero A, O'Connor JE, Gomez-Lechon MJ, Donato MT, Castell JV, Miranda MA.

Org Biomol Chem. 2009 Dec 7;7(23):4973-80. doi: 10.1039/b912134j. Epub 2009 Sep 24.

PMID:
19907789
50.

Functional characterization of hepatocytes for cell transplantation: customized cell preparation for each receptor.

Bonora-Centelles A, Donato MT, Lahoz A, Pareja E, Mir J, Castell JV, Gómez-Lechón MJ.

Cell Transplant. 2010;19(1):21-8. doi: 10.3727/096368909X474267.

PMID:
19796502

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