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Impact of CMV Infection on Natural Killer Cell Clonal Repertoire in CMV-Naïve Rhesus Macaques.

Truitt LL, Yang D, Espinoza DA, Fan X, Ram DR, Moström MJ, Tran D, Sprehe LM, Reeves RK, Donahue RE, Kaur A, Dunbar CE, Wu C.

Front Immunol. 2019 Oct 9;10:2381. doi: 10.3389/fimmu.2019.02381. eCollection 2019.


Clonal tracking of erythropoiesis in rhesus macaques.

Fan X, Wu C, Truitt LL, Espinoza DA, Sellers S, Bonifacino A, Zhou Y, Cordes SF, Krouse A, Metzger M, Donahue RE, Lu R, Dunbar CE.

Haematologica. 2019 Oct 3. pii: haematol.2019.231811. doi: 10.3324/haematol.2019.231811. [Epub ahead of print]


Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders.

Uchida N, Hsieh MM, Raines L, Haro-Mora JJ, Demirci S, Bonifacino AC, Krouse AE, Metzger ME, Donahue RE, Tisdale JF.

Nat Commun. 2019 Oct 2;10(1):4479. doi: 10.1038/s41467-019-12456-3.


Busulfan Combined with Immunosuppression Allows Efficient Engraftment of Gene-Modified Cells in a Rhesus Macaque Model.

Uchida N, Nassehi T, Drysdale CM, Gamer J, Yapundich M, Bonifacino AC, Krouse AE, Linde N, Hsieh MM, Donahue RE, Dunbar CE, Kean LS, Tisdale JF.

Mol Ther. 2019 Sep 4;27(9):1586-1596. doi: 10.1016/j.ymthe.2019.05.022. Epub 2019 Jun 5.


Fetal hemoglobin and F-cell variance in mobilized CD34+ cell-transplanted rhesus monkeys.

Demirci S, Mora JJH, Yapundich M, Drysdale C, Gamer J, Nassehi T, Bonifacino AC, Krouse AE, Linde NS, Donahue RE, Tisdale JF, Uchida N.

Exp Hematol. 2019 Jul;75:21-25.e1. doi: 10.1016/j.exphem.2019.05.005. Epub 2019 Jun 5.


Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque.

Espinoza DA, Fan X, Yang D, Cordes SF, Truitt LL, Calvo KR, Yabe IM, Demirci S, Hope KJ, Hong SG, Krouse A, Metzger M, Bonifacino A, Lu R, Uchida N, Tisdale JF, Wu X, DeRavin SS, Malech HL, Donahue RE, Wu C, Dunbar CE.

Mol Ther. 2019 Jun 5;27(6):1074-1086. doi: 10.1016/j.ymthe.2019.04.003. Epub 2019 Apr 9.


CRISPR/Cas9 PIG -A gene editing in nonhuman primate model demonstrates no intrinsic clonal expansion of PNH HSPCs.

Shin TH, Baek EJ, Corat MAF, Chen S, Metais JY, AlJanahi AA, Zhou Y, Donahue RE, Yu KR, Dunbar CE.

Blood. 2019 Jun 6;133(23):2542-2545. doi: 10.1182/blood.2019000800. Epub 2019 Apr 19. No abstract available.


Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity.

Yabe IM, Truitt LL, Espinoza DA, Wu C, Koelle S, Panch S, Corat MAF, Winkler T, Yu KR, Hong SG, Bonifacino A, Krouse A, Metzger M, Donahue RE, Dunbar CE.

Mol Ther Methods Clin Dev. 2018 Oct 25;11:143-154. doi: 10.1016/j.omtm.2018.10.009. eCollection 2018 Dec 14.


Clonal expansion and compartmentalized maintenance of rhesus macaque NK cell subsets.

Wu C, Espinoza DA, Koelle SJ, Yang D, Truitt L, Schlums H, Lafont BA, Davidson-Moncada JK, Lu R, Kaur A, Hammer Q, Li B, Panch S, Allan DA, Donahue RE, Childs RW, Romagnani C, Bryceson YT, Dunbar CE.

Sci Immunol. 2018 Nov 2;3(29). pii: eaat9781. doi: 10.1126/sciimmunol.aat9781.



Donahue RE, Muckler VC, Bradbury GR.

J Perianesth Nurs. 2018 Oct;33(5):580-581. doi: 10.1016/j.jopan.2018.07.005. No abstract available.


Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.

Kim MY, Yu KR, Kenderian SS, Ruella M, Chen S, Shin TH, Aljanahi AA, Schreeder D, Klichinsky M, Shestova O, Kozlowski MS, Cummins KD, Shan X, Shestov M, Bagg A, Morrissette JJD, Sekhri P, Lazzarotto CR, Calvo KR, Kuhns DB, Donahue RE, Behbehani GK, Tsai SQ, Dunbar CE, Gill S.

Cell. 2018 May 31;173(6):1439-1453.e19. doi: 10.1016/j.cell.2018.05.013. Epub 2018 May 31.


Multimodal Perioperative Analgesia Regimen to Improve Patient Outcomes After Total Knee Arthroplasty: A Multidisciplinary Quality Improvement Project.

Donahue RE, Bradbury GR, Zychowicz ME, Muckler VC.

J Perianesth Nurs. 2018 Apr;33(2):138-152. doi: 10.1016/j.jopan.2016.07.007. Epub 2017 Mar 22.


The impact of aging on primate hematopoiesis as interrogated by clonal tracking.

Yu KR, Espinoza DA, Wu C, Truitt L, Shin TH, Chen S, Fan X, Yabe IM, Panch S, Hong SG, Koelle S, Lu R, Bonifacino A, Krouse A, Metzger M, Donahue RE, Dunbar CE.

Blood. 2018 Mar 15;131(11):1195-1205. doi: 10.1182/blood-2017-08-802033. Epub 2018 Jan 2.


Geographic clonal tracking in macaques provides insights into HSPC migration and differentiation.

Wu C, Espinoza DA, Koelle SJ, Potter EL, Lu R, Li B, Yang D, Fan X, Donahue RE, Roederer M, Dunbar CE.

J Exp Med. 2018 Jan 2;215(1):217-232. doi: 10.1084/jem.20171341. Epub 2017 Nov 15.


CD4+ levels control the odds of induction of humoral immune responses to tracer doses of therapeutic antibodies.

Srinivasula S, Gabriel E, Kim I, DeGrange P, St Claire A, Mallow C, Donahue RE, Paik C, Lane HC, Di Mascio M.

PLoS One. 2017 Nov 9;12(11):e0187912. doi: 10.1371/journal.pone.0187912. eCollection 2017.


Bone Marrow as a Hematopoietic Stem Cell Source for Gene Therapy in Sickle Cell Disease: Evidence from Rhesus and SCD Patients.

Uchida N, Fujita A, Hsieh MM, Bonifacino AC, Krouse AE, Metzger ME, Donahue RE, Tisdale JF.

Hum Gene Ther Clin Dev. 2017 Sep;28(3):136-144. doi: 10.1089/humc.2017.029. Epub 2017 Apr 17.


Quantitative stability of hematopoietic stem and progenitor cell clonal output in rhesus macaques receiving transplants.

Koelle SJ, Espinoza DA, Wu C, Xu J, Lu R, Li B, Donahue RE, Dunbar CE.

Blood. 2017 Mar 16;129(11):1448-1457. doi: 10.1182/blood-2016-07-728691. Epub 2017 Jan 13.


Total body irradiation must be delivered at high dose for efficient engraftment and tolerance in a rhesus stem cell gene therapy model.

Uchida N, Weitzel RP, Shvygin A, Skala LP, Raines L, Bonifacino AC, Krouse AE, Metzger ME, Donahue RE, Tisdale JF.

Mol Ther Methods Clin Dev. 2016 Sep 14;3:16059. doi: 10.1038/mtm.2016.59. eCollection 2016.


Discordance in lymphoid tissue recovery following stem cell transplantation in rhesus macaques: an in vivo imaging study.

Donahue RE, Srinivasula S, Uchida N, Kim I, St Claire A, Duralde G, DeGrange P, St Claire M, Reba RC, Bonifacino AC, Krouse AE, Metzger ME, Paik CH, Lane HC, Tisdale JF, Di Mascio M.

Blood. 2015 Dec 10;126(24):2632-41. doi: 10.1182/blood-2015-07-657346. Epub 2015 Oct 22.


Regulated apoptosis of genetically modified hematopoietic stem and progenitor cells via an inducible caspase-9 suicide gene in rhesus macaques.

Barese CN, Felizardo TC, Sellers SE, Keyvanfar K, Di Stasi A, Metzger ME, Krouse AE, Donahue RE, Spencer DM, Dunbar CE.

Stem Cells. 2015 Jan;33(1):91-100. doi: 10.1002/stem.1869.


Path to the clinic: assessment of iPSC-based cell therapies in vivo in a nonhuman primate model.

Hong SG, Winkler T, Wu C, Guo V, Pittaluga S, Nicolae A, Donahue RE, Metzger ME, Price SD, Uchida N, Kuznetsov SA, Kilts T, Li L, Robey PG, Dunbar CE.

Cell Rep. 2014 May 22;7(4):1298-1309. doi: 10.1016/j.celrep.2014.04.019. Epub 2014 May 15.


Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.

Wu C, Li B, Lu R, Koelle SJ, Yang Y, Jares A, Krouse AE, Metzger M, Liang F, Loré K, Wu CO, Donahue RE, Chen ISY, Weissman I, Dunbar CE.

Cell Stem Cell. 2014 Apr 3;14(4):486-499. doi: 10.1016/j.stem.2014.01.020.


Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study.

Kim S, Kim N, Presson AP, Metzger ME, Bonifacino AC, Sehl M, Chow SA, Crooks GM, Dunbar CE, An DS, Donahue RE, Chen IS.

Cell Stem Cell. 2014 Apr 3;14(4):473-85. doi: 10.1016/j.stem.2013.12.012.


Evaluation of engraftment and immunological tolerance after reduced intensity conditioning in a rhesus hematopoietic stem cell gene therapy model.

Uchida N, Weitzel RP, Evans ME, Green R, Bonifacino AC, Krouse AE, Metzger ME, Hsieh MM, Donahue RE, Tisdale JF.

Gene Ther. 2014 Feb;21(2):148-57. doi: 10.1038/gt.2013.67. Epub 2013 Nov 21.


TRIM5α variations influence transduction efficiency with lentiviral vectors in both human and rhesus CD34(+) cells in vitro and in vivo.

Evans ME, Kumkhaek C, Hsieh MM, Donahue RE, Tisdale JF, Uchida N.

Mol Ther. 2014 Feb;22(2):348-358. doi: 10.1038/mt.2013.256. Epub 2013 Oct 23.


Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number.

Uchida N, Evans ME, Hsieh MM, Bonifacino AC, Krouse AE, Metzger ME, Sellers SE, Dunbar CE, Donahue RE, Tisdale JF.

Mol Ther Nucleic Acids. 2013 Sep 17;2:e122. doi: 10.1038/mtna.2013.49.


No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model.

Sellers SE, Dumitriu B, Morgan MJ, Hughes WM, Wu CO, Raghavarchari N, Yang Y, Uchida N, Tisdale JF, An DS, Chen IS, Hematti P, Donahue RE, Larochelle A, Young NS, Calado RT, Dunbar CE.

Mol Ther. 2014 Jan;22(1):52-8. doi: 10.1038/mt.2013.168. Epub 2013 Jul 18.


Peripheral blood stem cell transplants do not result in endometrial stromal engraftment.

Wolff EF, Uchida N, Donahue RE, Metzger ME, Hsieh MM, Libfraind LL, Hill MJ, Tisdale JF.

Fertil Steril. 2013 Feb;99(2):526-32. doi: 10.1016/j.fertnstert.2012.09.045. Epub 2012 Oct 25.


Thymidine kinase suicide gene-mediated ganciclovir ablation of autologous gene-modified rhesus hematopoiesis.

Barese CN, Krouse AE, Metzger ME, King CA, Traversari C, Marini FC, Donahue RE, Dunbar CE.

Mol Ther. 2012 Oct;20(10):1932-43. doi: 10.1038/mt.2012.166. Epub 2012 Aug 21.


High-efficiency transduction of rhesus hematopoietic repopulating cells by a modified HIV1-based lentiviral vector.

Uchida N, Hargrove PW, Lap CJ, Evans ME, Phang O, Bonifacino AC, Krouse AE, Metzger ME, Nguyen AD, Hsieh MM, Wolfsberg TG, Donahue RE, Persons DA, Tisdale JF.

Mol Ther. 2012 Oct;20(10):1882-92. doi: 10.1038/mt.2012.159. Epub 2012 Aug 7.


Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B.

Mingozzi F, Chen Y, Murphy SL, Edmonson SC, Tai A, Price SD, Metzger ME, Zhou S, Wright JF, Donahue RE, Dunbar CE, High KA.

Mol Ther. 2012 Jul;20(7):1410-6. doi: 10.1038/mt.2012.84. Epub 2012 May 8.


Identification of a cross-reacting, monoclonal anti-human CD233 antibody for identification and sorting of rhesus macaque erythrocytes.

Byrnes C, Terry Lee Y, Donahue RE, Miller JL.

Cytometry A. 2012 Feb;81(2):165-8. doi: 10.1002/cyto.a.22005. Epub 2011 Dec 13.


Significant mobilization of both conventional and regulatory T cells with AMD3100.

Kean LS, Sen S, Onabajo O, Singh K, Robertson J, Stempora L, Bonifacino AC, Metzger ME, Promislow DE, Mattapallil JJ, Donahue RE.

Blood. 2011 Dec 15;118(25):6580-90. doi: 10.1182/blood-2011-06-359331. Epub 2011 Oct 11.


Leukocyte integrin activation mediates transient neutropenia after G-CSF administration.

Donahue RE, Tuschong L, Bauer TR Jr, Yau YY, Leitman SF, Hickstein DD.

Blood. 2011 Oct 13;118(15):4209-14. doi: 10.1182/blood-2011-06-360461. Epub 2011 Aug 15.


Accelerated lymphocyte reconstitution and long-term recovery after transplantation of lentiviral-transduced rhesus CD34+ cells mobilized by G-CSF and plerixafor.

Uchida N, Bonifacino A, Krouse AE, Metzger ME, Csako G, Lee-Stroka A, Fasano RM, Leitman SF, Mattapallil JJ, Hsieh MM, Tisdale JF, Donahue RE.

Exp Hematol. 2011 Jul;39(7):795-805. doi: 10.1016/j.exphem.2011.04.002. Epub 2011 Apr 15.


Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models.

Goessling W, Allen RS, Guan X, Jin P, Uchida N, Dovey M, Harris JM, Metzger ME, Bonifacino AC, Stroncek D, Stegner J, Armant M, Schlaeger T, Tisdale JF, Zon LI, Donahue RE, North TE.

Cell Stem Cell. 2011 Apr 8;8(4):445-58. doi: 10.1016/j.stem.2011.02.003.


Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins.

Nathwani AC, Rosales C, McIntosh J, Rastegarlari G, Nathwani D, Raj D, Nawathe S, Waddington SN, Bronson R, Jackson S, Donahue RE, High KA, Mingozzi F, Ng CY, Zhou J, Spence Y, McCarville MB, Valentine M, Allay J, Coleman J, Sleep S, Gray JT, Nienhuis AW, Davidoff AM.

Mol Ther. 2011 May;19(5):876-85. doi: 10.1038/mt.2010.274. Epub 2011 Jan 18.


Transient neutropenia after granulocyte-colony stimulating factor administration is associated with neutrophil accumulation in pulmonary vasculature.

DeJesus CE, Egen J, Metzger M, Alvarez X, Combs CA, Malide D, Yu ZX, Tian X, Donahue RE.

Exp Hematol. 2011 Feb;39(2):142-50. doi: 10.1016/j.exphem.2010.11.004. Epub 2010 Nov 16.


High-throughput, sensitive quantification of repopulating hematopoietic stem cell clones.

Kim S, Kim N, Presson AP, An DS, Mao SH, Bonifacino AC, Donahue RE, Chow SA, Chen IS.

J Virol. 2010 Nov;84(22):11771-80. doi: 10.1128/JVI.01355-10. Epub 2010 Sep 15.


Ex vivo expansion of retrovirally transduced primate CD34+ cells results in overrepresentation of clones with MDS1/EVI1 insertion sites in the myeloid lineage after transplantation.

Sellers S, Gomes TJ, Larochelle A, Lopez R, Adler R, Krouse A, Donahue RE, Childs RW, Dunbar CE.

Mol Ther. 2010 Sep;18(9):1633-9. doi: 10.1038/mt.2010.117. Epub 2010 Jun 22.


Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands.

Zheng C, Voutetakis A, Metzger M, Afione S, Cotrim AP, Eckhaus MA, Rivera VM, Clackson T, Chiorini JA, Donahue RE, Dunbar CE, Baum BJ.

Oral Dis. 2010 Apr;16(3):269-77. doi: 10.1111/j.1601-0825.2009.01631.x.


Repetitive busulfan administration after hematopoietic stem cell gene therapy associated with a dominant HDAC7 clone in a nonhuman primate.

Xie J, Larochelle A, Maric I, Faulhaber M, Donahue RE, Dunbar CE.

Hum Gene Ther. 2010 Jun;21(6):695-703. doi: 10.1089/hum.2009.191.


AAV5-mediated gene transfer to the parotid glands of non-human primates.

Voutetakis A, Zheng C, Cotrim AP, Mineshiba F, Afione S, Roescher N, Swaim WD, Metzger M, Eckhaus MA, Donahue RE, Dunbar CE, Chiorini JA, Baum BJ.

Gene Ther. 2010 Jan;17(1):50-60. doi: 10.1038/gt.2009.123. Epub 2009 Sep 17.


Development of a human immunodeficiency virus type 1-based lentiviral vector that allows efficient transduction of both human and rhesus blood cells.

Uchida N, Washington KN, Hayakawa J, Hsieh MM, Bonifacino AC, Krouse AE, Metzger ME, Donahue RE, Tisdale JF.

J Virol. 2009 Oct;83(19):9854-62. doi: 10.1128/JVI.00357-09. Epub 2009 Jul 22.


Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+ cell populations based on global gene and microRNA expression signatures.

Donahue RE, Jin P, Bonifacino AC, Metzger ME, Ren J, Wang E, Stroncek DF.

Blood. 2009 Sep 17;114(12):2530-41. doi: 10.1182/blood-2009-04-214403. Epub 2009 Jul 14.


In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.

Larochelle A, Choi U, Shou Y, Naumann N, Loktionova NA, Clevenger JR, Krouse A, Metzger M, Donahue RE, Kang E, Stewart C, Persons D, Malech HL, Dunbar CE, Sorrentino BP.

J Clin Invest. 2009 Jul;119(7):1952-63. doi: 10.1172/JCI37506. Epub 2009 Jun 8.


Genetically modified CD34+ hematopoietic stem cells contribute to turnover of brain perivascular macrophages in long-term repopulated primates.

Soulas C, Donahue RE, Dunbar CE, Persons DA, Alvarez X, Williams KC.

Am J Pathol. 2009 May;174(5):1808-17. doi: 10.2353/ajpath.2009.081010. Epub 2009 Apr 6.


Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells.

Kim YJ, Kim YS, Larochelle A, Renaud G, Wolfsberg TG, Adler R, Donahue RE, Hematti P, Hong BK, Roayaei J, Akagi K, Riberdy JM, Nienhuis AW, Dunbar CE, Persons DA.

Blood. 2009 May 28;113(22):5434-43. doi: 10.1182/blood-2008-10-185199. Epub 2009 Apr 1.


Transient in vivo beta-globin production after lentiviral gene transfer to hematopoietic stem cells in the nonhuman primate.

Hayakawa J, Ueda T, Lisowski L, Hsieh MM, Washington K, Phang O, Metzger M, Krouse A, Donahue RE, Sadelain M, Tisdale JF.

Hum Gene Ther. 2009 Jun;20(6):563-72. doi: 10.1089/hum.2008.186.


Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer.

Voutetakis A, Zheng C, Metzger M, Cotrim AP, Donahue RE, Dunbar CE, Baum BJ.

Hum Gene Ther. 2008 Dec;19(12):1401-5. doi: 10.1089/hgt.2008.034.

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