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Items: 1 to 50 of 132

1.

Toward Single-Peak Dalbavancin Analogs through Biology and Chemistry.

Alt S, Bernasconi A, Sosio M, Brunati C, Donadio S, Maffioli SI.

ACS Chem Biol. 2019 Mar 15;14(3):356-360. doi: 10.1021/acschembio.9b00050. Epub 2019 Mar 7.

PMID:
30830742
2.

Zn-dependent bifunctional proteases are responsible for leader peptide processing of class III lanthipeptides.

Chen S, Xu B, Chen E, Wang J, Lu J, Donadio S, Ge H, Wang H.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2533-2538. doi: 10.1073/pnas.1815594116. Epub 2019 Jan 24.

PMID:
30679276
3.

Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.

Monciardini P, Bernasconi A, Iorio M, Brunati C, Sosio M, Campochiaro L, Landini P, Maffioli SI, Donadio S.

J Nat Prod. 2019 Jan 25;82(1):35-44. doi: 10.1021/acs.jnatprod.8b00354. Epub 2019 Jan 7.

4.

Discovery, properties, and biosynthesis of pseudouridimycin, an antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase.

Maffioli SI, Sosio M, Ebright RH, Donadio S.

J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):335-343. doi: 10.1007/s10295-018-2109-2. Epub 2018 Nov 21.

PMID:
30465105
5.

Iron chelation increases the tolerance of Escherichia coli to hyper-replication stress.

Charbon G, Klitgaard RN, Liboriussen CD, Thulstrup PW, Maffioli SI, Donadio S, Løbner-Olesen A.

Sci Rep. 2018 Jul 12;8(1):10550. doi: 10.1038/s41598-018-28841-9.

6.

Novel Polyethers from Screening Actinoallomurus spp.

Iorio M, Tocchetti A, Santos Cruz JC, Del Gatto G, Brunati C, Maffioli SI, Sosio M, Donadio S.

Antibiotics (Basel). 2018 Jun 14;7(2). pii: E47. doi: 10.3390/antibiotics7020047.

7.

Large inserts for big data: artificial chromosomes in the genomic era.

Tocchetti A, Donadio S, Sosio M.

FEMS Microbiol Lett. 2018 May 1;365(9). doi: 10.1093/femsle/fny064.

PMID:
29718215
8.

Complex Regulatory Networks Governing Production of the Glycopeptide A40926.

Alduina R, Sosio M, Donadio S.

Antibiotics (Basel). 2018 Apr 5;7(2). pii: E30. doi: 10.3390/antibiotics7020030. Review.

9.

Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).

Lin W, Das K, Degen D, Mazumder A, Duchi D, Wang D, Ebright YW, Ebright RY, Sineva E, Gigliotti M, Srivastava A, Mandal S, Jiang Y, Liu Y, Yin R, Zhang Z, Eng ET, Thomas D, Donadio S, Zhang H, Zhang C, Kapanidis AN, Ebright RH.

Mol Cell. 2018 Apr 5;70(1):60-71.e15. doi: 10.1016/j.molcel.2018.02.026. Epub 2018 Mar 29.

PMID:
29606590
10.

Analysis of the Pseudouridimycin Biosynthetic Pathway Provides Insights into the Formation of C-nucleoside Antibiotics.

Sosio M, Gaspari E, Iorio M, Pessina S, Medema MH, Bernasconi A, Simone M, Maffioli SI, Ebright RH, Donadio S.

Cell Chem Biol. 2018 May 17;25(5):540-549.e4. doi: 10.1016/j.chembiol.2018.02.008. Epub 2018 Mar 15.

PMID:
29551347
11.

Expanding the potential of NAI-107 for treating serious ESKAPE pathogens: synergistic combinations against Gram-negatives and bactericidal activity against non-dividing cells.

Brunati C, Thomsen TT, Gaspari E, Maffioli S, Sosio M, Jabes D, Løbner-Olesen A, Donadio S.

J Antimicrob Chemother. 2018 Feb 1;73(2):414-424. doi: 10.1093/jac/dkx395.

12.

Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.

Maffioli SI, Zhang Y, Degen D, Carzaniga T, Del Gatto G, Serina S, Monciardini P, Mazzetti C, Guglierame P, Candiani G, Chiriac AI, Facchetti G, Kaltofen P, Sahl HG, Dehò G, Donadio S, Ebright RH.

Cell. 2017 Jun 15;169(7):1240-1248.e23. doi: 10.1016/j.cell.2017.05.042.

13.

Antibacterial Paramagnetic Quinones from Actinoallomurus.

Iorio M, Cruz J, Simone M, Bernasconi A, Brunati C, Sosio M, Donadio S, Maffioli SI.

J Nat Prod. 2017 Apr 28;80(4):819-827. doi: 10.1021/acs.jnatprod.6b00654. Epub 2017 Feb 20.

PMID:
28218529
14.

Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis.

Ortega MA, Cogan DP, Mukherjee S, Garg N, Li B, Thibodeaux GN, Maffioli SI, Donadio S, Sosio M, Escano J, Smith L, Nair SK, van der Donk WA.

ACS Chem Biol. 2017 Feb 17;12(2):548-557. doi: 10.1021/acschembio.6b01031. Epub 2017 Jan 13.

15.

The Lantibiotic NAI-107 Efficiently Rescues Drosophila melanogaster from Infection with Methicillin-Resistant Staphylococcus aureus USA300.

Thomsen TT, Mojsoska B, Cruz JC, Donadio S, Jenssen H, Løbner-Olesen A, Rewitz K.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5427-36. doi: 10.1128/AAC.02965-15. Print 2016 Sep.

16.

The Oligopeptide Permease Opp Mediates Illicit Transport of the Bacterial P-site Decoding Inhibitor GE81112.

Maio A, Brandi L, Donadio S, Gualerzi CO.

Antibiotics (Basel). 2016 May 24;5(2). pii: E17. doi: 10.3390/antibiotics5020017.

17.

Allocyclinones, hyperchlorinated angucyclinones from Actinoallomurus.

Cruz JC, Maffioli SI, Bernasconi A, Brunati C, Gaspari E, Sosio M, Wellington E, Donadio S.

J Antibiot (Tokyo). 2017 Jan;70(1):73-78. doi: 10.1038/ja.2016.62. Epub 2016 May 25.

PMID:
27220409
18.

Combinatorial Lanthipeptides from a Ruminant Bacterium.

Donadio S.

Cell Chem Biol. 2016 Feb 18;23(2):204-205. doi: 10.1016/j.chembiol.2016.02.009.

19.

Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis.

Ortega MA, Hao Y, Walker MC, Donadio S, Sosio M, Nair SK, van der Donk WA.

Cell Chem Biol. 2016 Mar 17;23(3):370-380. doi: 10.1016/j.chembiol.2015.11.017. Epub 2016 Feb 11.

20.

Advancing cell wall inhibitors towards clinical applications.

Maffioli SI, Cruz JC, Monciardini P, Sosio M, Donadio S.

J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):177-84. doi: 10.1007/s10295-015-1703-9. Epub 2015 Oct 29. Review.

PMID:
26515981
21.

Brominated Variant of the Lantibiotic NAI-107 with Enhanced Antibacterial Potency.

Cruz JC, Iorio M, Monciardini P, Simone M, Brunati C, Gaspari E, Maffioli SI, Wellington E, Sosio M, Donadio S.

J Nat Prod. 2015 Nov 25;78(11):2642-7. doi: 10.1021/acs.jnatprod.5b00576. Epub 2015 Oct 29.

PMID:
26512731
22.

Erratum for Jabes et al., Pharmacological Properties of NAI-603, a Well-Tolerated Semisynthetic Derivative of Ramoplanin.

Jabes D, Brunati C, Candiani G, Riva S, Romanó G, Maffioli S, Rossi R, Simone M, Gaspari E, Donadio S.

Antimicrob Agents Chemother. 2015 Oct;59(10):6675. doi: 10.1128/AAC.01526-15. No abstract available.

23.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

24.

A Genomic, Transcriptomic and Proteomic Look at the GE2270 Producer Planobispora rosea, an Uncommon Actinomycete.

Tocchetti A, Bordoni R, Gallo G, Petiti L, Corti G, Alt S, Cruz JC, Salzano AM, Scaloni A, Puglia AM, De Bellis G, Peano C, Donadio S, Sosio M.

PLoS One. 2015 Jul 24;10(7):e0133705. doi: 10.1371/journal.pone.0133705. eCollection 2015.

25.

A Derivative of the Thiopeptide GE2270A Highly Selective against Propionibacterium acnes.

Fabbretti A, He CG, Gaspari E, Maffioli S, Brandi L, Spurio R, Sosio M, Jabes D, Donadio S.

Antimicrob Agents Chemother. 2015 Aug;59(8):4560-8. doi: 10.1128/AAC.05155-14. Epub 2015 May 18.

26.

Additional congeners of the macrolide neaumycin: structure revision and biological activity.

Simone M, Maffioli SI, Tocchetti A, Tretter S, Cattaneo M, Biunno I, Gaspari E, Donadio S.

J Antibiot (Tokyo). 2015 Jun;68(6):406-8. doi: 10.1038/ja.2014.168. Epub 2015 Jan 14. No abstract available.

PMID:
25586025
27.

Family of class I lantibiotics from actinomycetes and improvement of their antibacterial activities.

Maffioli SI, Monciardini P, Catacchio B, Mazzetti C, Münch D, Brunati C, Sahl HG, Donadio S.

ACS Chem Biol. 2015 Apr 17;10(4):1034-42. doi: 10.1021/cb500878h. Epub 2015 Jan 23.

PMID:
25574687
28.

GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.

Zhang Y, Degen D, Ho MX, Sineva E, Ebright KY, Ebright YW, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright RH.

Elife. 2014 Apr 22;3:e02450. doi: 10.7554/eLife.02450.

29.

Discovering new bioactive molecules from microbial sources.

Monciardini P, Iorio M, Maffioli S, Sosio M, Donadio S.

Microb Biotechnol. 2014 May;7(3):209-20. doi: 10.1111/1751-7915.12123. Epub 2014 Mar 24. Review.

30.

The lantibiotic NAI-107 binds to bactoprenol-bound cell wall precursors and impairs membrane functions.

Münch D, Müller A, Schneider T, Kohl B, Wenzel M, Bandow JE, Maffioli S, Sosio M, Donadio S, Wimmer R, Sahl HG.

J Biol Chem. 2014 Apr 25;289(17):12063-76. doi: 10.1074/jbc.M113.537449. Epub 2014 Mar 13.

31.

Characterization of the congeners in the lantibiotic NAI-107 complex.

Maffioli SI, Iorio M, Sosio M, Monciardini P, Gaspari E, Donadio S.

J Nat Prod. 2014 Jan 24;77(1):79-84. doi: 10.1021/np400702t. Epub 2014 Jan 14.

PMID:
24422756
32.

Pharmacological properties of NAI-603, a well-tolerated semisynthetic derivative of ramoplanin.

Jabes D, Brunati C, Candiani G, Riva S, Romanó G, Maffioli S, Rossi R, Simone M, Gaspari E, Donadio S.

Antimicrob Agents Chemother. 2014;58(4):1922-9. doi: 10.1128/AAC.01620-13. Epub 2014 Jan 13. Erratum in: Antimicrob Agents Chemother. 2015 Oct;59(10):6675.

33.

A glycosylated, labionin-containing lanthipeptide with marked antinociceptive activity.

Iorio M, Sasso O, Maffioli SI, Bertorelli R, Monciardini P, Sosio M, Bonezzi F, Summa M, Brunati C, Bordoni R, Corti G, Tarozzo G, Piomelli D, Reggiani A, Donadio S.

ACS Chem Biol. 2014 Feb 21;9(2):398-404. doi: 10.1021/cb400692w. Epub 2013 Nov 20.

34.

Capturing linear intermediates and C-terminal variants during maturation of the thiopeptide GE2270.

Tocchetti A, Maffioli S, Iorio M, Alt S, Mazzei E, Brunati C, Sosio M, Donadio S.

Chem Biol. 2013 Aug 22;20(8):1067-77. doi: 10.1016/j.chembiol.2013.07.005. Epub 2013 Aug 8.

35.

Orthoformimycin, a selective inhibitor of bacterial translation elongation from Streptomyces containing an unusual orthoformate.

Maffioli SI, Fabbretti A, Brandi L, Savelsbergh A, Monciardini P, Abbondi M, Rossi R, Donadio S, Gualerzi CO.

ACS Chem Biol. 2013 Sep 20;8(9):1939-46. doi: 10.1021/cb4004095. Epub 2013 Aug 15.

PMID:
23895646
36.

Isolation and characterization of NAI-802, a new lantibiotic produced by two different Actinoplanes strains.

Simone M, Monciardini P, Gaspari E, Donadio S, Maffioli SI.

J Antibiot (Tokyo). 2013 Feb;66(2):73-8. doi: 10.1038/ja.2012.92. Epub 2012 Nov 21.

PMID:
23168402
37.

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.

Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f. Review.

38.

Chrolactomycins from the actinomycete actinospica.

Iorio M, Maffioli SI, Gaspari E, Rossi R, Mauri P, Sosio M, Donadio S.

J Nat Prod. 2012 Nov 26;75(11):1991-3. doi: 10.1021/np300470f. Epub 2012 Oct 22.

PMID:
23088751
39.

Structural and functional characterization of the bacterial translocation inhibitor GE82832.

Brandi L, Maffioli S, Donadio S, Quaglia F, Sette M, Milón P, Gualerzi CO, Fabbretti A.

FEBS Lett. 2012 Sep 21;586(19):3373-8. doi: 10.1016/j.febslet.2012.07.040. Epub 2012 Jul 24.

40.

Halogenated spirotetronates from Actinoallomurus.

Mazzetti C, Ornaghi M, Gaspari E, Parapini S, Maffioli S, Sosio M, Donadio S.

J Nat Prod. 2012 Jun 22;75(6):1044-50. doi: 10.1021/np300003n. Epub 2012 May 22.

PMID:
22616554
41.

Characterization of madurastatin C1, a novel siderophore from Actinomadura sp.

Mazzei E, Iorio M, Maffioli SI, Sosio M, Donadio S.

J Antibiot (Tokyo). 2012 May;65(5):267-9. doi: 10.1038/ja.2012.10. Epub 2012 Feb 29. No abstract available.

PMID:
22377537
42.

Solution structure by nuclear magnetic resonance of the two lantibiotics 97518 and NAI-107.

Vasile F, Potenza D, Marsiglia B, Maffioli S, Donadio S.

J Pept Sci. 2012 Feb;18(2):129-34. doi: 10.1002/psc.1425. Epub 2011 Nov 14.

PMID:
22083835
43.

Expanding and enhancing our antibacterial arsenal.

Collins JJ, Donadio S.

Curr Opin Microbiol. 2011 Oct;14(5):511-2. doi: 10.1016/j.mib.2011.09.005. Epub 2011 Sep 22. No abstract available.

PMID:
21945218
44.

New target for inhibition of bacterial RNA polymerase: 'switch region'.

Srivastava A, Talaue M, Liu S, Degen D, Ebright RY, Sineva E, Chakraborty A, Druzhinin SY, Chatterjee S, Mukhopadhyay J, Ebright YW, Zozula A, Shen J, Sengupta S, Niedfeldt RR, Xin C, Kaneko T, Irschik H, Jansen R, Donadio S, Connell N, Ebright RH.

Curr Opin Microbiol. 2011 Oct;14(5):532-43. doi: 10.1016/j.mib.2011.07.030. Epub 2011 Aug 19. Review.

45.

Efficacy of the new lantibiotic NAI-107 in experimental infections induced by multidrug-resistant Gram-positive pathogens.

Jabés D, Brunati C, Candiani G, Riva S, Romanó G, Donadio S.

Antimicrob Agents Chemother. 2011 Apr;55(4):1671-6. doi: 10.1128/AAC.01288-10. Epub 2011 Jan 10.

46.

The genus Actinoallomurus and some of its metabolites.

Pozzi R, Simone M, Mazzetti C, Maffioli S, Monciardini P, Cavaletti L, Bamonte R, Sosio M, Donadio S.

J Antibiot (Tokyo). 2011 Jan;64(1):133-9. doi: 10.1038/ja.2010.149. Epub 2010 Dec 1.

PMID:
21119678
47.

Sources of novel antibiotics--aside the common roads.

Donadio S, Maffioli S, Monciardini P, Sosio M, Jabes D.

Appl Microbiol Biotechnol. 2010 Dec;88(6):1261-7. doi: 10.1007/s00253-010-2877-8. Epub 2010 Sep 24. Review.

PMID:
20865256
48.

Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster.

Binz TM, Maffioli SI, Sosio M, Donadio S, Müller R.

J Biol Chem. 2010 Oct 22;285(43):32710-9. doi: 10.1074/jbc.M110.146803. Epub 2010 Aug 14.

49.

Antibiotic discovery in the twenty-first century: current trends and future perspectives.

Donadio S, Maffioli S, Monciardini P, Sosio M, Jabes D.

J Antibiot (Tokyo). 2010 Aug;63(8):423-30. doi: 10.1038/ja.2010.62. Epub 2010 Jun 16. Review.

PMID:
20551985
50.

Improved production of A40926 by Nonomuraea sp. through deletion of a pathway-specific acetyltransferase.

Sosio M, Canavesi A, Stinchi S, Donadio S.

Appl Microbiol Biotechnol. 2010 Aug;87(5):1633-8. doi: 10.1007/s00253-010-2579-2. Epub 2010 Apr 23.

PMID:
20414653

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