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Items: 1 to 50 of 54

1.

Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes.

Tran C, Heng B, Teo JD, Humphrey SJ, Qi Y, Couttas TA, Stefen H, Brettle M, Fath T, Guillemin GJ, Don AS.

J Neurochem. 2019 Nov 19:e14917. doi: 10.1111/jnc.14917. [Epub ahead of print]

PMID:
31742704
2.

Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.

Lei M, Teo JD, Song H, McEwen HP, Yup Lee J, Couttas TA, Duncan T, Chesworth R, Bertz J, Przybyla M, Van Eersel J, Heng B, Guillemin GJ, Ittner LM, Fath T, Garner B, Ittner A, Karl T, Don AS.

J Neurosci. 2019 Nov 27;39(48):9645-9659. doi: 10.1523/JNEUROSCI.0524-19.2019. Epub 2019 Oct 22.

PMID:
31641049
3.

Pelvic Incidence: Computed Tomography Study Evaluating Correlation with Sagittal Sacropelvic Parameters.

Baker JF, Don AS, Robertson PA.

Clin Anat. 2019 Oct 1. doi: 10.1002/ca.23478. [Epub ahead of print]

PMID:
31576613
4.

High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma.

Lemay AM, Courtemanche O, Couttas TA, Jamsari G, Gagné A, Bossé Y, Joubert P, Don AS, Marsolais D.

J Lipid Res. 2019 Oct;60(10):1776-1786. doi: 10.1194/jlr.M093955. Epub 2019 Aug 13.

PMID:
31409741
5.

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.

Turner N, Lim XY, Toop HD, Osborne B, Brandon AE, Taylor EN, Fiveash CE, Govindaraju H, Teo JD, McEwen HP, Couttas TA, Butler SM, Das A, Kowalski GM, Bruce CR, Hoehn KL, Fath T, Schmitz-Peiffer C, Cooney GJ, Montgomery MK, Morris JC, Don AS.

Nat Commun. 2018 Aug 21;9(1):3165. doi: 10.1038/s41467-018-05613-7.

6.

Age-Dependent Changes to Sphingolipid Balance in the Human Hippocampus are Gender-Specific and May Sensitize to Neurodegeneration.

Couttas TA, Kain N, Tran C, Chatterton Z, Kwok JB, Don AS.

J Alzheimers Dis. 2018;63(2):503-514. doi: 10.3233/JAD-171054.

PMID:
29660940
7.

Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.

Chen J, Qi Y, Zhao Y, Kaczorowski D, Couttas TA, Coleman PR, Don AS, Bertolino P, Gamble JR, Vadas MA, Xia P, McCaughan GW.

Oncotarget. 2018 Feb 26;9(21):15635-15649. doi: 10.18632/oncotarget.24583. eCollection 2018 Mar 20.

8.

Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy.

von Jonquieres G, Spencer ZHT, Rowlands BD, Klugmann CB, Bongers A, Harasta AE, Parley KE, Cederholm J, Teahan O, Pickford R, Delerue F, Ittner LM, Fröhlich D, McLean CA, Don AS, Schneider M, Housley GD, Rae CD, Klugmann M.

Acta Neuropathol. 2018 Jan;135(1):95-113. doi: 10.1007/s00401-017-1784-9. Epub 2017 Nov 7.

9.

Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice.

Tonkin RS, Bowles C, Perera CJ, Keating BA, Makker PGS, Duffy SS, Lees JG, Tran C, Don AS, Fath T, Liu L, O'Carroll SJ, Nicholson LFB, Green CR, Gorrie C, Moalem-Taylor G.

Exp Neurol. 2018 Feb;300:1-12. doi: 10.1016/j.expneurol.2017.10.016. Epub 2017 Oct 18.

PMID:
29055716
10.

Contextual fear conditioning is enhanced in mice lacking functional sphingosine kinase 2.

Lei M, Shafique A, Shang K, Couttas TA, Zhao H, Don AS, Karl T.

Behav Brain Res. 2017 Aug 30;333:9-16. doi: 10.1016/j.bbr.2017.06.019. Epub 2017 Jun 15.

PMID:
28625547
11.

Do position and size matter? An analysis of cage and placement variables for optimum lordosis in PLIF reconstruction.

Landham PR, Don AS, Robertson PA.

Eur Spine J. 2017 Nov;26(11):2843-2850. doi: 10.1007/s00586-017-5170-z. Epub 2017 Jun 15.

PMID:
28620787
12.

A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma.

Gendron DR, Lecours PB, Lemay AM, Beaulieu MJ, Huppé CA, Lee-Gosselin A, Flamand N, Don AS, Bissonnette É, Blanchet MR, Laplante M, Bourgoin SG, Bossé Y, Marsolais D.

Front Pharmacol. 2017 Feb 21;8:78. doi: 10.3389/fphar.2017.00078. eCollection 2017.

13.

Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species.

Montgomery MK, Brown SH, Lim XY, Fiveash CE, Osborne B, Bentley NL, Braude JP, Mitchell TW, Coster AC, Don AS, Cooney GJ, Schmitz-Peiffer C, Turner N.

Biochim Biophys Acta. 2016 Nov;1861(11):1828-1839. doi: 10.1016/j.bbalip.2016.08.016. Epub 2016 Aug 31.

PMID:
27591968
14.

Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors.

Smith AM, Dun MD, Lee EM, Harrison C, Kahl R, Flanagan H, Panicker N, Mashkani B, Don AS, Morris J, Toop H, Lock RB, Powell JA, Thomas D, Guthridge MA, Moore A, Ashman LK, Skelding KA, Enjeti A, Verrills NM.

Oncotarget. 2016 Jul 26;7(30):47465-47478. doi: 10.18632/oncotarget.10167.

15.

Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease.

Couttas TA, Kain N, Suchowerska AK, Quek LE, Turner N, Fath T, Garner B, Don AS.

Neurobiol Aging. 2016 Jul;43:89-100. doi: 10.1016/j.neurobiolaging.2016.03.027. Epub 2016 Apr 4.

PMID:
27255818
16.

Universal No-fault Compensation is Associated With Improved Return to Work Rates in Spine Fusion.

Manson JF, Landham PR, Cunningham JE, Montgomery AS, Don AS, Robertson PA.

Spine (Phila Pa 1976). 2015 Oct 15;40(20):1620-31. doi: 10.1097/BRS.0000000000001096.

PMID:
26731707
17.

Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ.

Chen J, Wang W, Qi Y, Kaczorowski D, McCaughan GW, Gamble JR, Don AS, Gao X, Vadas MA, Xia P.

Biochim Biophys Acta. 2016 Feb;1861(2):138-147. doi: 10.1016/j.bbalip.2015.11.006. Epub 2015 Nov 23.

PMID:
26615875
18.

Fluorescent Assays for Ceramide Synthase Activity.

Couttas TA, Don AS.

Methods Mol Biol. 2016;1376:23-33. doi: 10.1007/978-1-4939-3170-5_3.

PMID:
26552672
19.

Assaying Ceramide Synthase Activity In Vitro and in Living Cells Using Liquid Chromatography-Mass Spectrometry.

Lim XY, Pickford R, Don AS.

Methods Mol Biol. 2016;1376:11-22. doi: 10.1007/978-1-4939-3170-5_2.

PMID:
26552671
20.

Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors.

Toop HD, Don AS, Morris JC.

Org Biomol Chem. 2015 Dec 28;13(48):11593-6. doi: 10.1039/c5ob01931a. Epub 2015 Nov 4.

PMID:
26535908
21.

Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy.

Yaghobian D, Don AS, Yaghobian S, Chen X, Pollock CA, Saad S.

Clin Exp Pharmacol Physiol. 2016 Jan;43(1):56-66. doi: 10.1111/1440-1681.12494.

PMID:
26414003
22.

A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties.

Pitman MR, Powell JA, Coolen C, Moretti PA, Zebol JR, Pham DH, Finnie JW, Don AS, Ebert LM, Bonder CS, Gliddon BL, Pitson SM.

Oncotarget. 2015 Mar 30;6(9):7065-83.

23.

Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma.

Gendron D, Lemay AM, Tremblay C, Lai LJ, Langlois A, Bernatchez É, Flamand N, Blanchet MR, Don AS, Bossé Y, Bissonnette É, Marsolais D.

Respir Res. 2015 Feb 3;16:7. doi: 10.1186/s12931-015-0180-z.

24.

A three-step assay for ceramide synthase activity using a fluorescent substrate and HPLC.

Couttas TA, Lim XY, Don AS.

Lipids. 2015 Jan;50(1):101-9. doi: 10.1007/s11745-014-3969-5. Epub 2014 Nov 18.

PMID:
25403920
25.

Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy.

Don AS, Hsiao JH, Bleasel JM, Couttas TA, Halliday GM, Kim WS.

Acta Neuropathol Commun. 2014 Oct 29;2:150. doi: 10.1186/s40478-014-0150-6.

26.

Re-configuration of sphingolipid metabolism by oncogenic transformation.

Don AS, Lim XY, Couttas TA.

Biomolecules. 2014 Mar 14;4(1):315-53. doi: 10.3390/biom4010315. Review.

27.

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis.

Couttas TA, Kain N, Daniels B, Lim XY, Shepherd C, Kril J, Pickford R, Li H, Garner B, Don AS.

Acta Neuropathol Commun. 2014 Jan 23;2:9. doi: 10.1186/2051-5960-2-9.

28.

A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.

Abuhusain HJ, Matin A, Qiao Q, Shen H, Kain N, Day BW, Stringer BW, Daniels B, Laaksonen MA, Teo C, McDonald KL, Don AS.

J Biol Chem. 2013 Dec 27;288(52):37355-64. doi: 10.1074/jbc.M113.494740. Epub 2013 Nov 21.

29.

ABCA8 stimulates sphingomyelin production in oligodendrocytes.

Kim WS, Hsiao JH, Bhatia S, Glaros EN, Don AS, Tsuruoka S, Shannon Weickert C, Halliday GM.

Biochem J. 2013 Jun 15;452(3):401-10. doi: 10.1042/BJ20121764.

PMID:
23560799
30.

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.

Collison A, Hatchwell L, Verrills N, Wark PA, de Siqueira AP, Tooze M, Carpenter H, Don AS, Morris JC, Zimmermann N, Bartlett NW, Rothenberg ME, Johnston SL, Foster PS, Mattes J.

Nat Med. 2013 Feb;19(2):232-7. doi: 10.1038/nm.3049. Epub 2013 Jan 20.

PMID:
23334847
31.

A fluorescent assay for ceramide synthase activity.

Kim HJ, Qiao Q, Toop HD, Morris JC, Don AS.

J Lipid Res. 2012 Aug;53(8):1701-7. doi: 10.1194/jlr.D025627. Epub 2012 Jun 1.

32.

Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia.

Wallington-Beddoe CT, Don AS, Hewson J, Qiao Q, Papa RA, Lock RB, Bradstock KF, Bendall LJ.

PLoS One. 2012;7(5):e36429. doi: 10.1371/journal.pone.0036429. Epub 2012 May 3. Erratum in: PLoS One. 2012;7(8). doi: 10.1371/annotation/d7342840-682b-4ee2-bb41-7b41aa5dedf7.

33.

Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries.

Don AS, Tsang CK, Kazdoba TM, D'Arcangelo G, Young W, Zheng XF.

Drug Discov Today. 2012 Aug;17(15-16):861-8. doi: 10.1016/j.drudis.2012.04.010. Epub 2012 Apr 27. Review.

34.

MMSAT: automated quantification of metabolites in selected reaction monitoring experiments.

Wong JW, Abuhusain HJ, McDonald KL, Don AS.

Anal Chem. 2012 Jan 3;84(1):470-4. doi: 10.1021/ac2026578. Epub 2011 Dec 13.

PMID:
22111688
35.

Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order.

Magenau A, Benzing C, Proschogo N, Don AS, Hejazi L, Karunakaran D, Jessup W, Gaus K.

Traffic. 2011 Dec;12(12):1730-43. doi: 10.1111/j.1600-0854.2011.01272.x. Epub 2011 Sep 21.

36.

Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains.

Hejazi L, Wong JW, Cheng D, Proschogo N, Ebrahimi D, Garner B, Don AS.

Biochem J. 2011 Aug 15;438(1):165-75. doi: 10.1042/BJ20110566.

PMID:
21639855
37.

Noninvasive imaging of cell death using an Hsp90 ligand.

Park D, Don AS, Massamiri T, Karwa A, Warner B, MacDonald J, Hemenway C, Naik A, Kuan KT, Dilda PJ, Wong JW, Camphausen K, Chinen L, Dyszlewski M, Hogg PJ.

J Am Chem Soc. 2011 Mar 9;133(9):2832-5. doi: 10.1021/ja110226y. Epub 2011 Feb 15.

PMID:
21322555
38.

Recent clinical trials of mTOR-targeted cancer therapies.

Don AS, Zheng XF.

Rev Recent Clin Trials. 2011 Jan;6(1):24-35. Review.

PMID:
20868343
39.

Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate.

Jary E, Bee T, Walker SR, Chung SK, Seo KC, Morris JC, Don AS.

Mol Pharmacol. 2010 Oct;78(4):685-92. doi: 10.1124/mol.110.064873. Epub 2010 Jul 7.

PMID:
20610734
40.

2009 ISSLS Prize Winner: Does discography cause accelerated progression of degeneration changes in the lumbar disc: a ten-year matched cohort study.

Carragee EJ, Don AS, Hurwitz EL, Cuellar JM, Carrino JA, Herzog R.

Spine (Phila Pa 1976). 2009 Oct 1;34(21):2338-45. doi: 10.1097/BRS.0b013e3181ab5432. Erratum in: Spine (Phila Pa 1976). 2010 Jun 15;35(14):1414. Carrino, John [corrected to Carrino, John A].

PMID:
19755936
41.

Anatomic determination of optimal entry point and direction for C1 lateral mass screw placement.

Blagg SE, Don AS, Robertson PA.

J Spinal Disord Tech. 2009 Jun;22(4):233-9. doi: 10.1097/BSD.0b013e31817ff95a.

PMID:
19494741
42.

A lipid binding domain in sphingosine kinase 2.

Don AS, Rosen H.

Biochem Biophys Res Commun. 2009 Feb 27;380(1):87-92. doi: 10.1016/j.bbrc.2009.01.075. Epub 2009 Jan 23.

43.

Is the self-reported history accurate in patients with persistent axial pain after a motor vehicle accident?

Don AS, Carragee EJ.

Spine J. 2009 Jan-Feb;9(1):4-12. doi: 10.1016/j.spinee.2008.11.002.

PMID:
19111258
44.

Selection of fusion levels in adolescent idiopathic scoliosis using fulcrum bending prediction: a prospective study.

Luk KD, Don AS, Chong CS, Wong YW, Cheung KM.

Spine (Phila Pa 1976). 2008 Sep 15;33(20):2192-8. doi: 10.1097/BRS.0b013e31817bd86a.

PMID:
18794761
45.

Modulating tone: the overture of S1P receptor immunotherapeutics.

Rosen H, Gonzalez-Cabrera P, Marsolais D, Cahalan S, Don AS, Sanna MG.

Immunol Rev. 2008 Jun;223:221-35. doi: 10.1111/j.1600-065X.2008.00645.x. Review.

PMID:
18613839
46.

Facet joint orientation in spondylolysis and isthmic spondylolisthesis.

Don AS, Robertson PA.

J Spinal Disord Tech. 2008 Apr;21(2):112-5. doi: 10.1097/BSD.0b013e3180600902.

PMID:
18391715
47.

A fluorescent plate reader assay for ceramide kinase.

Don AS, Rosen H.

Anal Biochem. 2008 Apr 15;375(2):265-71. doi: 10.1016/j.ab.2007.12.024. Epub 2007 Dec 25.

48.

A brief overview of evidence-informed management of chronic low back pain with surgery.

Don AS, Carragee E.

Spine J. 2008 Jan-Feb;8(1):258-65. doi: 10.1016/j.spinee.2007.10.027. Review.

PMID:
18164474
49.

Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.

Don AS, Martinez-Lamenca C, Webb WR, Proia RL, Roberts E, Rosen H.

J Biol Chem. 2007 May 25;282(21):15833-42. Epub 2007 Mar 30.

50.

Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains.

Dilda PJ, Don AS, Tanabe KM, Higgins VJ, Allen JD, Dawes IW, Hogg PJ.

J Natl Cancer Inst. 2005 Oct 19;97(20):1539-47.

PMID:
16234568

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