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Viral quasispecies.

Domingo E, Perales C.

PLoS Genet. 2019 Oct 17;15(10):e1008271. doi: 10.1371/journal.pgen.1008271. eCollection 2019 Oct.


Synergistic lethal mutagenesis of hepatitis C virus.

Gallego I, Soria ME, Gregori J, de Ávila AI, García-Crespo C, Moreno E, Gadea I, Esteban J, Fernández-Roblas R, Esteban JI, Gómez J, Quer J, Domingo E, Perales C.

Antimicrob Agents Chemother. 2019 Sep 30. pii: AAC.01653-19. doi: 10.1128/AAC.01653-19. [Epub ahead of print]


Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification.

Kleeman SO, Koelzer VH, Jones HJ, Vazquez EG, Davis H, East JE, Arnold R, Koppens MA, Blake A, Domingo E, Cunningham C, Beggs AD, Pestinger V, Loughrey MB, Wang LM, Lannagan TR, Woods SL, Worthley D, Consortium SC, Tomlinson I, Dunne PD, Maughan T, Leedham SJ.

Gut. 2019 Sep 28. pii: gutjnl-2019-319126. doi: 10.1136/gutjnl-2019-319126. [Epub ahead of print]


Correction: Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage.

Glaire MA, Domingo E, Sveen A, Bruun J, Nesbakken A, Nicholson G, Novelli M, Lawson K, Oukrif D, Kildal W, Danielsen HE, Kerr R, Kerr D, Tomlinson I, Lothe RA, Church DN.

Br J Cancer. 2019 Sep 23. doi: 10.1038/s41416-019-0590-7. [Epub ahead of print]


The increasing impact of lethal mutagenesis of viruses.

Perales C, Gallego I, de Ávila AI, Soria ME, Gregori J, Quer J, Domingo E.

Future Med Chem. 2019 Jul;11(13):1645-1657. doi: 10.4155/fmc-2018-0457.


Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage.

Glaire MA, Domingo E, Sveen A, Bruun J, Nesbakken A, Nicholson G, Novelli M, Lawson K, Oukrif D, Kildal W, Danielsen HE, Kerr R, Kerr D, Tomlinson I, Lothe RA, Church DN.

Br J Cancer. 2019 Sep;121(6):474-482. doi: 10.1038/s41416-019-0540-4. Epub 2019 Aug 7. Erratum in: Br J Cancer. 2019 Sep 23;:.


The archaeology of coding RNA.

Ariza-Mateos A, Briones C, Perales C, Domingo E, Gómez J.

Ann N Y Acad Sci. 2019 Jul;1447(1):119-134. doi: 10.1111/nyas.14173. Epub 2019 Jun 25. Review.


Targeted next generation sequencing reveals a common genetic pathway for colorectal cancers with chromosomal instability and those with microsatellite and chromosome stability.

Ham-Karim HA, Ebili HO, Bradshaw K, Richman SD, Fadhil W, Domingo E, Tomlinson I, Ilyas M.

Pathol Res Pract. 2019 Jul;215(7):152445. doi: 10.1016/j.prp.2019.152445. Epub 2019 May 20.


Systemic Inflammation in Metabolic Syndrome: Increased Platelet and Leukocyte Activation, and Key Role of CX3CL1/CX3CR1 and CCL2/CCR2 Axes in Arterial Platelet-Proinflammatory Monocyte Adhesion.

Marques P, Collado A, Martinez-Hervás S, Domingo E, Benito E, Piqueras L, Real JT, Ascaso JF, Sanz MJ.

J Clin Med. 2019 May 18;8(5). pii: E708. doi: 10.3390/jcm8050708.


Lethal Mutagenesis of Rift Valley Fever Virus Induced by Favipiravir.

Borrego B, de Ávila AI, Domingo E, Brun A.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00669-19. doi: 10.1128/AAC.00669-19. Print 2019 Aug.


Viral fitness: history and relevance for viral pathogenesis and antiviral interventions.

Domingo E, de Ávila AI, Gallego I, Sheldon J, Perales C.

Pathog Dis. 2019 Mar 1;77(2). pii: ftz021. doi: 10.1093/femspd/ftz021.


Guidelines for using sigQC for systematic evaluation of gene signatures.

Dhawan A, Barberis A, Cheng WC, Domingo E, West C, Maughan T, Scott JG, Harris AL, Buffa FM.

Nat Protoc. 2019 May;14(5):1377-1400. doi: 10.1038/s41596-019-0136-8. Epub 2019 Apr 10.


Extracellular vesicles: Vehicles of en bloc viral transmission.

Altan-Bonnet N, Perales C, Domingo E.

Virus Res. 2019 May;265:143-149. doi: 10.1016/j.virusres.2019.03.023. Epub 2019 Mar 27. Review.


Pulmonary hypertension associated with left heart disease: efforts to improve the meaning of haemodynamic phenotypes.

Grignola JC, Trujillo P, Domingo E.

Eur Respir J. 2019 Mar 7;53(3). pii: 1801894. doi: 10.1183/13993003.01894-2018. Print 2019 Mar. No abstract available.


An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.

Li N, Babaei-Jadidi R, Lorenzi F, Spencer-Dene B, Clarke P, Domingo E, Tulchinsky E, Vries RGJ, Kerr D, Pan Y, He Y, Bates DO, Tomlinson I, Clevers H, Nateri AS.

Oncogenesis. 2019 Feb 19;8(3):13. doi: 10.1038/s41389-019-0125-3.


Novel Immune Features of the Systemic Inflammation Associated with Primary Hypercholesterolemia: Changes in Cytokine/Chemokine Profile, Increased Platelet and Leukocyte Activation.

Collado A, Marques P, Domingo E, Perello E, González-Navarro H, Martinez-Hervás S, Real JT, Piqueras L, Ascaso JF, Sanz MJ.

J Clin Med. 2018 Dec 22;8(1). pii: E18. doi: 10.3390/jcm8010018.


Baseline hepatitis C virus resistance-associated substitutions present at frequencies lower than 15% may be clinically significant.

Perales C, Chen Q, Soria ME, Gregori J, Garcia-Cehic D, Nieto-Aponte L, Castells L, Imaz A, Llorens-Revull M, Domingo E, Buti M, Esteban JI, Rodriguez-Frias F, Quer J.

Infect Drug Resist. 2018 Nov 8;11:2207-2210. doi: 10.2147/IDR.S172226. eCollection 2018.


Proximal pulmonary arterial wall disease in patients with persistent pulmonary hypertension after successful left-sided valve replacement according to the hemodynamic phenotype.

Domingo E, Grignola JC, Trujillo P, Aguilar R, Roman A.

Pulm Circ. 2019 Jan-Mar;9(1):2045894018816972. doi: 10.1177/2045894018816972. Epub 2018 Nov 15.


Corneal Abrasion.

Domingo E, Zabbo CP.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-.
2019 Feb 19.


Rare haplotype load as marker for lethal mutagenesis.

Gregori J, Soria ME, Gallego I, Guerrero-Murillo M, Esteban JI, Quer J, Perales C, Domingo E.

PLoS One. 2018 Oct 3;13(10):e0204877. doi: 10.1371/journal.pone.0204877. eCollection 2018.


Selection of Tumor-Specific Cytotoxic T Lymphocytes in Acute Myeloid Leukemia Patients Through the Identification of T-Cells Capable to Establish Stable Interactions With the Leukemic Cells: "Doublet Technology".

García-Guerrero E, Sánchez-Abarca LI, Domingo E, Ramos TL, Bejarano-García JA, Gonzalez-Campos JA, Caballero-Velázquez T, Pérez-Simón JA.

Front Immunol. 2018 Sep 3;9:1971. doi: 10.3389/fimmu.2018.01971. eCollection 2018.


Toll-Like Receptor 7 (TLR-7) and TLR-9 Agonists Improve Hepatitis C Virus Replication and Infectivity Inhibition by Plasmacytoid Dendritic Cells.

Dominguez-Molina B, Machmach K, Perales C, Tarancon-Diez L, Gallego I, Sheldon JL, Leal M, Domingo E, Ruiz-Mateos E.

J Virol. 2018 Nov 12;92(23). pii: e01219-18. doi: 10.1128/JVI.01219-18. Print 2018 Dec 1.


The evolutionary landscape of colorectal tumorigenesis.

Cross W, Kovac M, Mustonen V, Temko D, Davis H, Baker AM, Biswas S, Arnold R, Chegwidden L, Gatenbee C, Anderson AR, Koelzer VH, Martinez P, Jiang X, Domingo E, Woodcock DJ, Feng Y, Kovacova M, Maughan T; S:CORT Consortium, Jansen M, Rodriguez-Justo M, Ashraf S, Guy R, Cunningham C, East JE, Wedge DC, Wang LM, Palles C, Heinimann K, Sottoriva A, Leedham SJ, Graham TA, Tomlinson IPM.

Nat Ecol Evol. 2018 Oct;2(10):1661-1672. doi: 10.1038/s41559-018-0642-z. Epub 2018 Aug 31.


Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus.

Soria ME, Gregori J, Chen Q, García-Cehic D, Llorens M, de Ávila AI, Beach NM, Domingo E, Rodríguez-Frías F, Buti M, Esteban R, Esteban JI, Quer J, Perales C.

BMC Infect Dis. 2018 Sep 3;18(1):446. doi: 10.1186/s12879-018-3356-6.


Resistance of high fitness hepatitis C virus to lethal mutagenesis.

Gallego I, Gregori J, Soria ME, García-Crespo C, García-Álvarez M, Gómez-González A, Valiergue R, Gómez J, Esteban JI, Quer J, Domingo E, Perales C.

Virology. 2018 Oct;523:100-109. doi: 10.1016/j.virol.2018.07.030. Epub 2018 Aug 11.


Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis.

de la Higuera I, Ferrer-Orta C, Moreno E, de Ávila AI, Soria ME, Singh K, Caridi F, Sobrino F, Sarafianos SG, Perales C, Verdaguer N, Domingo E.

J Virol. 2018 Sep 26;92(20). pii: e01119-18. doi: 10.1128/JVI.01119-18. Print 2018 Oct 15.


Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series.

Domingo E, Camps C, Kaisaki PJ, Parsons MJ, Mouradov D, Pentony MM, Makino S, Palmieri M, Ward RL, Hawkins NJ, Gibbs P, Askautrud H, Oukrif D, Wang H, Wood J, Tomlinson E, Bark Y, Kaur K, Johnstone EC, Palles C, Church DN, Novelli M, Danielsen HE, Sherlock J, Kerr D, Kerr R, Sieber O, Taylor JC, Tomlinson I.

Lancet Gastroenterol Hepatol. 2018 Sep;3(9):635-643. doi: 10.1016/S2468-1253(18)30117-1. Epub 2018 Jul 2.


MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353.

Annang F, Pérez-Victoria I, Pérez-Moreno G, Domingo E, González I, Tormo JR, Martín J, Ruiz-Pérez LM, Genilloud O, González-Pacanowska D, Vicente F, Reyes F.

J Nat Prod. 2018 Jul 27;81(7):1687-1691. doi: 10.1021/acs.jnatprod.8b00323. Epub 2018 Jun 20.


Functional role of endothelial CXCL16/CXCR6-platelet-leucocyte axis in angiotensin II-associated metabolic disorders.

Collado A, Marques P, Escudero P, Rius C, Domingo E, Martinez-Hervás S, Real JT, Ascaso JF, Piqueras L, Sanz MJ.

Cardiovasc Res. 2018 Nov 1;114(13):1764-1775. doi: 10.1093/cvr/cvy135.


Antiprotozoan sesterterpenes and triterpenes isolated from two Ghanaian mushrooms.

Annang F, Pérez-Victoria I, Appiah T, Pérez-Moreno G, Domingo E, Martín J, Mackenzie T, Ruiz-Pérez L, González-Pacanowska D, Genilloud O, Vicente F, Agyare C, Reyes F.

Fitoterapia. 2018 Jun;127:341-348. doi: 10.1016/j.fitote.2018.03.016. Epub 2018 Apr 3.


Quasispecies and virus.

Domingo E, Perales C.

Eur Biophys J. 2018 May;47(4):443-457. doi: 10.1007/s00249-018-1282-6. Epub 2018 Feb 3. Review.


Area at risk and collateral circulation in a first acute myocardial infarction with occluded culprit artery. STEMI vs non-STEMI patients.

Figueras J, Otaegui I, Marti G, Domingo E, Bañeras J, Barrabés JA, Del Blanco BG, Garcia-Dorado D.

Int J Cardiol. 2018 May 15;259:14-19. doi: 10.1016/j.ijcard.2018.01.047. Epub 2018 Jan 31.


Prognostic markers for colorectal cancer: estimating ploidy and stroma.

Danielsen HE, Hveem TS, Domingo E, Pradhan M, Kleppe A, Syvertsen RA, Kostolomov I, Nesheim JA, Askautrud HA, Nesbakken A, Lothe RA, Svindland A, Shepherd N, Novelli M, Johnstone E, Tomlinson I, Kerr R, Kerr DJ.

Ann Oncol. 2018 Mar 1;29(3):616-623. doi: 10.1093/annonc/mdx794.


Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Baker AM, Huang W, Wang XM, Jansen M, Ma XJ, Kim J, Anderson CM, Wu X, Pan L, Su N, Luo Y, Domingo E, Heide T, Sottoriva A, Lewis A, Beggs AD, Wright NA, Rodriguez-Justo M, Park E, Tomlinson I, Graham TA.

Nat Commun. 2017 Dec 8;8(1):1998. doi: 10.1038/s41467-017-02295-5.


Acute Right Ventricular Dysfunction in Intensive Care Unit.

Grignola JC, Domingo E.

Biomed Res Int. 2017;2017:8217105. doi: 10.1155/2017/8217105. Epub 2017 Oct 19. Review.


Pharmacoproteomic characterisation of human colon and rectal cancer.

Frejno M, Zenezini Chiozzi R, Wilhelm M, Koch H, Zheng R, Klaeger S, Ruprecht B, Meng C, Kramer K, Jarzab A, Heinzlmeir S, Johnstone E, Domingo E, Kerr D, Jesinghaus M, Slotta-Huspenina J, Weichert W, Knapp S, Feller SM, Kuster B.

Mol Syst Biol. 2017 Nov 3;13(11):951. doi: 10.15252/msb.20177701.


Short-term exposure to air pollutants increases the risk of ST elevation myocardial infarction and of infarct-related ventricular arrhythmias and mortality.

Bañeras J, Ferreira-González I, Marsal JR, Barrabés JA, Ribera A, Lidón RM, Domingo E, Martí G, García-Dorado D; Codi IAM Registry investigators.

Int J Cardiol. 2018 Jan 1;250:35-42. doi: 10.1016/j.ijcard.2017.10.004. Epub 2017 Oct 5.


Pulmonary vascular disease due to left heart disease: how to achieve a more accurate approach beyond the haemodynamic phenotype.

Grignola JC, Trujillo P, Domingo E.

Eur J Heart Fail. 2018 May;20(5):942-943. doi: 10.1002/ejhf.954. Epub 2017 Sep 26. No abstract available.


Extinction of West Nile Virus by Favipiravir through Lethal Mutagenesis.

Escribano-Romero E, Jiménez de Oya N, Domingo E, Saiz JC.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01400-17. doi: 10.1128/AAC.01400-17. Print 2017 Nov.


High sensitivity and negative predictive value of the DETECT algorithm for an early diagnosis of pulmonary arterial hypertension in systemic sclerosis: application in a single center.

Guillén-Del Castillo A, Callejas-Moraga EL, García G, Rodríguez-Palomares JF, Román A, Berastegui C, López-Meseguer M, Domingo E, Fonollosa-Plá V, Simeón-Aznar CP.

Arthritis Res Ther. 2017 Jun 14;19(1):135. doi: 10.1186/s13075-017-1327-8.


Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1.

Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA.

Genome Med. 2017 May 24;9(1):46. doi: 10.1186/s13073-017-0434-0.


Pulmonary arterial wall disease in COPD and interstitial lung diseases candidates for lung transplantation.

Domingo E, Grignola JC, Aguilar R, Messeguer ML, Roman A.

Respir Res. 2017 May 6;18(1):85. doi: 10.1186/s12931-017-0568-z.


Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.

de la Higuera I, Ferrer-Orta C, de Ávila AI, Perales C, Sierra M, Singh K, Sarafianos SG, Dehouck Y, Bastolla U, Verdaguer N, Domingo E.

Genome Biol Evol. 2017 May 1;9(5):1212-1228. doi: 10.1093/gbe/evx075.


Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study.

Domingo E, Freeman-Mills L, Rayner E, Glaire M, Briggs S, Vermeulen L, Fessler E, Medema JP, Boot A, Morreau H, van Wezel T, Liefers GJ, Lothe RA, Danielsen SA, Sveen A, Nesbakken A, Zlobec I, Lugli A, Koelzer VH, Berger MD, Castellví-Bel S, Muñoz J; Epicolon consortium, de Bruyn M, Nijman HW, Novelli M, Lawson K, Oukrif D, Frangou E, Dutton P, Tejpar S, Delorenzi M, Kerr R, Kerr D, Tomlinson I, Church DN.

Lancet Gastroenterol Hepatol. 2016 Nov;1(3):207-216. doi: 10.1016/S2468-1253(16)30014-0. Epub 2016 Jul 20.


Favipiravir can evoke lethal mutagenesis and extinction of foot-and-mouth disease virus.

de Avila AI, Moreno E, Perales C, Domingo E.

Virus Res. 2017 Apr 2;233:105-112. doi: 10.1016/j.virusres.2017.03.014. Epub 2017 Mar 18.


Internal Disequilibria and Phenotypic Diversification during Replication of Hepatitis C Virus in a Noncoevolving Cellular Environment.

Moreno E, Gallego I, Gregori J, Lucía-Sanz A, Soria ME, Castro V, Beach NM, Manrubia S, Quer J, Esteban JI, Rice CM, Gómez J, Gastaminza P, Domingo E, Perales C.

J Virol. 2017 Apr 28;91(10). pii: e02505-16. doi: 10.1128/JVI.02505-16. Print 2017 May 15.


BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer.

López-García C, Sansregret L, Domingo E, McGranahan N, Hobor S, Birkbak NJ, Horswell S, Grönroos E, Favero F, Rowan AJ, Matthews N, Begum S, Phillimore B, Burrell R, Oukrif D, Spencer-Dene B, Kovac M, Stamp G, Stewart A, Danielsen H, Novelli M, Tomlinson I, Swanton C.

Cancer Cell. 2017 Jan 9;31(1):79-93. doi: 10.1016/j.ccell.2016.11.001.


Deep sequencing in the management of hepatitis virus infections.

Quer J, Rodríguez-Frias F, Gregori J, Tabernero D, Soria ME, García-Cehic D, Homs M, Bosch A, Pintó RM, Esteban JI, Domingo E, Perales C.

Virus Res. 2017 Jul 15;239:115-125. doi: 10.1016/j.virusres.2016.12.020. Epub 2016 Dec 28. Review.


An Efficient Microarray-Based Genotyping Platform for the Identification of Drug-Resistance Mutations in Majority and Minority Subpopulations of HIV-1 Quasispecies.

Martín V, Perales C, Fernández-Algar M, Dos Santos HG, Garrido P, Pernas M, Parro V, Moreno M, García-Pérez J, Alcamí J, Torán JL, Abia D, Domingo E, Briones C.

PLoS One. 2016 Dec 13;11(12):e0166902. doi: 10.1371/journal.pone.0166902. eCollection 2016.


Is sidedness prognostically important across all stages of colorectal cancer?

Kerr DJ, Domingo E, Kerr R.

Lancet Oncol. 2016 Nov;17(11):1480-1482. doi: 10.1016/S1470-2045(16)30431-4. No abstract available. Erratum in: Lancet Oncol. 2016 Dec;17 (12 ):e519.


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