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Items: 24


Concentrations of oxidized linoleic acid derived lipid mediators in the amygdala and periaqueductal grey are reduced in a mouse model of chronic inflammatory pain.

Jensen JR, Pitcher MH, Yuan ZX, Ramsden CE, Domenichiello AF.

Prostaglandins Leukot Essent Fatty Acids. 2018 Aug;135:128-136. doi: 10.1016/j.plefa.2018.07.015. Epub 2018 Jul 23.


Quantitation of Human Whole-Body Synthesis-Secretion Rates of Docosahexaenoic Acid and Eicosapentaenoate Acid from Circulating Unesterified α-Linolenic Acid at Steady State.

Lin YH, Hibbeln JR, Domenichiello AF, Ramsden CE, Salem NM, Chen CT, Jin H, Courville AB, Majchrzak-Hong SF, Rapoport SI, Bazinet RP, Miller BV 3rd.

Lipids. 2018 May;53(5):547-558. doi: 10.1002/lipd.12055. Epub 2018 Aug 3.


Bioactive Lipid Mediator Profiles in Human Psoriasis Skin and Blood.

Sorokin AV, Domenichiello AF, Dey AK, Yuan ZX, Goyal A, Rose SM, Playford MP, Ramsden CE, Mehta NN.

J Invest Dermatol. 2018 Jul;138(7):1518-1528. doi: 10.1016/j.jid.2018.02.003. Epub 2018 Feb 15.


A dose response study of the effect of prostaglandin E2 on thermal nociceptive sensitivity.

Domenichiello AF, Wilhite BC, Keyes GS, Ramsden CE.

Prostaglandins Leukot Essent Fatty Acids. 2017 Nov;126:20-24. doi: 10.1016/j.plefa.2017.08.015. Epub 2017 Aug 31.


Docosahexaenoic acid (DHA) accretion in the placenta but not the fetus is matched by plasma unesterified DHA uptake rates in pregnant Long Evans rats.

Metherel AH, Kitson AP, Domenichiello AF, Lacombe RJS, Hopperton KE, Trépanier MO, Alashmali SM, Lin L, Bazinet RP.

Placenta. 2017 Oct;58:90-97. doi: 10.1016/j.placenta.2017.08.072. Epub 2017 Sep 1.


PURE study challenges the definition of a healthy diet: but key questions remain.

Ramsden CE, Domenichiello AF.

Lancet. 2017 Nov 4;390(10107):2018-2019. doi: 10.1016/S0140-6736(17)32241-9. Epub 2017 Aug 29. No abstract available.


A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch.

Ramsden CE, Domenichiello AF, Yuan ZX, Sapio MR, Keyes GS, Mishra SK, Gross JR, Majchrzak-Hong S, Zamora D, Horowitz MS, Davis JM, Sorokin AV, Dey A, LaPaglia DM, Wheeler JJ, Vasko MR, Mehta NN, Mannes AJ, Iadarola MJ.

Sci Signal. 2017 Aug 22;10(493). pii: eaal5241. doi: 10.1126/scisignal.aal5241.


Maternal liver docosahexaenoic acid (DHA) stores are increased via higher serum unesterified DHA uptake in pregnant long Evans rats.

Metherel AH, Kitson AP, Domenichiello AF, Lacombe RJS, Hopperton KE, Trépanier MO, Alashmali SM, Lin L, Bazinet RP.

J Nutr Biochem. 2017 Aug;46:143-150. doi: 10.1016/j.jnutbio.2017.05.011. Epub 2017 Jun 1.


Serum n-3 Tetracosapentaenoic Acid and Tetracosahexaenoic Acid Increase Following Higher Dietary α-Linolenic Acid but not Docosahexaenoic Acid.

Metherel AH, Domenichiello AF, Kitson AP, Lin YH, Bazinet RP.

Lipids. 2017 Feb;52(2):167-172. doi: 10.1007/s11745-016-4223-0. Epub 2016 Dec 22.


Whole-Body Docosahexaenoic Acid Synthesis-Secretion Rates in Rats Are Constant across a Large Range of Dietary α-Linolenic Acid Intakes.

Domenichiello AF, Kitson AP, Metherel AH, Chen CT, Hopperton KE, Stavro PM, Bazinet RP.

J Nutr. 2017 Jan;147(1):37-44. doi: 10.3945/jn.116.232074. Epub 2016 Nov 16.


Whole-body DHA synthesis-secretion kinetics from plasma eicosapentaenoic acid and alpha-linolenic acid in the free-living rat.

Metherel AH, Domenichiello AF, Kitson AP, Hopperton KE, Bazinet RP.

Biochim Biophys Acta. 2016 Sep;1861(9 Pt A):997-1004. doi: 10.1016/j.bbalip.2016.05.014. Epub 2016 Jun 2.


Effect of dietary docosahexaenoic acid (DHA) in phospholipids or triglycerides on brain DHA uptake and accretion.

Kitson AP, Metherel AH, Chen CT, Domenichiello AF, Trépanier MO, Berger A, Bazinet RP.

J Nutr Biochem. 2016 Jul;33:91-102. doi: 10.1016/j.jnutbio.2016.02.009. Epub 2016 Mar 21.


The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats.

Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP.

J Nutr Biochem. 2016 Apr;30:167-76. doi: 10.1016/j.jnutbio.2015.11.016. Epub 2015 Dec 12.


A comparison of effects of lard and hydrogenated vegetable shortening on the development of high-fat diet-induced obesity in rats.

Kubant R, Poon AN, Sánchez-Hernández D, Domenichiello AF, Huot PS, Pannia E, Cho CE, Hunschede S, Bazinet RP, Anderson GH.

Nutr Diabetes. 2015 Dec 14;5:e188. doi: 10.1038/nutd.2015.40.


Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain.

Chen CT, Kitson AP, Hopperton KE, Domenichiello AF, Trépanier MO, Lin LE, Ermini L, Post M, Thies F, Bazinet RP.

Sci Rep. 2015 Oct 29;5:15791. doi: 10.1038/srep15791.


Intravenous infusion of docosahexaenoic acid increases serum concentrations in a dose-dependent manner and increases seizure latency in the maximal PTZ model.

Trépanier MO, Kwong KM, Domenichiello AF, Chen CT, Bazinet RP, Burnham WM.

Epilepsy Behav. 2015 Sep;50:71-6. doi: 10.1016/j.yebeh.2015.05.034. Epub 2015 Jul 1.


Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain?

Domenichiello AF, Kitson AP, Bazinet RP.

Prog Lipid Res. 2015 Jul;59:54-66. doi: 10.1016/j.plipres.2015.04.002. Epub 2015 Apr 25. Review.


Intraperitoneal administration of docosahexaenoic acid for 14days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazol model.

Trépanier MO, Lim J, Lai TK, Cho HJ, Domenichiello AF, Chen CT, Taha AY, Bazinet RP, Burnham WM.

Epilepsy Behav. 2014 Apr;33:138-43. doi: 10.1016/j.yebeh.2014.02.020. Epub 2014 Mar 22.


Inhibiting mitochondrial β-oxidation selectively reduces levels of nonenzymatic oxidative polyunsaturated fatty acid metabolites in the brain.

Chen CT, Trépanier MO, Hopperton KE, Domenichiello AF, Masoodi M, Bazinet RP.

J Cereb Blood Flow Metab. 2014 Mar;34(3):376-9. doi: 10.1038/jcbfm.2013.221. Epub 2013 Dec 11.


Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats.

Domenichiello AF, Chen CT, Trepanier MO, Stavro PM, Bazinet RP.

J Lipid Res. 2014 Jan;55(1):62-74. doi: 10.1194/jlr.M042275. Epub 2013 Nov 9.


The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms.

Chen CT, Domenichiello AF, Trépanier MO, Liu Z, Masoodi M, Bazinet RP.

J Lipid Res. 2013 Sep;54(9):2410-22. doi: 10.1194/jlr.M038505. Epub 2013 Jul 8.


Docosahexaenoic acid, but not eicosapentaenoic acid, supplementation reduces vulnerability to atrial fibrillation.

Ramadeen A, Connelly KA, Leong-Poi H, Hu X, Fujii H, Laurent G, Domenichiello AF, Bazinet RP, Dorian P.

Circ Arrhythm Electrophysiol. 2012 Oct;5(5):978-83. doi: 10.1161/CIRCEP.112.971515. Epub 2012 Aug 24.


Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses.

Trépanier MO, Taha AY, Mantha RL, Ciobanu FA, Zeng QH, Tchkhartichvili GM, Domenichiello AF, Bazinet RP, Burnham WM.

Epilepsy Res. 2012 May;99(3):225-32. doi: 10.1016/j.eplepsyres.2011.12.001. Epub 2012 Jan 28.


Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance.

Shi SY, Martin RG, Duncan RE, Choi D, Lu SY, Schroer SA, Cai EP, Luk CT, Hopperton KE, Domenichiello AF, Tang C, Naples M, Dekker MJ, Giacca A, Adeli K, Wagner KU, Bazinet RP, Woo M.

J Biol Chem. 2012 Mar 23;287(13):10277-88. doi: 10.1074/jbc.M111.317453. Epub 2012 Jan 24.

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