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Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface.

Wert KJ, Velez G, Cross MR, Wagner BA, Teoh-Fitzgerald ML, Buettner GR, McAnany JJ, Olivier A, Tsang SH, Harper MM, Domann FE, Bassuk AG, Mahajan VB.

Free Radic Biol Med. 2018 Aug 20;124:408-419. doi: 10.1016/j.freeradbiomed.2018.06.024. Epub 2018 Jun 22.


Limitations of oxygen delivery to cells in culture: An underappreciated problem in basic and translational research.

Place TL, Domann FE, Case AJ.

Free Radic Biol Med. 2017 Dec;113:311-322. doi: 10.1016/j.freeradbiomed.2017.10.003. Epub 2017 Oct 13. Review.


O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.

Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, Monga V, Bodeker KL, Ahmann L, Vollstedt S, Brown H, Kauffman EPS, Schall ME, Hohl RJ, Clamon GH, Greenlee JD, Howard MA, Schultz MK, Smith BJ, Riley DP, Domann FE, Cullen JJ, Buettner GR, Buatti JM, Spitz DR, Allen BG.

Cancer Cell. 2017 Aug 14;32(2):268. doi: 10.1016/j.ccell.2017.07.008. No abstract available.


Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy.

Mapuskar KA, Flippo KH, Schoenfeld JD, Riley DP, Strack S, Hejleh TA, Furqan M, Monga V, Domann FE, Buatti JM, Goswami PC, Spitz DR, Allen BG.

Cancer Res. 2017 Sep 15;77(18):5054-5067. doi: 10.1158/0008-5472.CAN-17-0106. Epub 2017 Aug 1.


Allele-specific interaction between glutathione peroxidase 1 and manganese superoxide dismutase affects the levels of Bcl-2, Sirt3 and E-cadherin.

Ekoue DN, Bera S, Ansong E, Hart PC, Zaichick S, Domann FE, Bonini MG, Diamond AM.

Free Radic Res. 2017 Jun;51(6):582-590. doi: 10.1080/10715762.2017.1339303. Epub 2017 Jul 4.


O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.

Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, Monga V, Bodeker KL, Ahmann L, Vollstedt S, Brown H, Shanahan Kauffman EP, Schall ME, Hohl RJ, Clamon GH, Greenlee JD, Howard MA, Schultz MK, Smith BJ, Riley DP, Domann FE, Cullen JJ, Buettner GR, Buatti JM, Spitz DR, Allen BG.

Cancer Cell. 2017 Apr 10;31(4):487-500.e8. doi: 10.1016/j.ccell.2017.02.018. Epub 2017 Mar 30. Erratum in: Cancer Cell. 2017 Aug 14;32(2):268.


Extracellular matrix 1 (ECM1) regulates the actin cytoskeletal architecture of aggressive breast cancer cells in part via S100A4 and Rho-family GTPases.

Gómez-Contreras P, Ramiro-Díaz JM, Sierra A, Stipp C, Domann FE, Weigel RJ, Lal G.

Clin Exp Metastasis. 2017 Jan;34(1):37-49. doi: 10.1007/s10585-016-9827-5. Epub 2016 Oct 21.


Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension.

Nozik-Grayck E, Woods C, Stearman RS, Venkataraman S, Ferguson BS, Swain K, Bowler RP, Geraci MW, Ihida-Stansbury K, Stenmark KR, McKinsey TA, Domann FE.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L124-34. doi: 10.1152/ajplung.00263.2015. Epub 2016 May 27.


SOD2 targeted gene editing by CRISPR/Cas9 yields Human cells devoid of MnSOD.

Cramer-Morales K, Heer CD, Mapuskar KA, Domann FE.

Free Radic Biol Med. 2015 Dec;89:379-86. doi: 10.1016/j.freeradbiomed.2015.07.017. Epub 2015 Jul 21.


Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells.

Hrabe JE, O'Leary BR, Fath MA, Rodman SN, Button AM, Domann FE, Spitz DR, Mezhir JJ.

Redox Biol. 2015 Aug;5:319-327. doi: 10.1016/j.redox.2015.06.004. Epub 2015 Jun 18.


Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling.

Jiménez-Chillarón JC, Nijland MJ, Ascensão AA, Sardão VA, Magalhães J, Hitchler MJ, Domann FE, Oliveira PJ.

Epigenetics. 2015;10(4):259-73. doi: 10.1080/15592294.2015.1020267. Epub 2015 Mar 16. Review.


The role of Tcfap2c in tumorigenesis and cancer growth in an activated Neu model of mammary carcinogenesis.

Park JM, Wu T, Cyr AR, Woodfield GW, De Andrade JP, Spanheimer PM, Li T, Sugg SL, Lal G, Domann FE, Zhang W, Weigel RJ.

Oncogene. 2015 Dec 10;34(50):6105-14. doi: 10.1038/onc.2015.59. Epub 2015 Mar 16.


Corrigendum to "Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest".

Duangmano S, Sae-Lim P, Suksamrarn A, Patmasiriwat P, Domann FE.

J Oncol. 2015;2015:486850. doi: 10.1155/2015/486850. Epub 2015 Feb 2.


Ligand-independent activation of aryl hydrocarbon receptor signaling in PCB3-quinone treated HaCaT human keratinocytes.

Xiao W, Son J, Vorrink SU, Domann FE, Goswami PC.

Toxicol Lett. 2015 Mar 18;233(3):258-66. doi: 10.1016/j.toxlet.2015.02.005. Epub 2015 Feb 7.


Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma.

O'Leary BR, Fath MA, Bellizzi AM, Hrabe JE, Button AM, Allen BG, Case AJ, Altekruse S, Wagner BA, Buettner GR, Lynch CF, Hernandez BY, Cozen W, Beardsley RA, Keene J, Henry MD, Domann FE, Spitz DR, Mezhir JJ.

Clin Cancer Res. 2015 Apr 1;21(7):1741-51. doi: 10.1158/1078-0432.CCR-14-1959. Epub 2015 Jan 29.


Aberrant CpG methylation of the TFAP2A gene constitutes a mechanism for loss of TFAP2A expression in human metastatic melanoma.

Hallberg AR, Vorrink SU, Hudachek DR, Cramer-Morales K, Milhem MM, Cornell RA, Domann FE.

Epigenetics. 2014 Dec;9(12):1641-7. doi: 10.4161/15592294.2014.988062.


SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort.

TenNapel MJ, Lynch CF, Burns TL, Wallace R, Smith BJ, Button A, Domann FE.

PLoS One. 2014 Dec 26;9(12):e115616. doi: 10.1371/journal.pone.0115616. eCollection 2014.


Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes.

Xiao W, Sarsour EH, Wagner BA, Doskey CM, Buettner GR, Domann FE, Goswami PC.

Arch Toxicol. 2016 Feb;90(2):319-32. doi: 10.1007/s00204-014-1407-3. Epub 2014 Nov 23.


Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer.

Yang S, Jia Y, Liu X, Winters C, Wang X, Zhang Y, Devor EJ, Hovey AM, Reyes HD, Xiao X, Xu Y, Dai D, Meng X, Thiel KW, Domann FE, Leslie KK.

Oncotarget. 2014 Oct 30;5(20):9783-97.


Mitochondria, energetics, epigenetics, and cellular responses to stress.

Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL.

Environ Health Perspect. 2014 Dec;122(12):1271-8. doi: 10.1289/ehp.1408418. Epub 2014 Aug 15. Review.


Epigenetic determinants of CYP1A1 induction by the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB 126).

Vorrink SU, Hudachek DR, Domann FE.

Int J Mol Sci. 2014 Aug 11;15(8):13916-31. doi: 10.3390/ijms150813916.


Retroviral-infection increases tumorigenic potential of MDA-MB-231 breast carcinoma cells by expanding an aldehyde dehydrogenase (ALDH1) positive stem-cell like population.

Wegman-Points LJ, Teoh-Fitzgerald ML, Mao G, Zhu Y, Fath MA, Spitz DR, Domann FE.

Redox Biol. 2014 Jun 24;2:847-54. doi: 10.1016/j.redox.2014.06.006. eCollection 2014.


PCB 126 perturbs hypoxia-induced HIF-1α activity and glucose consumption in human HepG2 cells.

Vorrink SU, Sarsour EH, Olivier AK, Robertson LW, Goswami PC, Domann FE.

Exp Toxicol Pathol. 2014 Oct;66(8):377-82. doi: 10.1016/j.etp.2014.05.005. Epub 2014 Jun 7.


Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1α signaling node.

Vorrink SU, Domann FE.

Chem Biol Interact. 2014 Jul 25;218:82-8. doi: 10.1016/j.cbi.2014.05.001. Epub 2014 May 10. Review.


Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival.

Hall DD, Wu Y, Domann FE, Spitz DR, Anderson ME.

PLoS One. 2014 May 6;9(5):e96866. doi: 10.1371/journal.pone.0096866. eCollection 2014.


Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein.

Place TL, Domann FE.

Hypoxia (Auckl). 2013 Oct 1;2013(1):13-17.


Locally targeted delivery of a micron-size radiation therapy source using temperature-sensitive hydrogel.

Kim Y, Seol DR, Mohapatra S, Sunderland JJ, Schultz MK, Domann FE, Lim TH.

Int J Radiat Oncol Biol Phys. 2014 Apr 1;88(5):1142-7. doi: 10.1016/j.ijrobp.2013.12.025. Epub 2014 Feb 1.


Absence of manganese superoxide dismutase delays p53-induced tumor formation.

Case AJ, Domann FE.

Redox Biol. 2014 Jan 13;2:220-3. doi: 10.1016/j.redox.2014.01.001. eCollection 2014.


Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses.

Gross TJ, Kremens K, Powers LS, Brink B, Knutson T, Domann FE, Philibert RA, Milhem MM, Monick MM.

J Immunol. 2014 Mar 1;192(5):2326-38. doi: 10.4049/jimmunol.1301758. Epub 2014 Jan 29.


TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis.

Cyr AR, Kulak MV, Park JM, Bogachek MV, Spanheimer PM, Woodfield GW, White-Baer LS, O'Malley YQ, Sugg SL, Olivier AK, Zhang W, Domann FE, Weigel RJ.

Oncogene. 2015 Jan 22;34(4):436-44. doi: 10.1038/onc.2013.569. Epub 2014 Jan 27.


Prolyl-4-hydroxylase 3 (PHD3) expression is downregulated during epithelial-to-mesenchymal transition.

Place TL, Nauseef JT, Peterson MK, Henry MD, Mezhir JJ, Domann FE.

PLoS One. 2013 Dec 18;8(12):e83021. doi: 10.1371/journal.pone.0083021. eCollection 2013.


Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines.

Vorrink SU, Severson PL, Kulak MV, Futscher BW, Domann FE.

Toxicol Appl Pharmacol. 2014 Feb 1;274(3):408-16. doi: 10.1016/j.taap.2013.12.002. Epub 2013 Dec 16.


Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes.

Cyr AR, Brown KE, McCormick ML, Coleman MC, Case AJ, Watts GS, Futscher BW, Spitz DR, Domann FE.

Redox Biol. 2013 Feb 5;1:172-7. doi: 10.1016/j.redox.2013.01.001. eCollection 2013.


Differential activation of catalase expression and activity by PPAR agonists: implications for astrocyte protection in anti-glioma therapy.

Khoo NK, Hebbar S, Zhao W, Moore SA, Domann FE, Robbins ME.

Redox Biol. 2013 Jan 26;1:70-9. doi: 10.1016/j.redox.2012.12.006. eCollection 2013.


Human Melanoma cells over-express extracellular matrix 1 (ECM1) which is regulated by TFAP2C.

Lal G, Contreras PG, Kulak M, Woodfield G, Bair T, Domann FE, Weigel RJ.

PLoS One. 2013 Sep 2;8(9):e73953. doi: 10.1371/journal.pone.0073953. eCollection 2013.


Integrin α3β1 can function to promote spontaneous metastasis and lung colonization of invasive breast carcinoma.

Zhou B, Gibson-Corley KN, Herndon ME, Sun Y, Gustafson-Wagner E, Teoh-Fitzgerald M, Domann FE, Henry MD, Stipp CS.

Mol Cancer Res. 2014 Jan;12(1):143-154. doi: 10.1158/1541-7786.MCR-13-0184. Epub 2013 Sep 3.


NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells.

Sobhakumari A, Schickling BM, Love-Homan L, Raeburn A, Fletcher EV, Case AJ, Domann FE, Miller FJ Jr, Simons AL.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):736-45. doi: 10.1016/j.taap.2013.07.013. Epub 2013 Jul 31.


Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender.

Jacobus JA, Duda CG, Coleman MC, Martin SM, Mapuskar K, Mao G, Smith BJ, Aykin-Burns N, Guida P, Gius D, Domann FE, Knudson CM, Spitz DR.

Radiat Res. 2013 Aug;180(2):156-65. doi: 10.1667/RR3293.1. Epub 2013 Jul 2.


Regulation of CuZnSOD and its redox signaling potential: implications for amyotrophic lateral sclerosis.

Hitchler MJ, Domann FE.

Antioxid Redox Signal. 2014 Apr 1;20(10):1590-8. doi: 10.1089/ars.2013.5385. Epub 2013 Aug 1. Review.


Aberrant free radical biology is a unifying theme in the etiology and pathogenesis of major human diseases.

Domann FE.

Int J Mol Sci. 2013 Apr 17;14(4):8491-5. doi: 10.3390/ijms14048491.


Rational design of a secreted enzymatically inactive mutant of extracellular superoxide dismutase.

Case AJ, Mezhir JJ, O'Leary BR, Hrabe JE, Domann FE.

Redox Rep. 2012;17(6):239-45. doi: 10.1179/1351000212Y.0000000028.


Epigenetic reprogramming governs EcSOD expression during human mammary epithelial cell differentiation, tumorigenesis and metastasis.

Teoh-Fitzgerald ML, Fitzgerald MP, Zhong W, Askeland RW, Domann FE.

Oncogene. 2014 Jan 16;33(3):358-68. doi: 10.1038/onc.2012.582. Epub 2013 Jan 14.


Manganese superoxide dismutase depletion in murine hematopoietic stem cells perturbs iron homeostasis, globin switching, and epigenetic control in erythrocyte precursor cells.

Case AJ, Madsen JM, Motto DG, Meyerholz DK, Domann FE.

Free Radic Biol Med. 2013 Mar;56:17-27. doi: 10.1016/j.freeradbiomed.2012.11.018. Epub 2012 Dec 5.


Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation.

Duangmano S, Sae-Lim P, Suksamrarn A, Domann FE, Patmasiriwat P.

BMC Complement Altern Med. 2012 Oct 12;12:185. doi: 10.1186/1472-6882-12-185.


Redox regulation of the epigenetic landscape in cancer: a role for metabolic reprogramming in remodeling the epigenome.

Hitchler MJ, Domann FE.

Free Radic Biol Med. 2012 Dec 1;53(11):2178-87. doi: 10.1016/j.freeradbiomed.2012.09.028. Epub 2012 Sep 26. Review.


Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer.

Kulak MV, Cyr AR, Woodfield GW, Bogachek M, Spanheimer PM, Li T, Price DH, Domann FE, Weigel RJ.

Oncogene. 2013 Aug 22;32(34):4043-51. doi: 10.1038/onc.2012.400. Epub 2012 Sep 10.


Regulation of SOD2 in cancer by histone modifications and CpG methylation: closing the loop between redox biology and epigenetics.

Cyr AR, Hitchler MJ, Domann FE.

Antioxid Redox Signal. 2013 May 20;18(15):1946-55. doi: 10.1089/ars.2012.4850. Epub 2012 Oct 18. Review.


Manganese superoxide dismutase is dispensable for post-natal development and lactation in the murine mammary gland.

Case AJ, Domann FE.

Free Radic Res. 2012 Nov;46(11):1361-8. doi: 10.3109/10715762.2012.715370. Epub 2012 Sep 5.


Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest.

Duangmano S, Sae-Lim P, Suksamrarn A, Patmasiriwat P, Domann FE.

J Oncol. 2012;2012:601682. doi: 10.1155/2012/601682. Epub 2012 May 28. Erratum in: J Oncol. 2015;2015:486850.


Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis.

Teoh-Fitzgerald ML, Fitzgerald MP, Jensen TJ, Futscher BW, Domann FE.

Mol Cancer Res. 2012 Jan;10(1):40-51. doi: 10.1158/1541-7786.MCR-11-0501. Epub 2011 Nov 7.

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