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Items: 19

1.

Amphiphilic nebramine-based hybrids Rescue legacy antibiotics from intrinsic resistance in multidrug-resistant Gram-negative bacilli.

Yang X, Ammeter D, Idowu T, Domalaon R, Brizuela M, Okunnu O, Bi L, Guerrero YA, Zhanel GG, Kumar A, Schweizer F.

Eur J Med Chem. 2019 Aug 1;175:187-200. doi: 10.1016/j.ejmech.2019.05.003. Epub 2019 May 2.

PMID:
31078866
2.

Polybasic peptide-levofloxacin conjugates potentiate fluoroquinolones and other classes of antibiotics against multidrug-resistant Gram-negative bacteria.

Berry L, Domalaon R, Brizuela M, Zhanel GG, Schweizer F.

Medchemcomm. 2019 Mar 7;10(4):517-527. doi: 10.1039/c9md00051h. eCollection 2019 Apr 1.

PMID:
31057731
3.

Synergistic combinations of anthelmintic salicylanilides oxyclozanide, rafoxanide, and closantel with colistin eradicates multidrug-resistant colistin-resistant Gram-negative bacilli.

Domalaon R, Okunnu O, Zhanel GG, Schweizer F.

J Antibiot (Tokyo). 2019 Apr 26. doi: 10.1038/s41429-019-0186-8. [Epub ahead of print]

PMID:
31028351
4.

The Anthelmintic Drug Niclosamide Synergizes with Colistin and Reverses Colistin Resistance in Gram-Negative Bacilli.

Domalaon R, De Silva PM, Kumar A, Zhanel GG, Schweizer F.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02574-18. doi: 10.1128/AAC.02574-18. Print 2019 Apr.

PMID:
30917988
5.

Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli.

Zhanel GG, Golden AR, Zelenitsky S, Wiebe K, Lawrence CK, Adam HJ, Idowu T, Domalaon R, Schweizer F, Zhanel MA, Lagacé-Wiens PRS, Walkty AJ, Noreddin A, Lynch Iii JP, Karlowsky JA.

Drugs. 2019 Feb;79(3):271-289. doi: 10.1007/s40265-019-1055-2. Review.

PMID:
30712199
6.

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria.

Domalaon R, Brizuela M, Eisner B, Findlay B, Zhanel GG, Schweizer F.

Amino Acids. 2019 Mar;51(3):383-393. doi: 10.1007/s00726-018-2673-9. Epub 2018 Nov 3.

PMID:
30392097
7.

Development of dilipid polymyxins: Investigation on the effect of hydrophobicity through its fatty acyl component.

Domalaon R, Berry L, Tays Q, Zhanel GG, Schweizer F.

Bioorg Chem. 2018 Oct;80:639-648. doi: 10.1016/j.bioorg.2018.07.018. Epub 2018 Jul 19.

PMID:
30053708
8.

Tobramycin-Linked Efflux Pump Inhibitor Conjugates Synergize Fluoroquinolones, Rifampicin and Fosfomycin against Multidrug-Resistant Pseudomonas aeruginosa.

Yang X, Domalaon R, Lyu Y, Zhanel GG, Schweizer F.

J Clin Med. 2018 Jun 22;7(7). pii: E158. doi: 10.3390/jcm7070158.

9.

Absolute Quantitation of Glycoforms of Two Human IgG Subclasses Using Synthetic Fc Peptides and Glycopeptides.

Roy R, Ang E, Komatsu E, Domalaon R, Bosseboeuf A, Harb J, Hermouet S, Krokhin O, Schweizer F, Perreault H.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1086-1098. doi: 10.1007/s13361-018-1900-7. Epub 2018 May 23.

PMID:
29796736
10.

Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?

Domalaon R, Idowu T, Zhanel GG, Schweizer F.

Clin Microbiol Rev. 2018 Mar 14;31(2). pii: e00077-17. doi: 10.1128/CMR.00077-17. Print 2018 Apr. Review.

11.

Short Proline-Rich Lipopeptide Potentiates Minocycline and Rifampin against Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa.

Domalaon R, Sanchak Y, Koskei LC, Lyu Y, Zhanel GG, Arthur G, Schweizer F.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02374-17. doi: 10.1128/AAC.02374-17. Print 2018 Apr.

12.

Amphiphilic lysine conjugated to tobramycin synergizes legacy antibiotics against wild-type and multidrug-resistant Pseudomonas aeruginosa.

Lyu Y, Domalaon R, Yang X, Schweizer F.

Biopolymers. 2017 Dec 4. doi: 10.1002/bip.23091. [Epub ahead of print]

PMID:
29205266
13.

Polymyxin B3-Tobramycin Hybrids with Pseudomonas aeruginosa-Selective Antibacterial Activity and Strong Potentiation of Rifampicin, Minocycline, and Vancomycin.

Domalaon R, Yang X, Lyu Y, Zhanel GG, Schweizer F.

ACS Infect Dis. 2017 Dec 8;3(12):941-954. doi: 10.1021/acsinfecdis.7b00145. Epub 2017 Oct 27.

PMID:
29045123
14.

Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline.

Lyu Y, Yang X, Goswami S, Gorityala BK, Idowu T, Domalaon R, Zhanel GG, Shan A, Schweizer F.

J Med Chem. 2017 May 11;60(9):3684-3702. doi: 10.1021/acs.jmedchem.6b01742. Epub 2017 Apr 24.

PMID:
28409644
15.

A Tobramycin Vector Enhances Synergy and Efficacy of Efflux Pump Inhibitors against Multidrug-Resistant Gram-Negative Bacteria.

Yang X, Goswami S, Gorityala BK, Domalaon R, Lyu Y, Kumar A, Zhanel GG, Schweizer F.

J Med Chem. 2017 May 11;60(9):3913-3932. doi: 10.1021/acs.jmedchem.7b00156. Epub 2017 Apr 24.

PMID:
28399372
16.

Multiplexed azido-group isotopic capture (MAGIC) beads: Selective analysis of azido compounds using a propargyl-based cleavable linker, a proof of concept.

McLellan M, Doyle MGJ, Bodnar ED, Lopez PG, Domalaon R, Roy R, Cordova K, Schweizer F, Perreault H.

Rapid Commun Mass Spectrom. 2016 Dec 15;30(23):2497-2507. doi: 10.1002/rcm.7744.

PMID:
27650360
17.

Ultrashort cationic lipopeptides and lipopeptoids: Evaluation and mechanistic insights against epithelial cancer cells.

Domalaon R, Findlay B, Ogunsina M, Arthur G, Schweizer F.

Peptides. 2016 Oct;84:58-67. doi: 10.1016/j.peptides.2016.07.007. Epub 2016 Jul 30.

PMID:
27486068
18.

Short Antimicrobial Peptides and Peptide Scaffolds as Promising Antibacterial Agents.

Domalaon R, Zhanel GG, Schweizer F.

Curr Top Med Chem. 2016;16(11):1217-30. Review.

PMID:
26369812
19.

Structure-activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity.

Domalaon R, Yang X, O'Neil J, Zhanel GG, Mookherjee N, Schweizer F.

Amino Acids. 2014 Nov;46(11):2517-30. doi: 10.1007/s00726-014-1806-z. Epub 2014 Jul 29.

PMID:
25069750

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