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Items: 43

1.

Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulators.

Galambos J, Bielik A, Wágner G, Domány G, Kóti J, Béni Z, Szigetvári Á, Sánta Z, Orgován Z, Bobok A, Kiss B, Mikó-Bakk ML, Vastag M, Sághy K, Krasavin M, Gál K, Greiner I, Szombathelyi Z, Keserű GM.

Eur J Med Chem. 2017 Jun 16;133:240-254. doi: 10.1016/j.ejmech.2017.03.071. Epub 2017 Mar 29.

PMID:
28390229
2.

Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications.

Galambos J, Bielik A, Krasavin M, Orgován Z, Domány G, Nógrádi K, Wágner G, Balogh GT, Béni Z, Kóti J, Szakács Z, Bobok A, Kolok S, Mikó-Bakk ML, Vastag M, Sághy K, Laszy J, Halász AS, Balázs O, Gál K, Greiner I, Szombathelyi Z, Keserű GM.

J Med Chem. 2017 Mar 23;60(6):2470-2484. doi: 10.1021/acs.jmedchem.6b01858. Epub 2017 Mar 1.

PMID:
28212015
3.

4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate.

Galambos J, Domány G, Nógrádi K, Wágner G, Keserű GM, Bobok A, Kolok S, Mikó-Bakk ML, Vastag M, Sághy K, Kóti J, Szakács Z, Béni Z, Gál K, Szombathelyi Z, Greiner I.

Bioorg Med Chem Lett. 2016 Feb 15;26(4):1249-52. doi: 10.1016/j.bmcl.2016.01.024. Epub 2016 Jan 11.

PMID:
26774652
4.

The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands.

Éliás O, Nógrádi K, Domány G, Szakács Z, Kóti J, Szántay C Jr, Tarcsay Á, Keserű GM, Gere A, Kiss B, Kurkó D, Kolok S, Némethy Z, Kapui Z, Hellinger É, Vastag M, Sághy K, Kedves R, Gyertyán I.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):914-920. doi: 10.1016/j.bmcl.2015.12.071. Epub 2015 Dec 21.

PMID:
26748694
5.

Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization.

Nógrádi K, Wágner G, Domány G, Bobok A, Magdó I, Kolok S, Mikó-Bakk ML, Vastag M, Sághy K, Gyertyán I, Kóti J, Gál K, Farkas S, Keserű GM, Greiner I, Szombathelyi Z.

Bioorg Med Chem Lett. 2015 Apr 15;25(8):1724-1729. doi: 10.1016/j.bmcl.2015.02.073. Epub 2015 Mar 7.

PMID:
25791451
6.

Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: hit-to-lead optimization.

Nógrádi K, Wágner G, Domány G, Bobok A, Magdó I, Kiss B, Kolok S, Fónagy K, Gyertyán I, Háda V, Kóti J, Gál K, Farkas S, Keserű GM, Greiner I, Szombathelyi Z.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3845-9. doi: 10.1016/j.bmcl.2014.06.057. Epub 2014 Jun 27.

PMID:
25017030
7.

Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors.

Eliás O, Agai-Csongor E, Domány G, Keserű GM, Gere A, Kiss B, Hellinger E, Vastag M, Gyertyán I.

Bioorg Med Chem Lett. 2014 May 1;24(9):2118-22. doi: 10.1016/j.bmcl.2014.03.043. Epub 2014 Mar 24.

PMID:
24717153
8.

Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.

Agai-Csongor E, Domány G, Nógrádi K, Galambos J, Vágó I, Keserű GM, Greiner I, Laszlovszky I, Gere A, Schmidt E, Kiss B, Vastag M, Tihanyi K, Sághy K, Laszy J, Gyertyán I, Zájer-Balázs M, Gémesi L, Kapás M, Szombathelyi Z.

Bioorg Med Chem Lett. 2012 May 15;22(10):3437-40. doi: 10.1016/j.bmcl.2012.03.104. Epub 2012 Apr 4.

PMID:
22537450
9.

Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists.

Eles J, Beke G, Vágó I, Bozó E, Huszár J, Tarcsay A, Kolok S, Schmidt E, Vastag M, Hornok K, Farkas S, Domány G, Keserű GM.

Bioorg Med Chem Lett. 2012 May 1;22(9):3095-9. doi: 10.1016/j.bmcl.2012.03.065. Epub 2012 Mar 21.

PMID:
22483585
10.

Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents.

Gyertyán I, Kiss B, Sághy K, Laszy J, Szabó G, Szabados T, Gémesi LI, Pásztor G, Zájer-Balázs M, Kapás M, Csongor EÁ, Domány G, Tihanyi K, Szombathelyi Z.

Neurochem Int. 2011 Nov;59(6):925-35. doi: 10.1016/j.neuint.2011.07.002. Epub 2011 Jul 13.

PMID:
21767587
11.

Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists.

Galambos J, Wágner G, Nógrádi K, Bielik A, Molnár L, Bobok A, Horváth A, Kiss B, Kolok S, Nagy J, Kurkó D, Bakk ML, Vastag M, Sághy K, Gyertyán I, Gál K, Greiner I, Szombathelyi Z, Keseru GM, Domány G.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4371-5. doi: 10.1016/j.bmcl.2010.06.075. Epub 2010 Jun 17.

PMID:
20615697
12.

Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs.

Wágner G, Wéber C, Nyéki O, Nógrádi K, Bielik A, Molnár L, Bobok A, Horváth A, Kiss B, Kolok S, Nagy J, Kurkó D, Gál K, Greiner I, Szombathelyi Z, Keseru GM, Domány G.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3737-41. doi: 10.1016/j.bmcl.2010.04.075. Epub 2010 Apr 22. Erratum in: Bioorg Med Chem Lett. 2011 Jun 15;21(12):3837-8.

PMID:
20483612
13.

Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile.

Kiss B, Horváth A, Némethy Z, Schmidt E, Laszlovszky I, Bugovics G, Fazekas K, Hornok K, Orosz S, Gyertyán I, Agai-Csongor E, Domány G, Tihanyi K, Adham N, Szombathelyi Z.

J Pharmacol Exp Ther. 2010 Apr;333(1):328-40. doi: 10.1124/jpet.109.160432. Epub 2010 Jan 21.

PMID:
20093397
14.

Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15.

Kiss B, Laszlovszky I, Horváth A, Némethy Z, Schmidt E, Bugovics G, Fazekas K, Gyertyán I, Agai-Csongor E, Domány G, Szombathelyi Z.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Nov;378(5):515-28. doi: 10.1007/s00210-008-0308-5. Epub 2008 Jun 13.

PMID:
18551280
15.

Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: II. behavioural characterisation of RG-15.

Gyertyán I, Sághy K, Laszy J, Elekes O, Kedves R, Gémesi LI, Pásztor G, Zájer-Balázs M, Kapás M, Agai Csongor E, Domány G, Kiss B, Szombathelyi Z.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Nov;378(5):529-39. doi: 10.1007/s00210-008-0311-x. Epub 2008 Jun 12.

PMID:
18548231
16.

Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile.

Agai-Csongor E, Nógrádi K, Galambos J, Vágó I, Bielik A, Magdó I, Ignácz-Szendrei G, Keseru GM, Greiner I, Laszlovszky I, Schmidt E, Kiss B, Sághy K, Laszy J, Gyertyán I, Zájer-Balázs M, Gémesi L, Domány G.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5340-4. Epub 2007 Aug 15.

PMID:
17720494
17.

Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides.

Borza I, Bozó E, Barta-Szalai G, Kiss C, Tárkányi G, Demeter A, Gáti T, Háda V, Kolok S, Gere A, Fodor L, Nagy J, Galgóczy K, Magdó I, Agai B, Fetter J, Bertha F, Keserü GM, Horváth C, Farkas S, Greiner I, Domány G.

J Med Chem. 2007 Mar 8;50(5):901-14. Epub 2007 Feb 10.

PMID:
17290978
18.

Effects of RGH-237 [N-{4-[4-(3-aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an orally active, selective dopamine D(3) receptor partial agonist in animal models of cocaine abuse.

Gyertyán I, Kiss B, Gál K, Laszlovszky I, Horváth A, Gémesi LI, Sághy K, Pásztor G, Zájer M, Kapás M, Csongor EA, Domány G, Tihanyi K, Szombathelyi Z.

J Pharmacol Exp Ther. 2007 Mar;320(3):1268-78. Epub 2006 Dec 14.

PMID:
17170312
19.

Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists.

Borza I, Kolok S, Galgóczy K, Gere A, Horváth C, Farkas S, Greiner I, Domány G.

Bioorg Med Chem Lett. 2007 Jan 15;17(2):406-9. Epub 2006 Oct 17.

PMID:
17074483
20.

New benzoyl urea derivatives as novel NR2B selective NMDA receptor antagonists.

Borza I, Greiner I, Kolok S, Galgóczy K, Ignácz-Szendrei G, Horváth C, Farkas S, Gáti T, Háda V, Domány G.

Pharmazie. 2006 Sep;61(9):799-800.

PMID:
17020160
21.

Influence of the type of management system on corticosterone transfer into eggs in laying hens.

Sas B, Domány G, Gyimóthy I, Gaál Kovácsné K, Süth M.

Acta Vet Hung. 2006 Sep;54(3):343-52.

PMID:
17020138
22.

Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists.

Borza I, Kolok S, Gere A, Nagy J, Fodor L, Galgóczy K, Fetter J, Bertha F, Agai B, Horváth C, Farkas S, Domány G.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4638-40. Epub 2006 Jun 16.

PMID:
16782335
23.

NR2B selective NMDA antagonists: the evolution of the ifenprodil-type pharmacophore.

Borza I, Domány G.

Curr Top Med Chem. 2006;6(7):687-95. Review.

PMID:
16719809
24.

Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists.

Borza I, Kolok S, Ignácz-Szendrei G, Greiner I, Tárkányi G, Galgóczy K, Horváth C, Farkas S, Domány G.

Bioorg Med Chem Lett. 2005 Dec 15;15(24):5439-41. Epub 2005 Oct 5.

PMID:
16213709
25.

Oxamides as novel NR2B selective NMDA receptor antagonists.

Barta-Szalai G, Borza I, Bozó E, Kiss C, Agai B, Proszenyák A, Keseru GM, Gere A, Kolok S, Galgóczy K, Horváth C, Farkas S, Domány G.

Bioorg Med Chem Lett. 2004 Aug 2;14(15):3953-6.

PMID:
15225705
26.

Synthesis and studies of 1,2-dihydroquinoline derivatives as inhibitors of lipid peroxidation.

Barta-Szalai G, Gere A, Takács-Novák K, Domány G.

Arzneimittelforschung. 2003;53(10):722-9.

PMID:
14650365
27.

Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists.

Borza I, Kolok S, Gere A, Agai-Csongor E, Agai B, Tárkányi G, Horváth C, Barta-Szalai G, Bozó E, Kiss C, Bielik A, Nagy J, Farkas S, Domány G.

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3859-61.

PMID:
14552795
28.

Substituted phenoxyalkylpiperazines as dopamine D3 receptor ligands.

Laszlovszky I, Acs T, Kiss B, Domány G.

Pharmazie. 2001 Apr;56(4):287-9.

PMID:
11338664
29.

Estimation of impurity profiles of drugs and related materials Part 15. Identification of minor impurities in cimetidine.

Halmos Z, Szántay C Jr, Brlik J, Csehi A, Varga K, Horváth P, Kislaki M, Domány G, Nemes A, Görög S.

J Pharm Biomed Anal. 1996 Oct;15(1):1-5.

PMID:
8895070
30.

Analogues of sabeluzole with gastric acid secretion inhibitory effect.

Domány G, Barta-Szalai G, Matúz J, Ezer E, Schön I.

Pharmazie. 1996 Jun;51(6):427-8. No abstract available.

PMID:
8767854
31.

4-(1-Naphthylamino)-piperidines as inhibitors of lipid peroxidation.

Domány G, Barta-Szalai G, Gere A, Farsang G, Schön I.

Arzneimittelforschung. 1996 Jun;46(6):553-6.

PMID:
8767342
32.

Inhibitors of lipid peroxidation among new pyrimido[1',6':1,2]pyrido[3,4-b]indoles.

Domány G, Gere A, Paróczai M, Szántay C Jr, Ferenczy GG, Schön I, Kiss B, Kárpáti E.

Pharmazie. 1994 Nov;49(11):807-10.

PMID:
7838865
33.

New 4-arylaminopiperidines with antihypoxic and anticonvulsive activity.

Domány G, Barta-Szalai G, Pálosi E, Szabó S, Schön I.

Arzneimittelforschung. 1994 Sep;44(9):989-91.

PMID:
7986252
34.

Novel pyrimido[6,1-a]isoquinolines with antioxidant and hepatoprotective activity.

Domány G, Gere A, Paróczai M, Szántay C Jr, Schön J.

Pharmazie. 1993 Dec;48(12):941-2. No abstract available.

PMID:
8115439
35.

[INTRAVENOUS APPLICATION OF GLANDUITRIN IN THE EXPULSION STAGE OF LABOR].

DOMANY G, GATI I, NAGY D, DOMANY S.

Magy Noorv Lapja. 1964 Jan;27:24-8. Hungarian. No abstract available.

PMID:
14128084
36.

[Importance of extensive liquid intake in prevention of thromboembolism according to coagulation tests].

GATI I, KISS D, DOMANY G, HUSVET F, HALVAX L.

Magy Noorv Lapja. 1955 May;18(3):167-70. Hungarian. No abstract available.

PMID:
13243867
37.

[Vaginal smears in cytologic research in determination of menstrual cycle and amenorrhea].

SZABO E, GORCS J, DOMANY G.

Magy Noorv Lapja. 1955 Mar;18(2):111-7. Hungarian. No abstract available.

PMID:
14382751
38.

[Shock in total vaginal extirpation, with special reference to the prevention of thromboembolism].

PALI K, LAJOS L, BACSA A, DOMANY G, ZOLTAN V.

Magy Noorv Lapja. 1953 Sep-Oct;16(9-10):282-7. Undetermined Language. No abstract available.

PMID:
13153364
39.

[Facilitation of forceps delivery by intravenous injection of posterior pituitary hormone].

LAJOS L, BACSO K, DOMANY G.

Gynaecologia. 1953 Aug;136(2):93-100. Undetermined Language. No abstract available.

PMID:
13095840
40.

[Blood coagulation in relation to the pathogenesis of the late pregnancy toxemias].

GATI I, KISS D, DOMANY G.

Magy Noorv Lapja. 1953 May-Jun;16(5-6):160-3. Undetermined Language. No abstract available.

PMID:
13098346
41.

[Essential hypertension in pregnancy in relation to mother and child].

DOMANY G, GATI I, ZOLTAN V.

Magy Noorv Lapja. 1953 May-Jun;16(5-6):157-60. Undetermined Language. No abstract available.

PMID:
13098345
42.

[Intravenous injection of gladuitrin for facilitation of forceps delivery].

LAJOS L, BACSO K, DOMANY G.

Magy Noorv Lapja. 1952 Jul;15(7):200-4. Undetermined Language. No abstract available.

PMID:
12991903
43.

[Experience gained through 800 titrations of gonadotropins].

PALI K, KUMMERLANDER L, DOMANY G.

Zentralbl Gynakol. 1951;73(14):1231-5. Undetermined Language. No abstract available.

PMID:
14867683

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