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Items: 1 to 50 of 192

1.

Disruption of the Key Ca2+ Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel Trafficking.

Meyer JO, Dahimene S, Page KM, Ferron L, Kadurin I, Ellaway JIJ, Zhao P, Patel T, Rothwell SW, Lin P, Pratt WS, Dolphin AC.

Cell Rep. 2019 Oct 1;29(1):22-33.e5. doi: 10.1016/j.celrep.2019.08.079.

2.

Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal.

Harrison PJ, Tunbridge EM, Dolphin AC, Hall J.

Br J Psychiatry. 2019 Jun 24:1-4. doi: 10.1192/bjp.2019.157. [Epub ahead of print]

PMID:
31230606
3.

Voltage-gated calcium channel α 2δ subunits: an assessment of proposed novel roles.

Dolphin AC.

F1000Res. 2018 Nov 21;7. pii: F1000 Faculty Rev-1830. doi: 10.12688/f1000research.16104.1. eCollection 2018. Review.

4.

Ablation of α2δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo.

Nieto-Rostro M, Ramgoolam K, Pratt WS, Kulik A, Dolphin AC.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12043-E12052. doi: 10.1073/pnas.1811212115. Epub 2018 Nov 28.

5.

The α2δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α2δ-1.

Dahimene S, Page KM, Kadurin I, Ferron L, Ho DY, Powell GT, Pratt WS, Wilson SW, Dolphin AC.

Cell Rep. 2018 Nov 6;25(6):1610-1621.e5. doi: 10.1016/j.celrep.2018.10.033.

6.

Voltage-gated calcium channels: their discovery, function and importance as drug targets.

Dolphin AC.

Brain Neurosci Adv. 2018 Oct 2;2. pii: 2398212818794805. doi: 10.1177/2398212818794805.

7.

Proteolytic maturation of α2δ controls the probability of synaptic vesicular release.

Ferron L, Kadurin I, Dolphin AC.

Elife. 2018 Jun 19;7. pii: e37507. doi: 10.7554/eLife.37507.

8.

Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene-targeted mice.

Kanellopoulos AH, Koenig J, Huang H, Pyrski M, Millet Q, Lolignier S, Morohashi T, Gossage SJ, Jay M, Linley JE, Baskozos G, Kessler BM, Cox JJ, Dolphin AC, Zufall F, Wood JN, Zhao J.

EMBO J. 2018 Feb 1;37(3):427-445. doi: 10.15252/embj.201796692. Epub 2018 Jan 15.

9.

Calmodulin regulates Cav3 T-type channels at their gating brake.

Chemin J, Taiakina V, Monteil A, Piazza M, Guan W, Stephens RF, Kitmitto A, Pang ZP, Dolphin AC, Perez-Reyes E, Dieckmann T, Guillemette JG, Spafford JD.

J Biol Chem. 2017 Dec 8;292(49):20010-20031. doi: 10.1074/jbc.M117.807925. Epub 2017 Sep 25.

10.

LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit.

Kadurin I, Rothwell SW, Lana B, Nieto-Rostro M, Dolphin AC.

Sci Rep. 2017 Mar 3;7:43802. doi: 10.1038/srep43802.

11.

T-type Ca2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling.

Kisiswa L, Erice C, Ferron L, Wyatt S, Osório C, Dolphin AC, Davies AM.

Open Biol. 2017 Jan;7(1). pii: 160288. doi: 10.1098/rsob.160288.

12.

Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels.

Kadurin I, Ferron L, Rothwell SW, Meyer JO, Douglas LR, Bauer CS, Lana B, Margas W, Alexopoulos O, Nieto-Rostro M, Pratt WS, Dolphin AC.

Elife. 2016 Oct 26;5. pii: e21143. doi: 10.7554/eLife.21143.

13.

The CaVβ Subunit Protects the I-II Loop of the Voltage-gated Calcium Channel CaV2.2 from Proteasomal Degradation but Not Oligoubiquitination.

Page KM, Rothwell SW, Dolphin AC.

J Biol Chem. 2016 Sep 23;291(39):20402-16. doi: 10.1074/jbc.M116.737270. Epub 2016 Aug 3.

14.

Effect of knockout of α2δ-1 on action potentials in mouse sensory neurons.

Margas W, Ferron L, Nieto-Rostro M, Schwartz A, Dolphin AC.

Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5;371(1700). pii: 20150430. doi: 10.1098/rstb.2015.0430.

15.

Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology.

Dolphin AC.

J Physiol. 2016 Oct 1;594(19):5369-90. doi: 10.1113/JP272262. Epub 2016 Jul 5. Review.

16.

A CaV2.1 N-terminal fragment relieves the dominant-negative inhibition by an Episodic ataxia 2 mutant.

Dahimene S, Page KM, Nieto-Rostro M, Pratt WS, D'Arco M, Dolphin AC.

Neurobiol Dis. 2016 Sep;93:243-56. doi: 10.1016/j.nbd.2016.05.020. Epub 2016 May 31.

17.
18.

Alternative Splicing in Ca(V)2.2 Regulates Neuronal Trafficking via Adaptor Protein Complex-1 Adaptor Protein Motifs.

Macabuag N, Dolphin AC.

J Neurosci. 2015 Oct 28;35(43):14636-52. doi: 10.1523/JNEUROSCI.3034-15.2015.

19.

Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders.

Heyes S, Pratt WS, Rees E, Dahimene S, Ferron L, Owen MJ, Dolphin AC.

Prog Neurobiol. 2015 Nov;134:36-54. doi: 10.1016/j.pneurobio.2015.09.002. Epub 2015 Sep 16. Review.

20.

The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential.

Zamponi GW, Striessnig J, Koschak A, Dolphin AC.

Pharmacol Rev. 2015 Oct;67(4):821-70. doi: 10.1124/pr.114.009654. Review.

21.

The upregulation of α2δ-1 subunit modulates activity-dependent Ca2+ signals in sensory neurons.

D'Arco M, Margas W, Cassidy JS, Dolphin AC.

J Neurosci. 2015 Apr 15;35(15):5891-903. doi: 10.1523/JNEUROSCI.3997-14.2015.

22.

Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunits.

Cassidy JS, Ferron L, Kadurin I, Pratt WS, Dolphin AC.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8979-84. doi: 10.1073/pnas.1403731111. Epub 2014 Jun 2.

23.

Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density.

Ferron L, Nieto-Rostro M, Cassidy JS, Dolphin AC.

Nat Commun. 2014 Apr 7;5:3628. doi: 10.1038/ncomms4628.

24.

Altered expression of the voltage-gated calcium channel subunit α₂δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain.

Nieto-Rostro M, Sandhu G, Bauer CS, Jiruska P, Jefferys JG, Dolphin AC.

Neuroscience. 2014 Dec 26;283:124-37. doi: 10.1016/j.neuroscience.2014.03.013. Epub 2014 Mar 15.

25.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

26.

The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α2δ for GPI-anchoring pathways.

Alvarez-Laviada A, Kadurin I, Senatore A, Chiesa R, Dolphin AC.

Biochem J. 2014 Mar 1;458(2):365-74. doi: 10.1042/BJ20131405.

27.

Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury.

Lana B, Schlick B, Martin S, Pratt WS, Page KM, Goncalves L, Rahman W, Dickenson AH, Bauer CS, Dolphin AC.

Pain. 2014 Mar;155(3):522-33. doi: 10.1016/j.pain.2013.12.001. Epub 2013 Dec 6.

28.

α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage.

Patel R, Bauer CS, Nieto-Rostro M, Margas W, Ferron L, Chaggar K, Crews K, Ramirez JD, Bennett DL, Schwartz A, Dickenson AH, Dolphin AC.

J Neurosci. 2013 Oct 16;33(42):16412-26. doi: 10.1523/JNEUROSCI.1026-13.2013.

29.

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.

Azizan EA, Poulsen H, Tuluc P, Zhou J, Clausen MV, Lieb A, Maniero C, Garg S, Bochukova EG, Zhao W, Shaikh LH, Brighton CA, Teo AE, Davenport AP, Dekkers T, Tops B, Küsters B, Ceral J, Yeo GS, Neogi SG, McFarlane I, Rosenfeld N, Marass F, Hadfield J, Margas W, Chaggar K, Solar M, Deinum J, Dolphin AC, Farooqi IS, Striessnig J, Nissen P, Brown MJ.

Nat Genet. 2013 Sep;45(9):1055-60. doi: 10.1038/ng.2716. Epub 2013 Aug 4.

PMID:
23913004
30.

The α2δ subunits of voltage-gated calcium channels.

Dolphin AC.

Biochim Biophys Acta. 2013 Jul;1828(7):1541-9. doi: 10.1016/j.bbamem.2012.11.019. Epub 2012 Nov 27. Review.

31.

L-type calcium channels: on the fast track to nuclear signaling.

D'Arco M, Dolphin AC.

Sci Signal. 2012 Aug 14;5(237):pe34. doi: 10.1126/scisignal.2003355.

PMID:
22894834
32.

Calcium currents are enhanced by α2δ-1 lacking its membrane anchor.

Kadurin I, Alvarez-Laviada A, Ng SF, Walker-Gray R, D'Arco M, Fadel MG, Pratt WS, Dolphin AC.

J Biol Chem. 2012 Sep 28;287(40):33554-66. Epub 2012 Aug 6.

33.

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond.

Dolphin AC.

Nat Rev Neurosci. 2012 Jul 18;13(8):542-55. doi: 10.1038/nrn3311. Review.

PMID:
22805911
34.

Calcium channel α2δ subunits in epilepsy and as targets for antiepileptic drugs.

Dolphin AC.

In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

35.

α2δ expression sets presynaptic calcium channel abundance and release probability.

Hoppa MB, Lana B, Margas W, Dolphin AC, Ryan TA.

Nature. 2012 May 13;486(7401):122-5. doi: 10.1038/nature11033.

36.

Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture.

Hendrich J, Bauer CS, Dolphin AC.

Channels (Austin). 2012 Mar-Apr;6(2):124-32. doi: 10.4161/chan.19805. Epub 2012 Mar 1.

37.

Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit.

Senatore A, Colleoni S, Verderio C, Restelli E, Morini R, Condliffe SB, Bertani I, Mantovani S, Canovi M, Micotti E, Forloni G, Dolphin AC, Matteoli M, Gobbi M, Chiesa R.

Neuron. 2012 Apr 26;74(2):300-13. doi: 10.1016/j.neuron.2012.02.027.

38.

Stargazin-related protein γ₇ is associated with signalling endosomes in superior cervical ganglion neurons and modulates neurite outgrowth.

Waithe D, Ferron L, Dolphin AC.

J Cell Sci. 2011 Jun 15;124(Pt 12):2049-57. doi: 10.1242/jcs.084988. Epub 2011 May 24.

39.

Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology.

Bannister K, Sikandar S, Bauer CS, Dolphin AC, Porreca F, Dickenson AH.

Anesthesiology. 2011 Jul;115(1):144-52. doi: 10.1097/ALN.0b013e31821f6545.

40.

Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses.

Huang Z, Lujan R, Kadurin I, Uebele VN, Renger JJ, Dolphin AC, Shah MM.

Nat Neurosci. 2011 Apr;14(4):478-86. doi: 10.1038/nn.2757. Epub 2011 Feb 27.

41.

Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation.

Waithe D, Ferron L, Page KM, Chaggar K, Dolphin AC.

J Biol Chem. 2011 Mar 18;286(11):9598-611. doi: 10.1074/jbc.M110.195909. Epub 2011 Jan 13.

42.

The alpha2delta ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit alpha2delta-2.

Tran-Van-Minh A, Dolphin AC.

J Neurosci. 2010 Sep 22;30(38):12856-67. doi: 10.1523/JNEUROSCI.2700-10.2010.

43.

Age of quantitative proteomics hits voltage-gated calcium channels.

Dolphin AC.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):14941-2. doi: 10.1073/pnas.1009102107. Epub 2010 Aug 12. No abstract available.

44.

A new look at calcium channel α2δ subunits.

Bauer CS, Tran-Van-Minh A, Kadurin I, Dolphin AC.

Curr Opin Neurobiol. 2010 Oct;20(5):563-71. doi: 10.1016/j.conb.2010.05.007. Epub 2010 Jun 25. Review.

PMID:
20579869
45.

The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo.

Bauer CS, Rahman W, Tran-van-Minh A, Lujan R, Dickenson AH, Dolphin AC.

Biochem Soc Trans. 2010 Apr;38(2):525-8. doi: 10.1042/BST0380525. Review.

PMID:
20298215
46.

The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function.

Davies A, Kadurin I, Alvarez-Laviada A, Douglas L, Nieto-Rostro M, Bauer CS, Pratt WS, Dolphin AC.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1654-9. doi: 10.1073/pnas.0908735107. Epub 2010 Jan 4.

47.

N terminus is key to the dominant negative suppression of Ca(V)2 calcium channels: implications for episodic ataxia type 2.

Page KM, Heblich F, Margas W, Pratt WS, Nieto-Rostro M, Chaggar K, Sandhu K, Davies A, Dolphin AC.

J Biol Chem. 2010 Jan 8;285(2):835-44. doi: 10.1074/jbc.M109.065045. Epub 2009 Nov 10.

48.

Labelling of the 3D structure of the cardiac L-type voltage-gated calcium channel.

Walsh CP, Davies A, Nieto-Rostro M, Dolphin AC, Kitmitto A.

Channels (Austin). 2009 Nov;3(6):387-92.

PMID:
19875947
49.

Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain.

Rahman W, Bauer CS, Bannister K, Vonsy JL, Dolphin AC, Dickenson AH.

Mol Pain. 2009 Aug 7;5:45. doi: 10.1186/1744-8069-5-45.

50.

Calcium channel diversity: multiple roles of calcium channel subunits.

Dolphin AC.

Curr Opin Neurobiol. 2009 Jun;19(3):237-44. doi: 10.1016/j.conb.2009.06.006. Epub 2009 Jun 24. Review.

PMID:
19559597

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