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Items: 44


Erratum: Investigating the Therapeutic Mechanism of Cannabidiol in a Human Induced Pluripotent Stem Cell (iPSC)-Based Model of Dravet Syndrome.

Sun Y, Dolmetsch RE.

Cold Spring Harb Symp Quant Biol. 2019 Aug 1. pii: 038919. doi: 10.1101/sqb.2018.83.038919. [Epub ahead of print] No abstract available.


Investigating the Therapeutic Mechanism of Cannabidiol in a Human Induced Pluripotent Stem Cell (iPSC)-Based Model of Dravet Syndrome.

Sun Y, Dolmetsch RE.

Cold Spring Harb Symp Quant Biol. 2018;83:185-191. doi: 10.1101/sqb.2018.83.038174. Epub 2019 Jun 11. Erratum in: Cold Spring Harb Symp Quant Biol. 2019 Aug 1;:.


A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients.

Sun Y, Paşca SP, Portmann T, Goold C, Worringer KA, Guan W, Chan KC, Gai H, Vogt D, Chen YJ, Mao R, Chan K, Rubenstein JL, Madison DV, Hallmayer J, Froehlich-Santino WM, Bernstein JA, Dolmetsch RE.

Elife. 2016 Jul 26;5. pii: e13073. doi: 10.7554/eLife.13073.


CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency.

Bidinosti M, Botta P, Krüttner S, Proenca CC, Stoehr N, Bernhard M, Fruh I, Mueller M, Bonenfant D, Voshol H, Carbone W, Neal SJ, McTighe SM, Roma G, Dolmetsch RE, Porter JA, Caroni P, Bouwmeester T, Lüthi A, Galimberti I.

Science. 2016 Mar 11;351(6278):1199-203. doi: 10.1126/science.aad5487. Epub 2016 Feb 4.


How induced pluripotent stem cells are informing drug discovery in psychiatry.

Sun Y, Dolmetsch RE.

Swiss Med Wkly. 2016 Jan 11;146:w14241. doi: 10.4414/smw.2016.14241. eCollection 2016. Review.


PIKfyve mediates the motility of late endosomes and lysosomes in neuronal dendrites.

Tsuruta F, Dolmetsch RE.

Neurosci Lett. 2015 Sep 25;605:18-23. doi: 10.1016/j.neulet.2015.07.021. Epub 2015 Jul 29.


Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels.

Rana A, Yen M, Sadaghiani AM, Malmersjö S, Park CY, Dolmetsch RE, Lewis RS.

J Cell Biol. 2015 Jun 8;209(5):653-69. doi: 10.1083/jcb.201412060. Epub 2015 Jun 1.


16p11.2 Deletion Syndrome Mice Display Sensory and Ultrasonic Vocalization Deficits During Social Interactions.

Yang M, Mahrt EJ, Lewis F, Foley G, Portmann T, Dolmetsch RE, Portfors CV, Crawley JN.

Autism Res. 2015 Oct;8(5):507-21. doi: 10.1002/aur.1465. Epub 2015 Feb 7.


Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome.

Tian Y, Voineagu I, Paşca SP, Won H, Chandran V, Horvath S, Dolmetsch RE, Geschwind DH.

Genome Med. 2014 Oct 10;6(10):75. doi: 10.1186/s13073-014-0075-5. eCollection 2014.


Identification of Orai1 channel inhibitors by using minimal functional domains to screen small molecule microarrays.

Sadaghiani AM, Lee SM, Odegaard JI, Leveson-Gower DB, McPherson OM, Novick P, Kim MR, Koehler AN, Negrin R, Dolmetsch RE, Park CY.

Chem Biol. 2014 Oct 23;21(10):1278-1292. doi: 10.1016/j.chembiol.2014.08.016. Epub 2014 Oct 9.


Generating human neurons in vitro and using them to understand neuropsychiatric disease.

Paşca SP, Panagiotakos G, Dolmetsch RE.

Annu Rev Neurosci. 2014;37:479-501. doi: 10.1146/annurev-neuro-062012-170328. Epub 2014 Jun 23. Review.


Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome.

Portmann T, Yang M, Mao R, Panagiotakos G, Ellegood J, Dolen G, Bader PL, Grueter BA, Goold C, Fisher E, Clifford K, Rengarajan P, Kalikhman D, Loureiro D, Saw NL, Zhengqui Z, Miller MA, Lerch JP, Henkelman M, Shamloo M, Malenka RC, Crawley JN, Dolmetsch RE.

Cell Rep. 2014 May 22;7(4):1077-1092. doi: 10.1016/j.celrep.2014.03.036. Epub 2014 May 1.


SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.

Shcheglovitov A, Shcheglovitova O, Yazawa M, Portmann T, Shu R, Sebastiano V, Krawisz A, Froehlich W, Bernstein JA, Hallmayer JF, Dolmetsch RE.

Nature. 2013 Nov 14;503(7475):267-71. doi: 10.1038/nature12618. Epub 2013 Oct 16.


Competition between α-actinin and Ca²⁺-calmodulin controls surface retention of the L-type Ca²⁺ channel Ca(V)1.2.

Hall DD, Dai S, Tseng PY, Malik Z, Nguyen M, Matt L, Schnizler K, Shephard A, Mohapatra DP, Tsuruta F, Dolmetsch RE, Christel CJ, Lee A, Burette A, Weinberg RJ, Hell JW.

Neuron. 2013 May 8;78(3):483-97. doi: 10.1016/j.neuron.2013.02.032.


A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT.

Gomez-Ospina N, Panagiotakos G, Portmann T, Pasca SP, Rabah D, Budzillo A, Kinet JP, Dolmetsch RE.

PLoS One. 2013 Apr 16;8(4):e60526. doi: 10.1371/journal.pone.0060526. Print 2013.


Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.

Ramachandran KV, Hennessey JA, Barnett AS, Yin X, Stadt HA, Foster E, Shah RA, Yazawa M, Dolmetsch RE, Kirby ML, Pitt GS.

J Clin Invest. 2013 Apr;123(4):1638-46. doi: 10.1172/JCI66903. Epub 2013 Mar 15.


Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons.

Krey JF, Paşca SP, Shcheglovitov A, Yazawa M, Schwemberger R, Rasmusson R, Dolmetsch RE.

Nat Neurosci. 2013 Feb;16(2):201-9. doi: 10.1038/nn.3307. Epub 2013 Jan 13.


Modeling Timothy syndrome with iPS cells.

Yazawa M, Dolmetsch RE.

J Cardiovasc Transl Res. 2013 Feb;6(1):1-9. doi: 10.1007/s12265-012-9444-x. Epub 2013 Jan 9.


Apelin enhances directed cardiac differentiation of mouse and human embryonic stem cells.

Wang IN, Wang X, Ge X, Anderson J, Ho M, Ashley E, Liu J, Butte MJ, Yazawa M, Dolmetsch RE, Quertermous T, Yang PC.

PLoS One. 2012;7(6):e38328. doi: 10.1371/journal.pone.0038328. Epub 2012 Jun 1.


Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy.

Sun N, Yazawa M, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S, Chen R, Hajjar RJ, Snyder MP, Dolmetsch RE, Butte MJ, Ashley EA, Longaker MT, Robbins RC, Wu JC.

Sci Transl Med. 2012 Apr 18;4(130):130ra47. doi: 10.1126/scitranslmed.3003552.


Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome.

Paşca SP, Portmann T, Voineagu I, Yazawa M, Shcheglovitov A, Paşca AM, Cord B, Palmer TD, Chikahisa S, Nishino S, Bernstein JA, Hallmayer J, Geschwind DH, Dolmetsch RE.

Nat Med. 2011 Nov 27;17(12):1657-62. doi: 10.1038/nm.2576.


MicroRNA-mediated conversion of human fibroblasts to neurons.

Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GR.

Nature. 2011 Jul 13;476(7359):228-31. doi: 10.1038/nature10323.


LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.

Nguyen HN, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P, Kee K, Schüle B, Dolmetsch RE, Langston W, Palmer TD, Pera RR.

Cell Stem Cell. 2011 Mar 4;8(3):267-80. doi: 10.1016/j.stem.2011.01.013.


Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome.

Yazawa M, Hsueh B, Jia X, Pasca AM, Bernstein JA, Hallmayer J, Dolmetsch RE.

Nature. 2011 Mar 10;471(7337):230-4. doi: 10.1038/nature09855. Epub 2011 Feb 9.


Using light to control signaling cascades in live neurons.

Rana A, Dolmetsch RE.

Curr Opin Neurobiol. 2010 Oct;20(5):617-22. doi: 10.1016/j.conb.2010.08.018. Epub 2010 Sep 17. Review.


PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death.

Tsuruta F, Green EM, Rousset M, Dolmetsch RE.

J Cell Biol. 2009 Oct 19;187(2):279-94. doi: 10.1083/jcb.200903028.


Induction of protein-protein interactions in live cells using light.

Yazawa M, Sadaghiani AM, Hsueh B, Dolmetsch RE.

Nat Biotechnol. 2009 Oct;27(10):941-5. doi: 10.1038/nbt.1569. Epub 2009 Oct 4.


STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels.

Mullins FM, Park CY, Dolmetsch RE, Lewis RS.

Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15495-500. doi: 10.1073/pnas.0906781106. Epub 2009 Aug 21.


STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.

Park CY, Hoover PJ, Mullins FM, Bachhawat P, Covington ED, Raunser S, Walz T, Garcia KC, Dolmetsch RE, Lewis RS.

Cell. 2009 Mar 6;136(5):876-90. doi: 10.1016/j.cell.2009.02.014. Epub 2009 Feb 26.


Calcium imaging of cortical neurons using Fura-2 AM.

Barreto-Chang OL, Dolmetsch RE.

J Vis Exp. 2009 Jan 19;(23). pii: 1067. doi: 10.3791/1067.


The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2.

Green EM, Barrett CF, Bultynck G, Shamah SM, Dolmetsch RE.

Neuron. 2007 Aug 16;55(4):615-32.


Calcium channels light up.

Green E, Dolmetsch RE.

Nat Chem Biol. 2007 Jul;3(7):369-70. No abstract available.


Molecular mechanisms of autism: a possible role for Ca2+ signaling.

Krey JF, Dolmetsch RE.

Curr Opin Neurobiol. 2007 Feb;17(1):112-9. Epub 2007 Feb 1. Review.


Time-lapse imaging of a dynamic phosphorylation-dependent protein-protein interaction in mammalian cells.

Spotts JM, Dolmetsch RE, Greenberg ME.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15142-7. Epub 2002 Nov 1.


CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events.

Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg ME.

Neuron. 2002 Apr 11;34(2):221-33.


Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway.

Dolmetsch RE, Pajvani U, Fife K, Spotts JM, Greenberg ME.

Science. 2001 Oct 12;294(5541):333-9.


Calcium regulation of neuronal gene expression.

West AE, Chen WG, Dalva MB, Dolmetsch RE, Kornhauser JM, Shaywitz AJ, Takasu MA, Tao X, Greenberg ME.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11024-31. Review.


Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes.

Healy JI, Dolmetsch RE, Lewis RS, Goodnow CC.

Novartis Found Symp. 1998;215:137-44; discussion 144-5, 186-90.


Calcium oscillations increase the efficiency and specificity of gene expression.

Dolmetsch RE, Xu K, Lewis RS.

Nature. 1998 Apr 30;392(6679):933-6.


Differential activation of transcription factors induced by Ca2+ response amplitude and duration.

Dolmetsch RE, Lewis RS, Goodnow CC, Healy JI.

Nature. 1997 Apr 24;386(6627):855-8. Erratum in: Nature 1997 Jul 17;388(6639):308.


Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

Healy JI, Dolmetsch RE, Timmerman LA, Cyster JG, Thomas ML, Crabtree GR, Lewis RS, Goodnow CC.

Immunity. 1997 Apr;6(4):419-28.


Positive and negative regulation of depletion-activated calcium channels by calcium.

Lewis RS, Dolmetsch RE, Zweifach A.

Soc Gen Physiol Ser. 1996;51:241-54. No abstract available.


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