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Items: 1 to 50 of 64

1.

p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells.

Ihry RJ, Worringer KA, Salick MR, Frias E, Ho D, Theriault K, Kommineni S, Chen J, Sondey M, Ye C, Randhawa R, Kulkarni T, Yang Z, McAllister G, Russ C, Reece-Hoyes J, Forrester W, Hoffman GR, Dolmetsch R, Kaykas A.

Nat Med. 2018 Jul;24(7):939-946. doi: 10.1038/s41591-018-0050-6. Epub 2018 Jun 11.

PMID:
29892062
2.

Translating genome-wide association findings into new therapeutics for psychiatry.

Breen G, Li Q, Roth BL, O'Donnell P, Didriksen M, Dolmetsch R, O'Reilly PF, Gaspar HA, Manji H, Huebel C, Kelsoe JR, Malhotra D, Bertolino A, Posthuma D, Sklar P, Kapur S, Sullivan PF, Collier DA, Edenberg HJ.

Nat Neurosci. 2016 Oct 26;19(11):1392-1396. doi: 10.1038/nn.4411. Review.

3.

A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients.

Sun Y, Paşca SP, Portmann T, Goold C, Worringer KA, Guan W, Chan KC, Gai H, Vogt D, Chen YJ, Mao R, Chan K, Rubenstein JL, Madison DV, Hallmayer J, Froehlich-Santino WM, Bernstein JA, Dolmetsch RE.

Elife. 2016 Jul 26;5. pii: e13073. doi: 10.7554/eLife.13073.

4.

CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency.

Bidinosti M, Botta P, Krüttner S, Proenca CC, Stoehr N, Bernhard M, Fruh I, Mueller M, Bonenfant D, Voshol H, Carbone W, Neal SJ, McTighe SM, Roma G, Dolmetsch RE, Porter JA, Caroni P, Bouwmeester T, Lüthi A, Galimberti I.

Science. 2016 Mar 11;351(6278):1199-203. doi: 10.1126/science.aad5487. Epub 2016 Feb 4.

5.

How induced pluripotent stem cells are informing drug discovery in psychiatry.

Sun Y, Dolmetsch RE.

Swiss Med Wkly. 2016 Jan 11;146:w14241. doi: 10.4414/smw.2016.14241. eCollection 2016. Review.

6.

PIKfyve mediates the motility of late endosomes and lysosomes in neuronal dendrites.

Tsuruta F, Dolmetsch RE.

Neurosci Lett. 2015 Sep 25;605:18-23. doi: 10.1016/j.neulet.2015.07.021. Epub 2015 Jul 29.

PMID:
26232680
7.

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels.

Rana A, Yen M, Sadaghiani AM, Malmersjö S, Park CY, Dolmetsch RE, Lewis RS.

J Cell Biol. 2015 Jun 8;209(5):653-69. doi: 10.1083/jcb.201412060. Epub 2015 Jun 1.

8.

Direct in vivo assessment of human stem cell graft-host neural circuits.

Byers B, Lee HJ, Liu J, Weitz AJ, Lin P, Zhang P, Shcheglovitov A, Dolmetsch R, Pera RR, Lee JH.

Neuroimage. 2015 Jul 1;114:328-37. doi: 10.1016/j.neuroimage.2015.03.079. Epub 2015 Apr 25.

9.

16p11.2 Deletion Syndrome Mice Display Sensory and Ultrasonic Vocalization Deficits During Social Interactions.

Yang M, Mahrt EJ, Lewis F, Foley G, Portmann T, Dolmetsch RE, Portfors CV, Crawley JN.

Autism Res. 2015 Oct;8(5):507-21. doi: 10.1002/aur.1465. Epub 2015 Feb 7.

10.

Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome.

Tian Y, Voineagu I, Paşca SP, Won H, Chandran V, Horvath S, Dolmetsch RE, Geschwind DH.

Genome Med. 2014 Oct 10;6(10):75. doi: 10.1186/s13073-014-0075-5. eCollection 2014.

11.

Identification of Orai1 channel inhibitors by using minimal functional domains to screen small molecule microarrays.

Sadaghiani AM, Lee SM, Odegaard JI, Leveson-Gower DB, McPherson OM, Novick P, Kim MR, Koehler AN, Negrin R, Dolmetsch RE, Park CY.

Chem Biol. 2014 Oct 23;21(10):1278-1292. doi: 10.1016/j.chembiol.2014.08.016. Epub 2014 Oct 9.

12.

Generating human neurons in vitro and using them to understand neuropsychiatric disease.

Paşca SP, Panagiotakos G, Dolmetsch RE.

Annu Rev Neurosci. 2014;37:479-501. doi: 10.1146/annurev-neuro-062012-170328. Epub 2014 Jun 23. Review.

PMID:
25002278
13.

Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome.

Portmann T, Yang M, Mao R, Panagiotakos G, Ellegood J, Dolen G, Bader PL, Grueter BA, Goold C, Fisher E, Clifford K, Rengarajan P, Kalikhman D, Loureiro D, Saw NL, Zhengqui Z, Miller MA, Lerch JP, Henkelman M, Shamloo M, Malenka RC, Crawley JN, Dolmetsch RE.

Cell Rep. 2014 May 22;7(4):1077-1092. doi: 10.1016/j.celrep.2014.03.036. Epub 2014 May 1.

14.

Straight talk with... Ricardo Dolmetsch. Interview by Elie Dolgin.

Dolmetsch R.

Nat Med. 2013 Nov;19(11):1360. doi: 10.1038/nm1113-1360.

PMID:
24202377
15.

SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.

Shcheglovitov A, Shcheglovitova O, Yazawa M, Portmann T, Shu R, Sebastiano V, Krawisz A, Froehlich W, Bernstein JA, Hallmayer JF, Dolmetsch RE.

Nature. 2013 Nov 14;503(7475):267-71. doi: 10.1038/nature12618. Epub 2013 Oct 16.

16.

State-dependent signaling by Cav1.2 regulates hair follicle stem cell function.

Yucel G, Altindag B, Gomez-Ospina N, Rana A, Panagiotakos G, Lara MF, Dolmetsch R, Oro AE.

Genes Dev. 2013 Jun 1;27(11):1217-22. doi: 10.1101/gad.216556.113.

17.

Competition between α-actinin and Ca²⁺-calmodulin controls surface retention of the L-type Ca²⁺ channel Ca(V)1.2.

Hall DD, Dai S, Tseng PY, Malik Z, Nguyen M, Matt L, Schnizler K, Shephard A, Mohapatra DP, Tsuruta F, Dolmetsch RE, Christel CJ, Lee A, Burette A, Weinberg RJ, Hell JW.

Neuron. 2013 May 8;78(3):483-97. doi: 10.1016/j.neuron.2013.02.032.

18.

A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT.

Gomez-Ospina N, Panagiotakos G, Portmann T, Pasca SP, Rabah D, Budzillo A, Kinet JP, Dolmetsch RE.

PLoS One. 2013 Apr 16;8(4):e60526. doi: 10.1371/journal.pone.0060526. Print 2013.

19.

Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.

Ramachandran KV, Hennessey JA, Barnett AS, Yin X, Stadt HA, Foster E, Shah RA, Yazawa M, Dolmetsch RE, Kirby ML, Pitt GS.

J Clin Invest. 2013 Apr;123(4):1638-46. doi: 10.1172/JCI66903. Epub 2013 Mar 15.

20.

Cytoplasmic location of α1A voltage-gated calcium channel C-terminal fragment (Cav2.1-CTF) aggregate is sufficient to cause cell death.

Takahashi M, Obayashi M, Ishiguro T, Sato N, Niimi Y, Ozaki K, Mogushi K, Mahmut Y, Tanaka H, Tsuruta F, Dolmetsch R, Yamada M, Takahashi H, Kato T, Mori O, Eishi Y, Mizusawa H, Ishikawa K.

PLoS One. 2013;8(3):e50121. doi: 10.1371/journal.pone.0050121. Epub 2013 Mar 7.

21.

In vitro human corticogenesis.

Wang Y, Dolmetsch R.

Neuron. 2013 Feb 6;77(3):379-81. doi: 10.1016/j.neuron.2013.01.023.

22.

Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons.

Krey JF, Paşca SP, Shcheglovitov A, Yazawa M, Schwemberger R, Rasmusson R, Dolmetsch RE.

Nat Neurosci. 2013 Feb;16(2):201-9. doi: 10.1038/nn.3307. Epub 2013 Jan 13.

23.

Modeling Timothy syndrome with iPS cells.

Yazawa M, Dolmetsch RE.

J Cardiovasc Transl Res. 2013 Feb;6(1):1-9. doi: 10.1007/s12265-012-9444-x. Epub 2013 Jan 9.

24.

Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy.

Tadmouri A, Kiyonaka S, Barbado M, Rousset M, Fablet K, Sawamura S, Bahembera E, Pernet-Gallay K, Arnoult C, Miki T, Sadoul K, Gory-Faure S, Lambrecht C, Lesage F, Akiyama S, Khochbin S, Baulande S, Janssens V, Andrieux A, Dolmetsch R, Ronjat M, Mori Y, De Waard M.

EMBO J. 2012 Sep 12;31(18):3730-44. doi: 10.1038/emboj.2012.226. Epub 2012 Aug 14.

25.

Apelin enhances directed cardiac differentiation of mouse and human embryonic stem cells.

Wang IN, Wang X, Ge X, Anderson J, Ho M, Ashley E, Liu J, Butte MJ, Yazawa M, Dolmetsch RE, Quertermous T, Yang PC.

PLoS One. 2012;7(6):e38328. doi: 10.1371/journal.pone.0038328. Epub 2012 Jun 1.

26.

Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy.

Sun N, Yazawa M, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S, Chen R, Hajjar RJ, Snyder MP, Dolmetsch RE, Butte MJ, Ashley EA, Longaker MT, Robbins RC, Wu JC.

Sci Transl Med. 2012 Apr 18;4(130):130ra47. doi: 10.1126/scitranslmed.3003552.

27.

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome.

Paşca SP, Portmann T, Voineagu I, Yazawa M, Shcheglovitov A, Paşca AM, Cord B, Palmer TD, Chikahisa S, Nishino S, Bernstein JA, Hallmayer J, Geschwind DH, Dolmetsch RE.

Nat Med. 2011 Nov 27;17(12):1657-62. doi: 10.1038/nm.2576.

28.

MicroRNA-mediated conversion of human fibroblasts to neurons.

Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GR.

Nature. 2011 Jul 13;476(7359):228-31. doi: 10.1038/nature10323.

29.

The human brain in a dish: the promise of iPSC-derived neurons.

Dolmetsch R, Geschwind DH.

Cell. 2011 Jun 10;145(6):831-4. doi: 10.1016/j.cell.2011.05.034. Review.

30.

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.

Nguyen HN, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P, Kee K, Schüle B, Dolmetsch RE, Langston W, Palmer TD, Pera RR.

Cell Stem Cell. 2011 Mar 4;8(3):267-80. doi: 10.1016/j.stem.2011.01.013.

31.

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome.

Yazawa M, Hsueh B, Jia X, Pasca AM, Bernstein JA, Hallmayer J, Dolmetsch RE.

Nature. 2011 Mar 10;471(7337):230-4. doi: 10.1038/nature09855. Epub 2011 Feb 9.

32.

The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels.

Park CY, Shcheglovitov A, Dolmetsch R.

Science. 2010 Oct 1;330(6000):101-5. doi: 10.1126/science.1191027.

33.

Using light to control signaling cascades in live neurons.

Rana A, Dolmetsch RE.

Curr Opin Neurobiol. 2010 Oct;20(5):617-22. doi: 10.1016/j.conb.2010.08.018. Epub 2010 Sep 17. Review.

34.

The carboxy-terminal fragment of alpha(1A) calcium channel preferentially aggregates in the cytoplasm of human spinocerebellar ataxia type 6 Purkinje cells.

Ishiguro T, Ishikawa K, Takahashi M, Obayashi M, Amino T, Sato N, Sakamoto M, Fujigasaki H, Tsuruta F, Dolmetsch R, Arai T, Sasaki H, Nagashima K, Kato T, Yamada M, Takahashi H, Hashizume Y, Mizusawa H.

Acta Neuropathol. 2010 Apr;119(4):447-64. doi: 10.1007/s00401-009-0630-0. Epub 2009 Dec 31.

35.

PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death.

Tsuruta F, Green EM, Rousset M, Dolmetsch RE.

J Cell Biol. 2009 Oct 19;187(2):279-94. doi: 10.1083/jcb.200903028.

36.

Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.

Eroglu C, Allen NJ, Susman MW, O'Rourke NA, Park CY, Ozkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, Luo ZD, Rosenthal A, Mosher DF, Barres BA.

Cell. 2009 Oct 16;139(2):380-92. doi: 10.1016/j.cell.2009.09.025. Epub 2009 Oct 8.

37.

Induction of protein-protein interactions in live cells using light.

Yazawa M, Sadaghiani AM, Hsueh B, Dolmetsch RE.

Nat Biotechnol. 2009 Oct;27(10):941-5. doi: 10.1038/nbt.1569. Epub 2009 Oct 4.

PMID:
19801976
38.

STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels.

Mullins FM, Park CY, Dolmetsch RE, Lewis RS.

Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15495-500. doi: 10.1073/pnas.0906781106. Epub 2009 Aug 21.

39.

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.

Park CY, Hoover PJ, Mullins FM, Bachhawat P, Covington ED, Raunser S, Walz T, Garcia KC, Dolmetsch RE, Lewis RS.

Cell. 2009 Mar 6;136(5):876-90. doi: 10.1016/j.cell.2009.02.014. Epub 2009 Feb 26.

40.

Calcium imaging of cortical neurons using Fura-2 AM.

Barreto-Chang OL, Dolmetsch RE.

J Vis Exp. 2009 Jan 19;(23). pii: 1067. doi: 10.3791/1067.

41.
42.

The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2.

Green EM, Barrett CF, Bultynck G, Shamah SM, Dolmetsch RE.

Neuron. 2007 Aug 16;55(4):615-32.

43.

Calcium channels light up.

Green E, Dolmetsch RE.

Nat Chem Biol. 2007 Jul;3(7):369-70. No abstract available.

PMID:
17576420
44.

Molecular mechanisms of autism: a possible role for Ca2+ signaling.

Krey JF, Dolmetsch RE.

Curr Opin Neurobiol. 2007 Feb;17(1):112-9. Epub 2007 Feb 1. Review.

PMID:
17275285
45.

The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor.

Gomez-Ospina N, Tsuruta F, Barreto-Chang O, Hu L, Dolmetsch R.

Cell. 2006 Nov 3;127(3):591-606.

46.

Cell signaling. The double life of a transcription factor takes it outside the nucleus.

Park CY, Dolmetsch R.

Science. 2006 Oct 6;314(5796):64-5. No abstract available.

PMID:
17023638
47.

Excitation-transcription coupling: signaling by ion channels to the nucleus.

Dolmetsch R.

Sci STKE. 2003 Jan 21;2003(166):PE4. Review.

PMID:
12538881
48.

Time-lapse imaging of a dynamic phosphorylation-dependent protein-protein interaction in mammalian cells.

Spotts JM, Dolmetsch RE, Greenberg ME.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15142-7. Epub 2002 Nov 1.

49.

CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events.

Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg ME.

Neuron. 2002 Apr 11;34(2):221-33.

50.

Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway.

Dolmetsch RE, Pajvani U, Fife K, Spotts JM, Greenberg ME.

Science. 2001 Oct 12;294(5541):333-9.

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