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Items: 1 to 50 of 122

1.

N-Acetyltransferase 1 Knockout Elevates Acetyl Coenzyme A Levels and Reduces Anchorage-Independent Growth in Human Breast Cancer Cell Lines.

Stepp MW, Salazar-González RA, Hong KU, Doll MA, Hein DW.

J Oncol. 2019 Aug 20;2019:3860426. doi: 10.1155/2019/3860426. eCollection 2019.

2.

Role of Human N-Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen-Induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary Cell Mutation Assay.

Baldauf KJ, Salazar-González RA, Doll MA, Pierce WM Jr, States JC, Hein DW.

Environ Mol Mutagen. 2019 Sep 6. doi: 10.1002/em.22331. [Epub ahead of print]

PMID:
31490564
3.

ALG-2/AGO-Dependent mir-35 Family Regulates DNA Damage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstream of the Core Apoptotic Machinery in Caenorhabditis elegans.

Doll MA, Soltanmohammadi N, Schumacher B.

Genetics. 2019 Sep;213(1):173-194. doi: 10.1534/genetics.119.302458. Epub 2019 Jul 11.

PMID:
31296532
4.

Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4'-methylenedianiline.

Salazar-González RA, Zhang X, Doll MA, Lykoudi A, Hein DW.

Arch Toxicol. 2019 Aug;93(8):2237-2246. doi: 10.1007/s00204-019-02516-4. Epub 2019 Jul 10.

PMID:
31292670
5.

Loss of the Na+/H+ Exchange Regulatory Factor 1 Increases Susceptibility to Cisplatin-Induced Acute Kidney Injury.

Bushau-Sprinkle A, Barati M, Conklin C, Dupre T, Gagnon KB, Khundmiri SJ, Clark B, Siskind L, Doll MA, Rane M, Brier M, Coventry S, Lederer ED.

Am J Pathol. 2019 Jun;189(6):1190-1200. doi: 10.1016/j.ajpath.2019.02.010. Epub 2019 Mar 27.

PMID:
30926337
6.

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors.

Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y.

Cell. 2019 Jan 24;176(3):505-519.e22. doi: 10.1016/j.cell.2018.11.024. Epub 2019 Jan 3.

PMID:
30612738
7.

Knockout of human arylamine N-acetyltransferase 1 (NAT1) in MDA-MB-231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity.

Carlisle SM, Trainor PJ, Doll MA, Stepp MW, Klinge CM, Hein DW.

Mol Carcinog. 2018 Nov;57(11):1458-1466. doi: 10.1002/mc.22869. Epub 2018 Jul 18.

8.

Subclinical kidney injury induced by repeated cisplatin administration results in progressive chronic kidney disease.

Sharp CN, Doll MA, Megyesi J, Oropilla GB, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F161-F172. doi: 10.1152/ajprenal.00636.2017. Epub 2018 Jan 31.

9.
10.

Genetic and small molecule inhibition of arylamine N-acetyltransferase 1 reduces anchorage-independent growth in human breast cancer cell line MDA-MB-231.

Stepp MW, Doll MA, Carlisle SM, States JC, Hein DW.

Mol Carcinog. 2018 Apr;57(4):549-558. doi: 10.1002/mc.22779. Epub 2018 Feb 3.

11.

Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation.

Hein DW, Zhang X, Doll MA.

Toxicol Lett. 2018 Feb;283:100-105. doi: 10.1016/j.toxlet.2017.11.028. Epub 2017 Nov 24.

12.

N-Acetyltransferase 2 Genotype-Dependent N-Acetylation of Hydralazine in Human Hepatocytes.

Allen CE, Doll MA, Hein DW.

Drug Metab Dispos. 2017 Dec;45(12):1276-1281. doi: 10.1124/dmd.117.078543. Epub 2017 Oct 10.

13.

Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes.

Doll MA, Salazar-González RA, Bodduluri S, Hein DW.

Acta Pharm Sin B. 2017 Jul;7(4):517-522. doi: 10.1016/j.apsb.2017.05.003. Epub 2017 Jun 7.

14.

Role of the N-acetylation polymorphism in solithromycin metabolism.

Hein DW, Doll MA.

Pharmacogenomics. 2017 Jun;18(8):765-772. doi: 10.2217/pgs-2017-0045. Epub 2017 Apr 24.

15.
16.
17.

Genetic heterogeneity among slow acetylator N-acetyltransferase 2 phenotypes in cryopreserved human hepatocytes.

Doll MA, Hein DW.

Arch Toxicol. 2017 Jul;91(7):2655-2661. doi: 10.1007/s00204-017-1988-8. Epub 2017 May 17.

18.

Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.

Dupre TV, Doll MA, Shah PP, Sharp CN, Siow D, Megyesi J, Shayman J, Bielawska A, Bielawski J, Beverly LJ, Hernandez-Corbacho M, Clarke CJ, Snider AJ, Schnellmann RG, Obeid LM, Hannun YA, Siskind LJ.

J Lipid Res. 2017 Jul;58(7):1439-1452. doi: 10.1194/jlr.M076745. Epub 2017 May 10.

19.

Daily Rhythm in Plasma N-acetyltryptamine.

Backlund PS, Urbanski HF, Doll MA, Hein DW, Bozinoski M, Mason CE, Coon SL, Klein DC.

J Biol Rhythms. 2017 Jun;32(3):195-211. doi: 10.1177/0748730417700458. Epub 2017 May 3.

20.

A simple answer to complex questions: Caenorhabditis elegans as an experimental model for examining the DNA damage response and disease genes.

Rieckher M, Bujarrabal A, Doll MA, Soltanmohammadi N, Schumacher B.

J Cell Physiol. 2018 Apr;233(4):2781-2790. doi: 10.1002/jcp.25979. Epub 2017 May 31. Review.

21.

Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism.

Stepp MW, Doll MA, Samuelson DJ, Sanders MA, States JC, Hein DW.

BMC Cancer. 2017 Mar 31;17(1):233. doi: 10.1186/s12885-017-3221-9.

22.

Untargeted polar metabolomics of transformed MDA-MB-231 breast cancer cells expressing varying levels of human arylamine N-acetyltransferase 1.

Carlisle SM, Trainor PJ, Yin X, Doll MA, Stepp MW, States JC, Zhang X, Hein DW.

Metabolomics. 2016 Jul;12(7). pii: 111. Epub 2016 Jun 21.

23.

Repeated administration of low-dose cisplatin in mice induces fibrosis.

Sharp CN, Doll MA, Dupre TV, Shah PP, Subathra M, Siow D, Arteel GE, Megyesi J, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2016 Mar 15;310(6):F560-8. doi: 10.1152/ajprenal.00512.2015. Epub 2016 Jan 6.

24.

Suramin protects from cisplatin-induced acute kidney injury.

Dupre TV, Doll MA, Shah PP, Sharp CN, Kiefer A, Scherzer MT, Saurabh K, Saforo D, Siow D, Casson L, Arteel GE, Jenson AB, Megyesi J, Schnellmann RG, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2016 Feb 1;310(3):F248-58. doi: 10.1152/ajprenal.00433.2015. Epub 2015 Dec 9.

25.

Folate-Dependent Hydrolysis of Acetyl-Coenzyme A by Recombinant Human and Rodent Arylamine N-Acetyltransferases.

Stepp MW, Mamaliga G, Doll MA, States JC, Hein DW.

Biochem Biophys Rep. 2015 Sep;3:45-50.

26.

Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells.

Teng Y, Radde BN, Litchfield LM, Ivanova MM, Prough RA, Clark BJ, Doll MA, Hein DW, Klinge CM.

J Biol Chem. 2015 Jun 19;290(25):15799-811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.

27.

The role of endogenous epidermal growth factor receptor ligands in mediating corneal epithelial homeostasis.

Peterson JL, Phelps ED, Doll MA, Schaal S, Ceresa BP.

Invest Ophthalmol Vis Sci. 2014 May 1;55(5):2870-80. doi: 10.1167/iovs.13-12943.

28.

S-adenosylhomocysteine inhibits NF-κB-mediated gene expression in hepatocytes and confers sensitivity to TNF cytotoxicity.

Watson WH, Burke TJ, Doll MA, McClain CJ.

Alcohol Clin Exp Res. 2014 Apr;38(4):889-96. doi: 10.1111/acer.12315. Epub 2013 Nov 13.

29.

Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice.

Sugamori KS, Brenneman D, Sanchez O, Doll MA, Hein DW, Pierce WM Jr, Grant DM.

Cancer Lett. 2012 May 28;318(2):206-13. doi: 10.1016/j.canlet.2011.12.022. Epub 2011 Dec 19.

30.

Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.

Millner LM, Doll MA, Stepp MW, States JC, Hein DW.

Carcinogenesis. 2012 Feb;33(2):348-55. doi: 10.1093/carcin/bgr273. Epub 2011 Nov 22. Erratum in: Carcinogenesis. 2012 Jul;33(7):1431.

31.

Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes.

Hein DW, Doll MA.

Pharmacogenomics. 2012 Jan;13(1):31-41. doi: 10.2217/pgs.11.122. Epub 2011 Nov 17.

32.

Phenotype of the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent.

Millner LM, Doll MA, Cai J, States JC, Hein DW.

Drug Metab Dispos. 2012 Jan;40(1):198-204. doi: 10.1124/dmd.111.041855. Epub 2011 Oct 18.

33.

NATb/NAT1*4 promotes greater arylamine N-acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4-aminobiphenyl.

Millner LM, Doll MA, Cai J, States JC, Hein DW.

Mol Carcinog. 2012 Aug;51(8):636-46. doi: 10.1002/mc.20836. Epub 2011 Aug 11.

34.

No association between variant N-acetyltransferase genes, cigarette smoking and Prostate Cancer susceptibility among men of African descent.

Kidd LC, Vancleave TT, Doll MA, Srivastava DS, Thacker B, Komolafe O, Pihur V, Brock GN, Hein DW.

Biomark Cancer. 2011 Feb 3;2011(3):1-13.

35.

Hair dye use and risk of bladder cancer in the New England bladder cancer study.

Koutros S, Silverman DT, Baris D, Zahm SH, Morton LM, Colt JS, Hein DW, Moore LE, Johnson A, Schwenn M, Cherala S, Schned A, Doll MA, Rothman N, Karagas MR.

Int J Cancer. 2011 Dec 15;129(12):2894-904. doi: 10.1002/ijc.26245. Epub 2011 Aug 12.

36.

A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background.

García-Closas M, Hein DW, Silverman D, Malats N, Yeager M, Jacobs K, Doll MA, Figueroa JD, Baris D, Schwenn M, Kogevinas M, Johnson A, Chatterjee N, Moore LE, Moeller T, Real FX, Chanock S, Rothman N.

Pharmacogenet Genomics. 2011 Apr;21(4):231-6. doi: 10.1097/FPC.0b013e32833e1b54.

37.

Manganese superoxide dismutase expression as a function of genotype and lung cancer pathology.

Martin RC, Li Y, Liu Q, Barker DF, Doll MA, Hein DW.

Cancer Invest. 2010 Oct;28(8):813-9. doi: 10.3109/07357900903405918.

38.

Codominant expression of N-acetylation and O-acetylation activities catalyzed by N-acetyltransferase 2 in human hepatocytes.

Doll MA, Zang Y, Moeller T, Hein DW.

J Pharmacol Exp Ther. 2010 Aug;334(2):540-4. doi: 10.1124/jpet.110.168567. Epub 2010 Apr 29.

39.

Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx).

Metry KJ, Neale JR, Doll MA, Howarth AL, States JC, McGregor WG, Pierce WM Jr, Hein DW.

Mutat Res. 2010 Feb 3;684(1-2):66-73. doi: 10.1016/j.mrfmmm.2009.12.001. Epub 2009 Dec 11.

40.

Relationship between N-acetyltransferase 2 single-nucleotide polymorphisms and phenotype.

Hein DW, Millner LM, Leggett CS, Doll MA.

Carcinogenesis. 2010 Feb;31(2):326-7; author reply 328-9. doi: 10.1093/carcin/bgp290. Epub 2009 Nov 23. No abstract available.

41.

N-acetyltransferase 2 genotype modification of active cigarette smoking on breast cancer risk among hispanic and non-hispanic white women.

Baumgartner KB, Schlierf TJ, Yang D, Doll MA, Hein DW.

Toxicol Sci. 2009 Nov;112(1):211-20. doi: 10.1093/toxsci/kfp199. Epub 2009 Aug 19.

42.

Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations.

Bendaly J, Doll MA, Millner LM, Metry KJ, Smith NB, Pierce WM Jr, Hein DW.

Mutat Res. 2009 Dec 1;671(1-2):13-9. doi: 10.1016/j.mrfmmm.2009.08.003. Epub 2009 Aug 12.

43.

Role of human CYP1A1 and NAT2 in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenicity and DNA adducts.

Bendaly J, Metry KJ, Doll MA, Jiang G, States JC, Smith NB, Neale JR, Holloman JL, Pierce WM, Hein DW.

Xenobiotica. 2009 May;39(5):399-406. doi: 10.1080/00498250902748953.

44.

The impact of NAT2 acetylator genotype on mutagenesis and DNA adducts from 2-amino-9H-pyrido[2,3-b]indole.

Turesky RJ, Bendaly J, Yasa I, Doll MA, Hein DW.

Chem Res Toxicol. 2009 Apr;22(4):726-33. doi: 10.1021/tx800473w.

45.

Association of the histamine N-methyltransferase C314T (Thr105Ile) polymorphism with atopic dermatitis in Caucasian children.

Kennedy MJ, Loehle JA, Griffin AR, Doll MA, Kearns GL, Sullivan JE, Hein DW.

Pharmacotherapy. 2008 Dec;28(12):1495-501. doi: 10.1592/phco.28.12.1495.

46.
47.

Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat.

Barker DF, Walraven JM, Ristagno EH, Doll MA, States JC, Hein DW.

Drug Metab Dispos. 2008 Dec;36(12):2445-51. doi: 10.1124/dmd.108.023564. Epub 2008 Sep 17.

48.

Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat.

Hein DW, Bendaly J, Neale JR, Doll MA.

Drug Metab Dispos. 2008 Dec;36(12):2452-9. doi: 10.1124/dmd.108.023960. Epub 2008 Sep 17.

49.

Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.

Suzuki H, Morris JS, Li Y, Doll MA, Hein DW, Liu J, Jiao L, Hassan MM, Day RS, Bondy ML, Abbruzzese JL, Li D.

Carcinogenesis. 2008 Jun;29(6):1184-91. doi: 10.1093/carcin/bgn085. Epub 2008 May 21.

50.

Manganese superoxide dismutase gene coding region polymorphisms lack clinical incidence in general population.

Martin RC, Barker DF, Doll MA, Pine SR, Mechanic L, Bowman ED, Harris CC, Hein DW.

DNA Cell Biol. 2008 Jun;27(6):321-3. doi: 10.1089/dna.2007.0725.

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