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Items: 1 to 50 of 169

1.

Comparison of high and low molar activity TSPO tracer [18F]F-DPA in a mouse model of Alzheimer's disease.

Keller T, López-Picón FR, Krzyczmonik A, Forsback S, Takkinen JS, Rajander J, Teperi S, Dollé F, Rinne JO, Haaparanta-Solin M, Solin O.

J Cereb Blood Flow Metab. 2019 May 29:271678X19853117. doi: 10.1177/0271678X19853117. [Epub ahead of print]

PMID:
31142224
2.

Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state.

Villa A, Klein B, Janssen B, Pedragosa J, Pepe G, Zinnhardt B, Vugts DJ, Gelosa P, Sironi L, Beaino W, Damont A, Dollé F, Jego B, Winkeler A, Ory D, Solin O, Vercouillie J, Funke U, Laner-Plamberger S, Blomster LV, Christophersen P, Vegeto E, Aigner L, Jacobs A, Planas AM, Maggi A, Windhorst AD.

Theranostics. 2018 Oct 27;8(19):5400-5418. doi: 10.7150/thno.25572. eCollection 2018.

3.

Extensive exploration of a novel rat model of Parkinson's disease using partial 6-hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches.

Vetel S, Sérrière S, Vercouillie J, Vergote J, Chicheri G, Deloye JB, Dollé F, Bodard S, Tronel C, Nadal-Desbarats L, Lefèvre A, Emond P, Chalon S.

Synapse. 2019 Mar;73(3):e22077. doi: 10.1002/syn.22077. Epub 2018 Nov 12.

PMID:
30368914
4.

[18F]F-DPA for the detection of activated microglia in a mouse model of Alzheimer's disease.

Keller T, López-Picón FR, Krzyczmonik A, Forsback S, Kirjavainen AK, Takkinen JS, Alzghool O, Rajander J, Teperi S, Cacheux F, Damont A, Dollé F, Rinne JO, Solin O, Haaparanta-Solin M.

Nucl Med Biol. 2018 Dec;67:1-9. doi: 10.1016/j.nucmedbio.2018.09.001. Epub 2018 Sep 26.

5.

From Structure-Activity Relationships on Thiazole Derivatives to the In Vivo Evaluation of a New Radiotracer for Cannabinoid Subtype 2 PET Imaging.

Caillé F, Cacheux F, Peyronneau MA, Jego B, Jaumain E, Pottier G, Ullmer C, Grether U, Winkeler A, Dollé F, Damont A, Kuhnast B.

Mol Pharm. 2017 Nov 6;14(11):4064-4078. doi: 10.1021/acs.molpharmaceut.7b00746. Epub 2017 Oct 18.

PMID:
28968497
6.

Avidin/Biotin Bioinspired Platform for Dual In Vivo 18F-PET/NIRF Molecular Imaging.

Damont A, Boisgard R, Dollé F, Hollocou M, Kuhnast B.

Bioconjug Chem. 2017 Oct 18;28(10):2524-2529. doi: 10.1021/acs.bioconjchem.7b00536. Epub 2017 Sep 26.

PMID:
28931274
7.

Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model.

Foucault-Fruchard L, Doméné A, Page G, Windsor M, Emond P, Rodrigues N, Dollé F, Damont A, Buron F, Routier S, Chalon S, Antier D.

Neuroscience. 2017 Jul 25;356:52-63. doi: 10.1016/j.neuroscience.2017.05.019. Epub 2017 May 18.

PMID:
28527955
8.

Radiosynthesis and Preclinical Evaluation of [18F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats.

Keller T, Krzyczmonik A, Forsback S, Picón FRL, Kirjavainen AK, Takkinen J, Rajander J, Cacheux F, Damont A, Dollé F, Rinne JO, Haaparanta-Solin M, Solin O.

Mol Imaging Biol. 2017 Oct;19(5):736-745. doi: 10.1007/s11307-016-1040-z.

9.

PET imaging of cannabinoid type 2 receptors with [11C]A-836339 did not evidence changes following neuroinflammation in rats.

Pottier G, Gómez-Vallejo V, Padro D, Boisgard R, Dollé F, Llop J, Winkeler A, Martín A.

J Cereb Blood Flow Metab. 2017 Mar;37(3):1163-1178. doi: 10.1177/0271678X16685105. Epub 2017 Jan 12.

10.

Synthesis and in vitro characterization of novel fluorinated derivatives of the translocator protein 18 kDa ligand CfO-DPA-714.

Cacheux F, Médran-Navarrete V, Dollé F, Marguet F, Puech F, Damont A.

Eur J Med Chem. 2017 Jan 5;125:346-359. doi: 10.1016/j.ejmech.2016.09.025. Epub 2016 Sep 9.

PMID:
27688189
11.

PET Imaging with [(18)F]FSPG Evidences the Role of System xc(-) on Brain Inflammation Following Cerebral Ischemia in Rats.

Domercq M, Szczupak B, Gejo J, Gómez-Vallejo V, Padro D, Gona KB, Dollé F, Higuchi M, Matute C, Llop J, Martín A.

Theranostics. 2016 Jul 9;6(11):1753-67. doi: 10.7150/thno.15616. eCollection 2016.

12.

(11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.

Rotstein BH, Liang SH, Placzek MS, Hooker JM, Gee AD, Dollé F, Wilson AA, Vasdev N.

Chem Soc Rev. 2016 Aug 22;45(17):4708-26. doi: 10.1039/c6cs00310a. Review.

13.

6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis.

Fricke IB, Viel T, Worlitzer MM, Collmann FM, Vrachimis A, Faust A, Wachsmuth L, Faber C, Dollé F, Kuhlmann MT, Schäfers K, Hermann S, Schwamborn JC, Jacobs AH.

Eur J Neurosci. 2016 May;43(10):1352-65. doi: 10.1111/ejn.13232. Epub 2016 Apr 5.

PMID:
26950181
14.

Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis.

Bodini B, Veronese M, García-Lorenzo D, Battaglini M, Poirion E, Chardain A, Freeman L, Louapre C, Tchikviladze M, Papeix C, Dollé F, Zalc B, Lubetzki C, Bottlaender M, Turkheimer F, Stankoff B.

Ann Neurol. 2016 May;79(5):726-738. doi: 10.1002/ana.24620.

15.

Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT.

Gargiulo S, Anzilotti S, Coda AR, Gramanzini M, Greco A, Panico M, Vinciguerra A, Zannetti A, Vicidomini C, Dollé F, Pignataro G, Quarantelli M, Annunziato L, Brunetti A, Salvatore M, Pappatà S.

Eur J Nucl Med Mol Imaging. 2016 Jul;43(7):1348-59. doi: 10.1007/s00259-016-3311-y. Epub 2016 Jan 27.

PMID:
26816193
16.

Synthesis, radiolabeling with fluorine-18 and preliminary in vivo evaluation of a heparan sulphate mimetic as potent angiogenesis and heparanase inhibitor for cancer applications.

Kuhnast B, El Hadri A, Boisgard R, Hinnen F, Richard S, Caravano A, Nancy-Portebois V, Petitou M, Tavitian B, Dollé F.

Org Biomol Chem. 2016 Feb 14;14(6):1915-20. doi: 10.1039/c5ob02513c.

PMID:
26757783
17.

Cell Therapy for Parkinson's Disease: A Translational Approach to Assess the Role of Local and Systemic Immunosuppression.

Aron Badin R, Vadori M, Vanhove B, Nerriere-Daguin V, Naveilhan P, Neveu I, Jan C, Lévèque X, Venturi E, Mermillod P, Van Camp N, Dollé F, Guillermier M, Denaro L, Manara R, Citton V, Simioni P, Zampieri P, D'avella D, Rubello D, Fante F, Boldrin M, De Benedictis GM, Cavicchioli L, Sgarabotto D, Plebani M, Stefani AL, Brachet P, Blancho G, Soulillou JP, Hantraye P, Cozzi E.

Am J Transplant. 2016 Jul;16(7):2016-29. doi: 10.1111/ajt.13704. Epub 2016 Mar 3.

18.

Multimodal In Vivo Imaging of Tumorigenesis and Response to Chemotherapy in a Transgenic Mouse Model of Mammary Cancer.

Alberini JL, Boisgard R, Guillermet S, Siquier K, Jego B, Thézé B, Urien S, Rezaï K, Menet E, Maroy R, Dollé F, Kühnast B, Tavitian B.

Mol Imaging Biol. 2016 Aug;18(4):617-26. doi: 10.1007/s11307-015-0916-7.

19.

Imaging the Impact of the P-Glycoprotein (ABCB1) Function on the Brain Kinetics of Metoclopramide.

Pottier G, Marie S, Goutal S, Auvity S, Peyronneau MA, Stute S, Boisgard R, Dollé F, Buvat I, Caillé F, Tournier N.

J Nucl Med. 2016 Feb;57(2):309-14. doi: 10.2967/jnumed.115.164350. Epub 2015 Nov 19.

20.

Microbial Safety Assessment of a Double Check-Valve Patient Line in a Multiuse Contrast Delivery System.

Vermeulen C, Noury B, Dolle F, Rebergue H, Boisgard R.

Radiol Technol. 2015 Nov-Dec;87(2):139-49.

PMID:
26538217
21.

The neuronal component of gray matter damage in multiple sclerosis: A [(11) C]flumazenil positron emission tomography study.

Freeman L, Garcia-Lorenzo D, Bottin L, Leroy C, Louapre C, Bodini B, Papeix C, Assouad R, Granger B, Tourbah A, Dollé F, Lubetzki C, Bottlaender M, Stankoff B.

Ann Neurol. 2015 Oct;78(4):554-67. doi: 10.1002/ana.24468. Epub 2015 Aug 21.

PMID:
26292991
22.

Novel Pyrazolo[1,5-a]pyrimidines as Translocator Protein 18 kDa (TSPO) Ligands: Synthesis, in Vitro Biological Evaluation, [(18)F]-Labeling, and in Vivo Neuroinflammation PET Images.

Damont A, Médran-Navarrete V, Cacheux F, Kuhnast B, Pottier G, Bernards N, Marguet F, Puech F, Boisgard R, Dollé F.

J Med Chem. 2015 Sep 24;58(18):7449-64. doi: 10.1021/acs.jmedchem.5b00932. Epub 2015 Sep 3.

PMID:
26280386
23.

Synthesis and in vitro characterization of novel fluorinated derivatives of the TSPO 18 kDa ligand SSR180575.

Damont A, Marguet F, Puech F, Dollé F.

Eur J Med Chem. 2015 Aug 28;101:736-45. doi: 10.1016/j.ejmech.2015.07.033. Epub 2015 Jul 17.

PMID:
26218651
24.

Radiosynthesis, In Vivo Biological Evaluation, and Imaging of Brain Lesions with [123I]-CLINME, a New SPECT Tracer for the Translocator Protein.

Mattner F, Quinlivan M, Greguric I, Pham T, Liu X, Jackson T, Berghofer P, Fookes CJ, Dikic B, Gregoire MC, Dolle F, Katsifis A.

Dis Markers. 2015;2015:729698. doi: 10.1155/2015/729698. Epub 2015 Jun 25.

25.

Evaluation of PET Imaging Performance of the TSPO Radioligand [18F]DPA-714 in Mouse and Rat Models of Cancer and Inflammation.

Zheng J, Winkeler A, Peyronneau MA, Dollé F, Boisgard R.

Mol Imaging Biol. 2016 Feb;18(1):127-34. doi: 10.1007/s11307-015-0877-x.

26.

Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke.

Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz HJ, Faust A, Hermann S, Kopka K, Faber C, Dollé F, Pappata S, Planas AM, Tavitian B, Schäfers M, Sorokin LM, Kuhlmann MT, Jacobs AH.

J Cereb Blood Flow Metab. 2015 Nov;35(11):1711-21. doi: 10.1038/jcbfm.2015.149. Epub 2015 Jul 1.

27.

Differential influence of propofol and isoflurane anesthesia in a non-human primate on the brain kinetics and binding of [(18)F]DPA-714, a positron emission tomography imaging marker of glial activation.

Saba W, Goutal S, Kuhnast B, Dollé F, Auvity S, Fontyn Y, Cayla J, Peyronneau MA, Valette H, Tournier N.

Eur J Neurosci. 2015 Jul;42(1):1738-45. doi: 10.1111/ejn.12946. Epub 2015 Jun 22.

PMID:
25962575
28.

Synthesis, radiolabeling and preliminary in vivo evaluation of multimodal radiotracers for PET imaging and targeted radionuclide therapy of pigmented melanoma.

Billaud EM, Maisonial-Besset A, Rbah-Vidal L, Vidal A, Besse S, Béquignat JB, Decombat C, Degoul F, Audin L, Deloye JB, Dollé F, Kuhnast B, Madelmont JC, Tarrit S, Galmier MJ, Borel M, Auzeloux P, Miot-Noirault E, Chezal JM.

Eur J Med Chem. 2015 Mar 6;92:818-38. doi: 10.1016/j.ejmech.2015.01.034. Epub 2015 Jan 21.

PMID:
25637883
29.

Efficient tritiation of the translocator protein (18 kDa) selective ligand DPA-714.

Damont A, Garcia-Argote S, Buisson DA, Rousseau B, Dollé F.

J Labelled Comp Radiopharm. 2015 Jan;58(1):1-6. doi: 10.1002/jlcr.3252.

PMID:
25616229
30.

In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET.

Vicidomini C, Panico M, Greco A, Gargiulo S, Coda AR, Zannetti A, Gramanzini M, Roviello GN, Quarantelli M, Alfano B, Tavitian B, Dollé F, Salvatore M, Brunetti A, Pappatà S.

Nucl Med Biol. 2015 Mar;42(3):309-16. doi: 10.1016/j.nucmedbio.2014.11.009. Epub 2014 Dec 6.

PMID:
25537727
31.

[18F]DPA-714 PET imaging of translocator protein TSPO (18 kDa) in the normal and excitotoxically-lesioned nonhuman primate brain.

Lavisse S, Inoue K, Jan C, Peyronneau MA, Petit F, Goutal S, Dauguet J, Guillermier M, Dollé F, Rbah-Vidal L, Van Camp N, Aron-Badin R, Remy P, Hantraye P.

Eur J Nucl Med Mol Imaging. 2015 Mar;42(3):478-94. doi: 10.1007/s00259-014-2962-9. Epub 2014 Dec 9.

PMID:
25488184
32.

In vivo evaluation of inflammatory bowel disease with the aid of μPET and the translocator protein 18 kDa radioligand [18F]DPA-714.

Bernards N, Pottier G, Thézé B, Dollé F, Boisgard R.

Mol Imaging Biol. 2015 Feb;17(1):67-75.

33.

[18F]DPA-C5yne, a novel fluorine-18-labelled analogue of DPA-714: radiosynthesis and preliminary evaluation as a radiotracer for imaging neuroinflammation with PET.

Médran-Navarrete V, Bernards N, Kuhnast B, Damont A, Pottier G, Peyronneau MA, Kassiou M, Marguet F, Puech F, Boisgard R, Dollé F.

J Labelled Comp Radiopharm. 2014 May 30;57(6):410-8. doi: 10.1002/jlcr.3199. Epub 2014 Apr 24.

PMID:
24764161
34.

[¹⁸F]DPA-714 as a biomarker for positron emission tomography imaging of rheumatoid arthritis in an animal model.

Pottier G, Bernards N, Dollé F, Boisgard R.

Arthritis Res Ther. 2014 Mar 13;16(2):R69. doi: 10.1186/ar4508.

35.

Differential dopamine receptor occupancy underlies L-DOPA-induced dyskinesia in a rat model of Parkinson's disease.

Sahin G, Thompson LH, Lavisse S, Ozgur M, Rbah-Vidal L, Dollé F, Hantraye P, Kirik D.

PLoS One. 2014 Mar 10;9(3):e90759. doi: 10.1371/journal.pone.0090759. eCollection 2014.

36.

Preparation and evaluation of novel pyrazolo[1,5-a]pyrimidine acetamides, closely related to DPA-714, as potent ligands for imaging the TSPO 18kDa with PET.

Médran-Navarrete V, Damont A, Peyronneau MA, Kuhnast B, Bernards N, Pottier G, Marguet F, Puech F, Boisgard R, Dollé F.

Bioorg Med Chem Lett. 2014 Mar 15;24(6):1550-6. doi: 10.1016/j.bmcl.2014.01.080. Epub 2014 Feb 7.

PMID:
24560538
37.

Synthesis of novel halo and tosyloxy nortropane derivatives as efficient precursors for the one-step synthesis of the dopamine transporter PET ligand [(18)F]FECNT.

Pijarowska-Kruszyna J, Jaron AW, Kachniarz A, Kasprzak K, Kowalska A, Malkowski B, Demphel S, Dollé F, Mikolajczak R.

J Labelled Comp Radiopharm. 2014 Mar;57(3):148-57. doi: 10.1002/jlcr.3181. Epub 2014 Feb 5.

PMID:
24497079
38.

The potential of carbon-11 and fluorine-18 chemistry: illustration through the development of positron emission tomography radioligands targeting the translocator protein 18 kDa.

Damont A, Roeda D, Dollé F.

J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):96-104. doi: 10.1002/jlcr.2992. Review.

PMID:
24285315
39.

Carbon-11 and fluorine-18 chemistry devoted to molecular probes for imaging the brain with positron emission tomography.

Dollé F.

J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):65-7. doi: 10.1002/jlcr.3037.

PMID:
24285311
40.

The translocator protein radioligand 18F-DPA-714 monitors antitumor effect of erufosine in a rat 9L intracranial glioma model.

Awde AR, Boisgard R, Thézé B, Dubois A, Zheng J, Dollé F, Jacobs AH, Tavitian B, Winkeler A.

J Nucl Med. 2013 Dec;54(12):2125-31. doi: 10.2967/jnumed.112.118794. Epub 2013 Nov 8.

41.

[¹¹C]befloxatone brain kinetics is not influenced by Bcrp function at the blood-brain barrier: a PET study using Bcrp TGEM knockout rats.

Hosten B, Boisgard R, Jacob A, Goutal S, Saubaméa B, Dollé F, Scherrmann JM, Cisternino S, Tournier N.

Eur J Pharm Sci. 2013 Nov 20;50(3-4):520-5. doi: 10.1016/j.ejps.2013.08.015. Epub 2013 Aug 24.

PMID:
23981334
42.

Easy upgrade of the TRACERLab FX C Pro for [¹¹C]carboxylation reactions: application to the routine production of [1-¹¹C]acetate.

Le Helleix S, Dollé F, Kuhnast B.

Appl Radiat Isot. 2013 Dec;82:7-11. doi: 10.1016/j.apradiso.2013.06.020. Epub 2013 Jul 10.

PMID:
23941748
43.

Effects of selected OATP and/or ABC transporter inhibitors on the brain and whole-body distribution of glyburide.

Tournier N, Saba W, Cisternino S, Peyronneau MA, Damont A, Goutal S, Dubois A, Dollé F, Scherrmann JM, Valette H, Kuhnast B, Bottlaender M.

AAPS J. 2013 Oct;15(4):1082-90. doi: 10.1208/s12248-013-9514-2. Epub 2013 Aug 2.

44.

[(18)F]Fallypride: metabolism studies and quantification of the radiotracer and its radiometabolites in plasma using a simple and rapid solid-phase extraction method.

Peyronneau MA, Saba W, Goutal S, Kuhnast B, Dollé F, Bottlaender M, Valette H.

Nucl Med Biol. 2013 Oct;40(7):887-95. doi: 10.1016/j.nucmedbio.2013.06.003. Epub 2013 Jul 25.

PMID:
23891202
45.

Synthesis and characterization of an MRI Gd-based probe designed to target the translocator protein.

Cerutti E, Damont A, Dollé F, Baroni S, Aime S.

Magn Reson Chem. 2013 Feb;51(2):116-22. doi: 10.1002/mrc.3919. Epub 2013 Jan 10.

PMID:
23303709
46.

IRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primates.

Aron Badin R, Spinnewyn B, Gaillard MC, Jan C, Malgorn C, Van Camp N, Dollé F, Guillermier M, Boulet S, Bertrand A, Savasta M, Auguet M, Brouillet E, Chabrier PE, Hantraye P.

PLoS One. 2013;8(1):e52680. doi: 10.1371/journal.pone.0052680. Epub 2013 Jan 3.

47.

Metabolism and quantification of [(18)F]DPA-714, a new TSPO positron emission tomography radioligand.

Peyronneau MA, Saba W, Goutal S, Damont A, Dollé F, Kassiou M, Bottlaender M, Valette H.

Drug Metab Dispos. 2013 Jan;41(1):122-31. doi: 10.1124/dmd.112.046342. Epub 2012 Oct 12.

PMID:
23065531
48.

Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging.

Lavisse S, Guillermier M, Hérard AS, Petit F, Delahaye M, Van Camp N, Ben Haim L, Lebon V, Remy P, Dollé F, Delzescaux T, Bonvento G, Hantraye P, Escartin C.

J Neurosci. 2012 Aug 8;32(32):10809-18. doi: 10.1523/JNEUROSCI.1487-12.2012.

49.

Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [¹⁰F]ICF01006, a highly promising melanoma PET tracer.

Rbah-Vidal L, Vidal A, Besse S, Cachin F, Bonnet M, Audin L, Askienazy S, Dollé F, Degoul F, Miot-Noirault E, Moins N, Auzeloux P, Chezal JM.

Eur J Nucl Med Mol Imaging. 2012 Sep;39(9):1449-61. doi: 10.1007/s00259-012-2168-y. Epub 2012 Jun 16.

PMID:
22707183
50.

Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases.

Ching AS, Kuhnast B, Damont A, Roeda D, Tavitian B, Dollé F.

Insights Imaging. 2012 Feb;3(1):111-9. doi: 10.1007/s13244-011-0128-x. Epub 2011 Oct 16.

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