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Items: 42

1.

Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility.

Yeshaw WM, van der Zwaag M, Pinto F, Lahaye LL, Faber AI, Gómez-Sánchez R, Dolga AM, Poland C, Monaco AP, van IJzendoorn S, Grzeschik NA, Velayos-Baeza A, Sibon OC.

Elife. 2019 Feb 11;8. pii: e43561. doi: 10.7554/eLife.43561. [Epub ahead of print]

2.

The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function.

Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L, Decher N.

FASEB J. 2018 Jun 7:fj201800246R. doi: 10.1096/fj.201800246R. [Epub ahead of print]

PMID:
29879376
3.

SK channel activation is neuroprotective in conditions of enhanced ER-mitochondrial coupling.

Honrath B, Krabbendam IE, IJsebaart C, Pegoretti V, Bendridi N, Rieusset J, Schmidt M, Culmsee C, Dolga AM.

Cell Death Dis. 2018 May 22;9(6):593. doi: 10.1038/s41419-018-0590-1.

4.

ACO2 homozygous missense mutation associated with complicated hereditary spastic paraplegia.

Bouwkamp CG, Afawi Z, Fattal-Valevski A, Krabbendam IE, Rivetti S, Masalha R, Quadri M, Breedveld GJ, Mandel H, Tailakh MA, Beverloo HB, Stevanin G, Brice A, van IJcken WFJ, Vernooij MW, Dolga AM, de Vrij FMS, Bonifati V, Kushner SA.

Neurol Genet. 2018 Mar 21;4(2):e223. doi: 10.1212/NXG.0000000000000223. eCollection 2018 Apr.

5.

Calcium-activated SK potassium channels are key modulators of the pacemaker frequency in locus coeruleus neurons.

Matschke LA, Rinné S, Snutch TP, Oertel WH, Dolga AM, Decher N.

Mol Cell Neurosci. 2018 Apr;88:330-341. doi: 10.1016/j.mcn.2018.03.002. Epub 2018 Mar 8.

PMID:
29524627
6.

Glucose-regulated protein 75 determines ER-mitochondrial coupling and sensitivity to oxidative stress in neuronal cells.

Honrath B, Metz I, Bendridi N, Rieusset J, Culmsee C, Dolga AM.

Cell Death Discov. 2017 Nov 6;3:17076. doi: 10.1038/cddiscovery.2017.76. eCollection 2017.

7.

One protein, different cell fate: the differential outcome of depleting GRP75 during oxidative stress in neurons.

Honrath B, Culmsee C, Dolga AM.

Cell Death Dis. 2018 Jan 18;9(2):32. doi: 10.1038/s41419-017-0148-7. No abstract available.

8.

Mitochondrial Ca2+-activated K+ channels and their role in cell life and death pathways.

Krabbendam IE, Honrath B, Culmsee C, Dolga AM.

Cell Calcium. 2018 Jan;69:101-111. doi: 10.1016/j.ceca.2017.07.005. Epub 2017 Jul 22. Review.

PMID:
28818302
9.

Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core.

Lin HK, Boatz JC, Krabbendam IE, Kodali R, Hou Z, Wetzel R, Dolga AM, Poirier MA, van der Wel PCA.

Nat Commun. 2017 May 24;8:15462. doi: 10.1038/ncomms15462.

10.

Small conductance Ca2+-activated K+ channels in the plasma membrane, mitochondria and the ER: Pharmacology and implications in neuronal diseases.

Honrath B, Krabbendam IE, Culmsee C, Dolga AM.

Neurochem Int. 2017 Oct;109:13-23. doi: 10.1016/j.neuint.2017.05.005. Epub 2017 May 13. Review.

PMID:
28511953
11.

Lithium protects hippocampal progenitors, cognitive performance and hypothalamus-pituitary function after irradiation to the juvenile rat brain.

Zhou K, Xie C, Wickström M, Dolga AM, Zhang Y, Li T, Xu Y, Culmsee C, Kogner P, Zhu C, Blomgren K.

Oncotarget. 2017 May 23;8(21):34111-34127. doi: 10.18632/oncotarget.16292.

12.

BID links ferroptosis to mitochondrial cell death pathways.

Neitemeier S, Jelinek A, Laino V, Hoffmann L, Eisenbach I, Eying R, Ganjam GK, Dolga AM, Oppermann S, Culmsee C.

Redox Biol. 2017 Aug;12:558-570. doi: 10.1016/j.redox.2017.03.007. Epub 2017 Mar 9.

13.

SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake.

Honrath B, Matschke L, Meyer T, Magerhans L, Perocchi F, Ganjam GK, Zischka H, Krasel C, Gerding A, Bakker BM, Bünemann M, Strack S, Decher N, Culmsee C, Dolga AM.

Cell Death Differ. 2017 May;24(5):761-773. doi: 10.1038/cdd.2017.2. Epub 2017 Mar 10.

14.

Targeting pathogen metabolism without collateral damage to the host.

Haanstra JR, Gerding A, Dolga AM, Sorgdrager FJH, Buist-Homan M, du Toit F, Faber KN, Holzhütter HG, Szöör B, Matthews KR, Snoep JL, Westerhoff HV, Bakker BM.

Sci Rep. 2017 Jan 13;7:40406. doi: 10.1038/srep40406.

15.

Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis.

Neitemeier S, Dolga AM, Honrath B, Karuppagounder SS, Alim I, Ratan RR, Culmsee C.

Cell Death Dis. 2016 May 5;7:e2214. doi: 10.1038/cddis.2016.107.

16.

Activation of SK2 channels preserves ER Ca²⁺ homeostasis and protects against ER stress-induced cell death.

Richter M, Vidovic N, Honrath B, Mahavadi P, Dodel R, Dolga AM, Culmsee C.

Cell Death Differ. 2016 May;23(5):814-27. doi: 10.1038/cdd.2015.146. Epub 2015 Nov 20.

17.

Small-conductance Ca2+-activated potassium type 2 channels regulate the formation of contextual fear memory.

Murthy SR, Sherrin T, Jansen C, Nijholt I, Robles M, Dolga AM, Andreotti N, Sabatier JM, Knaus HG, Penner R, Todorovic C, Blank T.

PLoS One. 2015 May 4;10(5):e0127264. doi: 10.1371/journal.pone.0127264. eCollection 2015.

18.

The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells.

Dong F, Eibach M, Bartsch JW, Dolga AM, Schlomann U, Conrad C, Schieber S, Schilling O, Biniossek ML, Culmsee C, Strik H, Koller G, Carl B, Nimsky C.

Neuro Oncol. 2015 Nov;17(11):1474-85. doi: 10.1093/neuonc/nov042. Epub 2015 Mar 29.

19.

SK channel activation modulates mitochondrial respiration and attenuates neuronal HT-22 cell damage induced by H2O2.

Richter M, Nickel C, Apel L, Kaas A, Dodel R, Culmsee C, Dolga AM.

Neurochem Int. 2015 Feb;81:63-75. doi: 10.1016/j.neuint.2014.12.007. Epub 2015 Jan 6.

PMID:
25576183
20.

α1-antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-β-induced toxicity.

Gold M, Dolga AM, Koepke J, Mengel D, Culmsee C, Dodel R, Koczulla AR, Bach JP.

J Neuroinflammation. 2014 Sep 23;11:165. doi: 10.1186/s12974-014-0165-8.

21.

The serine protease inhibitor TLCK attenuates intrinsic death pathways in neurons upstream of mitochondrial demise.

Reuther C, Ganjam GK, Dolga AM, Culmsee C.

Apoptosis. 2014 Nov;19(11):1545-58. doi: 10.1007/s10495-014-1027-7.

PMID:
25146045
22.

RNA editing in the central cavity as a mechanism to regulate surface expression of the voltage-gated potassium channel Kv1.1.

Streit AK, Matschke LA, Dolga AM, Rinné S, Decher N.

J Biol Chem. 2014 Sep 26;289(39):26762-71. doi: 10.1074/jbc.M113.545731. Epub 2014 Aug 6.

23.

Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity.

Oppermann S, Schrader FC, Elsässer K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C.

J Pharmacol Exp Ther. 2014 Aug;350(2):273-89. doi: 10.1124/jpet.114.213777. Epub 2014 May 21.

PMID:
24849923
24.

Regulators of mitochondrial Ca(2+) homeostasis in cerebral ischemia.

Schäfer MK, Pfeiffer A, Jaeckel M, Pouya A, Dolga AM, Methner A.

Cell Tissue Res. 2014 Aug;357(2):395-405. doi: 10.1007/s00441-014-1807-y. Epub 2014 Apr 9. Review.

PMID:
24715113
25.

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons.

Dolga AM, de Andrade A, Meissner L, Knaus HG, Höllerhage M, Christophersen P, Zischka H, Plesnila N, Höglinger GU, Culmsee C.

Cell Death Dis. 2014 Jan 16;5:e999. doi: 10.1038/cddis.2013.530.

26.

Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress.

Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C.

Cell Death Dis. 2014 Jan 16;5:e993. doi: 10.1038/cddis.2013.518.

27.

Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction.

Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C.

J Biol Chem. 2013 Apr 12;288(15):10792-804. doi: 10.1074/jbc.M113.453522. Epub 2013 Feb 19.

28.

Protective Roles for Potassium SK/K(Ca)2 Channels in Microglia and Neurons.

Dolga AM, Culmsee C.

Front Pharmacol. 2012 Nov 26;3:196. doi: 10.3389/fphar.2012.00196. eCollection 2012.

29.

Activation of KCNN3/SK3/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia.

Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C.

Glia. 2012 Dec;60(12):2050-64. doi: 10.1002/glia.22419. Epub 2012 Sep 21.

30.

Impedance measurement for real time detection of neuronal cell death.

Diemert S, Dolga AM, Tobaben S, Grohm J, Pfeifer S, Oexler E, Culmsee C.

J Neurosci Methods. 2012 Jan 15;203(1):69-77. doi: 10.1016/j.jneumeth.2011.09.012. Epub 2011 Sep 22.

PMID:
21963366
31.

KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.

Dolga AM, Terpolilli N, Kepura F, Nijholt IM, Knaus HG, D'Orsi B, Prehn JH, Eisel UL, Plant T, Plesnila N, Culmsee C.

Cell Death Dis. 2011 Apr 21;2:e147. doi: 10.1038/cddis.2011.30.

32.

Statins--increasing or reducing the risk of Parkinson's disease?

Dolga AM, Culmsee C, de Lau L, Winter Y, Oertel WH, Luiten PG, Eisel UL.

Exp Neurol. 2011 Mar;228(1):1-4. doi: 10.1016/j.expneurol.2010.11.013. Epub 2010 Nov 24. Review. No abstract available.

PMID:
21111736
33.

KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation.

Alves MM, Burzynski G, Delalande JM, Osinga J, van der Goot A, Dolga AM, de Graaff E, Brooks AS, Metzger M, Eisel UL, Shepherd I, Eggen BJ, Hofstra RM.

Hum Mol Genet. 2010 Sep 15;19(18):3642-51. doi: 10.1093/hmg/ddq280. Epub 2010 Jul 9.

PMID:
20621975
34.

Statins: mechanisms of neuroprotection.

van der Most PJ, Dolga AM, Nijholt IM, Luiten PG, Eisel UL.

Prog Neurobiol. 2009 May;88(1):64-75. doi: 10.1016/j.pneurobio.2009.02.002. Epub 2009 Feb 21. Review.

PMID:
19428962
35.

Inflammation and NF-kappaB in Alzheimer's disease and diabetes.

Granic I, Dolga AM, Nijholt IM, van Dijk G, Eisel UL.

J Alzheimers Dis. 2009;16(4):809-21. doi: 10.3233/JAD-2009-0976. Review.

PMID:
19387114
36.

Pretreatment with lovastatin prevents N-methyl-D-aspartate-induced neurodegeneration in the magnocellular nucleus basalis and behavioral dysfunction.

Dolga AM, Granic I, Nijholt IM, Nyakas C, van der Zee EA, Luiten PG, Eisel UL.

J Alzheimers Dis. 2009;17(2):327-36. doi: 10.3233/JAD-2009-1052.

PMID:
19363269
37.

TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels.

Dolga AM, Granic I, Blank T, Knaus HG, Spiess J, Luiten PG, Eisel UL, Nijholt IM.

J Neurochem. 2008 Nov;107(4):1158-67. doi: 10.1111/j.1471-4159.2008.05701.x. Epub 2008 Sep 24.

38.

Identification and characterization of a novel, shorter isoform of the small conductance Ca2+ -activated K+ channel SK2.

Murthy SR, Teodorescu G, Nijholt IM, Dolga AM, Grissmer S, Spiess J, Blank T.

J Neurochem. 2008 Sep;106(6):2312-21. doi: 10.1111/j.1471-4159.2008.05557.x. Epub 2008 Jul 9.

39.

Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation.

Nijholt IM, Dolga AM, Ostroveanu A, Luiten PG, Schmidt M, Eisel UL.

Cell Signal. 2008 Oct;20(10):1715-24. doi: 10.1016/j.cellsig.2008.05.001. Epub 2008 May 16.

PMID:
18565730
40.

Lovastatin induces neuroprotection through tumor necrosis factor receptor 2 signaling pathways.

Dolga AM, Nijholt IM, Ostroveanu A, Ten Bosch Q, Luiten PG, Eisel UL.

J Alzheimers Dis. 2008 Mar;13(2):111-22.

PMID:
18376053
41.

Interleukin-6 upregulates neuronal adenosine A1 receptors: implications for neuromodulation and neuroprotection.

Biber K, Pinto-Duarte A, Wittendorp MC, Dolga AM, Fernandes CC, Von Frijtag Drabbe Künzel J, Keijser JN, de Vries R, Ijzerman AP, Ribeiro JA, Eisel U, Sebastião AM, Boddeke HW.

Neuropsychopharmacology. 2008 Aug;33(9):2237-50. Epub 2007 Nov 7. Erratum in: Neuropsychopharmacology. 2008 Oct;33(11):2789.

42.

A-kinase anchoring protein 150 in the mouse brain is concentrated in areas involved in learning and memory.

Ostroveanu A, Van der Zee EA, Dolga AM, Luiten PG, Eisel UL, Nijholt IM.

Brain Res. 2007 May 11;1145:97-107. Epub 2007 Feb 2.

PMID:
17321504

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