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Items: 1 to 50 of 86

1.

The Essentiality Status of Mouse Duplicate Gene Pairs Correlates with Developmental Co-Expression Patterns.

Kabir M, Wenlock S, Doig AJ, Hentges KE.

Sci Rep. 2019 Mar 1;9(1):3224. doi: 10.1038/s41598-019-39894-9.

2.

Identifying mouse developmental essential genes using machine learning.

Tian D, Wenlock S, Kabir M, Tzotzos G, Doig AJ, Hentges KE.

Dis Model Mech. 2018 Dec 13;11(12). pii: dmm034546. doi: 10.1242/dmm.034546.

3.

Effect of IAPP on the proteome of cultured Rin-5F cells.

Miraee-Nedjad S, Sims PFG, Schwartz JM, Doig AJ.

BMC Biochem. 2018 Nov 12;19(1):9. doi: 10.1186/s12858-018-0099-3.

4.

Positive Feedback Loops in Alzheimer's Disease: The Alzheimer's Feedback Hypothesis.

Doig AJ.

J Alzheimers Dis. 2018;66(1):25-36. doi: 10.3233/JAD-180583.

5.

Amyloid-β/Drug Interactions from Computer Simulations and Cell-Based Assays.

Nguyen PH, Del Castillo-Frias MP, Berthoumieux O, Faller P, Doig AJ, Derreumaux P.

J Alzheimers Dis. 2018;64(s1):S659-S672. doi: 10.3233/JAD-179902.

PMID:
29562512
6.

Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer's Disease?

Doig AJ, Del Castillo-Frias MP, Berthoumieu O, Tarus B, Nasica-Labouze J, Sterpone F, Nguyen PH, Hooper NM, Faller P, Derreumaux P.

ACS Chem Neurosci. 2017 Jul 19;8(7):1435-1437. doi: 10.1021/acschemneuro.7b00188. Epub 2017 Jun 6.

PMID:
28586203
7.

Properties of genes essential for mouse development.

Kabir M, Barradas A, Tzotzos GT, Hentges KE, Doig AJ.

PLoS One. 2017 May 31;12(5):e0178273. doi: 10.1371/journal.pone.0178273. eCollection 2017.

8.

Frozen, but no accident - why the 20 standard amino acids were selected.

Doig AJ.

FEBS J. 2017 May;284(9):1296-1305. doi: 10.1111/febs.13982. Epub 2017 Jan 13. Review.

9.

Secondary Structure and Glycosylation of Mucus Glycoproteins by Raman Spectroscopies.

Davies HS, Singh P, Deckert-Gaudig T, Deckert V, Rousseau K, Ridley CE, Dowd SE, Doig AJ, Pudney PD, Thornton DJ, Blanch EW.

Anal Chem. 2016 Dec 6;88(23):11609-11615. Epub 2016 Nov 11.

10.

Determination of Protein Secondary Structure from Infrared Spectra Using Partial Least-Squares Regression.

Wilcox KE, Blanch EW, Doig AJ.

Biochemistry. 2016 Jul 12;55(27):3794-802. doi: 10.1021/acs.biochem.6b00403. Epub 2016 Jun 29.

PMID:
27322779
11.

Combined experimental and simulation studies suggest a revised mode of action of the anti-Alzheimer disease drug NQ-Trp.

Berthoumieu O, Nguyen PH, Castillo-Frias MP, Ferre S, Tarus B, Nasica-Labouze J, Noël S, Saurel O, Rampon C, Doig AJ, Derreumaux P, Faller P.

Chemistry. 2015 Sep 1;21(36):12657-66. doi: 10.1002/chem.201500888. Epub 2015 Jul 14.

PMID:
26179053
12.

Properties of protein drug target classes.

Bull SC, Doig AJ.

PLoS One. 2015 Mar 30;10(3):e0117955. doi: 10.1371/journal.pone.0117955. eCollection 2015.

13.

Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.

Nasica-Labouze J, Nguyen PH, Sterpone F, Berthoumieu O, Buchete NV, Coté S, De Simone A, Doig AJ, Faller P, Garcia A, Laio A, Li MS, Melchionna S, Mousseau N, Mu Y, Paravastu A, Pasquali S, Rosenman DJ, Strodel B, Tarus B, Viles JH, Zhang T, Wang C, Derreumaux P.

Chem Rev. 2015 May 13;115(9):3518-63. doi: 10.1021/cr500638n. Epub 2015 Mar 19. Review. No abstract available.

14.

Inhibition of protein aggregation and amyloid formation by small molecules.

Doig AJ, Derreumaux P.

Curr Opin Struct Biol. 2015 Feb;30:50-56. doi: 10.1016/j.sbi.2014.12.004. Epub 2015 Jan 2. Review.

PMID:
25559306
15.

Molecular structure of the NQTrp inhibitor with the Alzheimer Aβ1-28 monomer.

Tarus B, Nguyen PH, Berthoumieu O, Faller P, Doig AJ, Derreumaux P.

Eur J Med Chem. 2015 Feb 16;91:43-50. doi: 10.1016/j.ejmech.2014.07.002. Epub 2014 Jul 1.

PMID:
25011560
16.

Maximising the size of non-redundant protein datasets using graph theory.

Bull SC, Muldoon MR, Doig AJ.

PLoS One. 2013;8(2):e55484. doi: 10.1371/journal.pone.0055484. Epub 2013 Feb 5.

17.

The N-methylated peptide SEN304 powerfully inhibits Aβ(1-42) toxicity by perturbing oligomer formation.

Amijee H, Bate C, Williams A, Virdee J, Jeggo R, Spanswick D, Scopes DI, Treherne JM, Mazzitelli S, Chawner R, Eyers CE, Doig AJ.

Biochemistry. 2012 Oct 23;51(42):8338-52. doi: 10.1021/bi300415v. Epub 2012 Oct 12.

PMID:
23025847
18.

Random-coil:α-helix equilibria as a reporter for the Lewis(X)-Lewis(X) interaction.

Altamore TM, Fernández-García C, Gordon AH, Hübscher T, Promsawan N, Ryadnov MG, Doig AJ, Woolfson DN, Gallagher T.

Angew Chem Int Ed Engl. 2011 Nov 18;50(47):11167-71. doi: 10.1002/anie.201101055. Epub 2011 Sep 9. No abstract available.

PMID:
21910188
19.

Determination of protein fold class from Raman or Raman optical activity spectra using random forests.

Kinalwa M, Blanch EW, Doig AJ.

Protein Sci. 2011 Oct;20(10):1668-74. doi: 10.1002/pro.695. Epub 2011 Aug 18.

20.

Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E.

Tait S, Dutta K, Cowburn D, Warwicker J, Doig AJ, McCarthy JE.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17627-32. doi: 10.1073/pnas.1008242107. Epub 2010 Sep 28.

21.

Accurate determination of protein secondary structure content from Raman and Raman optical activity spectra.

Kinalwa MN, Blanch EW, Doig AJ.

Anal Chem. 2010 Aug 1;82(15):6347-9. doi: 10.1021/ac101334h.

PMID:
20669990
22.

Properties and identification of antibiotic drug targets.

Bakheet TM, Doig AJ.

BMC Bioinformatics. 2010 Apr 20;11:195. doi: 10.1186/1471-2105-11-195.

23.

Amyloidogenic sequences in native protein structures.

Tzotzos S, Doig AJ.

Protein Sci. 2010 Feb;19(2):327-48. doi: 10.1002/pro.314.

24.

SitesIdentify: a protein functional site prediction tool.

Bray T, Chan P, Bougouffa S, Greaves R, Doig AJ, Warwicker J.

BMC Bioinformatics. 2009 Nov 18;10:379. doi: 10.1186/1471-2105-10-379.

25.

Inhibitors of protein aggregation and toxicity.

Amijee H, Madine J, Middleton DA, Doig AJ.

Biochem Soc Trans. 2009 Aug;37(Pt 4):692-6. doi: 10.1042/BST0370692. Review.

PMID:
19614577
26.

Stability and design of alpha-helical peptides.

Doig AJ.

Prog Mol Biol Transl Sci. 2008;83:1-52. doi: 10.1016/S0079-6603(08)00601-6. Review. No abstract available.

PMID:
19186251
27.

Properties and identification of human protein drug targets.

Bakheet TM, Doig AJ.

Bioinformatics. 2009 Feb 15;25(4):451-7. doi: 10.1093/bioinformatics/btp002. Epub 2009 Jan 21.

PMID:
19164304
28.

Sequence and structural features of enzymes and their active sites by EC class.

Bray T, Doig AJ, Warwicker J.

J Mol Biol. 2009 Mar 13;386(5):1423-36. doi: 10.1016/j.jmb.2008.11.057. Epub 2008 Dec 10.

PMID:
19100748
29.
30.

The effects of alpha-synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy.

Madine J, Hughes E, Doig AJ, Middleton DA.

Mol Membr Biol. 2008 Sep;25(6-7):518-27. doi: 10.1080/09687680802467977.

PMID:
18949627
31.

Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR.

Madine J, Doig AJ, Middleton DA.

J Am Chem Soc. 2008 Jun 25;130(25):7873-81. doi: 10.1021/ja075356q. Epub 2008 May 30.

32.

Peptide inhibitors of beta-amyloid aggregation.

Doig AJ.

Curr Opin Drug Discov Devel. 2007 Sep;10(5):533-9. Review.

PMID:
17786851
33.

Inhibitors of amyloid aggregation: technologies for the discovery of novel lead compounds.

Doig AJ, Stott K, Treherne JM.

Biotechnol Genet Eng Rev. 2004;21:197-212. Review. No abstract available.

PMID:
17017033
34.

Structure and stability of the alpha-helix: lessons for design.

Errington N, Iqbalsyah T, Doig AJ.

Methods Mol Biol. 2006;340:3-26.

PMID:
16957330
35.

N-Methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structure.

Kokkoni N, Stott K, Amijee H, Mason JM, Doig AJ.

Biochemistry. 2006 Aug 15;45(32):9906-18.

PMID:
16893191
36.

The CXXC motif at the N terminus of an alpha-helical peptide.

Iqbalsyah TM, Moutevelis E, Warwicker J, Errington N, Doig AJ.

Protein Sci. 2006 Aug;15(8):1945-50.

37.

A study of the regional effects of alpha-synuclein on the organization and stability of phospholipid bilayers.

Madine J, Doig AJ, Middleton DA.

Biochemistry. 2006 May 9;45(18):5783-92.

PMID:
16669622
38.

Studies of the aggregation of an amyloidogenic alpha-synuclein peptide fragment.

Madine J, Doig AJ, Kitmitto A, Middleton DA.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1113-5.

PMID:
16246058
39.
40.

A simple approach to normalization for spectroscopic data mining.

Dobson PD, Doig AJ, Blanch EW.

Appl Spectrosc. 2005 Apr;59(4):542-4. No abstract available.

PMID:
15901341
41.
42.
43.

Predicting enzyme class from protein structure without alignments.

Dobson PD, Doig AJ.

J Mol Biol. 2005 Jan 7;345(1):187-99.

PMID:
15567421
44.

The aggregation and membrane-binding properties of an alpha-synuclein peptide fragment.

Madine J, Doig AJ, Middleton DA.

Biochem Soc Trans. 2004 Dec;32(Pt 6):1127-9.

PMID:
15506987
45.

Improved prediction for N-termini of alpha-helices using empirical information.

Wilson CL, Boardman PE, Doig AJ, Hubbard SJ.

Proteins. 2004 Nov 1;57(2):322-30.

PMID:
15340919
46.

Prediction of protein function in the absence of significant sequence similarity.

Dobson PD, Cai YD, Stapley BJ, Doig AJ.

Curr Med Chem. 2004 Aug;11(16):2135-42. Review.

PMID:
15279553
47.

Length preferences and periodicity in beta-strands. Antiparallel edge beta-sheets are more likely to finish in non-hydrogen bonded rings.

Penel S, Morrison RG, Dobson PD, Mortishire-Smith RJ, Doig AJ.

Protein Eng. 2003 Dec;16(12):957-61.

PMID:
14983075
48.

Prediction of Saccharomyces cerevisiae protein functional class from functional domain composition.

Cai YD, Doig AJ.

Bioinformatics. 2004 May 22;20(8):1292-300. Epub 2004 Feb 19.

PMID:
14976029
49.

Cellular kinetics of murine lung: model system to determine basis for radioprotection with keratinocyte growth factor.

Terry NH, Brinkley J, Doig AJ, Ma J, Patel N, White RA, Mahajan N, Kang Y.

Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):435-44.

PMID:
14751513
50.

Effect of the N3 residue on the stability of the alpha-helix.

Iqbalsyah TM, Doig AJ.

Protein Sci. 2004 Jan;13(1):32-9.

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