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Quantitative analysis of the yeast pheromone pathway.

Shellhammer JP, Pomeroy AE, Li Y, Dujmusic L, Elston TC, Hao N, Dohlman HG.

Yeast. 2019 Apr 25. doi: 10.1002/yea.3395. [Epub ahead of print]


Coordinated regulation of intracellular pH by two glucose-sensing pathways in yeast.

Isom DG, Page SC, Collins LB, Kapolka NJ, Taghon GJ, Dohlman HG.

J Biol Chem. 2018 Feb 16;293(7):2318-2329. doi: 10.1074/jbc.RA117.000422. Epub 2017 Dec 28.


Amino acid metabolites that regulate G protein signaling during osmotic stress.

Shellhammer JP, Morin-Kensicki E, Matson JP, Yin G, Isom DG, Campbell SL, Mohney RP, Dohlman HG.

PLoS Genet. 2017 May 30;13(5):e1006829. doi: 10.1371/journal.pgen.1006829. eCollection 2017 May.


Thematic Minireview Series: Complexities of Cellular Signaling Revealed by Simple Model Organisms.

Dohlman HG.

J Biol Chem. 2016 Apr 8;291(15):7786-7. doi: 10.1074/jbc.R116.722934. Epub 2016 Feb 23.


Regulation of Ras Paralog Thermostability by Networks of Buried Ionizable Groups.

Isom DG, Sridharan V, Dohlman HG.

Biochemistry. 2016 Jan 26;55(3):534-42. doi: 10.1021/acs.biochem.5b00901. Epub 2016 Jan 6.


The experimental power of FR900359 to study Gq-regulated biological processes.

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E.

Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156.


Modulation of receptor dynamics by the regulator of G protein signaling Sst2.

Venkatapurapu SP, Kelley JB, Dixit G, Pena M, Errede B, Dohlman HG, Elston TC.

Mol Biol Cell. 2015 Nov 5;26(22):4124-34. doi: 10.1091/mbc.E14-12-1635. Epub 2015 Aug 26.


Signal inhibition by a dynamically regulated pool of monophosphorylated MAPK.

Nagiec MJ, McCarter PC, Kelley JB, Dixit G, Elston TC, Dohlman HG.

Mol Biol Cell. 2015 Sep 15;26(18):3359-71. doi: 10.1091/mbc.E15-01-0037. Epub 2015 Jul 15.


Thematic Minireview Series: New Directions in G Protein-coupled Receptor Pharmacology.

Dohlman HG.

J Biol Chem. 2015 Aug 7;290(32):19469-70. doi: 10.1074/jbc.R115.675728. Epub 2015 Jun 30. Review.


Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation.

Isom DG, Dohlman HG.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5702-7. doi: 10.1073/pnas.1417888112. Epub 2015 Apr 20.


Thematic minireview series: cell biology of G protein signaling.

Dohlman HG.

J Biol Chem. 2015 Mar 13;290(11):6679-80. doi: 10.1074/jbc.R114.631093. Epub 2015 Jan 20.


RGS proteins and septins cooperate to promote chemotropism by regulating polar cap mobility.

Kelley JB, Dixit G, Sheetz JB, Venkatapurapu SP, Elston TC, Dohlman HG.

Curr Biol. 2015 Feb 2;25(3):275-285. doi: 10.1016/j.cub.2014.11.047. Epub 2015 Jan 15.


MAPK feedback encodes a switch and timer for tunable stress adaptation in yeast.

English JG, Shellhammer JP, Malahe M, McCarter PC, Elston TC, Dohlman HG.

Sci Signal. 2015 Jan 13;8(359):ra5. doi: 10.1126/scisignal.2005774.


Cellular noise suppression by the regulator of G protein signaling Sst2.

Dixit G, Kelley JB, Houser JR, Elston TC, Dohlman HG.

Mol Cell. 2014 Jul 3;55(1):85-96. doi: 10.1016/j.molcel.2014.05.019. Epub 2014 Jun 19.


Guanine nucleotide-binding protein (Gα) endocytosis by a cascade of ubiquitin binding domain proteins is required for sustained morphogenesis and proper mating in yeast.

Dixit G, Baker R, Sacks CM, Torres MP, Dohlman HG.

J Biol Chem. 2014 May 23;289(21):15052-63. doi: 10.1074/jbc.M114.566117. Epub 2014 Apr 10.


Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination.

Baker R, Wilkerson EM, Sumita K, Isom DG, Sasaki AT, Dohlman HG, Campbell SL.

J Biol Chem. 2013 Dec 27;288(52):36856-62. doi: 10.1074/jbc.C113.525691. Epub 2013 Nov 18.


Regulation of yeast G protein signaling by the kinases that activate the AMPK homolog Snf1.

Clement ST, Dixit G, Dohlman HG.

Sci Signal. 2013 Sep 3;6(291):ra78. doi: 10.1126/scisignal.2004143.


Protons as second messenger regulators of G protein signaling.

Isom DG, Sridharan V, Baker R, Clement ST, Smalley DM, Dohlman HG.

Mol Cell. 2013 Aug 22;51(4):531-8. doi: 10.1016/j.molcel.2013.07.012. Epub 2013 Aug 15.


Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.

Hurst JH, Dohlman HG.

J Biol Chem. 2013 Jun 28;288(26):18660-71. doi: 10.1074/jbc.M113.475707. Epub 2013 May 3.


Proper protein glycosylation promotes mitogen-activated protein kinase signal fidelity.

Lien EC, Nagiec MJ, Dohlman HG.

Biochemistry. 2013 Jan 8;52(1):115-24. doi: 10.1021/bi3009483. Epub 2012 Dec 20.


Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.

Baker R, Lewis SM, Sasaki AT, Wilkerson EM, Locasale JW, Cantley LC, Kuhlman B, Dohlman HG, Campbell SL.

Nat Struct Mol Biol. 2013 Jan;20(1):46-52. doi: 10.1038/nsmb.2430. Epub 2012 Nov 25.


The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae.

Fernandez-Piñar P, Alemán A, Sondek J, Dohlman HG, Molina M, Martín H.

Mol Biol Cell. 2012 Nov;23(22):4430-43. doi: 10.1091/mbc.E12-03-0243. Epub 2012 Sep 26.


Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity.

Hao N, Yildirim N, Nagiec MJ, Parnell SC, Errede B, Dohlman HG, Elston TC.

Mol Biol Cell. 2012 Oct;23(19):3899-910. doi: 10.1091/mbc.E12-04-0333. Epub 2012 Aug 8.


Signal activation and inactivation by the Gα helical domain: a long-neglected partner in G protein signaling.

Dohlman HG, Jones JC.

Sci Signal. 2012 May 29;5(226):re2. doi: 10.1126/scisignal.2003013. Review.


PhDs: Acquired skills good for marketplace.

Dohlman HG.

Nature. 2012 May 2;485(7396):41. doi: 10.1038/485041b. No abstract available.


Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar Gα proteins.

Jones JC, Jones AM, Temple BR, Dohlman HG.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7275-9. doi: 10.1073/pnas.1202943109. Epub 2012 Apr 23.


Checkpoints in a yeast differentiation pathway coordinate signaling during hyperosmotic stress.

Nagiec MJ, Dohlman HG.

PLoS Genet. 2012 Jan;8(1):e1002437. doi: 10.1371/journal.pgen.1002437. Epub 2012 Jan 5.


Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis.

Cronan MR, Nakamura K, Johnson NL, Granger DA, Cuevas BD, Wang JG, Mackman N, Scott JE, Dohlman HG, Johnson GL.

Oncogene. 2012 Aug 23;31(34):3889-900. doi: 10.1038/onc.2011.544. Epub 2011 Dec 5.


Yeast dynamically modify their environment to achieve better mating efficiency.

Jin M, Errede B, Behar M, Mather W, Nayak S, Hasty J, Dohlman HG, Elston TC.

Sci Signal. 2011 Aug 16;4(186):ra54. doi: 10.1126/scisignal.2001763.


Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast.

Zhu M, Torres MP, Kelley JB, Dohlman HG, Wang Y.

J Biol Chem. 2011 Aug 5;286(31):27147-55. doi: 10.1074/jbc.M111.254193. Epub 2011 Jun 17.


Cell cycle-dependent phosphorylation and ubiquitination of a G protein alpha subunit.

Torres MP, Clement ST, Cappell SD, Dohlman HG.

J Biol Chem. 2011 Jun 10;286(23):20208-16. doi: 10.1074/jbc.M111.239343. Epub 2011 Apr 26.


Selective regulation of MAP kinase signaling by an endomembrane phosphatidylinositol 4-kinase.

Cappell SD, Dohlman HG.

J Biol Chem. 2011 Apr 29;286(17):14852-60. doi: 10.1074/jbc.M110.195073. Epub 2011 Mar 9.


Functional reconstitution of an atypical G protein heterotrimer and regulator of G protein signaling protein (RGS1) from Arabidopsis thaliana.

Jones JC, Temple BR, Jones AM, Dohlman HG.

J Biol Chem. 2011 Apr 15;286(15):13143-50. doi: 10.1074/jbc.M110.190355. Epub 2011 Feb 16.


The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation.

Jones JC, Duffy JW, Machius M, Temple BR, Dohlman HG, Jones AM.

Sci Signal. 2011 Feb 8;4(159):ra8. doi: 10.1126/scisignal.2001446.


Structures of Get3, Get4, and Get5 provide new models for TA membrane protein targeting.

Simpson PJ, Schwappach B, Dohlman HG, Isaacson RL.

Structure. 2010 Aug 11;18(8):897-902. doi: 10.1016/j.str.2010.07.003. Review.


Systematic analysis of essential genes reveals important regulators of G protein signaling.

Cappell SD, Baker R, Skowyra D, Dohlman HG.

Mol Cell. 2010 Jun 11;38(5):746-57. doi: 10.1016/j.molcel.2010.05.026.


Structure and function of Vps15 in the endosomal G protein signaling pathway.

Heenan EJ, Vanhooke JL, Temple BR, Betts L, Sondek JE, Dohlman HG.

Biochemistry. 2009 Jul 14;48(27):6390-401. doi: 10.1021/bi900621w.


G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase.

Torres MP, Lee MJ, Ding F, Purbeck C, Kuhlman B, Dokholyan NV, Dohlman HG.

J Biol Chem. 2009 Mar 27;284(13):8940-50. doi: 10.1074/jbc.M809058200. Epub 2009 Jan 27.


RGS proteins the early days.

Dohlman HG.

Prog Mol Biol Transl Sci. 2009;86:1-14. doi: 10.1016/S1877-1173(09)86001-8. Epub 2009 Oct 7.


A scaffold makes the switch.

Dohlman HG.

Sci Signal. 2008 Oct 21;1(42):pe46. doi: 10.1126/scisignal.142pe46. Review.


Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50.

Hao N, Zeng Y, Elston TC, Dohlman HG.

J Biol Chem. 2008 Dec 5;283(49):33798-802. doi: 10.1074/jbc.C800179200. Epub 2008 Oct 14.


Dose-to-duration encoding and signaling beyond saturation in intracellular signaling networks.

Behar M, Hao N, Dohlman HG, Elston TC.

PLoS Comput Biol. 2008 Oct;4(10):e1000197. doi: 10.1371/journal.pcbi.1000197. Epub 2008 Oct 10.


Similarities between UDP-glucose and adenine nucleotide release in yeast: involvement of the secretory pathway.

Esther CR Jr, Sesma JI, Dohlman HG, Ault AD, Clas ML, Lazarowski ER, Boucher RC.

Biochemistry. 2008 Sep 2;47(35):9269-78. doi: 10.1021/bi800855k. Epub 2008 Aug 12. Erratum in: Biochemistry. 2008 Nov 4;47(44):11693. Sesma, Juliana I [added].


Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5.

Hao N, Nayak S, Behar M, Shanks RH, Nagiec MJ, Errede B, Hasty J, Elston TC, Dohlman HG.

Mol Cell. 2008 Jun 6;30(5):649-56. doi: 10.1016/j.molcel.2008.04.016.


Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor.

Lee MJ, Dohlman HG.

Curr Biol. 2008 Feb 12;18(3):211-5. doi: 10.1016/j.cub.2008.01.007.


Kinetic insulation as an effective mechanism for achieving pathway specificity in intracellular signaling networks.

Behar M, Dohlman HG, Elston TC.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16146-51. Epub 2007 Oct 3.


Illuminating Gbeta5 signaling.

Zeller CE, Dohlman HG.

Mol Pharmacol. 2007 Oct;72(4):810-1. Epub 2007 Jul 16.


The RACK1 ortholog Asc1 functions as a G-protein beta subunit coupled to glucose responsiveness in yeast.

Zeller CE, Parnell SC, Dohlman HG.

J Biol Chem. 2007 Aug 24;282(34):25168-76. Epub 2007 Jun 25.


Mathematical and computational analysis of adaptation via feedback inhibition in signal transduction pathways.

Behar M, Hao N, Dohlman HG, Elston TC.

Biophys J. 2007 Aug 1;93(3):806-21. Epub 2007 May 18.


Systems biology analysis of G protein and MAP kinase signaling in yeast.

Hao N, Behar M, Elston TC, Dohlman HG.

Oncogene. 2007 May 14;26(22):3254-66. Review.


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