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Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations.

Bekken GK, Ritz C, Selvam S, Jesuraj N, Hesseling AC, Doherty TM, Grewal HMS, Vaz M, Jenum S.

BMC Infect Dis. 2020 Jan 31;20(1):96. doi: 10.1186/s12879-020-4800-y.


Precision Medicine and Vaccination of Older Adults: From Reactive to Proactive (A Mini-Review).

Doherty TM, Di Pasquale A, Michel JP, Del Giudice G.

Gerontology. 2019 Nov 26:1-11. doi: 10.1159/000503141. [Epub ahead of print] Review.


Bleeding Disorders.

Doherty TM, Kelley A.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.
2019 Jun 16.


Safety of AS03-adjuvanted influenza vaccines: A review of the evidence.

Cohet C, van der Most R, Bauchau V, Bekkat-Berkani R, Doherty TM, Schuind A, Tavares Da Silva F, Rappuoli R, Garçon N, Innis BL.

Vaccine. 2019 May 21;37(23):3006-3021. doi: 10.1016/j.vaccine.2019.04.048. Epub 2019 Apr 25. Review.


Adult vaccination as part of a healthy lifestyle: moving from medical intervention to health promotion.

Doherty TM, Del Giudice G, Maggi S.

Ann Med. 2019 Mar;51(2):128-140. doi: 10.1080/07853890.2019.1588470. Epub 2019 Apr 26.


Physiology, Neonatal.

Doherty TM, Salik I.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.
2019 Mar 12.


Mendelson Syndrome.

Salik I, Doherty TM.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.
2019 Oct 30.


Would immunization be the same without cross-reactivity?

Vojtek I, Buchy P, Doherty TM, Hoet B.

Vaccine. 2019 Jan 21;37(4):539-549. doi: 10.1016/j.vaccine.2018.12.005. Epub 2018 Dec 24. Review.


Incidence of tuberculosis and the influence of surveillance strategy on tuberculosis case-finding and all-cause mortality: a cluster randomised trial in Indian neonates vaccinated with BCG.

Jenum S, Selvam S, Jesuraj N, Ritz C, Hesseling AC, Cardenas V, Lau E, Doherty TM, Grewal HMS, Vaz M.

BMJ Open Respir Res. 2018 Oct 9;5(1):e000304. doi: 10.1136/bmjresp-2018-000304. eCollection 2018.


Vaccination programs for older adults in an era of demographic change.

Doherty TM, Connolly MP, Del Giudice G, Flamaing J, Goronzy JJ, Grubeck-Loebenstein B, Lambert PH, Maggi S, McElhaney JE, Nagai H, Schaffner W, Schmidt-Ott R, Walsh E, Di Pasquale A.

Eur Geriatr Med. 2018;9(3):289-300. doi: 10.1007/s41999-018-0040-8. Epub 2018 Mar 19. Review.


Challenges in adult vaccination.

de Gomensoro E, Del Giudice G, Doherty TM.

Ann Med. 2018 May;50(3):181-192. doi: 10.1080/07853890.2017.1417632. Epub 2018 Jan 16. Review.


Staphylococcal Superantigens Use LAMA2 as a Coreceptor To Activate T Cells.

Li Z, Zeppa JJ, Hancock MA, McCormick JK, Doherty TM, Hendy GN, Madrenas J.

J Immunol. 2018 Feb 15;200(4):1471-1479. doi: 10.4049/jimmunol.1701212. Epub 2018 Jan 15.


A phase I, open-label trial on the safety and immunogenicity of the adjuvanted tuberculosis subunit vaccine H1/IC31® in people living in a TB-endemic area.

Hussein J, Zewdie M, Yamuah L, Bedru A, Abebe M, Dagnew AF, Chanyalew M, Yohannes AG, Ahmed J, Engers H, Doherty TM, Bang P, Kromann I, Hoff ST, Aseffa A.

Trials. 2018 Jan 10;19(1):24. doi: 10.1186/s13063-017-2354-0.


Maternal immunization: where are we now and how to move forward?

Vojtek I, Dieussaert I, Doherty TM, Franck V, Hanssens L, Miller J, Bekkat-Berkani R, Kandeil W, Prado-Cohrs D, Vyse A.

Ann Med. 2018 May;50(3):193-208. doi: 10.1080/07853890.2017.1421320. Epub 2018 Jan 17. Review.


Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging.

Del Giudice G, Goronzy JJ, Grubeck-Loebenstein B, Lambert PH, Mrkvan T, Stoddard JJ, Doherty TM.

NPJ Aging Mech Dis. 2017 Dec 21;4:1. doi: 10.1038/s41514-017-0020-0. eCollection 2018.


A Humoral Immune Response Alters the Distribution of Enzyme Replacement Therapy in Murine Mucopolysaccharidosis Type I.

Le SQ, Kan SH, Clarke D, Sanghez V, Egeland M, Vondrak KN, Doherty TM, Vera MU, Iacovino M, Cooper JD, Sands MS, Dickson PI.

Mol Ther Methods Clin Dev. 2017 Oct 5;8:42-51. doi: 10.1016/j.omtm.2017.09.008. eCollection 2018 Mar 16.


Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE.

Nielsen TB, Pantapalangkoor P, Yan J, Luna BM, Dekitani K, Bruhn K, Tan B, Junus J, Bonomo RA, Schmidt AM, Everson M, Duncanson F, Doherty TM, Lin L, Spellberg B.

mBio. 2017 Aug 22;8(4). pii: e00818-17. doi: 10.1128/mBio.00818-17.


Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children.

Gjøen JE, Jenum S, Sivakumaran D, Mukherjee A, Macaden R, Kabra SK, Lodha R, Ottenhoff THM, Haks MC, Doherty TM, Ritz C, Grewal HMS.

Sci Rep. 2017 Jul 19;7(1):5839. doi: 10.1038/s41598-017-05057-x.


BLR1 and FCGR1A transcripts in peripheral blood associate with the extent of intrathoracic tuberculosis in children and predict treatment outcome.

Jenum S, Bakken R, Dhanasekaran S, Mukherjee A, Lodha R, Singh S, Singh V, Haks MC, Ottenhoff TH, Kabra SK, Doherty TM, Ritz C, Grewal HM.

Sci Rep. 2016 Dec 12;6:38841. doi: 10.1038/srep38841.


Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children.

Jenum S, Dhanasekaran S, Ritz C, Macaden R, Doherty TM, Grewal HM; TB Trials Study Group.

Pediatr Infect Dis J. 2016 Dec;35(12):1336-1338.


Ex-vivo characterization of regulatory T cells in pulmonary tuberculosis patients, latently infected persons, and healthy endemic controls.

Zewdie M, Howe R, Hoff ST, Doherty TM, Getachew N, Tarekegne A, Tessema B, Yamuah L, Aseffa A, Abebe M.

Tuberculosis (Edinb). 2016 Sep;100:61-68. doi: 10.1016/ Epub 2016 Jul 9.


Incidence of tuberculosis among school-going adolescents in South India.

Uppada DR, Selvam S, Jesuraj N, Lau EL, Doherty TM, Grewal HM, Vaz M, Lindtjørn B; TB Trials Study Group.

BMC Public Health. 2016 Jul 26;16:641. doi: 10.1186/s12889-016-3342-0.


Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum.

Jenum S, Dhanasekaran S, Lodha R, Mukherjee A, Kumar Saini D, Singh S, Singh V, Medigeshi G, Haks MC, Ottenhoff TH, Doherty TM, Kabra SK, Ritz C, Grewal HM.

Sci Rep. 2016 Jan 4;6:18520. doi: 10.1038/srep18520.


Biomarkers for risk of developing active tuberculosis in contacts of TB patients: a prospective cohort study.

Rakotosamimanana N, Richard V, Raharimanga V, Gicquel B, Doherty TM, Zumla A, Rasolofo Razanamparany V.

Eur Respir J. 2015 Oct;46(4):1095-103. doi: 10.1183/13993003.00263-2015. Epub 2015 Aug 6.


Effect of non-tuberculous Mycobacteria on host biomarkers potentially relevant for tuberculosis management.

Dhanasekaran S, Jenum S, Stavrum R, Wiker HG, Kenneth J, Vaz M, Doherty TM, Grewal HM; TB Trials Study Group.

PLoS Negl Trop Dis. 2014 Oct 16;8(10):e3243. doi: 10.1371/journal.pntd.0003243. eCollection 2014 Oct.


The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy indian adolescents.

Jenum S, Grewal HM, Hokey DA, Kenneth J, Vaz M, Doherty TM, Jahnsen FL; TB Trials Study Group.

PLoS One. 2014 Jul 3;9(7):e101224. doi: 10.1371/journal.pone.0101224. eCollection 2014.


Influence of age and nutritional status on the performance of the tuberculin skin test and QuantiFERON-TB gold in-tube in young children evaluated for tuberculosis in Southern India.

Jenum S, Selvam S, Mahelai D, Jesuraj N, Cárdenas V, Kenneth J, Hesseling AC, Doherty TM, Vaz M, Grewal HM.

Pediatr Infect Dis J. 2014 Oct;33(10):e260-9. doi: 10.1097/INF.0000000000000399.


Concordant or discordant results by the tuberculin skin test and the quantiFERON-TB test in children reflect immune biomarker profiles.

Dhanasekaran S, Jenum S, Stavrum R, Ritz C, Kenneth J, Vaz M, Doherty TM, Grewal HM; TB Trials Study Group.

Genes Immun. 2014 Jul-Aug;15(5):265-74. doi: 10.1038/gene.2014.13. Epub 2014 Apr 17.


Transferrin iron starvation therapy for lethal bacterial and fungal infections.

Lin L, Pantapalangkoor P, Tan B, Bruhn KW, Ho T, Nielsen T, Skaar EP, Zhang Y, Bai R, Wang A, Doherty TM, Spellberg B.

J Infect Dis. 2014 Jul 15;210(2):254-64. doi: 10.1093/infdis/jiu049. Epub 2014 Jan 19.


Combination of cytokine responses indicative of latent TB and active TB in Malawian adults.

Hur YG, Gorak-Stolinska P, Ben-Smith A, Lalor MK, Chaguluka S, Dacombe R, Doherty TM, Ottenhoff TH, Dockrell HM, Crampin AC.

PLoS One. 2013 Nov 18;8(11):e79742. doi: 10.1371/journal.pone.0079742. eCollection 2013.


Development of a proof of concept immunochromatographic lateral flow assay for point of care diagnosis of Mycobacterium tuberculosis.

Wassie L, Abebe M, Aseffa A, Bobosha K, Zewdie M, Chanyalew M, Yamuah LK, Cortés A, González JR, Delgado JM, Ceyhan I, Rosenkrands I, Weldingh K, Andersen P, Doherty TM.

BMC Res Notes. 2013 May 21;6:202. doi: 10.1186/1756-0500-6-202.


Identification of biomarkers for Mycobacterium tuberculosis infection and disease in BCG-vaccinated young children in Southern India.

Dhanasekaran S, Jenum S, Stavrum R, Ritz C, Faurholt-Jepsen D, Kenneth J, Vaz M, Grewal HM, Doherty TM; TB Trials Study Group.

Genes Immun. 2013 Sep;14(6):356-64. doi: 10.1038/gene.2013.26. Epub 2013 May 16.


Expression of TNF-alpha-dependent apoptosis-related genes in the peripheral blood of Malagasy subjects with tuberculosis.

Rakotosamimanana N, Doherty TM, Andriamihantasoa LH, Richard V, Gicquel B, Soares JL, Zumla A, Razanamparany VR.

PLoS One. 2013 Apr 12;8(4):e61154. doi: 10.1371/journal.pone.0061154. Print 2013.


Risk stratification of latent tuberculosis defined by combined interferon gamma release assays.

Corbière V, Pottier G, Bonkain F, Schepers K, Verscheure V, Lecher S, Doherty TM, Locht C, Mascart F.

PLoS One. 2012;7(8):e43285. doi: 10.1371/journal.pone.0043285. Epub 2012 Aug 17.


Diagnosis of latent tuberculosis infection in healthy young adults in a country with high tuberculosis burden and BCG vaccination at birth.

Dagnew AF, Hussein J, Abebe M, Zewdie M, Mihret A, Bedru A, Chanyalew M, Yamuah L, Medhin G, Bang P, Doherty TM, Hailu A, Aseffa A.

BMC Res Notes. 2012 Aug 7;5:415. doi: 10.1186/1756-0500-5-415.


Immunotherapy for TB.

Doherty TM.

Immunotherapy. 2012 Jun;4(6):629-47. doi: 10.2217/imt.12.52. Review.


Mycobacterium tuberculosis Mce1 protein complex initiates rapid induction of transcription of genes involved in substrate trafficking.

Stavrum R, Valvatne H, Stavrum AK, Riley LW, Ulvestad E, Jonassen I, Doherty TM, Grewal HM.

Genes Immun. 2012 Sep;13(6):496-502. doi: 10.1038/gene.2012.24. Epub 2012 Jun 14.



Cohavy O, Shih DQ, Doherty TM, Ware CF, Targan SR.

Eur J Microbiol Immunol (Bp). 2011 Mar;1(1):70-79.


Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting.

Chegou NN, Black GF, Loxton AG, Stanley K, Essone PN, Klein MR, Parida SK, Kaufmann SH, Doherty TM, Friggen AH, Franken KL, Ottenhoff TH, Walzl G.

BMC Infect Dis. 2012 Jan 20;12:10. doi: 10.1186/1471-2334-12-10.


Modulation of transcriptional and inflammatory responses in murine macrophages by the Mycobacterium tuberculosis mammalian cell entry (Mce) 1 complex.

Stavrum R, Stavrum AK, Valvatne H, Riley LW, Ulvestad E, Jonassen I, Assmus J, Doherty TM, Grewal HM.

PLoS One. 2011;6(10):e26295. doi: 10.1371/journal.pone.0026295. Epub 2011 Oct 24. Erratum in: PLoS One. 2011;6(11). doi:10.1371/annotation/934c5cbd-c70d-40d0-9d65-36dbecd7ad17.


Explaining household socio-economic related child health inequalities using multiple methods in three diverse settings in South Africa.

Nkonki LL, Chopra M, Doherty TM, Jackson D, Robberstad B.

Int J Equity Health. 2011 Apr 4;10:13. doi: 10.1186/1475-9276-10-13.


Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection.

van Dissel JT, Soonawala D, Joosten SA, Prins C, Arend SM, Bang P, Tingskov PN, Lingnau K, Nouta J, Hoff ST, Rosenkrands I, Kromann I, Ottenhoff TH, Doherty TM, Andersen P.

Vaccine. 2011 Mar 3;29(11):2100-9. doi: 10.1016/j.vaccine.2010.12.135. Epub 2011 Jan 20.


Modulation of cell death by M. tuberculosis as a strategy for pathogen survival.

Abebe M, Kim L, Rook G, Aseffa A, Wassie L, Zewdie M, Zumla A, Engers H, Andersen P, Doherty TM.

Clin Dev Immunol. 2011;2011:678570. doi: 10.1155/2011/678570. Epub 2011 Jan 4.


First in humans: a new molecularly defined vaccine shows excellent safety and strong induction of long-lived Mycobacterium tuberculosis-specific Th1-cell like responses.

Ottenhoff TH, Doherty TM, van Dissel JT, Bang P, Lingnau K, Kromann I, Andersen P.

Hum Vaccin. 2010 Dec;6(12):1007-15. Epub 2010 Dec 1. Review.


Immunodiagnosis of Tuberculosis: New Questions, New Tools Virginia, VA, USA. 21-23 September 2008. Abstracts.

Gennaro ML, Doherty TM.

BMC Proc. 2010;4 Suppl 3:I1. doi: 10.1186/1753-6561-4-S3-I1. Epub 2010 Dec 17. No abstract available.


Splenic lymphopenia in the endothelin receptor B-null mouse: implications for Hirschsprung associated enterocolitis.

Cheng Z, Wang X, Dhall D, Zhao L, Bresee C, Doherty TM, Frykman PK.

Pediatr Surg Int. 2011 Feb;27(2):145-50. doi: 10.1007/s00383-010-2787-y.


Impact of age and sex on mycobacterial immunity in an area of high tuberculosis incidence.

Gallant CJ, Cobat A, Simkin L, Black GF, Stanley K, Hughes J, Doherty TM, Hanekom WA, Eley B, Beyers N, Jaïs JP, van Helden P, Abel L, Alcaïs A, Hoal EG, Schurr E.

Int J Tuberc Lung Dis. 2010 Aug;14(8):952-9.


Heparin-binding, hemagglutinin-specific IFN-gamma synthesis at the site of infection during active tuberculosis in humans.

Place S, Verscheure V, de San N, Hougardy JM, Schepers K, Dirix V, Dediste A, Michel O, Drowart A, Allard SD, Doherty TM, Lecher S, Locht C, Mascart F.

Am J Respir Crit Care Med. 2010 Sep 15;182(6):848-54. doi: 10.1164/rccm.201001-0083OC. Epub 2010 May 27.


Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice.

Wallis RS, Pai M, Menzies D, Doherty TM, Walzl G, Perkins MD, Zumla A.

Lancet. 2010 May 29;375(9729):1920-37. doi: 10.1016/S0140-6736(10)60359-5. Epub 2010 May 18. Review.


Variation in gamma interferon responses to different infecting strains of Mycobacterium tuberculosis in acid-fast bacillus smear-positive patients and household contacts in Antananarivo, Madagascar.

Rakotosamimanana N, Raharimanga V, Andriamandimby SF, Soares JL, Doherty TM, Ratsitorahina M, Ramarokoto H, Zumla A, Huggett J, Rook G, Richard V, Gicquel B, Rasolofo-Razanamparany V; VACSEL/VACSIS Study Group.

Clin Vaccine Immunol. 2010 Jul;17(7):1094-103. doi: 10.1128/CVI.00049-10. Epub 2010 May 12.

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