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Items: 1 to 50 of 449

1.

Potential killers exposed: tracking endogenous influenza-specific CD8+ T cells.

Keating R, Morris MY, Yue W, Reynolds CE, Harris TL, Brown SA, Doherty PC, Thomas PG, McGargill MA.

Immunol Cell Biol. 2018 Jul 4. doi: 10.1111/imcb.12189. [Epub ahead of print]

PMID:
29972699
2.

Influenza.

Krammer F, Smith GJD, Fouchier RAM, Peiris M, Kedzierska K, Doherty PC, Palese P, Shaw ML, Treanor J, Webster RG, García-Sastre A.

Nat Rev Dis Primers. 2018 Jun 28;4(1):3. doi: 10.1038/s41572-018-0002-y. Review. No abstract available.

PMID:
29955068
3.

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells.

Quinn KM, Fox A, Harland KL, Russ BE, Li J, Nguyen THO, Loh L, Olshanksy M, Naeem H, Tsyganov K, Wiede F, Webster R, Blyth C, Sng XYX, Tiganis T, Powell D, Doherty PC, Turner SJ, Kedzierska K, La Gruta NL.

Cell Rep. 2018 Jun 19;23(12):3512-3524. doi: 10.1016/j.celrep.2018.05.057.

4.

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease.

Wang Z, Zhu L, Nguyen THO, Wan Y, Sant S, Quiñones-Parra SM, Crawford JC, Eltahla AA, Rizzetto S, Bull RA, Qiu C, Koutsakos M, Clemens EB, Loh L, Chen T, Liu L, Cao P, Ren Y, Kedzierski L, Kotsimbos T, McCaw JM, La Gruta NL, Turner SJ, Cheng AC, Luciani F, Zhang X, Doherty PC, Thomas PG, Xu J, Kedzierska K.

Nat Commun. 2018 Feb 26;9(1):824. doi: 10.1038/s41467-018-03243-7.

5.

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+ T cell response magnitude.

Quinn KM, Kan WT, Watson KA, Liddicoat BJ, Swan NG, McQuilten H, Denton AE, Li J, Chen W, Brown LE, Jackson DC, Reading PC, Doherty PC, Kedzierska K, Kedzierski L, Turner SJ, La Gruta NL.

PLoS One. 2017 Sep 8;12(9):e0184732. doi: 10.1371/journal.pone.0184732. eCollection 2017.

6.

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation.

Loh L, Wang Z, Sant S, Koutsakos M, Jegaskanda S, Corbett AJ, Liu L, Fairlie DP, Crowe J, Rossjohn J, Xu J, Doherty PC, McCluskey J, Kedzierska K.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10133-8. doi: 10.1073/pnas.1610750113. Epub 2016 Aug 19.

7.

Competition within the virus-specific CD4 T-cell pool limits the T follicular helper response after influenza infection.

Olson MR, Chua BY, Good-Jacobson KL, Doherty PC, Jackson DC, Turner SJ.

Immunol Cell Biol. 2016 Sep;94(8):729-40. doi: 10.1038/icb.2016.42. Epub 2016 Apr 22.

PMID:
27101922
8.

Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses.

Valkenburg SA, Josephs TM, Clemens EB, Grant EJ, Nguyen TH, Wang GC, Price DA, Miller A, Tong SY, Thomas PG, Doherty PC, Rossjohn J, Gras S, Kedzierska K.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4440-5. doi: 10.1073/pnas.1603106113. Epub 2016 Mar 31.

9.

Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice.

Quinn KM, Zaloumis SG, Cukalac T, Kan WT, Sng XY, Mirams M, Watson KA, McCaw JM, Doherty PC, Thomas PG, Handel A, La Gruta NL.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1333-8. doi: 10.1073/pnas.1525167113. Epub 2016 Jan 19.

10.

Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity.

Chua BY, Wong CY, Mifsud EJ, Edenborough KM, Sekiya T, Tan AC, Mercuri F, Rockman S, Chen W, Turner SJ, Doherty PC, Kelso A, Brown LE, Jackson DC.

MBio. 2015 Oct 27;6(6):e01024-15. doi: 10.1128/mBio.01024-15.

11.

Sizing up the key determinants of the CD8(+) T cell response.

Tscharke DC, Croft NP, Doherty PC, La Gruta NL.

Nat Rev Immunol. 2015 Nov;15(11):705-16. doi: 10.1038/nri3905. Epub 2015 Oct 9. Review.

PMID:
26449178
12.

Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8⁺ T cells.

Wang Z, Wan Y, Qiu C, Quiñones-Parra S, Zhu Z, Loh L, Tian D, Ren Y, Hu Y, Zhang X, Thomas PG, Inouye M, Doherty PC, Kedzierska K, Xu J.

Nat Commun. 2015 May 13;6:6833. doi: 10.1038/ncomms7833.

13.

Diverse heterologous primary infections radically alter immunodominance hierarchies and clinical outcomes following H7N9 influenza challenge in mice.

Duan S, Meliopoulos VA, McClaren JL, Guo XZ, Sanders CJ, Smallwood HS, Webby RJ, Schultz-Cherry SL, Doherty PC, Thomas PG.

PLoS Pathog. 2015 Feb 10;11(2):e1004642. doi: 10.1371/journal.ppat.1004642. eCollection 2015 Feb.

14.

Fixed expression of single influenza virus-specific TCR chains demonstrates the capacity for TCR α- and β-chain diversity in the face of peptide-MHC class I specificity.

Clemens EB, Doherty PC, La Gruta NL, Turner SJ.

J Immunol. 2015 Feb 1;194(3):898-910. doi: 10.4049/jimmunol.1401792. Epub 2014 Dec 22.

15.

Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells.

Olson MR, Seah SG, Cullen J, Greyer M, Edenborough K, Doherty PC, Bedoui S, Lew AM, Turner SJ.

J Immunol. 2014 Dec 1;193(11):5420-33. doi: 10.4049/jimmunol.1303359. Epub 2014 Oct 22.

16.

Open letter to the Hon Tony Abbott MP.

McMichael AJ, Leeder SR, Armstrong BK, Basten A, Doherty PC, Douglas RM, Green AC, Nossal GJ, Shearman DJ, Stanley FJ, Vimpani GV, Wodak AD.

Med J Aust. 2014 Sep 1;201(5):252. No abstract available.

PMID:
25163366
17.

CD154+ CD4+ T-cell dependence for effective memory influenza virus-specific CD8+ T-cell responses.

Olson MR, Seah SG, Edenborough K, Doherty PC, Lew AM, Turner SJ.

Immunol Cell Biol. 2014 Aug;92(7):605-11. doi: 10.1038/icb.2014.28. Epub 2014 Apr 29.

PMID:
24777309
18.

The influenza virus-specific CTL immunodominance hierarchy in mice is determined by the relative frequency of high-avidity T cells.

Cukalac T, Chadderton J, Zeng W, Cullen JG, Kan WT, Doherty PC, Jackson DC, Turner SJ, La Gruta NL.

J Immunol. 2014 May 1;192(9):4061-8. doi: 10.4049/jimmunol.1301403. Epub 2014 Apr 2.

19.

Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.

Harland KL, Day EB, Apte SH, Russ BE, Doherty PC, Turner SJ, Kelso A.

Nat Commun. 2014 Mar 28;5:3547. doi: 10.1038/ncomms4547.

20.

Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection.

Cukalac T, Chadderton J, Handel A, Doherty PC, Turner SJ, Thomas PG, La Gruta NL.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1485-90. doi: 10.1073/pnas.1323736111. Epub 2014 Jan 13.

21.

Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities.

Quiñones-Parra S, Grant E, Loh L, Nguyen TH, Campbell KA, Tong SY, Miller A, Doherty PC, Vijaykrishna D, Rossjohn J, Gras S, Kedzierska K.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1049-54. doi: 10.1073/pnas.1322229111. Epub 2014 Jan 6.

22.

Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection.

Wang Z, Zhang A, Wan Y, Liu X, Qiu C, Xi X, Ren Y, Wang J, Dong Y, Bao M, Li L, Zhou M, Yuan S, Sun J, Zhu Z, Chen L, Li Q, Zhang Z, Zhang X, Lu S, Doherty PC, Kedzierska K, Xu J.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):769-74. doi: 10.1073/pnas.1321748111. Epub 2013 Dec 23.

23.

Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8+ T cells.

Rutigliano JA, Sharma S, Morris MY, Oguin TH 3rd, McClaren JL, Doherty PC, Thomas PG.

J Virol. 2014 Feb;88(3):1636-51. doi: 10.1128/JVI.02851-13. Epub 2013 Nov 20.

24.

Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model.

Rosenberger CM, Podyminogin RL, Askovich PS, Navarro G, Kaiser SM, Sanders CJ, McClaren JL, Tam VC, Dash P, Noonan JG, Jones BG, Surman SL, Peschon JJ, Diercks AH, Hurwitz JL, Doherty PC, Thomas PG, Aderem A.

J Gen Virol. 2014 Feb;95(Pt 2):350-62. doi: 10.1099/vir.0.058438-0. Epub 2013 Nov 16.

25.

Acute emergence and reversion of influenza A virus quasispecies within CD8+ T cell antigenic peptides.

Valkenburg SA, Quiñones-Parra S, Gras S, Komadina N, McVernon J, Wang Z, Halim H, Iannello P, Cole C, Laurie K, Kelso A, Rossjohn J, Doherty PC, Turner SJ, Kedzierska K.

Nat Commun. 2013;4:2663. doi: 10.1038/ncomms3663.

PMID:
24173108
26.

The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.

Keating R, Hertz T, Wehenkel M, Harris TL, Edwards BA, McClaren JL, Brown SA, Surman S, Wilson ZS, Bradley P, Hurwitz J, Chi H, Doherty PC, Thomas PG, McGargill MA.

Nat Immunol. 2013 Dec;14(12):1266-76. doi: 10.1038/ni.2741. Epub 2013 Oct 20.

27.

Differential host response, rather than early viral replication efficiency, correlates with pathogenicity caused by influenza viruses.

Askovich PS, Sanders CJ, Rosenberger CM, Diercks AH, Dash P, Navarro G, Vogel P, Doherty PC, Thomas PG, Aderem A.

PLoS One. 2013 Sep 20;8(9):e74863. doi: 10.1371/journal.pone.0074863. eCollection 2013.

28.

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.

Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD.

Nat Immunol. 2013 May;14(5):480-8. doi: 10.1038/ni.2563. Epub 2013 Mar 24.

29.

Preemptive priming readily overcomes structure-based mechanisms of virus escape.

Valkenburg SA, Gras S, Guillonneau C, Hatton LA, Bird NA, Twist KA, Halim H, Jackson DC, Purcell AW, Turner SJ, Doherty PC, Rossjohn J, Kedzierska K.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5570-5. doi: 10.1073/pnas.1302935110. Epub 2013 Mar 14.

30.

Compromised respiratory function in lethal influenza infection is characterized by the depletion of type I alveolar epithelial cells beyond threshold levels.

Sanders CJ, Vogel P, McClaren JL, Bajracharya R, Doherty PC, Thomas PG.

Am J Physiol Lung Cell Mol Physiol. 2013 Apr 1;304(7):L481-8. doi: 10.1152/ajplung.00343.2012. Epub 2013 Jan 25.

31.

Transmission studies resume for avian flu.

Fouchier RA, García-Sastre A, Kawaoka Y, Barclay WS, Bouvier NM, Brown IH, Capua I, Chen H, Compans RW, Couch RB, Cox NJ, Doherty PC, Donis RO, Feldmann H, Guan Y, Katz JM, Kiselev OI, Klenk HD, Kobinger G, Liu J, Liu X, Lowen A, Mettenleiter TC, Osterhaus AD, Palese P, Peiris JS, Perez DR, Richt JA, Schultz-Cherry S, Steel J, Subbarao K, Swayne DE, Takimoto T, Tashiro M, Taubenberger JK, Thomas PG, Tripp RA, Tumpey TM, Webby RJ, Webster RG.

Science. 2013 Feb 1;339(6119):520-1. doi: 10.1126/science.1235140. Epub 2013 Jan 23. No abstract available.

32.

Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations.

Thomas PG, Handel A, Doherty PC, La Gruta NL.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1839-44. doi: 10.1073/pnas.1222149110. Epub 2013 Jan 14.

33.

Use it or lose it: establishment and persistence of T cell memory.

Kedzierska K, Valkenburg SA, Doherty PC, Davenport MP, Venturi V.

Front Immunol. 2012 Nov 27;3:357. doi: 10.3389/fimmu.2012.00357. eCollection 2012.

34.

Reconstruction of the 1918 influenza virus: unexpected rewards from the past.

Taubenberger JK, Baltimore D, Doherty PC, Markel H, Morens DM, Webster RG, Wilson IA.

MBio. 2012 Sep 11;3(5). pii: e00201-12. doi: 10.1128/mBio.00201-12. Print 2012. Review.

35.

T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection.

Wang GC, Dash P, McCullers JA, Doherty PC, Thomas PG.

Sci Transl Med. 2012 Apr 4;4(128):128ra42. doi: 10.1126/scitranslmed.3003647.

36.

Induction of protective CD4+ T cell-mediated immunity by a Leishmania peptide delivered in recombinant influenza viruses.

Kedzierska K, Curtis JM, Valkenburg SA, Hatton LA, Kiu H, Doherty PC, Kedzierski L.

PLoS One. 2012;7(3):e33161. doi: 10.1371/journal.pone.0033161. Epub 2012 Mar 21.

37.

Early priming minimizes the age-related immune compromise of CD8⁺ T cell diversity and function.

Valkenburg SA, Venturi V, Dang TH, Bird NL, Doherty PC, Turner SJ, Davenport MP, Kedzierska K.

PLoS Pathog. 2012 Feb;8(2):e1002544. doi: 10.1371/journal.ppat.1002544. Epub 2012 Feb 23. Erratum in: PLoS Pathog. 2012 Mar;8(3). doi: 10.1371/annotation/e142f9de-7f30-4759-bda1-a651e86d5ba6.

38.

Dangerous for ferrets: lethal for humans?

Doherty PC, Thomas PG.

BMC Biol. 2012 Feb 20;10:10. doi: 10.1186/1741-7007-10-10. No abstract available.

39.

Pause on avian flu transmission research.

Fouchier RA, García-Sastre A, Kawaoka Y, Barclay WS, Bouvier NM, Brown IH, Capua I, Chen H, Compans RW, Couch RB, Cox NJ, Doherty PC, Donis RO, Feldmann H, Guan Y, Katz J, Klenk HD, Kobinger G, Liu J, Liu X, Lowen A, Mettenleiter TC, Osterhaus AD, Palese P, Peiris JS, Perez DR, Richt JA, Schultz-Cherry S, Steel J, Subbarao K, Swayne DE, Takimoto T, Tashiro M, Taubenberger JK, Thomas PG, Tripp RA, Tumpey TM, Webby RJ, Webster RG.

Science. 2012 Jan 27;335(6067):400-1. doi: 10.1126/science.335.6067.400. No abstract available.

40.

Affinity thresholds for naive CD8+ CTL activation by peptides and engineered influenza A viruses.

Denton AE, Wesselingh R, Gras S, Guillonneau C, Olson MR, Mintern JD, Zeng W, Jackson DC, Rossjohn J, Hodgkin PD, Doherty PC, Turner SJ.

J Immunol. 2011 Dec 1;187(11):5733-44. doi: 10.4049/jimmunol.1003937. Epub 2011 Oct 28.

41.

Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells.

Denton AE, Russ BE, Doherty PC, Rao S, Turner SJ.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15306-11. doi: 10.1073/pnas.1112520108. Epub 2011 Aug 29.

42.

The tetramer transformation.

Doherty PC.

J Immunol. 2011 Jul 1;187(1):5-6. doi: 10.4049/jimmunol.1101297. No abstract available.

43.

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses.

Day EB, Guillonneau C, Gras S, La Gruta NL, Vignali DA, Doherty PC, Purcell AW, Rossjohn J, Turner SJ.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9536-41. doi: 10.1073/pnas.1106851108. Epub 2011 May 23.

44.

Systematic identification of immunodominant CD8+ T-cell responses to influenza A virus in HLA-A2 individuals.

Wu C, Zanker D, Valkenburg S, Tan B, Kedzierska K, Zou QM, Doherty PC, Chen W.

Proc Natl Acad Sci U S A. 2011 May 31;108(22):9178-83. doi: 10.1073/pnas.1105624108. Epub 2011 May 11.

45.

Consequences of suboptimal priming are apparent for low-avidity T-cell responses.

Venturi V, Davenport MP, Swan NG, Doherty PC, Kedzierska K.

Immunol Cell Biol. 2012 Feb;90(2):216-23. doi: 10.1038/icb.2011.36. Epub 2011 May 10.

PMID:
21556018
46.

Effect of MHC class I diversification on influenza epitope-specific CD8+ T cell precursor frequency and subsequent effector function.

Day EB, Charlton KL, La Gruta NL, Doherty PC, Turner SJ.

J Immunol. 2011 Jun 1;186(11):6319-28. doi: 10.4049/jimmunol.1000883. Epub 2011 May 2.

47.

Immunity to seasonal and pandemic influenza A viruses.

Valkenburg SA, Rutigliano JA, Ellebedy AH, Doherty PC, Thomas PG, Kedzierska K.

Microbes Infect. 2011 May;13(5):489-501. doi: 10.1016/j.micinf.2011.01.007. Epub 2011 Feb 2. Review.

48.

Memory precursor phenotype of CD8+ T cells reflects early antigenic experience rather than memory numbers in a model of localized acute influenza infection.

Croom HA, Denton AE, Valkenburg SA, Swan NG, Olson MR, Turner SJ, Doherty PC, Kedzierska K.

Eur J Immunol. 2011 Mar;41(3):682-93. doi: 10.1002/eji.201040625. Epub 2011 Jan 25.

49.

Paired analysis of TCRα and TCRβ chains at the single-cell level in mice.

Dash P, McClaren JL, Oguin TH 3rd, Rothwell W, Todd B, Morris MY, Becksfort J, Reynolds C, Brown SA, Doherty PC, Thomas PG.

J Clin Invest. 2011 Jan;121(1):288-95. doi: 10.1172/JCI44752. Epub 2010 Dec 6.

50.

Influenza epitope-specific CD8+ T cell avidity, but not cytokine polyfunctionality, can be determined by TCRβ clonotype.

Moffat JM, Handel A, Doherty PC, Turner SJ, Thomas PG, La Gruta NL.

J Immunol. 2010 Dec 1;185(11):6850-6. doi: 10.4049/jimmunol.1002025. Epub 2010 Nov 1.

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