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Healthcare practitioners' views and experiences of barriers and facilitators to weight management interventions for adults with intellectual disabilities.

Doherty AJ, Jones SP, Chauhan U, Gibson JME.

J Appl Res Intellect Disabil. 2019 Sep;32(5):1067-1077. doi: 10.1111/jar.12596. Epub 2019 Apr 15.


PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching.

Tsuda M, Ogawa S, Ooka M, Kobayashi K, Hirota K, Wakasugi M, Matsunaga T, Sakuma T, Yamamoto T, Chikuma S, Sasanuma H, Debatisse M, Doherty AJ, Fuchs RP, Takeda S.

PLoS One. 2019 Mar 6;14(3):e0213383. doi: 10.1371/journal.pone.0213383. eCollection 2019.


PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells.

Bailey LJ, Bianchi J, Doherty AJ.

Nucleic Acids Res. 2019 May 7;47(8):4026-4038. doi: 10.1093/nar/gkz056.


R-loop formation during S phase is restricted by PrimPol-mediated repriming.

Šviković S, Crisp A, Tan-Wong SM, Guilliam TA, Doherty AJ, Proudfoot NJ, Guilbaud G, Sale JE.

EMBO J. 2019 Feb 1;38(3). pii: e99793. doi: 10.15252/embj.201899793. Epub 2018 Nov 26.


The Involvement of Aβ42 and Tau in Nucleolar and Protein Synthesis Machinery Dysfunction.

Maina MB, Bailey LJ, Doherty AJ, Serpell LC.

Front Cell Neurosci. 2018 Aug 3;12:220. doi: 10.3389/fncel.2018.00220. eCollection 2018.


The involvement of tau in nucleolar transcription and the stress response.

Maina MB, Bailey LJ, Wagih S, Biasetti L, Pollack SJ, Quinn JP, Thorpe JR, Doherty AJ, Serpell LC.

Acta Neuropathol Commun. 2018 Jul 31;6(1):70. doi: 10.1186/s40478-018-0565-6.


Eating well, living well and weight management: A co-produced semi-qualitative study of barriers and facilitators experienced by adults with intellectual disabilities.

Doherty AJ, Jones SP, Chauhan U, Gibson J.

J Intellect Disabil. 2018 Jan 1:1744629518773938. doi: 10.1177/1744629518773938. [Epub ahead of print]


EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation.

Silva J, Aivio S, Knobel PA, Bailey LJ, Casali A, Vinaixa M, Garcia-Cao I, Coyaud É, Jourdain AA, Pérez-Ferreros P, Rojas AM, Antolin-Fontes A, Samino-Gené S, Raught B, González-Reyes A, Ribas de Pouplana L, Doherty AJ, Yanes O, Stracker TH.

Nat Cell Biol. 2018 Feb;20(2):162-174. doi: 10.1038/s41556-017-0016-9. Epub 2018 Jan 15.


DNA Ligase C and Prim-PolC participate in base excision repair in mycobacteria.

Płociński P, Brissett NC, Bianchi J, Brzostek A, Korycka-Machała M, Dziembowski A, Dziadek J, Doherty AJ.

Nat Commun. 2017 Nov 1;8(1):1251. doi: 10.1038/s41467-017-01365-y.


Current and Emerging Assays for Studying the Primer Synthesis Activities of DNA Primases.

Guilliam TA, Doherty AJ.

Methods Enzymol. 2017;591:327-353. doi: 10.1016/bs.mie.2017.03.006. Epub 2017 Apr 20.


An integrative review of multicomponent weight management interventions for adults with intellectual disabilities.

Doherty AJ, Jones SP, Chauhan U, Gibson JME.

J Appl Res Intellect Disabil. 2018 Jan;31 Suppl 1:39-51. doi: 10.1111/jar.12367. Epub 2017 Jun 20. Review.


Molecular basis for PrimPol recruitment to replication forks by RPA.

Guilliam TA, Brissett NC, Ehlinger A, Keen BA, Kolesar P, Taylor EM, Bailey LJ, Lindsay HD, Chazin WJ, Doherty AJ.

Nat Commun. 2017 May 23;8:15222. doi: 10.1038/ncomms15222.


Mitochondrial DNA replication: a PrimPol perspective.

Bailey LJ, Doherty AJ.

Biochem Soc Trans. 2017 Apr 15;45(2):513-529. doi: 10.1042/BST20160162. Review.


A non-canonical mismatch repair pathway in prokaryotes.

Castañeda-García A, Prieto AI, Rodríguez-Beltrán J, Alonso N, Cantillon D, Costas C, Pérez-Lago L, Zegeye ED, Herranz M, Plociński P, Tonjum T, García de Viedma D, Paget M, Waddell SJ, Rojas AM, Doherty AJ, Blázquez J.

Nat Commun. 2017 Jan 27;8:14246. doi: 10.1038/ncomms14246.


PrimPol-Prime Time to Reprime.

Guilliam TA, Doherty AJ.

Genes (Basel). 2017 Jan 6;8(1). pii: E20. doi: 10.3390/genes8010020. Review.


Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides.

Kobayashi K, Guilliam TA, Tsuda M, Yamamoto J, Bailey LJ, Iwai S, Takeda S, Doherty AJ, Hirota K.

Cell Cycle. 2016 Aug 2;15(15):1997-2008. doi: 10.1080/15384101.2016.1191711. Epub 2016 May 26.


PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities.

Guilliam TA, Bailey LJ, Brissett NC, Doherty AJ.

Nucleic Acids Res. 2016 Apr 20;44(7):3317-29. doi: 10.1093/nar/gkw175. Epub 2016 Mar 16.


PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage.

Bailey LJ, Bianchi J, Hégarat N, Hochegger H, Doherty AJ.

Cell Cycle. 2016;15(7):908-18. doi: 10.1080/15384101.2015.1128597. Epub 2015 Dec 22.


PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells.

Schiavone D, Jozwiakowski SK, Romanello M, Guilbaud G, Guilliam TA, Bailey LJ, Sale JE, Doherty AJ.

Mol Cell. 2016 Jan 7;61(1):161-9. doi: 10.1016/j.molcel.2015.10.038. Epub 2015 Nov 25.


Molecular basis for DNA strand displacement by NHEJ repair polymerases.

Bartlett EJ, Brissett NC, Plocinski P, Carlberg T, Doherty AJ.

Nucleic Acids Res. 2016 Mar 18;44(5):2173-86. doi: 10.1093/nar/gkv965. Epub 2015 Sep 23.


Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes.

Guilliam TA, Keen BA, Brissett NC, Doherty AJ.

Nucleic Acids Res. 2015 Aug 18;43(14):6651-64. doi: 10.1093/nar/gkv625. Epub 2015 Jun 24. Review.


Author response: PRIMPOL mutation: functional study does not always reveal the truth.

Keen BA, Bailey LJ, Jozwiakowski SK, Doherty AJ.

Invest Ophthalmol Vis Sci. 2015 Feb 13;56(2):1183. doi: 10.1167/iovs.14-16123. No abstract available.


Archaeal replicative primases can perform translesion DNA synthesis.

Jozwiakowski SK, Borazjani Gholami F, Doherty AJ.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E633-8. doi: 10.1073/pnas.1412982112. Epub 2015 Feb 2.


Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins.

Guilliam TA, Jozwiakowski SK, Ehlinger A, Barnes RP, Rudd SG, Bailey LJ, Skehel JM, Eckert KA, Chazin WJ, Doherty AJ.

Nucleic Acids Res. 2015 Jan;43(2):1056-68. doi: 10.1093/nar/gku1321. Epub 2014 Dec 29.


Cdk1 restrains NHEJ through phosphorylation of XRCC4-like factor Xlf1.

Hentges P, Waller H, Reis CC, Ferreira MG, Doherty AJ.

Cell Rep. 2014 Dec 24;9(6):2011-7. doi: 10.1016/j.celrep.2014.11.044. Epub 2014 Dec 18.


Human PrimPol mutation associated with high myopia has a DNA replication defect.

Keen BA, Bailey LJ, Jozwiakowski SK, Doherty AJ.

Nucleic Acids Res. 2014 Oct 29;42(19):12102-11. doi: 10.1093/nar/gku879. Epub 2014 Sep 27.


Rapid regulation of endoplasmic reticulum dynamics in dendritic spines by NMDA receptor activation.

Ng AN, Doherty AJ, Lombroso PJ, Emptage NJ, Collingridge GL.

Mol Brain. 2014 Aug 19;7:60. doi: 10.1186/s13041-014-0060-3.


An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family.

Jozwiakowski SK, Keith BJ, Gilroy L, Doherty AJ, Connolly BA.

Nucleic Acids Res. 2014 Sep;42(15):9949-63. doi: 10.1093/nar/gku683. Epub 2014 Jul 24.


Ribosomal oxygenases are structurally conserved from prokaryotes to humans.

Chowdhury R, Sekirnik R, Brissett NC, Krojer T, Ho CH, Ng SS, Clifton IJ, Ge W, Kershaw NJ, Fox GC, Muniz JRC, Vollmar M, Phillips C, Pilka ES, Kavanagh KL, von Delft F, Oppermann U, McDonough MA, Doherty AJ, Schofield CJ.

Nature. 2014 Jun 19;510(7505):422-426. doi: 10.1038/nature13263. Epub 2014 May 11.


Molecular dissection of the domain architecture and catalytic activities of human PrimPol.

Keen BA, Jozwiakowski SK, Bailey LJ, Bianchi J, Doherty AJ.

Nucleic Acids Res. 2014 May;42(9):5830-45. doi: 10.1093/nar/gku214. Epub 2014 Mar 20.


PrimPol-A new polymerase on the block.

Rudd SG, Bianchi J, Doherty AJ.

Mol Cell Oncol. 2014 Oct 29;1(2):e960754. doi: 10.4161/23723548.2014.960754. eCollection 2014 Apr-Jun. Review.


PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication.

Bianchi J, Rudd SG, Jozwiakowski SK, Bailey LJ, Soura V, Taylor E, Stevanovic I, Green AJ, Stracker TH, Lindsay HD, Doherty AJ.

Mol Cell. 2013 Nov 21;52(4):566-73. doi: 10.1016/j.molcel.2013.10.035.


PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome.

Rudd SG, Glover L, Jozwiakowski SK, Horn D, Doherty AJ.

Mol Cell. 2013 Nov 21;52(4):554-65. doi: 10.1016/j.molcel.2013.10.034.


Molecular basis for DNA double-strand break annealing and primer extension by an NHEJ DNA polymerase.

Brissett NC, Martin MJ, Bartlett EJ, Bianchi J, Blanco L, Doherty AJ.

Cell Rep. 2013 Nov 27;5(4):1108-20. doi: 10.1016/j.celrep.2013.10.016. Epub 2013 Nov 14.


Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates.

Bartlett EJ, Brissett NC, Doherty AJ.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):E1984-91. doi: 10.1073/pnas.1302616110. Epub 2013 May 13.


Structure of a preternary complex involving a prokaryotic NHEJ DNA polymerase.

Brissett NC, Martin MJ, Pitcher RS, Bianchi J, Juarez R, Green AJ, Fox GC, Blanco L, Doherty AJ.

Mol Cell. 2011 Jan 21;41(2):221-31. doi: 10.1016/j.molcel.2010.12.026.


Characterization of the roles of the catalytic domains of Mycobacterium tuberculosis ligase D in Ku-dependent error-prone DNA end joining.

Wright D, DeBeaux A, Shi R, Doherty AJ, Harrison L.

Mutagenesis. 2010 Sep;25(5):473-81. doi: 10.1093/mutage/geq029. Epub 2010 Jun 7.


Functional interaction between Epstein-Barr virus replication protein Zta and host DNA damage response protein 53BP1.

Bailey SG, Verrall E, Schelcher C, Rhie A, Doherty AJ, Sinclair AJ.

J Virol. 2009 Nov;83(21):11116-22. doi: 10.1128/JVI.00512-09. Epub 2009 Aug 5.


Repairing DNA double-strand breaks by the prokaryotic non-homologous end-joining pathway.

Brissett NC, Doherty AJ.

Biochem Soc Trans. 2009 Jun;37(Pt 3):539-45. doi: 10.1042/BST0370539.


The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage.

Eliezer Y, Argaman L, Rhie A, Doherty AJ, Goldberg M.

J Biol Chem. 2009 Jan 2;284(1):426-35. doi: 10.1074/jbc.M807375200. Epub 2008 Nov 5.


ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.

Dargan SL, Clarke VR, Alushin GM, Sherwood JL, Nisticò R, Bortolotto ZA, Ogden AM, Bleakman D, Doherty AJ, Lodge D, Mayer ML, Fitzjohn SM, Jane DE, Collingridge GL.

Neuropharmacology. 2009 Jan;56(1):121-30. doi: 10.1016/j.neuropharm.2008.08.016. Epub 2008 Aug 22.


The induction of long-term plasticity of non-synaptic, synchronized activity by the activation of group I mGluRs.

Piccinin S, Thuault SJ, Doherty AJ, Brown JT, Randall AD, Davies CH, Bortolotto ZA, Collingridge GL.

Neuropharmacology. 2008 Sep;55(4):459-63. doi: 10.1016/j.neuropharm.2008.05.017. Epub 2008 May 28.


The use of the hippocampal slice preparation in the study of Alzheimer's disease.

Fitzjohn SM, Doherty AJ, Collingridge GL.

Eur J Pharmacol. 2008 May 6;585(1):50-9. doi: 10.1016/j.ejphar.2008.02.077. Epub 2008 Feb 29. Review.


Structure of a NHEJ polymerase-mediated DNA synaptic complex.

Brissett NC, Pitcher RS, Juarez R, Picher AJ, Green AJ, Dafforn TR, Fox GC, Blanco L, Doherty AJ.

Science. 2007 Oct 19;318(5849):456-9.


Expression of Mycobacterium tuberculosis Ku and Ligase D in Escherichia coli results in RecA and RecB-independent DNA end-joining at regions of microhomology.

Malyarchuk S, Wright D, Castore R, Klepper E, Weiss B, Doherty AJ, Harrison L.

DNA Repair (Amst). 2007 Oct 1;6(10):1413-24. Epub 2007 Jun 7.


Nonhomologous end-joining in bacteria: a microbial perspective.

Pitcher RS, Brissett NC, Doherty AJ.

Annu Rev Microbiol. 2007;61:259-82. Review.


Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P.

Dhir V, Ivison HE, Krone N, Shackleton CH, Doherty AJ, Stewart PM, Arlt W.

Mol Endocrinol. 2007 Aug;21(8):1958-68. Epub 2007 May 15.


NHEJ protects mycobacteria in stationary phase against the harmful effects of desiccation.

Pitcher RS, Green AJ, Brzostek A, Korycka-Machala M, Dziadek J, Doherty AJ.

DNA Repair (Amst). 2007 Sep 1;6(9):1271-6. Epub 2007 Mar 13.


Role of DNA repair by nonhomologous-end joining in Bacillus subtilis spore resistance to extreme dryness, mono- and polychromatic UV, and ionizing radiation.

Moeller R, Stackebrandt E, Reitz G, Berger T, Rettberg P, Doherty AJ, Horneck G, Nicholson WL.

J Bacteriol. 2007 Apr;189(8):3306-11. Epub 2007 Feb 9.

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