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Items: 40

1.

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome.

Bridgford JL, Xie SC, Cobbold SA, Pasaje CFA, Herrmann S, Yang T, Gillett DL, Dick LR, Ralph SA, Dogovski C, Spillman NJ, Tilley L.

Nat Commun. 2018 Sep 18;9(1):3801. doi: 10.1038/s41467-018-06221-1.

2.

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target.

Atkinson SC, Dogovski C, Wood K, Griffin MDW, Gorman MA, Hor L, Reboul CF, Buckle AM, Wuttke J, Parker MW, Dobson RCJ, Perugini MA.

Structure. 2018 Jul 3;26(7):948-959.e5. doi: 10.1016/j.str.2018.04.014. Epub 2018 May 24.

3.

Comparison of untagged and his-tagged dihydrodipicolinate synthase from the enteric pathogen Vibrio cholerae.

Gupta R, Soares da Costa TP, Faou P, Dogovski C, Perugini MA.

Protein Expr Purif. 2018 May;145:85-93. doi: 10.1016/j.pep.2018.01.003. Epub 2018 Jan 11.

PMID:
29337198
4.

Nanocrystallography measurements of early stage synthetic malaria pigment.

Dilanian RA, Streltsov V, Coughlan HD, Quiney HM, Martin AV, Klonis N, Dogovski C, Boutet S, Messerschmidt M, Williams GJ, Williams S, Phillips NW, Nugent KA, Tilley L, Abbey B.

J Appl Crystallogr. 2017 Sep 28;50(Pt 5):1533-1540. doi: 10.1107/S1600576717012663. eCollection 2017 Oct 1.

5.

A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum.

Cao P, Klonis N, Zaloumis S, Dogovski C, Xie SC, Saralamba S, White LJ, Fowkes FJI, Tilley L, Simpson JA, McCaw JM.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e00618-17. doi: 10.1128/AAC.00618-17. Print 2017 Dec.

6.

Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target.

Soares da Costa TP, Desbois S, Dogovski C, Gorman MA, Ketaren NE, Paxman JJ, Siddiqui T, Zammit LM, Abbott BM, Robins-Browne RM, Parker MW, Jameson GB, Hall NE, Panjikar S, Perugini MA.

Structure. 2016 Aug 2;24(8):1282-1291. doi: 10.1016/j.str.2016.05.019. Epub 2016 Jul 14.

7.

i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4.

Griffiths K, Dolezal O, Cao B, Nilsson SK, See HB, Pfleger KD, Roche M, Gorry PR, Pow A, Viduka K, Lim K, Lu BG, Chang DH, Murray-Rust T, Kvansakul M, Perugini MA, Dogovski C, Doerflinger M, Zhang Y, Parisi K, Casey JL, Nuttall SD, Foley M.

J Biol Chem. 2016 Jun 10;291(24):12641-57. doi: 10.1074/jbc.M116.721050. Epub 2016 Apr 1.

8.

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins.

Xie SC, Dogovski C, Hanssen E, Chiu F, Yang T, Crespo MP, Stafford C, Batinovic S, Teguh S, Charman S, Klonis N, Tilley L.

J Cell Sci. 2016 Jan 15;129(2):406-16. doi: 10.1242/jcs.178830. Epub 2015 Dec 16.

9.

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.

Dogovski C, Xie SC, Burgio G, Bridgford J, Mok S, McCaw JM, Chotivanich K, Kenny S, Gn├Ądig N, Straimer J, Bozdech Z, Fidock DA, Simpson JA, Dondorp AM, Foote S, Klonis N, Tilley L.

PLoS Biol. 2015 Apr 22;13(4):e1002132. doi: 10.1371/journal.pbio.1002132. eCollection 2015 Apr.

10.

Optimal assay design for determining the in vitro sensitivity of ring stage Plasmodium falciparum to artemisinins.

Xie SC, Dogovski C, Kenny S, Tilley L, Klonis N.

Int J Parasitol. 2014 Oct 15;44(12):893-9. doi: 10.1016/j.ijpara.2014.07.008. Epub 2014 Aug 23. Review.

PMID:
25161101
11.

Identification of the bona fide DHDPS from a common plant pathogen.

Atkinson SC, Hor L, Dogovski C, Dobson RC, Perugini MA.

Proteins. 2014 Sep;82(9):1869-83. doi: 10.1002/prot.24539. Epub 2014 Jun 11.

PMID:
24677246
12.

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae.

Dogovski C, Gorman MA, Ketaren NE, Praszkier J, Zammit LM, Mertens HD, Bryant G, Yang J, Griffin MD, Pearce FG, Gerrard JA, Jameson GB, Parker MW, Robins-Browne RM, Perugini MA.

PLoS One. 2013 Dec 13;8(12):e83419. doi: 10.1371/journal.pone.0083419. eCollection 2013.

13.

Cloning to crystallization of dihydrodipicolinate synthase from the intracellular pathogen Legionella pneumophila.

Siddiqui T, Paxman JJ, Dogovski C, Panjikar S, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Oct;69(Pt 10):1177-81. doi: 10.1107/S1744309113024639. Epub 2013 Sep 30.

14.

Defining the interaction of perforin with calcium and the phospholipid membrane.

Traore DA, Brennan AJ, Law RH, Dogovski C, Perugini MA, Lukoyanova N, Leung EW, Norton RS, Lopez JA, Browne KA, Yagita H, Lloyd GJ, Ciccone A, Verschoor S, Trapani JA, Whisstock JC, Voskoboinik I.

Biochem J. 2013 Dec 15;456(3):323-35. doi: 10.1042/BJ20130999.

PMID:
24070258
15.

Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein.

Yang J, Hocking DM, Cheng C, Dogovski C, Perugini MA, Holien JK, Parker MW, Hartland EL, Tauschek M, Robins-Browne RM.

J Biol Chem. 2013 Oct 25;288(43):31115-26. doi: 10.1074/jbc.M113.503912. Epub 2013 Sep 9.

16.

Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition.

Atkinson SC, Dogovski C, Downton MT, Czabotar PE, Dobson RC, Gerrard JA, Wagner J, Perugini MA.

Plant Mol Biol. 2013 Mar;81(4-5):431-46. doi: 10.1007/s11103-013-0014-7. Epub 2013 Jan 26.

PMID:
23354837
17.

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from Agrobacterium tumefaciens.

Atkinson SC, Dogovski C, Dobson RC, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Sep 1;68(Pt 9):1040-7. doi: 10.1107/S1744309112033052. Epub 2012 Aug 30.

18.

Comparative structure and function analyses of native and his-tagged forms of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus.

Dogovski C, Dommaraju SR, Small LC, Perugini MA.

Protein Expr Purif. 2012 Sep;85(1):66-76. doi: 10.1016/j.pep.2012.06.017. Epub 2012 Jul 6.

PMID:
22776412
19.

Crystal, solution and in silico structural studies of dihydrodipicolinate synthase from the common grapevine.

Atkinson SC, Dogovski C, Downton MT, Pearce FG, Reboul CF, Buckle AM, Gerrard JA, Dobson RC, Wagner J, Perugini MA.

PLoS One. 2012;7(6):e38318. doi: 10.1371/journal.pone.0038318. Epub 2012 Jun 25.

20.

Dimerization of plant defensin NaD1 enhances its antifungal activity.

Lay FT, Mills GD, Poon IK, Cowieson NP, Kirby N, Baxter AA, van der Weerden NL, Dogovski C, Perugini MA, Anderson MA, Kvansakul M, Hulett MD.

J Biol Chem. 2012 Jun 8;287(24):19961-72. doi: 10.1074/jbc.M111.331009. Epub 2012 Apr 17.

21.

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the grapevine Vitis vinifera.

Atkinson SC, Dogovski C, Newman J, Dobson RC, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1537-41. doi: 10.1107/S1744309111038395. Epub 2011 Nov 25.

22.

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins.

Lee EF, Dewson G, Smith BJ, Evangelista M, Pettikiriarachchi A, Dogovski C, Perugini MA, Colman PM, Fairlie WD.

Structure. 2011 Oct 12;19(10):1467-76. doi: 10.1016/j.str.2011.07.015.

23.

Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus.

Dommaraju SR, Dogovski C, Czabotar PE, Hor L, Smith BJ, Perugini MA.

Arch Biochem Biophys. 2011 Aug 15;512(2):167-74. doi: 10.1016/j.abb.2011.06.006. Epub 2011 Jun 16.

PMID:
21704017
24.

Crystal structure of the Leishmania major MIX protein: a scaffold protein that mediates protein-protein interactions.

Gorman MA, Uboldi AD, Walsh PJ, Tan KS, Hansen G, Huyton T, Ji H, Curtis J, Kedzierski L, Papenfuss AT, Dogovski C, Perugini MA, Simpson RJ, Handman E, Parker MW.

Protein Sci. 2011 Jun;20(6):1060-8. doi: 10.1002/pro.631. Epub 2011 Apr 27.

25.

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide.

Ngoei KR, Catimel B, Church N, Lio DS, Dogovski C, Perugini MA, Watt PM, Cheng HC, Ng DC, Bogoyevitch MA.

Biochem J. 2011 Mar 15;434(3):399-413. doi: 10.1042/BJ20101244.

PMID:
21162712
26.

Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica.

Wubben JM, Dogovski C, Dobson RC, Codd R, Gerrard JA, Parker MW, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1511-6. doi: 10.1107/S1744309110036791. Epub 2010 Oct 29.

27.

Cloning, expression and crystallization of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus.

Dommaraju S, Gorman MA, Dogovski C, Pearce FG, Gerrard JA, Dobson RC, Parker MW, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):57-60. doi: 10.1107/S1744309109047964. Epub 2009 Dec 25.

28.

Crystallization and preliminary X-ray diffraction analysis of diaminopimelate epimerase from Escherichia coli.

Hor L, Dobson RC, Dogovski C, Hutton CA, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):37-40. doi: 10.1107/S1744309109047708. Epub 2009 Dec 25.

29.

Crystallization of dihydrodipicolinate synthase from a clinical isolate of Streptococcus pneumoniae.

Sibarani NE, Gorman MA, Dogovski C, Parker MW, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):32-6. doi: 10.1107/S174430910904771X. Epub 2009 Dec 25.

30.

Substrate-mediated stabilization of a tetrameric drug target reveals Achilles heel in anthrax.

Voss JE, Scally SW, Taylor NL, Atkinson SC, Griffin MD, Hutton CA, Parker MW, Alderton MR, Gerrard JA, Dobson RC, Dogovski C, Perugini MA.

J Biol Chem. 2010 Feb 19;285(8):5188-95. doi: 10.1074/jbc.M109.038166. Epub 2009 Nov 30.

31.

Bicarbonate-mediated stimulation of RegA, the global virulence regulator from Citrobacter rodentium.

Yang J, Dogovski C, Hocking D, Tauschek M, Perugini M, Robins-Browne RM.

J Mol Biol. 2009 Dec 11;394(4):591-9. doi: 10.1016/j.jmb.2009.10.033. Epub 2009 Oct 21.

PMID:
19853617
32.

Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate.

Atkinson SC, Dobson RC, Newman JM, Gorman MA, Dogovski C, Parker MW, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Mar 1;65(Pt 3):253-5. doi: 10.1107/S1744309108039018. Epub 2009 Feb 14.

33.

Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate.

Voss JE, Scally SW, Taylor NL, Dogovski C, Alderton MR, Hutton CA, Gerrard JA, Parker MW, Dobson RC, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt 2):188-91. doi: 10.1107/S1744309109000670. Epub 2009 Jan 31.

34.

Aromatic residues in the C-terminal helix of human apoC-I mediate phospholipid interactions and particle morphology.

James PF, Dogovski C, Dobson RC, Bailey MF, Goldie KN, Karas JA, Scanlon DB, O'Hair RA, Perugini MA.

J Lipid Res. 2009 Jul;50(7):1384-94. doi: 10.1194/jlr.M800529-JLR200. Epub 2008 Nov 4.

35.

Surface plasmon resonance detection of ricin and horticultural ricin variants in environmental samples.

Tran H, Leong C, Loke WK, Dogovski C, Liu CQ.

Toxicon. 2008 Sep 15;52(4):582-8. doi: 10.1016/j.toxicon.2008.07.008. Epub 2008 Jul 24.

PMID:
18694776
36.

Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus.

Burgess BR, Dobson RC, Dogovski C, Jameson GB, Parker MW, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt 7):659-61. doi: 10.1107/S1744309108016746. Epub 2008 Jun 28.

37.

Food vacuole-associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum.

Jackson KE, Klonis N, Ferguson DJ, Adisa A, Dogovski C, Tilley L.

Mol Microbiol. 2004 Oct;54(1):109-22.

38.
39.

A study of AroP-PheP chimeric proteins and identification of a residue involved in tryptophan transport.

Cosgriff AJ, Brasier G, Pi J, Dogovski C, Sarsero JP, Pittard AJ.

J Bacteriol. 2000 Apr;182(8):2207-17.

40.

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