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Items: 1 to 50 of 78

1.

A FTIR microspectroscopy study of the structural and biochemical perturbations induced by natively folded and aggregated transthyretin in HL-1 cardiomyocytes.

Ami D, Mereghetti P, Leri M, Giorgetti S, Natalello A, Doglia SM, Stefani M, Bucciantini M.

Sci Rep. 2018 Aug 21;8(1):12508. doi: 10.1038/s41598-018-30995-5.

2.

Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms.

Di Bonaventura I, Jin X, Visini R, Probst D, Javor S, Gan BH, Michaud G, Natalello A, Doglia SM, Köhler T, van Delden C, Stocker A, Darbre T, Reymond JL.

Chem Sci. 2017 Oct 1;8(10):6784-6798. doi: 10.1039/c7sc01314k. Epub 2017 Jul 13.

3.

In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study.

Ami D, Lavatelli F, Rognoni P, Palladini G, Raimondi S, Giorgetti S, Monti L, Doglia SM, Natalello A, Merlini G.

Sci Rep. 2016 Jul 4;6:29096. doi: 10.1038/srep29096.

4.

The polyphenol Oleuropein aglycone hinders the growth of toxic transthyretin amyloid assemblies.

Leri M, Nosi D, Natalello A, Porcari R, Ramazzotti M, Chiti F, Bellotti V, Doglia SM, Stefani M, Bucciantini M.

J Nutr Biochem. 2016 Apr;30:153-66. doi: 10.1016/j.jnutbio.2015.12.009. Epub 2016 Jan 12.

PMID:
27012632
5.

Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS.

Natalello A, Mangione PP, Giorgetti S, Porcari R, Marchese L, Zorzoli I, Relini A, Ami D, Faravelli G, Valli M, Stoppini M, Doglia SM, Bellotti V, Raimondi S.

J Biol Chem. 2016 Apr 29;291(18):9678-89. doi: 10.1074/jbc.M116.720573. Epub 2016 Feb 26.

6.

Biochemical nature of Russell Bodies.

Mossuto MF, Ami D, Anelli T, Fagioli C, Doglia SM, Sitia R.

Sci Rep. 2015 Jul 30;5:12585. doi: 10.1038/srep12585.

7.

Wild type beta-2 microglobulin and DE loop mutants display a common fibrillar architecture.

Natalello A, Relini A, Penco A, Halabelian L, Bolognesi M, Doglia SM, Ricagno S.

PLoS One. 2015 Mar 24;10(3):e0122449. doi: 10.1371/journal.pone.0122449. eCollection 2015.

8.

Insoluble protein assemblies characterized by fourier transform infrared spectroscopy.

Natalello A, Doglia SM.

Methods Mol Biol. 2015;1258:347-69. doi: 10.1007/978-1-4939-2205-5_20. Review.

PMID:
25447875
9.

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery.

Pascucci L, Coccè V, Bonomi A, Ami D, Ceccarelli P, Ciusani E, Viganò L, Locatelli A, Sisto F, Doglia SM, Parati E, Bernardo ME, Muraca M, Alessandri G, Bondiolotti G, Pessina A.

J Control Release. 2014 Oct 28;192:262-70. doi: 10.1016/j.jconrel.2014.07.042. Epub 2014 Jul 30.

PMID:
25084218
10.

Epigallocatechin-3-gallate and tetracycline differently affect ataxin-3 fibrillogenesis and reduce toxicity in spinocerebellar ataxia type 3 model.

Bonanomi M, Natalello A, Visentin C, Pastori V, Penco A, Cornelli G, Colombo G, Malabarba MG, Doglia SM, Relini A, Regonesi ME, Tortora P.

Hum Mol Genet. 2014 Dec 15;23(24):6542-52. doi: 10.1093/hmg/ddu373. Epub 2014 Jul 16.

PMID:
25030034
11.

A Fourier transform infrared spectroscopy study of cell membrane domain modifications induced by docosahexaenoic acid.

Mereghetti P, Corsetto PA, Cremona A, Rizzo AM, Doglia SM, Ami D.

Biochim Biophys Acta. 2014 Oct;1840(10):3115-22. doi: 10.1016/j.bbagen.2014.07.003. Epub 2014 Jul 10.

PMID:
25018005
12.

Role of water in chromosome spreading and swelling induced by acetic acid treatment: a FTIR spectroscopy study.

Ami D, Di Segni M, Forcella M, Meraviglia V, Baccarin M, Doglia SM, Terzoli G.

Eur J Histochem. 2014 Feb 11;58(1):2330. doi: 10.4081/ejh.2014.2330.

13.

Neoglucosylated collagen matrices drive neuronal cells to differentiate.

Russo L, Sgambato A, Lecchi M, Pastori V, Raspanti M, Natalello A, Doglia SM, Nicotra F, Cipolla L.

ACS Chem Neurosci. 2014 Apr 16;5(4):261-5. doi: 10.1021/cn400222s. Epub 2014 Mar 19.

14.

Dendron synthesis and carbohydrate immobilization on a biomaterial surface by a double-click reaction.

Bini D, Russo L, Battocchio C, Natalello A, Polzonetti G, Doglia SM, Nicotra F, Cipolla L.

Org Lett. 2014 Mar 7;16(5):1298-301. doi: 10.1021/ol403476z. Epub 2014 Feb 19.

PMID:
24552198
15.

Fourier transform infrared spectroscopy as a method to study lipid accumulation in oleaginous yeasts.

Ami D, Posteri R, Mereghetti P, Porro D, Doglia SM, Branduardi P.

Biotechnol Biofuels. 2014 Jan 23;7(1):12. doi: 10.1186/1754-6834-7-12.

16.

Thiol-ene mediated neoglycosylation of collagen patches: a preliminary study.

Russo L, Battocchio C, Secchi V, Magnano E, Nappini S, Taraballi F, Gabrielli L, Comelli F, Papagni A, Costa B, Polzonetti G, Nicotra F, Natalello A, Doglia SM, Cipolla L.

Langmuir. 2014 Feb 11;30(5):1336-42. doi: 10.1021/la404310p. Epub 2014 Jan 28.

PMID:
24443819
17.

Reciprocal influence of protein domains in the cold-adapted acyl aminoacyl peptidase from Sporosarcina psychrophila.

Parravicini F, Natalello A, Papaleo E, De Gioia L, Doglia SM, Lotti M, Brocca S.

PLoS One. 2013;8(2):e56254. doi: 10.1371/journal.pone.0056254. Epub 2013 Feb 15.

18.

Why and how protein aggregation has to be studied in vivo.

Ami D, Natalello A, Lotti M, Doglia SM.

Microb Cell Fact. 2013 Feb 15;12:17. doi: 10.1186/1475-2859-12-17.

19.

Effects of methanol on a methanol-tolerant bacterial lipase.

Santambrogio C, Sasso F, Natalello A, Brocca S, Grandori R, Doglia SM, Lotti M.

Appl Microbiol Biotechnol. 2013 Oct;97(19):8609-18. doi: 10.1007/s00253-013-4712-5. Epub 2013 Feb 1.

PMID:
23371296
20.

Biophysical characterization of two different stable misfolded monomeric polypeptides that are chaperone-amenable substrates.

Natalello A, Mattoo RU, Priya S, Sharma SK, Goloubinoff P, Doglia SM.

J Mol Biol. 2013 Apr 12;425(7):1158-71. doi: 10.1016/j.jmb.2012.12.025. Epub 2013 Jan 7.

PMID:
23306033
21.

The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli.

Invernizzi G, Aprile FA, Natalello A, Ghisleni A, Penco A, Relini A, Doglia SM, Tortora P, Regonesi ME.

PLoS One. 2012;7(12):e51890. doi: 10.1371/journal.pone.0051890. Epub 2012 Dec 14.

22.

Synthesis and characterization of designed BMHP1-derived self-assembling peptides for tissue engineering applications.

Silva D, Natalello A, Sanii B, Vasita R, Saracino G, Zuckermann RN, Doglia SM, Gelain F.

Nanoscale. 2013 Jan 21;5(2):704-18. doi: 10.1039/c2nr32656f. Epub 2012 Dec 10.

PMID:
23223865
23.

Biophysical characterization of Met-G-CSF: effects of different site-specific mono-pegylations on protein stability and aggregation.

Natalello A, Ami D, Collini M, D'Alfonso L, Chirico G, Tonon G, Scaramuzza S, Schrepfer R, Doglia SM.

PLoS One. 2012;7(8):e42511. doi: 10.1371/journal.pone.0042511. Epub 2012 Aug 8.

24.

The influence of plasma technology coupled to chemical grafting on the cell growth compliance of 3D hydroxyapatite scaffolds.

Russo L, Zanini S, Giannoni P, Landi E, Villa A, Sandri M, Riccardi C, Quarto R, Doglia SM, Nicotra F, Cipolla L.

J Mater Sci Mater Med. 2012 Nov;23(11):2727-38. doi: 10.1007/s10856-012-4727-y. Epub 2012 Aug 9.

PMID:
22875605
25.

Fourier transform infrared spectroscopy of intrinsically disordered proteins: measurement procedures and data analyses.

Natalello A, Ami D, Doglia SM.

Methods Mol Biol. 2012;895:229-44. doi: 10.1007/978-1-61779-927-3_16.

PMID:
22760323
26.

Fourier transform infrared microspectroscopy of complex biological systems: from intact cells to whole organisms.

Ami D, Natalello A, Doglia SM.

Methods Mol Biol. 2012;895:85-100. doi: 10.1007/978-1-61779-927-3_7.

PMID:
22760314
27.

Ethidium bromide as a marker of mtDNA replication in living cells.

Villa AM, Fusi P, Pastori V, Amicarelli G, Pozzi C, Adlerstein D, Doglia SM.

J Biomed Opt. 2012 Apr;17(4):046001. doi: 10.1117/1.JBO.17.4.046001.

28.

Structure, stability, and aggregation of β-2 microglobulin mutants: insights from a Fourier transform infrared study in solution and in the crystalline state.

Ami D, Ricagno S, Bolognesi M, Bellotti V, Doglia SM, Natalello A.

Biophys J. 2012 Apr 4;102(7):1676-84. doi: 10.1016/j.bpj.2012.02.045. Epub 2012 Apr 3.

29.

Temperature profoundly affects ataxin-3 fibrillogenesis.

Apicella A, Natalello A, Frana AM, Baserga A, Casari CS, Bottani CE, Doglia SM, Tortora P, Regonesi ME.

Biochimie. 2012 Apr;94(4):1026-31. doi: 10.1016/j.biochi.2012.01.002. Epub 2012 Jan 9.

PMID:
22234302
30.

The role of the central flexible region on the aggregation and conformational properties of human ataxin-3.

Santambrogio C, Frana AM, Natalello A, Papaleo E, Regonesi ME, Doglia SM, Tortora P, Invernizzi G, Grandori R.

FEBS J. 2012 Feb;279(3):451-63. doi: 10.1111/j.1742-4658.2011.08438.x. Epub 2012 Jan 9.

31.

Sugar-decorated hydroxyapatite: an inorganic material bioactivated with carbohydrates.

Russo L, Landi E, Tampieri A, Natalello A, Doglia SM, Gabrielli L, Cipolla L, Nicotra F.

Carbohydr Res. 2011 Sep 6;346(12):1564-8. doi: 10.1016/j.carres.2011.04.044. Epub 2011 May 3.

PMID:
21600566
32.

Concepts and tools to exploit the potential of bacterial inclusion bodies in protein science and biotechnology.

Gatti-Lafranconi P, Natalello A, Ami D, Doglia SM, Lotti M.

FEBS J. 2011 Jul;278(14):2408-18. doi: 10.1111/j.1742-4658.2011.08163.x. Epub 2011 May 31. Review.

33.

Compaction properties of an intrinsically disordered protein: Sic1 and its kinase-inhibitor domain.

Brocca S, Testa L, Sobott F, Samalikova M, Natalello A, Papaleo E, Lotti M, De Gioia L, Doglia SM, Alberghina L, Grandori R.

Biophys J. 2011 May 4;100(9):2243-52. doi: 10.1016/j.bpj.2011.02.055.

34.

A major role for side-chain polyglutamine hydrogen bonding in irreversible ataxin-3 aggregation.

Natalello A, Frana AM, Relini A, Apicella A, Invernizzi G, Casari C, Gliozzi A, Doglia SM, Tortora P, Regonesi ME.

PLoS One. 2011 Apr 13;6(4):e18789. doi: 10.1371/journal.pone.0018789.

35.

FTIR spectral signatures of mouse antral oocytes: molecular markers of oocyte maturation and developmental competence.

Ami D, Mereghetti P, Natalello A, Doglia SM, Zanoni M, Redi CA, Monti M.

Biochim Biophys Acta. 2011 Jun;1813(6):1220-9. doi: 10.1016/j.bbamcr.2011.03.009. Epub 2011 Mar 22.

36.

BMHP1-derived self-assembling peptides: hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications.

Gelain F, Silva D, Caprini A, Taraballi F, Natalello A, Villa O, Nam KT, Zuckermann RN, Doglia SM, Vescovi A.

ACS Nano. 2011 Mar 22;5(3):1845-59. doi: 10.1021/nn102663a. Epub 2011 Feb 11.

PMID:
21314189
37.

Effects of the known pathogenic mutations on the aggregation pathway of the amyloidogenic peptide of apolipoprotein A-I.

Raimondi S, Guglielmi F, Giorgetti S, Di Gaetano S, Arciello A, Monti DM, Relini A, Nichino D, Doglia SM, Natalello A, Pucci P, Mangione P, Obici L, Merlini G, Stoppini M, Robustelli P, Tartaglia GG, Vendruscolo M, Dobson CM, Piccoli R, Bellotti V.

J Mol Biol. 2011 Apr 1;407(3):465-76. doi: 10.1016/j.jmb.2011.01.044. Epub 2011 Feb 4.

PMID:
21296086
38.

Compact conformations of α-synuclein induced by alcohols and copper.

Natalello A, Benetti F, Doglia SM, Legname G, Grandori R.

Proteins. 2011 Feb;79(2):611-21. doi: 10.1002/prot.22909.

PMID:
21120859
39.

Tetracycline prevents Aβ oligomer toxicity through an atypical supramolecular interaction.

Airoldi C, Colombo L, Manzoni C, Sironi E, Natalello A, Doglia SM, Forloni G, Tagliavini F, Del Favero E, Cantù L, Nicotra F, Salmona M.

Org Biomol Chem. 2011 Jan 21;9(2):463-72. doi: 10.1039/c0ob00303d. Epub 2010 Nov 10.

PMID:
21063627
40.

Investigating the structural biofunctionality of antibodies conjugated to magnetic nanoparticles.

Occhipinti E, Verderio P, Natalello A, Galbiati E, Colombo M, Mazzucchelli S, Salvadè A, Tortora P, Doglia SM, Prosperi D.

Nanoscale. 2011 Feb;3(2):387-90. doi: 10.1039/c0nr00436g. Epub 2010 Sep 29.

PMID:
20877896
41.

Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers.

Diomede L, Cassata G, Fiordaliso F, Salio M, Ami D, Natalello A, Doglia SM, De Luigi A, Salmona M.

Neurobiol Dis. 2010 Nov;40(2):424-31. doi: 10.1016/j.nbd.2010.07.002. Epub 2010 Jul 14.

PMID:
20637283
42.

Glycine-spacers influence functional motifs exposure and self-assembling propensity of functionalized substrates tailored for neural stem cell cultures.

Taraballi F, Natalello A, Campione M, Villa O, Doglia SM, Paleari A, Gelain F.

Front Neuroeng. 2010 Feb 8;3:1. doi: 10.3389/neuro.16.001.2010. eCollection 2010.

43.

Structure and binding of peptide-dendrimer ligands to vitamin B12.

Uhlich NA, Natalello A, Kadam RU, Doglia SM, Reymond JL, Darbre T.

Chembiochem. 2010 Feb 15;11(3):358-65. doi: 10.1002/cbic.200900657.

PMID:
20014271
44.

Evolution of stability in a cold-active enzyme elicits specificity relaxation and highlights substrate-related effects on temperature adaptation.

Gatti-Lafranconi P, Natalello A, Rehm S, Doglia SM, Pleiss J, Lotti M.

J Mol Biol. 2010 Jan 8;395(1):155-66. doi: 10.1016/j.jmb.2009.10.026. Epub 2009 Oct 20.

PMID:
19850050
45.

Plasma-induced graft-polymerization of polyethylene glycol acrylate on polypropylene films: chemical characterization and evaluation of the protein adsorption.

Zanini S, Riccardi C, Grimoldi E, Colombo C, Villa AM, Natalello A, Gatti-Lafranconi P, Lotti M, Doglia SM.

J Colloid Interface Sci. 2010 Jan 1;341(1):53-8. doi: 10.1016/j.jcis.2009.09.012. Epub 2009 Sep 16.

PMID:
19822326
46.

Ethidium bromide as a vital probe of mitochondrial DNA in carcinoma cells.

Villa AM, Doglia SM.

Eur J Cancer. 2009 Sep;45(14):2588-97. doi: 10.1016/j.ejca.2009.06.022. Epub 2009 Jul 27.

PMID:
19640699
47.

Effects of recombinant protein misfolding and aggregation on bacterial membranes.

Ami D, Natalello A, Schultz T, Gatti-Lafranconi P, Lotti M, Doglia SM, de Marco A.

Biochim Biophys Acta. 2009 Feb;1794(2):263-9. doi: 10.1016/j.bbapap.2008.10.015. Epub 2008 Nov 11.

PMID:
19059501
48.

Alpha-helix stabilization within a peptide dendrimer.

Javor S, Natalello A, Doglia SM, Reymond JL.

J Am Chem Soc. 2008 Dec 24;130(51):17248-9. doi: 10.1021/ja8076236.

PMID:
19053200
49.

The osmolyte betaine promotes protein misfolding and disruption of protein aggregates.

Natalello A, Liu J, Ami D, Doglia SM, de Marco A.

Proteins. 2009 May 1;75(2):509-17. doi: 10.1002/prot.22266.

PMID:
18951407
50.

In vivo aggregation of bovine beta-lactoglobulin is affected by Cys at position 121.

Invernizzi G, Annoni E, Natalello A, Doglia SM, Lotti M.

Protein Expr Purif. 2008 Nov;62(1):111-5. doi: 10.1016/j.pep.2008.06.012. Epub 2008 Jul 8.

PMID:
18662787

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