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Epigenetic Activation of BRCA1 by Genistein In Vivo and Triple Negative Breast Cancer Cells Linked to Antagonism toward Aryl Hydrocarbon Receptor.

Donovan MG, Selmin OI, Doetschman TC, Romagnolo DF.

Nutrients. 2019 Oct 23;11(11). pii: E2559. doi: 10.3390/nu11112559.


Modulating smooth muscle cell response by the release of TGFβ2 from tubular scaffolds for vascular tissue engineering.

Ardila DC, Tamimi E, Doetschman T, Wagner WR, Vande Geest JP.

J Control Release. 2019 Apr 10;299:44-52. doi: 10.1016/j.jconrel.2019.02.024. Epub 2019 Feb 20.


n-6 Linoleic Acid Induces Epigenetics Alterations Associated with Colonic Inflammation and Cancer.

Romagnolo DF, Donovan MG, Doetschman TC, Selmin OI.

Nutrients. 2019 Jan 15;11(1). pii: E171. doi: 10.3390/nu11010171.


Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection.

Burt PM, Xiao L, Doetschman T, Hurley MM.

J Cell Physiol. 2019 Apr;234(4):4418-4431. doi: 10.1002/jcp.27230. Epub 2018 Aug 25.


Genistein Prevents BRCA1 CpG Methylation and Proliferation in Human Breast Cancer Cells with Activated Aromatic Hydrocarbon Receptor.

Romagnolo DF, Donovan MG, Papoutsis AJ, Doetschman TC, Selmin OI.

Curr Dev Nutr. 2017 May 19;1(6):e000562. doi: 10.3945/cdn.117.000562. eCollection 2017 Jun.


Mediterranean Diet: Prevention of Colorectal Cancer.

Donovan MG, Selmin OI, Doetschman TC, Romagnolo DF.

Front Nutr. 2017 Dec 5;4:59. doi: 10.3389/fnut.2017.00059. eCollection 2017. Review.


Functional Changes in the Gut Microbiome Contribute to Transforming Growth Factor β-Deficient Colon Cancer.

Daniel SG, Ball CL, Besselsen DG, Doetschman T, Hurwitz BL.

mSystems. 2017 Sep 26;2(5). pii: e00065-17. doi: 10.1128/mSystems.00065-17. eCollection 2017 Sep-Oct.


Gene Editing With CRISPR/Cas9 RNA-Directed Nuclease.

Doetschman T, Georgieva T.

Circ Res. 2017 Mar 3;120(5):876-894. doi: 10.1161/CIRCRESAHA.116.309727. Review.


Corrigendum to "Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells".

Yan J, Mitra A, Hu J, Cutrera JJ, Xia X, Doetschman T, Gagea M, Mishra L, Li S.

J Hepatol. 2016 May 27. pii: S0168-8278(16)30180-5. doi: 10.1016/j.jhep.2016.04.028. [Epub ahead of print] No abstract available.


Flow cytometry and single nucleus sorting for Cre-based analysis of changes in transcriptional states.

Samadder P, Weng N, Doetschman T, Heimark RL, Galbraith DW.

Cytometry A. 2016 May;89(5):430-42. doi: 10.1002/cyto.a.22847. Epub 2016 Mar 22.


2-Photon Characterization of Optical Proteolytic Beacons for Imaging Changes in Matrix-Metalloprotease Activity in a Mouse Model of Aneurysm.

Haskett DG, Maestas D, Howerton SJ, Smith T, Ardila DC, Doetschman T, Utzinger U, McGrath D, McIntyre JO, Vande Geest JP.

Microsc Microanal. 2016 Apr;22(2):349-60. doi: 10.1017/S1431927616000088. Epub 2016 Feb 23.


Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells.

Yan J, Mitra A, Hu J, Cutrera JJ, Xia X, Doetschman T, Gagea M, Mishra L, Li S.

J Hepatol. 2016 May;64(5):1128-1136. doi: 10.1016/j.jhep.2015.12.020. Epub 2016 Jan 6.


Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells.

Selmin OI, Fang C, Lyon AM, Doetschman TC, Thompson PA, Martinez JD, Smith JW, Lance PM, Romagnolo DF.

J Nutr. 2016 Feb;146(2):236-42. doi: 10.3945/jn.115.216580. Epub 2015 Nov 25.


Biomechanical Comparison of Glutaraldehyde-Crosslinked Gelatin Fibrinogen Electrospun Scaffolds to Porcine Coronary Arteries.

Tamimi E, Ardila DC, Haskett DG, Doetschman T, Slepian MJ, Kellar RS, Vande Geest JP.

J Biomech Eng. 2016 Jan;138(1). doi: 10.1115/1.4031847.


TGFβ2 differentially modulates smooth muscle cell proliferation and migration in electrospun gelatin-fibrinogen constructs.

Ardila DC, Tamimi E, Danford FL, Haskett DG, Kellar RS, Doetschman T, Vande Geest JP.

Biomaterials. 2015 Jan;37:164-73. doi: 10.1016/j.biomaterials.2014.10.021. Epub 2014 Oct 22.


Knockout of nuclear high molecular weight FGF2 isoforms in mice modulates bone and phosphate homeostasis.

Homer-Bouthiette C, Doetschman T, Xiao L, Hurley MM.

J Biol Chem. 2014 Dec 26;289(52):36303-14. doi: 10.1074/jbc.M114.619569. Epub 2014 Nov 11.


Cardiac development and physiology are modulated by FGF2 in an isoform- and sex-specific manner.

Nusayr E, Doetschman T.

Physiol Rep. 2013 Sep;1(4). doi: 10.1002/phy2.87.


FGF2 modulates cardiac remodeling in an isoform- and sex-specific manner.

Nusayr E, Sadideen DT, Doetschman T.

Physiol Rep. 2013 Sep;1(4). doi: 10.1002/phy2.88.


Cardiac-specific inducible and conditional gene targeting in mice.

Doetschman T, Azhar M.

Circ Res. 2012 May 25;110(11):1498-512. doi: 10.1161/CIRCRESAHA.112.265066. Review.


Fibroblast growth factor-2-induced cardioprotection against myocardial infarction occurs via the interplay between nitric oxide, protein kinase signaling, and ATP-sensitive potassium channels.

Manning JR, Carpenter G, Porter DR, House SL, Pietras DA, Doetschman T, Schultz Jel J.

Growth Factors. 2012 Apr;30(2):124-39. doi: 10.3109/08977194.2012.656759. Epub 2012 Feb 6. Erratum in: Growth Factors. 2012 Dec;30(6):418.


Generation of mice with a conditional allele for the transforming growth factor beta3 gene.

Doetschman T, Georgieva T, Li H, Reed TD, Grisham C, Friel J, Estabrook MA, Gard C, Sanford LP, Azhar M.

Genesis. 2012 Jan;50(1):59-66. doi: 10.1002/dvg.20789. Epub 2012 Jan 6.


Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway.

Fei Y, Xiao L, Doetschman T, Coffin DJ, Hurley MM.

J Biol Chem. 2011 Nov 25;286(47):40575-83. doi: 10.1074/jbc.M111.274910. Epub 2011 Oct 10.


Transforming growth factor beta signaling in adult cardiovascular diseases and repair.

Doetschman T, Barnett JV, Runyan RB, Camenisch TD, Heimark RL, Granzier HL, Conway SJ, Azhar M.

Cell Tissue Res. 2012 Jan;347(1):203-23. doi: 10.1007/s00441-011-1241-3. Epub 2011 Sep 28. Review.


The inter-relationship of periostin, TGF beta, and BMP in heart valve development and valvular heart diseases.

Conway SJ, Doetschman T, Azhar M.

ScientificWorldJournal. 2011 Jul 28;11:1509-24. doi: 10.1100/tsw.2011.132. Review.


Transforming growth factor Beta2 is required for valve remodeling during heart development.

Azhar M, Brown K, Gard C, Chen H, Rajan S, Elliott DA, Stevens MV, Camenisch TD, Conway SJ, Doetschman T.

Dev Dyn. 2011 Sep;240(9):2127-41. doi: 10.1002/dvdy.22702. Epub 2011 Jul 20.


Fibroblast Growth Factor 2 Mediates Isoproterenol-induced Cardiac Hypertrophy through Activation of the Extracellular Regulated Kinase.

House SL, House BE, Glascock B, Kimball T, Nusayr E, Schultz JE, Doetschman T.

Mol Cell Pharmacol. 2010;2(4):143-154.


Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis.

Doetschman T, Sholl A, Chen Hd, Gard C, Hildeman DA, Bommireddy R.

Clin Immunol. 2011 Mar;138(3):321-30. doi: 10.1016/j.clim.2010.12.020. Epub 2011 Jan 20.


GI GEMs: genetically engineered mouse models of gastrointestinal disease.

Doetschman T.

Gastroenterology. 2011 Feb;140(2):380-385.e2. doi: 10.1053/j.gastro.2010.12.013. Epub 2010 Dec 15. Review. No abstract available.


Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells.

Xiao L, Sobue T, Esliger A, Kronenberg MS, Coffin JD, Doetschman T, Hurley MM.

Bone. 2010 Aug;47(2):360-70. doi: 10.1016/j.bone.2010.05.021. Epub 2010 May 25.


The influence of FGF2 high molecular weight (HMW) isoforms in the development of cardiac ischemia-reperfusion injury.

Liao S, Bodmer JR, Azhar M, Newman G, Coffin JD, Doetschman T, Schultz Jel J.

J Mol Cell Cardiol. 2010 Jun;48(6):1245-54. doi: 10.1016/j.yjmcc.2010.01.014. Epub 2010 Jan 29.


Origin of cardiac fibroblasts and the role of periostin.

Snider P, Standley KN, Wang J, Azhar M, Doetschman T, Conway SJ.

Circ Res. 2009 Nov 6;105(10):934-47. doi: 10.1161/CIRCRESAHA.109.201400. Review.


Lymphangiogenesis and angiogenesis: concurrence and/or dependence? Studies in inbred mouse strains.

Nakao S, Maruyama K, Zandi S, Melhorn MI, Taher M, Noda K, Nusayr E, Doetschman T, Hafezi-Moghadam A.

FASEB J. 2010 Feb;24(2):504-13. doi: 10.1096/fj.09-134056. Epub 2009 Oct 26.


Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice.

Bommireddy R, Bueno OF, Martin J, Ormsby I, Chen H, Gard C, Molkentin JD, Boivin GP, Babcock GF, Doetschman T.

Clin Exp Immunol. 2009 Dec;158(3):317-24. doi: 10.1111/j.1365-2249.2009.04015.x. Epub 2009 Aug 18.


Generation of mice with a conditional allele for transforming growth factor beta 1 gene.

Azhar M, Yin M, Bommireddy R, Duffy JJ, Yang J, Pawlowski SA, Boivin GP, Engle SJ, Sanford LP, Grisham C, Singh RR, Babcock GF, Doetschman T.

Genesis. 2009 Jun;47(6):423-31. doi: 10.1002/dvg.20516.


Influence of genetic background on genetically engineered mouse phenotypes.

Doetschman T.

Methods Mol Biol. 2009;530:423-33. doi: 10.1007/978-1-59745-471-1_23. Review.


Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development.

Azhar M, Runyan RB, Gard C, Sanford LP, Miller ML, Andringa A, Pawlowski S, Rajan S, Doetschman T.

Dev Dyn. 2009 Feb;238(2):431-42. doi: 10.1002/dvdy.21854.


Endogenous FGF-2 is critically important in PTH anabolic effects on bone.

Sabbieti MG, Agas D, Xiao L, Marchetti L, Coffin JD, Doetschman T, Hurley MM.

J Cell Physiol. 2009 Apr;219(1):143-51. doi: 10.1002/jcp.21661.


Gene targeted ablation of high molecular weight fibroblast growth factor-2.

Azhar M, Yin M, Zhou M, Li H, Mustafa M, Nusayr E, Keenan JB, Chen H, Pawlosky S, Gard C, Grisham C, Sanford LP, Doetschman T.

Dev Dyn. 2009 Feb;238(2):351-7. doi: 10.1002/dvdy.21835.


Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice.

Xiao L, Liu P, Li X, Doetschman T, Coffin JD, Drissi H, Hurley MM.

J Biol Chem. 2009 Jan 30;284(5):3170-82. doi: 10.1074/jbc.M804900200. Epub 2008 Dec 4.


Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene.

Chen K, Ohkubo Y, Shin D, Doetschman T, Sanford LP, Li H, Vaccarino FM.

BMC Neurosci. 2008 Sep 30;9:94. doi: 10.1186/1471-2202-9-94.


Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.

Prasad V, Bodi I, Meyer JW, Wang Y, Ashraf M, Engle SJ, Doetschman T, Sisco K, Nieman ML, Miller ML, Lorenz JN, Shull GE.

J Biol Chem. 2008 Nov 14;283(46):31303-14. doi: 10.1074/jbc.M803706200. Epub 2008 Sep 8.


Biological functions of the low and high molecular weight protein isoforms of fibroblast growth factor-2 in cardiovascular development and disease.

Liao S, Bodmer J, Pietras D, Azhar M, Doetschman T, Schultz Jel J.

Dev Dyn. 2009 Feb;238(2):249-64. doi: 10.1002/dvdy.21677. Review.


Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-beta1 pathway.

Lee HT, Chen SW, Doetschman TC, Deng C, D'Agati VD, Kim M.

Am J Physiol Renal Physiol. 2008 Jul;295(1):F128-36. doi: 10.1152/ajprenal.00577.2007. Epub 2008 Apr 23.


TGFbeta1 deficiency does not affect the generation and maintenance of CD4+CD25+FOXP3+ putative Treg cells, but causes their numerical inadequacy and loss of regulatory function.

Bommireddy R, Babcock GF, Singh RR, Doetschman T.

Clin Immunol. 2008 May;127(2):206-13. doi: 10.1016/j.clim.2007.12.008. Epub 2008 Mar 4.


Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage.

Saxena V, Lienesch DW, Zhou M, Bommireddy R, Azhar M, Doetschman T, Singh RR.

J Immunol. 2008 Feb 1;180(3):1903-12.


TGFbeta1 and Treg cells: alliance for tolerance.

Bommireddy R, Doetschman T.

Trends Mol Med. 2007 Nov;13(11):492-501. Epub 2007 Oct 30. Review.


Reduced expression and function of bone morphogenetic protein-2 in bones of Fgf2 null mice.

Naganawa T, Xiao L, Coffin JD, Doetschman T, Sabbieti MG, Agas D, Hurley MM.

J Cell Biochem. 2008 Apr 15;103(6):1975-88.


Endogenous transforming growth factor beta 1 suppresses inflammation and promotes survival in adult CNS.

Makwana M, Jones LL, Cuthill D, Heuer H, Bohatschek M, Hristova M, Friedrichsen S, Ormsby I, Bueringer D, Koppius A, Bauer K, Doetschman T, Raivich G.

J Neurosci. 2007 Oct 17;27(42):11201-13.


Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer.

Kaiser S, Park YK, Franklin JL, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga AG, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Boivin GP, Roberts RB, Bissahoyo AC, Gonzales F, Bloom GC, Eschrich S, Carter SL, Aronow JE, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Boone B, Levy S, Graff JM, Doetschman T, Groden J, Dove WF, Threadgill DW, Yeatman TJ, Coffey RJ Jr, Aronow BJ.

Genome Biol. 2007;8(7):R131.


Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes.

Okunade GW, Miller ML, Azhar M, Andringa A, Sanford LP, Doetschman T, Prasad V, Shull GE.

J Biol Chem. 2007 Sep 7;282(36):26517-27. Epub 2007 Jun 27.

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