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Items: 1 to 50 of 149

1.

E-Cigarette Exposure Delays Implantation and Causes Reduced Weight Gain in Female Offspring Exposed In Utero.

Wetendorf M, Randall LT, Lemma MT, Hurr SH, Pawlak JB, Tarran R, Doerschuk CM, Caron KM.

J Endocr Soc. 2019 Sep 5;3(10):1907-1916. doi: 10.1210/js.2019-00216. eCollection 2019 Oct 1.

2.

Inhibition of glutamine metabolism accelerates resolution of acute lung injury.

Vigeland CL, Beggs HS, Collins SL, Chan-Li Y, Powell JD, Doerschuk CM, Horton MR.

Physiol Rep. 2019 Mar;7(5):e14019. doi: 10.14814/phy2.14019.

3.

Dynamic changes in lung responses after single and repeated exposures to cigarette smoke in mice.

Engle ML, Monk JN, Jania CM, Martin JR, Gomez JC, Dang H, Parker JS, Doerschuk CM.

PLoS One. 2019 Feb 28;14(2):e0212866. doi: 10.1371/journal.pone.0212866. eCollection 2019.

4.

Transcriptional analysis of Foxp3+ Tregs and functions of two identified molecules during resolution of ALI.

Mock JR, Dial CF, Tune MK, Norton DL, Martin JR, Gomez JC, Hagan RS, Dang H, Doerschuk CM.

JCI Insight. 2019 Mar 21;4(6). pii: 124958. doi: 10.1172/jci.insight.124958. eCollection 2019 Mar 21.

5.

Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities. An Analysis from SPIROMICS.

Putcha N, Fawzy A, Paul GG, Lambert AA, Psoter KJ, Sidhaye VK, Woo J, Wells JM, Labaki WW, Doerschuk CM, Kanner RE, Han MK, Martinez C, Paulin LM, Martinez FJ, Wise RA, O'Neal WK, Barr RG, Hansel NN; SPIROMICS investigators.

Ann Am Thorac Soc. 2018 Jun;15(6):710-717. doi: 10.1513/AnnalsATS.201708-687OC.

6.

A perpetual switching system in pulmonary capillaries.

Wagner WW Jr, Jaryszak EM, Peterson AJ, Doerschuk CM, Bohlen HG, King JAC, Tanner JA, Crockett ES, Glenny RW, Presson RG Jr.

J Appl Physiol (1985). 2019 Feb 1;126(2):494-501. doi: 10.1152/japplphysiol.00507.2018. Epub 2018 Dec 20.

PMID:
30571293
7.

Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.

Okuda K, Chen G, Subramani DB, Wolf M, Gilmore RC, Kato T, Radicioni G, Kesimer M, Chua M, Dang H, Livraghi-Butrico A, Ehre C, Doerschuk CM, Randell SH, Matsui H, Nagase T, O'Neal WK, Boucher RC.

Am J Respir Crit Care Med. 2019 Mar 15;199(6):715-727. doi: 10.1164/rccm.201804-0734OC.

PMID:
30352166
8.

Myeloid TBK1 Signaling Contributes to the Immune Response to Influenza.

Hagan RS, Torres-Castillo J, Doerschuk CM.

Am J Respir Cell Mol Biol. 2019 Mar;60(3):335-345. doi: 10.1165/rcmb.2018-0122OC.

PMID:
30290124
9.

A Rnd3/p190RhoGAP pathway regulates RhoA activity in idiopathic pulmonary fibrosis fibroblasts.

Monaghan-Benson E, Wittchen ES, Doerschuk CM, Burridge K.

Mol Biol Cell. 2018 Sep 1;29(18):2165-2175. doi: 10.1091/mbc.E17-11-0642. Epub 2018 Jul 11.

10.

Neuropilin-2 regulates airway inflammatory responses to inhaled lipopolysaccharide.

Immormino RM, Lauzier DC, Nakano H, Hernandez ML, Alexis NE, Ghio AJ, Tilley SL, Doerschuk CM, Peden DB, Cook DN, Moran TP.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L202-L211. doi: 10.1152/ajplung.00067.2018. Epub 2018 Apr 19.

11.

Future Research Directions in Pneumonia. NHLBI Working Group Report.

Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):256-263. doi: 10.1164/rccm.201801-0139WS.

12.

Blocking CXCL1-dependent neutrophil recruitment prevents immune damage and reduces pulmonary bacterial infection after inhalation injury.

Dunn JLM, Kartchner LB, Stepp WH, Glenn LI, Malfitano MM, Jones SW, Doerschuk CM, Maile R, Cairns BA.

Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L822-L834. doi: 10.1152/ajplung.00272.2017. Epub 2018 Jan 25.

13.

Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort.

Hastie AT, Martinez FJ, Curtis JL, Doerschuk CM, Hansel NN, Christenson S, Putcha N, Ortega VE, Li X, Barr RG, Carretta EE, Couper DJ, Cooper CB, Hoffman EA, Kanner RE, Kleerup E, O'Neal WK, Paine R 3rd, Peters SP, Alexis NE, Woodruff PG, Han MK, Meyers DA, Bleecker ER; SPIROMICS investigators.

Lancet Respir Med. 2017 Dec;5(12):956-967. doi: 10.1016/S2213-2600(17)30432-0. Epub 2017 Nov 13.

14.

Variability in objective and subjective measures affects baseline values in studies of patients with COPD.

Anderson WH, Ha JW, Couper DJ, O'Neal WK, Barr RG, Bleecker ER, Carretta EE, Cooper CB, Doerschuk CM, Drummond MB, Han MK, Hansel NN, Kim V, Kleerup EC, Martinez FJ, Rennard SI, Tashkin D, Woodruff PG, Paine R 3rd, Curtis JL, Kanner RE; SPIROMICS Research Group.

PLoS One. 2017 Sep 21;12(9):e0184606. doi: 10.1371/journal.pone.0184606. eCollection 2017.

15.

Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.

Martinez CH, Li SX, Hirzel AJ, Stolberg VR, Alexis NE, Barr RG, Bleecker ER, Carretta EE, Christenson SA, Cooper CB, Couper DJ, Doerschuk CM, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Martinez FJ, Meyers DA, O'Neal WK, Paine R 3rd, Putcha N, Rennard SI, Woodruff PG, Zeidler M, Curtis JL, Freeman CM; SPIROMICS Investigators.

J Allergy Clin Immunol. 2018 Jan;141(1):429-432. doi: 10.1016/j.jaci.2017.07.039. Epub 2017 Sep 12. No abstract available.

16.

Predicted effects of observed changes in the mRNA and microRNA transcriptome of lung neutrophils during S. pneumoniae pneumonia in mice.

Gomez JC, Dang H, Kanke M, Hagan RS, Mock JR, Kelada SNP, Sethupathy P, Doerschuk CM.

Sci Rep. 2017 Sep 12;7(1):11258. doi: 10.1038/s41598-017-11638-7.

17.

Airway Mucin Concentration as a Marker of Chronic Bronchitis.

Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, Doerschuk CM, Alexis NE, Anderson WH, Henderson AG, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez F, Paine R 3rd, Woodruff PG, O'Neal WK, Boucher RC.

N Engl J Med. 2017 Sep 7;377(10):911-922. doi: 10.1056/NEJMoa1701632.

18.

Biomarkers of exposure to new and emerging tobacco delivery products.

Schick SF, Blount BC, Jacob P Rd, Saliba NA, Bernert JT, El Hellani A, Jatlow P, Pappas RS, Wang L, Foulds J, Ghosh A, Hecht SS, Gomez JC, Martin JR, Mesaros C, Srivastava S, St Helen G, Tarran R, Lorkiewicz PK, Blair IA, Kimmel HL, Doerschuk CM, Benowitz NL, Bhatnagar A.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L425-L452. doi: 10.1152/ajplung.00343.2016. Epub 2017 May 18. Review.

19.

Activating Integrins Isn't Always "Beta" for Neutrophil Migration!

Gomez JC, Doerschuk CM.

Am J Respir Cell Mol Biol. 2017 May;56(5):561-562. doi: 10.1165/rcmb.2017-0066ED. No abstract available.

20.

Foxp3+ Regulatory T Cell Expression of Keratinocyte Growth Factor Enhances Lung Epithelial Proliferation.

Dial CF, Tune MK, Doerschuk CM, Mock JR.

Am J Respir Cell Mol Biol. 2017 Aug;57(2):162-173. doi: 10.1165/rcmb.2017-0019OC.

21.

Sialic acid-to-urea ratio as a measure of airway surface hydration.

Esther CR Jr, Hill DB, Button B, Shi S, Jania C, Duncan EA, Doerschuk CM, Chen G, Ranganathan S, Stick SM, Boucher RC.

Am J Physiol Lung Cell Mol Physiol. 2017 Mar 1;312(3):L398-L404. doi: 10.1152/ajplung.00398.2016. Epub 2017 Jan 6.

22.

Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.

Keene JD, Jacobson S, Kechris K, Kinney GL, Foreman MG, Doerschuk CM, Make BJ, Curtis JL, Rennard SI, Barr RG, Bleecker ER, Kanner RE, Kleerup EC, Hansel NN, Woodruff PG, Han MK, Paine R 3rd, Martinez FJ, Bowler RP, O'Neal WK; COPDGene and SPIROMICS Investigators ‡.

Am J Respir Crit Care Med. 2017 Feb 15;195(4):473-481. doi: 10.1164/rccm.201607-1330OC.

23.

Nrf2 Modulates Host Defense during Streptococcus pneumoniae Pneumonia in Mice.

Gomez JC, Dang H, Martin JR, Doerschuk CM.

J Immunol. 2016 Oct 1;197(7):2864-79. doi: 10.4049/jimmunol.1600043. Epub 2016 Aug 26.

24.

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ, Curtis JL, Doerschuk CM, Freeman CM, Gouskova NA, Han MK, Hanania NA, Hansel NN, Hersh CP, Hoffman EA, Kaner RJ, Kanner RE, Kleerup EC, Lutz S, Martinez FJ, Meyers DA, Peters SP, Regan EA, Rennard SI, Scholand MB, Silverman EK, Woodruff PG, O'Neal WK, Bowler RP; SPIROMICS Research Group; COPDGene Investigators.

PLoS Genet. 2016 Aug 17;12(8):e1006011. doi: 10.1371/journal.pgen.1006011. eCollection 2016 Aug.

25.

Mast Cell Deficiency Limits the Development of Chronic Rhinosinusitis in Mice.

Hua X, Naselsky WC, Jania CM, Chason KD, Huang JJ, Doerschuk CM, Graham SM, Senior BA, Tilley SL.

Ann Otol Rhinol Laryngol. 2016 Apr;125(4):290-6. doi: 10.1177/0003489415610775. Epub 2015 Dec 17.

PMID:
26681624
26.

Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses.

Saini Y, Wilkinson KJ, Terrell KA, Burns KA, Livraghi-Butrico A, Doerschuk CM, O'Neal WK, Boucher RC.

Am J Respir Cell Mol Biol. 2016 Feb;54(2):210-21. doi: 10.1165/rcmb.2014-0111OC.

27.

Pulmonary alveolar proteinosis and macrophage transplantation.

Doerschuk CM.

N Engl J Med. 2015 Apr 30;372(18):1762-4. doi: 10.1056/NEJMcibr1413035. No abstract available.

PMID:
25923557
28.

Cardiovascular risk factors cause premature rarefaction of the collateral circulation and greater ischemic tissue injury.

Moore SM, Zhang H, Maeda N, Doerschuk CM, Faber JE.

Angiogenesis. 2015 Jul;18(3):265-81. doi: 10.1007/s10456-015-9465-6. Epub 2015 Apr 11.

29.

Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).

Freeman CM, Crudgington S, Stolberg VR, Brown JP, Sonstein J, Alexis NE, Doerschuk CM, Basta PV, Carretta EE, Couper DJ, Hastie AT, Kaner RJ, O'Neal WK, Paine R 3rd, Rennard SI, Shimbo D, Woodruff PG, Zeidler M, Curtis JL.

J Transl Med. 2015 Jan 27;13:19. doi: 10.1186/s12967-014-0374-z.

30.

Mechanisms of interferon-γ production by neutrophils and its function during Streptococcus pneumoniae pneumonia.

Gomez JC, Yamada M, Martin JR, Dang H, Brickey WJ, Bergmeier W, Dinauer MC, Doerschuk CM.

Am J Respir Cell Mol Biol. 2015 Mar;52(3):349-64. doi: 10.1165/rcmb.2013-0316OC.

31.

Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study.

O'Neal WK, Anderson W, Basta PV, Carretta EE, Doerschuk CM, Barr RG, Bleecker ER, Christenson SA, Curtis JL, Han MK, Hansel NN, Kanner RE, Kleerup EC, Martinez FJ, Miller BE, Peters SP, Rennard SI, Scholand MB, Tal-Singer R, Woodruff PG, Couper DJ, Davis SM; SPIROMICS Investigators.

J Transl Med. 2014 Jan 8;12:9. doi: 10.1186/1479-5876-12-9.

32.

Staphylococcus aureus α-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome.

Kebaier C, Chamberland RR, Allen IC, Gao X, Broglie PM, Hall JD, Jania C, Doerschuk CM, Tilley SL, Duncan JA.

J Infect Dis. 2012 Mar 1;205(5):807-17. doi: 10.1093/infdis/jir846. Epub 2012 Jan 25.

33.

Effect of PAR-2 Deficiency in Mice on KC Expression after Intratracheal LPS Administration.

Williams JC, Lee RD, Doerschuk CM, Mackman N.

J Signal Transduct. 2011;2011:415195. doi: 10.1155/2011/415195. Epub 2011 Dec 7.

34.

Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner.

Wang JG, Williams JC, Davis BK, Jacobson K, Doerschuk CM, Ting JP, Mackman N.

Blood. 2011 Aug 25;118(8):2366-74. doi: 10.1182/blood-2011-01-330878. Epub 2011 Jun 23.

35.

Interferon-γ production by neutrophils during bacterial pneumonia in mice.

Yamada M, Gomez JC, Chugh PE, Lowell CA, Dinauer MC, Dittmer DP, Doerschuk CM.

Am J Respir Crit Care Med. 2011 May 15;183(10):1391-401. doi: 10.1164/rccm.201004-0592OC. Epub 2010 Dec 17.

36.

The role of CD18 in the production and release of neutrophils from the bone marrow.

Gomez JC, Doerschuk CM.

Lab Invest. 2010 Apr;90(4):599-610. doi: 10.1038/labinvest.2010.4. Epub 2010 Feb 8.

37.

Effect of neutrophil adhesion on the mechanical properties of lung microvascular endothelial cells.

Kang I, Wang Q, Eppell SJ, Marchant RE, Doerschuk CM.

Am J Respir Cell Mol Biol. 2010 Nov;43(5):591-8. doi: 10.1165/rcmb.2006-0381OC. Epub 2009 Dec 18.

38.

The role of Rac2 in regulating neutrophil production in the bone marrow and circulating neutrophil counts.

Gomez JC, Soltys J, Okano K, Dinauer MC, Doerschuk CM.

Am J Pathol. 2008 Aug;173(2):507-17. doi: 10.2353/ajpath.2008.071059. Epub 2008 Jun 26.

39.

Changes in the hyperelastic properties of endothelial cells induced by tumor necrosis factor-alpha.

Kang I, Panneerselvam D, Panoskaltsis VP, Eppell SJ, Marchant RE, Doerschuk CM.

Biophys J. 2008 Apr 15;94(8):3273-85. doi: 10.1529/biophysj.106.099333. Epub 2008 Jan 16.

40.

CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages.

Vachon E, Martin R, Kwok V, Cherepanov V, Chow CW, Doerschuk CM, Plumb J, Grinstein S, Downey GP.

Blood. 2007 Dec 15;110(13):4492-502. Epub 2007 Sep 7.

41.

Pulmonary alveolar proteinosis--is host defense awry?

Doerschuk CM.

N Engl J Med. 2007 Feb 8;356(6):547-9. No abstract available.

PMID:
17287475
42.

The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria.

Tatro JM, Taki N, Islam AS, Goldberg VM, Rimnac CM, Doerschuk CM, Stewart MC, Greenfield EM.

J Orthop Res. 2007 Mar;25(3):361-9.

43.

Neutrophil cytoskeletal rearrangements during capillary sequestration in bacterial pneumonia in rats.

Yoshida K, Kondo R, Wang Q, Doerschuk CM.

Am J Respir Crit Care Med. 2006 Sep 15;174(6):689-98. Epub 2006 Jun 1.

44.

Ezrin/radixin/moesin proteins are phosphorylated by TNF-alpha and modulate permeability increases in human pulmonary microvascular endothelial cells.

Koss M, Pfeiffer GR 2nd, Wang Y, Thomas ST, Yerukhimovich M, Gaarde WA, Doerschuk CM, Wang Q.

J Immunol. 2006 Jan 15;176(2):1218-27.

45.

Neutrophils in innate immunity.

Wang Q, Doerschuk CM, Mizgerd JP.

Semin Respir Crit Care Med. 2004 Feb;25(1):33-41.

PMID:
16088447
46.

Circulating endothelial progenitor cells in pulmonary inflammation.

Doerschuk CM.

Thorax. 2005 May;60(5):362-4. No abstract available.

47.

Attenuation of endotoxin-induced acute lung injury by the Rho-associated kinase inhibitor, Y-27632.

Tasaka S, Koh H, Yamada W, Shimizu M, Ogawa Y, Hasegawa N, Yamaguchi K, Ishii Y, Richer SE, Doerschuk CM, Ishizaka A.

Am J Respir Cell Mol Biol. 2005 Jun;32(6):504-10. Epub 2005 Mar 18.

PMID:
15778497
48.

MKK3 and -6-dependent activation of p38alpha MAP kinase is required for cytoskeletal changes in pulmonary microvascular endothelial cells induced by ICAM-1 ligation.

Wang Q, Yerukhimovich M, Gaarde WA, Popoff IJ, Doerschuk CM.

Am J Physiol Lung Cell Mol Physiol. 2005 Feb;288(2):L359-69. Epub 2004 Oct 29.

49.

NO and neutrophils during sepsis: NO says "yes" to sequestration but "no" to migration.

Doerschuk CM.

Am J Respir Crit Care Med. 2004 Aug 1;170(3):205-6. No abstract available.

PMID:
15280167
50.

Biomaterial surface-dependent neutrophil mobility.

Zhou Y, Doerschuk CM, Anderson JM, Marchant RE.

J Biomed Mater Res A. 2004 Jun 15;69(4):611-20.

PMID:
15162402

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