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An Automated Assay to Measure Phagocytosis of Cryptococcus neoformans.

Chang AL, Hole CR, Doering TL.

Curr Protoc Microbiol. 2019 Jun;53(1):e79. doi: 10.1002/cpmc.79. Epub 2019 Feb 25.


An In Vitro Brain Endothelial Model for Studies of Cryptococcal Transmigration into the Central Nervous System.

Santiago-Tirado FH, Klein RS, Doering TL.

Curr Protoc Microbiol. 2019 Jun;53(1):e78. doi: 10.1002/cpmc.78. Epub 2019 Feb 18.


Cdk8 and Ssn801 Regulate Oxidative Stress Resistance and Virulence in Cryptococcus neoformans.

Chang AL, Kang Y, Doering TL.

MBio. 2019 Feb 12;10(1). pii: e02818-18. doi: 10.1128/mBio.02818-18.


Maintenance of Mitochondrial Morphology in Cryptococcus neoformans Is Critical for Stress Resistance and Virulence.

Chang AL, Doering TL.

MBio. 2018 Nov 6;9(6). pii: e01375-18. doi: 10.1128/mBio.01375-18.


Peeling the onion: the outer layers of Cryptococcus neoformans.

Agustinho DP, Miller LC, Li LX, Doering TL.

Mem Inst Oswaldo Cruz. 2018;113(7):e180040. doi: 10.1590/0074-02760180040. Epub 2018 May 7. Review.


Unraveling synthesis of the cryptococcal cell wall and capsule.

Wang ZA, Li LX, Doering TL.

Glycobiology. 2018 Oct 1;28(10):719-730. doi: 10.1093/glycob/cwy030. Review.


LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens.

Yokoyama CC, Baldridge MT, Leung DW, Zhao G, Desai C, Liu TC, Diaz-Ochoa VE, Huynh JP, Kimmey JM, Sennott EL, Hole CR, Idol RA, Park S, Storek KM, Wang C, Hwang S, Viehmann Milam A, Chen E, Kerrinnes T, Starnbach MN, Handley SA, Mysorekar IU, Allen PM, Monack DM, Dinauer MC, Doering TL, Tsolis RM, Dworkin JE, Stallings CL, Amarasinghe GK, Micchelli CA, Virgin HW.

J Biol Chem. 2018 Apr 20;293(16):6022-6038. doi: 10.1074/jbc.RA117.001246. Epub 2018 Mar 1.


UDP-Glucuronic Acid Transport Is Required for Virulence of Cryptococcus neoformans.

Li LX, Rautengarten C, Heazlewood JL, Doering TL.

MBio. 2018 Jan 30;9(1). pii: e02319-17. doi: 10.1128/mBio.02319-17.


Xylose donor transport is critical for fungal virulence.

Li LX, Rautengarten C, Heazlewood JL, Doering TL.

PLoS Pathog. 2018 Jan 18;14(1):e1006765. doi: 10.1371/journal.ppat.1006765. eCollection 2018 Jan.


Unintended Side Effects of Transformation Are Very Rare in Cryptococcus neoformans.

Friedman RZ, Gish SR, Brown H, Brier L, Howard N, Doering TL, Brent MR.

G3 (Bethesda). 2018 Mar 2;8(3):815-822. doi: 10.1534/g3.117.300357.


False friends: Phagocytes as Trojan horses in microbial brain infections.

Santiago-Tirado FH, Doering TL.

PLoS Pathog. 2017 Dec 14;13(12):e1006680. doi: 10.1371/journal.ppat.1006680. eCollection 2017 Dec. Review. No abstract available.


RNA Interference Screening Reveals Host CaMK4 as a Regulator of Cryptococcal Uptake and Pathogenesis.

Srikanta D, Hole CR, Williams M, Khader SA, Doering TL.

Infect Immun. 2017 Nov 17;85(12). pii: e00195-17. doi: 10.1128/IAI.00195-17. Print 2017 Dec.



Doering TL, Cummings RD, Aebi M.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 23.


A fluorogenic C. neoformans reporter strain with a robust expression of m-cherry expressed from a safe haven site in the genome.

Upadhya R, Lam WC, Maybruck BT, Donlin MJ, Chang AL, Kayode S, Ormerod KL, Fraser JA, Doering TL, Lodge JK.

Fungal Genet Biol. 2017 Nov;108:13-25. doi: 10.1016/j.fgb.2017.08.008. Epub 2017 Sep 12.


Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen.

Santiago-Tirado FH, Onken MD, Cooper JA, Klein RS, Doering TL.

MBio. 2017 Jan 31;8(1). pii: e02183-16. doi: 10.1128/mBio.02183-16.


Cryptococcus neoformans UGT1 encodes a UDP-Galactose/UDP-GalNAc transporter.

Li LX, Ashikov A, Liu H, Griffith CL, Bakker H, Doering TL.

Glycobiology. 2017 Jan;27(1):87-98. doi: 10.1093/glycob/cww078. Epub 2016 Aug 3.


Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host Response.

Gish SR, Maier EJ, Haynes BC, Santiago-Tirado FH, Srikanta DL, Ma CZ, Li LX, Williams M, Crouch EC, Khader SA, Brent MR, Doering TL.

MBio. 2016 Apr 19;7(2):e00313-16. doi: 10.1128/mBio.00313-16.


All about that fat: Lipid modification of proteins in Cryptococcus neoformans.

Santiago-Tirado FH, Doering TL.

J Microbiol. 2016 Mar;54(3):212-22. doi: 10.1007/s12275-016-5626-6. Epub 2016 Feb 27. Review.


A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.

Santiago-Tirado FH, Peng T, Yang M, Hang HC, Doering TL.

PLoS Pathog. 2015 May 13;11(5):e1004908. doi: 10.1371/journal.ppat.1004908. eCollection 2015 May.


Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation.

Maier EJ, Haynes BC, Gish SR, Wang ZA, Skowyra ML, Marulli AL, Doering TL, Brent MR.

Genome Res. 2015 May;25(5):690-700. doi: 10.1101/gr.184101.114. Epub 2015 Feb 2.


Cryptococcus neoformans Yap1 is required for normal fluconazole and oxidative stress resistance.

Paul S, Doering TL, Moye-Rowley WS.

Fungal Genet Biol. 2015 Jan;74:1-9. doi: 10.1016/j.fgb.2014.10.015. Epub 2014 Nov 1.


Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis.

Kwon-Chung KJ, Fraser JA, Doering TL, Wang Z, Janbon G, Idnurm A, Bahn YS.

Cold Spring Harb Perspect Med. 2014 Jul 1;4(7):a019760. doi: 10.1101/cshperspect.a019760. Review.


Cryptococcus neoformans dual GDP-mannose transporters and their role in biology and virulence.

Wang ZA, Griffith CL, Skowyra ML, Salinas N, Williams M, Maier EJ, Gish SR, Liu H, Brent MR, Doering TL.

Eukaryot Cell. 2014 Jun;13(6):832-42. doi: 10.1128/EC.00054-14. Epub 2014 Apr 18.


Pbx proteins in Cryptococcus neoformans cell wall remodeling and capsule assembly.

Kumar P, Heiss C, Santiago-Tirado FH, Black I, Azadi P, Doering TL.

Eukaryot Cell. 2014 May;13(5):560-71. doi: 10.1128/EC.00290-13. Epub 2014 Feb 28.


Cryptococcus neoformans: historical curiosity to modern pathogen.

Srikanta D, Santiago-Tirado FH, Doering TL.

Yeast. 2014 Feb;31(2):47-60. doi: 10.1002/yea.2997. Epub 2014 Jan 19. Review.


Identification of the galactosyltransferase of Cryptococcus neoformans involved in the biosynthesis of basidiomycete-type glycosylinositolphosphoceramide.

Wohlschlager T, Buser R, Skowyra ML, Haynes BC, Henrissat B, Doering TL, K├╝nzler M, Aebi M.

Glycobiology. 2013 Nov;23(11):1210-9. doi: 10.1093/glycob/cwt057. Epub 2013 Aug 6.


Unusual galactofuranose modification of a capsule polysaccharide in the pathogenic yeast Cryptococcus neoformans.

Heiss C, Skowyra ML, Liu H, Klutts JS, Wang Z, Williams M, Srikanta D, Beverley SM, Azadi P, Doering TL.

J Biol Chem. 2013 Apr 19;288(16):10994-1003. doi: 10.1074/jbc.M112.441998. Epub 2013 Feb 13.


Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier.

Daniels BP, Cruz-Orengo L, Pasieka TJ, Couraud PO, Romero IA, Weksler B, Cooper JA, Doering TL, Klein RS.

J Neurosci Methods. 2013 Jan 15;212(1):173-9. doi: 10.1016/j.jneumeth.2012.10.001. Epub 2012 Oct 13.


RNA interference in Cryptococcus neoformans.

Skowyra ML, Doering TL.

Methods Mol Biol. 2012;845:165-86. doi: 10.1007/978-1-61779-539-8_11.


Toward an integrated model of capsule regulation in Cryptococcus neoformans.

Haynes BC, Skowyra ML, Spencer SJ, Gish SR, Williams M, Held EP, Brent MR, Doering TL.

PLoS Pathog. 2011 Dec;7(12):e1002411. doi: 10.1371/journal.ppat.1002411. Epub 2011 Dec 8.


Emerging themes in cryptococcal capsule synthesis.

Kumar P, Yang M, Haynes BC, Skowyra ML, Doering TL.

Curr Opin Struct Biol. 2011 Oct;21(5):597-602. doi: 10.1016/ Epub 2011 Sep 1. Review.


A sensitive high-throughput assay for evaluating host-pathogen interactions in Cryptococcus neoformans infection.

Srikanta D, Yang M, Williams M, Doering TL.

PLoS One. 2011;6(7):e22773. doi: 10.1371/journal.pone.0022773. Epub 2011 Jul 28.


A xylosylphosphotransferase of Cryptococcus neoformans acts in protein O-glycan synthesis.

Reilly MC, Aoki K, Wang ZA, Skowyra ML, Williams M, Tiemeyer M, Doering TL.

J Biol Chem. 2011 Jul 29;286(30):26888-99. doi: 10.1074/jbc.M111.262162. Epub 2011 May 23.


Efficient implementation of RNA interference in the pathogenic yeast Cryptococcus neoformans.

Bose I, Doering TL.

J Microbiol Methods. 2011 Aug;86(2):156-9. doi: 10.1016/j.mimet.2011.04.014. Epub 2011 Apr 29.


Eubacteria and Archaea.

Esko JD, Doering TL, Raetz CRH.

In: Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Bertozzi CR, Hart GW, Etzler ME, editors. Essentials of Glycobiology. 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009. Chapter 20.



Cummings RD, Doering TL.

In: Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Bertozzi CR, Hart GW, Etzler ME, editors. Essentials of Glycobiology. 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009. Chapter 21.


A novel xylosylphosphotransferase activity discovered in Cryptococcus neoformans.

Reilly MC, Levery SB, Castle SA, Klutts JS, Doering TL.

J Biol Chem. 2009 Dec 25;284(52):36118-27. doi: 10.1074/jbc.M109.056226. Epub 2009 Oct 28.


How sweet it is! Cell wall biogenesis and polysaccharide capsule formation in Cryptococcus neoformans.

Doering TL.

Annu Rev Microbiol. 2009;63:223-47. doi: 10.1146/annurev.micro.62.081307.162753. Review.


An unusual organelle in Cryptococcus neoformans links luminal pH and capsule biosynthesis.

Yoneda A, Doering TL.

Fungal Genet Biol. 2009 Sep;46(9):682-7. doi: 10.1016/j.fgb.2009.05.001. Epub 2009 May 18.


The structure of Cryptococcus neoformans galactoxylomannan contains beta-D-glucuronic acid.

Heiss C, Klutts JS, Wang Z, Doering TL, Azadi P.

Carbohydr Res. 2009 May 12;344(7):915-20. doi: 10.1016/j.carres.2009.03.003. Epub 2009 Mar 10.


Beta1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids.

Castle SA, Owuor EA, Thompson SH, Garnsey MR, Klutts JS, Doering TL, Levery SB.

Eukaryot Cell. 2008 Sep;7(9):1611-5. doi: 10.1128/EC.00458-07. Epub 2008 Aug 1.


Detection of glycophospholipid anchors on proteins.

Doering TL, Englund PT, Hart GW.

Curr Protoc Protein Sci. 2001 May;Chapter 12:Unit 12.5. doi: 10.1002/0471140864.ps1205s02.


Cryptococcal xylosyltransferase 1 (Cxt1p) from Cryptococcus neoformans plays a direct role in the synthesis of capsule polysaccharides.

Klutts JS, Doering TL.

J Biol Chem. 2008 May 23;283(21):14327-34. doi: 10.1074/jbc.M708927200. Epub 2008 Mar 17.


Detection of glycophospholipid anchors on proteins.

Doering TL, Englund PT, Hart GW.

Curr Protoc Mol Biol. 2001 May;Chapter 17:Unit17.8. doi: 10.1002/0471142727.mb1708s22.


Regulation of Cryptococcus neoformans capsule size is mediated at the polymer level.

Yoneda A, Doering TL.

Eukaryot Cell. 2008 Mar;7(3):546-9. Epub 2007 Dec 21.


A beta-1,2-xylosyltransferase from Cryptococcus neoformans defines a new family of glycosyltransferases.

Klutts JS, Levery SB, Doering TL.

J Biol Chem. 2007 Jun 15;282(24):17890-9. Epub 2007 Apr 12.


Loss of cell wall alpha(1-3) glucan affects Cryptococcus neoformans from ultrastructure to virulence.

Reese AJ, Yoneda A, Breger JA, Beauvais A, Liu H, Griffith CL, Bose I, Kim MJ, Skau C, Yang S, Sefko JA, Osumi M, Latge JP, Mylonakis E, Doering TL.

Mol Microbiol. 2007 Mar;63(5):1385-98.


A eukaryotic capsular polysaccharide is synthesized intracellularly and secreted via exocytosis.

Yoneda A, Doering TL.

Mol Biol Cell. 2006 Dec;17(12):5131-40. Epub 2006 Oct 4.


Glycosyltransferases and their products: cryptococcal variations on fungal themes.

Klutts JS, Yoneda A, Reilly MC, Bose I, Doering TL.

FEMS Yeast Res. 2006 Jun;6(4):499-512. Review.

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