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Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite Plasmodium falciparum.

Bui HTN, Niederwieser I, Bird MJ, Dai W, Brancucci NMB, Moes S, Jenoe P, Lucet IS, Doerig C, Voss TS.

Sci Rep. 2019 Nov 13;9(1):16720. doi: 10.1038/s41598-019-53325-9.


Infrared spectroscopy coupled to cloud-based data management as a tool to diagnose malaria: a pilot study in a malaria-endemic country.

Heraud P, Chatchawal P, Wongwattanakul M, Tippayawat P, Doerig C, Jearanaikoon P, Perez-Guaita D, Wood BR.

Malar J. 2019 Oct 16;18(1):348. doi: 10.1186/s12936-019-2945-1.


Targeting of host cell receptor tyrosine kinases by intracellular pathogens.

Haqshenas G, Doerig C.

Sci Signal. 2019 Sep 17;12(599). pii: eaau9894. doi: 10.1126/scisignal.aau9894. Review.


Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target.

Alam MM, Sanchez-Azqueta A, Janha O, Flannery EL, Mahindra A, Mapesa K, Char AB, Sriranganadane D, Brancucci NMB, Antonova-Koch Y, Crouch K, Simwela NV, Millar SB, Akinwale J, Mitcheson D, Solyakov L, Dudek K, Jones C, Zapatero C, Doerig C, Nwakanma DC, Vázquez MJ, Colmenarejo G, Lafuente-Monasterio MJ, Leon ML, Godoi PHC, Elkins JM, Waters AP, Jamieson AG, Álvaro EF, Ranford-Cartwright LC, Marti M, Winzeler EA, Gamo FJ, Tobin AB.

Science. 2019 Aug 30;365(6456). pii: eaau1682. doi: 10.1126/science.aau1682.


Post-Genomic Approaches to Understanding Malaria Parasite Biology: Linking Genes to Biological Functions.

Sexton AE, Doerig C, Creek DJ, Carvalho TG.

ACS Infect Dis. 2019 Aug 9;5(8):1269-1278. doi: 10.1021/acsinfecdis.9b00093. Epub 2019 Jun 20.


Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA.

Dorin-Semblat D, Tétard M, Claës A, Semblat JP, Dechavanne S, Fourati Z, Hamelin R, Armand F, Matesic G, Nunes-Silva S, Srivastava A, Gangnard S, Lopez-Rubio JJ, Moniatte M, Doerig C, Scherf A, Gamain B.

PLoS Biol. 2019 Jun 10;17(6):e3000308. doi: 10.1371/journal.pbio.3000308. eCollection 2019 Jun.


Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines.

Masch A, Nasereddin A, Alder A, Bird MJ, Schweda SI, Preu L, Doerig C, Dzikowski R, Gilberger TW, Kunick C.

Malar J. 2019 Mar 21;18(1):89. doi: 10.1186/s12936-019-2725-y.


A Role for the Insulin Receptor in the Suppression of Dengue Virus and Zika Virus in Wolbachia-Infected Mosquito Cells.

Haqshenas G, Terradas G, Paradkar PN, Duchemin JB, McGraw EA, Doerig C.

Cell Rep. 2019 Jan 15;26(3):529-535.e3. doi: 10.1016/j.celrep.2018.12.068.


Manipulating Eryptosis of Human Red Blood Cells: A Novel Antimalarial Strategy?

Boulet C, Doerig CD, Carvalho TG.

Front Cell Infect Microbiol. 2018 Nov 30;8:419. doi: 10.3389/fcimb.2018.00419. eCollection 2018. Review. Erratum in: Front Cell Infect Microbiol. 2019 Jan 14;8:455.


Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites.

van Biljon R, Niemand J, van Wyk R, Clark K, Verlinden B, Abrie C, von Grüning H, Smidt W, Smit A, Reader J, Painter H, Llinás M, Doerig C, Birkholtz LM.

Sci Rep. 2018 Nov 8;8(1):16581. doi: 10.1038/s41598-018-34964-w.


Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites.

Fang H, Gomes AR, Klages N, Pino P, Maco B, Walker EM, Zenonos ZA, Angrisano F, Baum J, Doerig C, Baker DA, Billker O, Brochet M.

Nat Commun. 2018 Oct 12;9(1):4248. doi: 10.1038/s41467-018-06733-w.


The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition.

Ruiz-Carrillo D, Lin J, El Sahili A, Wei M, Sze SK, Cheung PCF, Doerig C, Lescar J.

Sci Rep. 2018 May 9;8(1):7365. doi: 10.1038/s41598-018-25738-5.


Characterization of Plasmodium falciparum Atypical Kinase PfPK7- Dependent Phosphoproteome.

Pease BN, Huttlin EL, Jedrychowski MP, Dorin-Semblat D, Sebastiani D, Segarra DT, Roberts BF, Chakrabarti R, Doerig C, Gygi SP, Chakrabarti D.

J Proteome Res. 2018 Jun 1;17(6):2112-2123. doi: 10.1021/acs.jproteome.8b00062. Epub 2018 Apr 30.


Parasites under the Spotlight: Applications of Vibrational Spectroscopy to Malaria Research.

Perez-Guaita D, Marzec KM, Hudson A, Evans C, Chernenko T, Matthäus C, Miljkovic M, Diem M, Heraud P, Richards JS, Andrew D, Anderson DA, Doerig C, Garcia-Bustos J, McNaughton D, Wood BR.

Chem Rev. 2018 Jun 13;118(11):5330-5358. doi: 10.1021/acs.chemrev.7b00661. Epub 2018 Apr 20. Review.


Multispectral Atomic Force Microscopy-Infrared Nano-Imaging of Malaria Infected Red Blood Cells.

Perez-Guaita D, Kochan K, Batty M, Doerig C, Garcia-Bustos J, Espinoza S, McNaughton D, Heraud P, Wood BR.

Anal Chem. 2018 Mar 6;90(5):3140-3148. doi: 10.1021/acs.analchem.7b04318. Epub 2018 Feb 14.


The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.

Harding SD, Sharman JL, Faccenda E, Southan C, Pawson AJ, Ireland S, Gray AJG, Bruce L, Alexander SPH, Anderton S, Bryant C, Davenport AP, Doerig C, Fabbro D, Levi-Schaffer F, Spedding M, Davies JA; NC-IUPHAR.

Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106. doi: 10.1093/nar/gkx1121.


Malaria Parasites in a Hungry Host: Kinases and Host Caloric Restriction Brought Together.

Garcia-Bustos JF, Doerig C.

Trends Parasitol. 2017 Nov;33(11):831-832. doi: 10.1016/ Epub 2017 Sep 8.


Characteristics of patients with hepatitis B virus and hepatitis C virus dual infection in a Western European country: Comparison with monoinfected patients.

Marot A, Belaid A, Orlent H, Sersté T, Michielsen P, Colle I, Laleman W, de Galocsy C, Reynaert H, D'Heygere F, Moreno C, Doerig C, Henrion J, Deltenre P.

Clin Res Hepatol Gastroenterol. 2017 Dec;41(6):656-663. doi: 10.1016/j.clinre.2017.05.003. Epub 2017 Sep 1.


Hepatitis E virus as a cause of acute hepatitis acquired in Switzerland.

Fraga M, Doerig C, Moulin H, Bihl F, Brunner F, Müllhaupt B, Ripellino P, Semela D, Stickel F, Terziroli Beretta-Piccoli B, Aubert V, Telenti A, Greub G, Sahli R, Moradpour D.

Liver Int. 2018 Apr;38(4):619-626. doi: 10.1111/liv.13557. Epub 2017 Sep 7.


Signalome-wide assessment of host cell response to hepatitis C virus.

Haqshenas G, Wu J, Simpson KJ, Daly RJ, Netter HJ, Baumert TF, Doerig C.

Nat Commun. 2017 May 8;8:15158. doi: 10.1038/ncomms15158.


Subverting Host Cell P21-Activated Kinase: A Case of Convergent Evolution across Pathogens.

John Von Freyend S, Kwok-Schuelein T, Netter HJ, Haqshenas G, Semblat JP, Doerig C.

Pathogens. 2017 Apr 21;6(2). pii: E17. doi: 10.3390/pathogens6020017. Review.


Effect of abstinence on the prognosis of patients with alcoholic liver disease: A word of caution.

Deltenre P, Marot A, Knebel JF, Doerig C, Henrion J, Moreno C.

J Hepatol. 2017 Jun;66(6):1329-1330. doi: 10.1016/j.jhep.2017.02.029. Epub 2017 Mar 2. No abstract available.


Liver stiffness and platelet count for identifying patients with compensated liver disease at low risk of variceal bleeding.

Marot A, Trépo E, Doerig C, Schoepfer A, Moreno C, Deltenre P.

Liver Int. 2017 May;37(5):707-716. doi: 10.1111/liv.13318. Epub 2016 Dec 6. Review.


A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase.

Mitcheson DF, Bottrill AR, Carr K, Coxon CR, Cano C, Golding BT, Griffin RJ, Fry AM, Doerig C, Bayliss R, Tobin AB.

Malar J. 2016 Nov 7;15(1):535.


External validation of the nomogram for individualized prediction of hepatocellular carcinoma occurrence in patients with hepatitis C virus-related compensated cirrhosis.

Marot A, Vandenbulcke H, Knebel JF, Doerig C, Moreno C, Deltenre P.

Hepatology. 2017 Apr;65(4):1419-1421. doi: 10.1002/hep.28865. Epub 2016 Nov 29. No abstract available.


Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites.

Prinz B, Harvey KL, Wilcke L, Ruch U, Engelberg K, Biller L, Lucet I, Erkelenz S, Heincke D, Spielmann T, Doerig C, Kunick C, Crabb BS, Gilson PR, Gilberger TW.

Sci Rep. 2016 Oct 4;6:34479. doi: 10.1038/srep34479.


Management of viral hepatitis in patients with haematological malignancy and in patients undergoing haemopoietic stem cell transplantation: recommendations of the 5th European Conference on Infections in Leukaemia (ECIL-5).

Mallet V, van Bömmel F, Doerig C, Pischke S, Hermine O, Locasciulli A, Cordonnier C, Berg T, Moradpour D, Wedemeyer H, Ljungman P; ECIL-5.

Lancet Infect Dis. 2016 May;16(5):606-617. doi: 10.1016/S1473-3099(16)00118-3. Epub 2016 Apr 18. Review.


Self-expanding metal stent should be considered in patients with cirrhosis and uncontrolled variceal bleeding.

Marot A, Trépo E, Doerig C, Moreno C, Deltenre P.

Hepatology. 2016 Dec;64(6):2273. doi: 10.1002/hep.28738. Epub 2016 Aug 26. No abstract available.


The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation.

Carvalho TG, Morahan B, John von Freyend S, Boeuf P, Grau G, Garcia-Bustos J, Doerig C.

Mol Biochem Parasitol. 2016 Jul;208(1):2-15. doi: 10.1016/j.molbiopara.2016.05.006. Epub 2016 May 17. Review.


Alcohol intake increases the risk of HCC in hepatitis C virus-related compensated cirrhosis: A prospective study.

Vandenbulcke H, Moreno C, Colle I, Knebel JF, Francque S, Sersté T, George C, de Galocsy C, Laleman W, Delwaide J, Orlent H, Lasser L, Trépo E, Van Vlierberghe H, Michielsen P, van Gossum M, de Vos M, Marot A, Doerig C, Henrion J, Deltenre P.

J Hepatol. 2016 Sep;65(3):543-51. doi: 10.1016/j.jhep.2016.04.031. Epub 2016 May 13.


Hepatitis E virus infection as a direct cause of neuralgic amyotrophy.

Silva M, Wicki B, Tsouni P, Cunningham S, Doerig C, Zanetti G, Aubert V, Sahli R, Moradpour D, Kuntzer T.

Muscle Nerve. 2016 Aug;54(2):325-7. doi: 10.1002/mus.25096. Epub 2016 Jun 28.


The conserved apicomplexan Aurora kinase TgArk3 is involved in endodyogeny, duplication rate and parasite virulence.

Berry L, Chen CT, Reininger L, Carvalho TG, El Hajj H, Morlon-Guyot J, Bordat Y, Lebrun M, Gubbels MJ, Doerig C, Daher W.

Cell Microbiol. 2016 Aug;18(8):1106-1120. doi: 10.1111/cmi.12571. Epub 2016 Feb 22.


Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes.

Tham WH, Lim NT, Weiss GE, Lopaticki S, Ansell BR, Bird M, Lucet I, Dorin-Semblat D, Doerig C, Gilson PR, Crabb BS, Cowman AF.

PLoS Pathog. 2015 Dec 22;11(12):e1005343. doi: 10.1371/journal.ppat.1005343. eCollection 2015 Dec.


Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1.

Dorin-Semblat D, Demarta-Gatsi C, Hamelin R, Armand F, Carvalho TG, Moniatte M, Doerig C.

PLoS One. 2015 Dec 2;10(12):e0139591. doi: 10.1371/journal.pone.0139591. eCollection 2015.


Two-dimensional single-cell patterning with one cell per well driven by surface acoustic waves.

Collins DJ, Morahan B, Garcia-Bustos J, Doerig C, Plebanski M, Neild A.

Nat Commun. 2015 Nov 2;6:8686. doi: 10.1038/ncomms9686.


Systematic review with meta-analysis: self-expanding metal stents in patients with cirrhosis and severe or refractory oesophageal variceal bleeding.

Marot A, Trépo E, Doerig C, Moreno C, Moradpour D, Deltenre P.

Aliment Pharmacol Ther. 2015 Dec;42(11-12):1250-60. doi: 10.1111/apt.13424. Epub 2015 Oct 16. Review.


Loperamide-induced recurrent acute pancreatitis.

Labgaa I, Uldry E, Doerig C, Schmidt S, Demartines N, Halkic N.

Clin Res Hepatol Gastroenterol. 2016 Feb;40(1):e13-4. doi: 10.1016/j.clinre.2015.06.008. Epub 2015 Jul 14. No abstract available.


Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites.

Woo YH, Ansari H, Otto TD, Klinger CM, Kolisko M, Michálek J, Saxena A, Shanmugam D, Tayyrov A, Veluchamy A, Ali S, Bernal A, del Campo J, Cihlář J, Flegontov P, Gornik SG, Hajdušková E, Horák A, Janouškovec J, Katris NJ, Mast FD, Miranda-Saavedra D, Mourier T, Naeem R, Nair M, Panigrahi AK, Rawlings ND, Padron-Regalado E, Ramaprasad A, Samad N, Tomčala A, Wilkes J, Neafsey DE, Doerig C, Bowler C, Keeling PJ, Roos DS, Dacks JB, Templeton TJ, Waller RF, Lukeš J, Oborník M, Pain A.

Elife. 2015 Jul 15;4:e06974. doi: 10.7554/eLife.06974.


Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion.

Alam MM, Solyakov L, Bottrill AR, Flueck C, Siddiqui FA, Singh S, Mistry S, Viskaduraki M, Lee K, Hopp CS, Chitnis CE, Doerig C, Moon RW, Green JL, Holder AA, Baker DA, Tobin AB.

Nat Commun. 2015 Jul 7;6:7285. doi: 10.1038/ncomms8285.


Regulation of Plasmodium falciparum Origin Recognition Complex subunit 1 (PfORC1) function through phosphorylation mediated by CDK-like kinase PK5.

Deshmukh AS, Agarwal M, Mehra P, Gupta A, Gupta N, Doerig CD, Dhar SK.

Mol Microbiol. 2015 Oct;98(1):17-33. doi: 10.1111/mmi.13099. Epub 2015 Jul 17.


Early transjugular intrahepatic portosystemic shunt in cirrhotic patients with acute variceal bleeding: a systematic review and meta-analysis of controlled trials.

Deltenre P, Trépo E, Rudler M, Monescillo A, Fraga M, Denys A, Doerig C, Fournier N, Moreno C, Moradpour D, Bureau C, Thabut D.

Eur J Gastroenterol Hepatol. 2015 Sep;27(9):e1-9. doi: 10.1097/MEG.0000000000000403. Review.


Host cell kinases and the hepatitis C virus life cycle.

Colpitts CC, Lupberger J, Doerig C, Baumert TF.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1657-62. doi: 10.1016/j.bbapap.2015.04.011. Epub 2015 Apr 18. Review.


Targeting kinases in Plasmodium and Schistosoma: Same goals, different challenges.

Doerig C, Grevelding CG.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1637-43. doi: 10.1016/j.bbapap.2015.03.002. Epub 2015 Mar 12.


Post-translational protein modifications in malaria parasites.

Doerig C, Rayner JC, Scherf A, Tobin AB.

Nat Rev Microbiol. 2015 Mar;13(3):160-72. doi: 10.1038/nrmicro3402. Epub 2015 Feb 9. Review.


Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission.

Kern S, Agarwal S, Huber K, Gehring AP, Strödke B, Wirth CC, Brügl T, Abodo LO, Dandekar T, Doerig C, Fischer R, Tobin AB, Alam MM, Bracher F, Pradel G.

PLoS One. 2014 Sep 4;9(9):e105732. doi: 10.1371/journal.pone.0105732. eCollection 2014.


Genomic analysis of the causative agents of coccidiosis in domestic chickens.

Reid AJ, Blake DP, Ansari HR, Billington K, Browne HP, Bryant J, Dunn M, Hung SS, Kawahara F, Miranda-Saavedra D, Malas TB, Mourier T, Naghra H, Nair M, Otto TD, Rawlings ND, Rivailler P, Sanchez-Flores A, Sanders M, Subramaniam C, Tay YL, Woo Y, Wu X, Barrell B, Dear PH, Doerig C, Gruber A, Ivens AC, Parkinson J, Rajandream MA, Shirley MW, Wan KL, Berriman M, Tomley FM, Pain A.

Genome Res. 2014 Oct;24(10):1676-85. doi: 10.1101/gr.168955.113. Epub 2014 Jul 11.


Regulation of Plasmodium falciparum development by calcium-dependent protein kinase 7 (PfCDPK7).

Kumar P, Tripathi A, Ranjan R, Halbert J, Gilberger T, Doerig C, Sharma P.

J Biol Chem. 2014 Jul 18;289(29):20386-95. doi: 10.1074/jbc.M114.561670. Epub 2014 Jun 3.


Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation.

Graciotti M, Alam M, Solyakov L, Schmid R, Burley G, Bottrill AR, Doerig C, Cullis P, Tobin AB.

PLoS One. 2014 Mar 21;9(3):e85391. doi: 10.1371/journal.pone.0085391. eCollection 2014.


[Highlights in gastroenterology and hepatology 2013].

Hessler R, Godat S, Fraga M, Burgmann K, Doerig C, Deltenre P, Schoepfer A.

Rev Med Suisse. 2014 Jan 15;10(412-413):41-4. Review. French.


CRIMALDDI: platform technologies and novel anti-malarial drug targets.

Vial H, Taramelli D, Boulton IC, Ward SA, Doerig C, Chibale K.

Malar J. 2013 Nov 5;12:396. doi: 10.1186/1475-2875-12-396.

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