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Licorice root components mimic estrogens in an object location task but not an object recognition task.

Kundu P, Korol DL, Bandara S, Monaikul S, Ondera CE, Helferich WG, Khan IA, Doerge DR, Schantz SL.

Horm Behav. 2018 Jul;103:97-106. doi: 10.1016/j.yhbeh.2018.06.002. Epub 2018 Jul 1.


Comparative estrogenicity of endogenous, environmental and dietary estrogens in pregnant women I: Serum levels, variability and the basis for urinary biomonitoring of serum estrogenicity.

Fleck SC, Twaddle NC, Churchwell MI, Doerge DR, Pande P, Teeguarden JG.

Food Chem Toxicol. 2018 May;115:511-522. doi: 10.1016/j.fct.2018.03.017. Epub 2018 Mar 13.


Metabolism and disposition of arsenic species after repeated oral dosing with sodium arsenite in drinking water. II. Measurements in pregnant and fetal CD-1 mice.

Twaddle NC, Vanlandingham M, Beland FA, Doerge DR.

Food Chem Toxicol. 2018 May;115:178-184. doi: 10.1016/j.fct.2018.03.010. Epub 2018 Mar 10.


The effects of the botanical estrogen, isoliquiritigenin on delayed spatial alternation.

Kundu P, Neese SL, Bandara S, Monaikul S, Helferich WG, Doerge DR, Khan IA, Schantz SL.

Neurotoxicol Teratol. 2018 Mar - Apr;66:55-62. doi: 10.1016/ Epub 2018 Feb 3.


Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells.

Dreval K, Tryndyak V, Kindrat I, Twaddle NC, Orisakwe OE, Mudalige TK, Beland FA, Doerge DR, Pogribny IP.

Toxicol Sci. 2018 Apr 1;162(2):676-687. doi: 10.1093/toxsci/kfx290.


Metabolism and disposition of arsenic species from controlled oral dosing with sodium arsenite in adult female CD-1 mice. I. Pilot study to determine dosing, analytical measurements, and sampling strategies.

Twaddle NC, Vanlandingham M, Churchwell MI, Doerge DR.

Food Chem Toxicol. 2018 Jan;111:482-493. doi: 10.1016/j.fct.2017.12.005. Epub 2017 Dec 5.


Metabolism and pharmacokinetics of zearalenone following oral and intravenous administration in juvenile female pigs.

Fleck SC, Churchwell MI, Doerge DR.

Food Chem Toxicol. 2017 Aug;106(Pt A):193-201. doi: 10.1016/j.fct.2017.05.048. Epub 2017 May 25.


Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study.

Von Tungeln LS, Walker NJ, Olson GR, Mendoza MC, Felton RP, Thorn BT, Marques MM, Pogribny IP, Doerge DR, Beland FA.

Food Chem Toxicol. 2017 Jan;99:170-181. doi: 10.1016/j.fct.2016.11.015. Epub 2016 Nov 18.


Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure.

de Conti A, Tryndyak V, Doerge DR, Beland FA, Pogribny IP.

Food Chem Toxicol. 2016 Dec;98(Pt A):2-10. doi: 10.1016/j.fct.2016.06.027. Epub 2016 Jun 28.


Furan-induced transcriptomic and gene-specific DNA methylation changes in the livers of Fischer 344 rats in a 2-year carcinogenicity study.

Tryndyak V, de Conti A, Doerge DR, Olson GR, Beland FA, Pogribny IP.

Arch Toxicol. 2017 Mar;91(3):1233-1243. doi: 10.1007/s00204-016-1786-8. Epub 2016 Jul 7.


Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women.

Fleck SC, Churchwell MI, Doerge DR, Teeguarden JG.

Food Chem Toxicol. 2016 Sep;95:19-27. doi: 10.1016/j.fct.2016.05.021. Epub 2016 May 30.


Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents.

Camacho L, Lewis SM, Vanlandingham MM, Juliar BE, Olson GR, Patton RE, Gamboa da Costa G, Woodling K, Sepehr E, Bryant MS, Doerge DR, Basavarajappa MS, Felton RP, Delclos KB.

Food Chem Toxicol. 2016 Aug;94:39-56. doi: 10.1016/j.fct.2016.05.014. Epub 2016 May 24.


Effects of letrozole on breast cancer micro-metastatic tumor growth in bone and lung in mice inoculated with murine 4T1 cells.

Wang W, Belosay A, Yang X, Hartman JA, Song H, Iwaniec UT, Turner RT, Churchwell MI, Doerge DR, Helferich WG.

Clin Exp Metastasis. 2016 Jun;33(5):475-85. doi: 10.1007/s10585-016-9792-z. Epub 2016 May 21.


Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys.

Doerge DR, Woodling KA, Churchwell MI, Fleck SC, Helferich WG.

Food Chem Toxicol. 2016 Jun;92:165-76. doi: 10.1016/j.fct.2016.04.005. Epub 2016 Apr 12.


Urine and serum biomonitoring of exposure to environmental estrogens I: Bisphenol A in pregnant women.

Teeguarden JG, Twaddle NC, Churchwell MI, Doerge DR.

Food Chem Toxicol. 2016 Jun;92:129-42. doi: 10.1016/j.fct.2016.03.023. Epub 2016 Mar 30.


Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities.

Boonmuen N, Gong P, Ali Z, Chittiboyina AG, Khan I, Doerge DR, Helferich WG, Carlson KE, Martin T, Piyachaturawat P, Katzenellenbogen JA, Katzenellenbogen BS.

Steroids. 2016 Jan;105:42-9. doi: 10.1016/j.steroids.2015.11.006. Epub 2015 Nov 26.


Dietary licorice root supplementation reduces diet-induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland.

Madak-Erdogan Z, Gong P, Zhao YC, Xu L, Wrobel KU, Hartman JA, Wang M, Cam A, Iwaniec UT, Turner RT, Twaddle NC, Doerge DR, Khan IA, Katzenellenbogen JA, Katzenellenbogen BS, Helferich WG.

Mol Nutr Food Res. 2016 Feb;60(2):369-80. doi: 10.1002/mnfr.201500445. Epub 2015 Nov 10.


Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A.

Yang X, Doerge DR, Teeguarden JG, Fisher JW.

Toxicol Appl Pharmacol. 2015 Dec 15;289(3):442-56. doi: 10.1016/j.taap.2015.10.016. Epub 2015 Oct 29.


Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure.

Beland FA, Olson GR, Mendoza MC, Marques MM, Doerge DR.

Food Chem Toxicol. 2015 Dec;86:104-15. doi: 10.1016/j.fct.2015.09.017. Epub 2015 Sep 30.


Evaluation of serum and liver toxicokinetics for furan and liver DNA adduct formation in male Fischer 344 rats.

Churchwell MI, Scheri RC, Von Tungeln LS, Gamboa da Costa G, Beland FA, Doerge DR.

Food Chem Toxicol. 2015 Dec;86:1-8. doi: 10.1016/j.fct.2015.08.029. Epub 2015 Sep 11.


24-hour human urine and serum profiles of bisphenol A following ingestion in soup: Individual pharmacokinetic data and emographics.

Teeguarden JG, Twaddle NC, Churchwell MI, Yang X, Fisher JW, Seryak LM, Doerge DR.

Data Brief. 2015 Mar 17;4:83-6. doi: 10.1016/j.dib.2015.03.002. eCollection 2015 Sep.


Pharmacokinetics of bisphenol A in humans following a single oral administration.

Thayer KA, Doerge DR, Hunt D, Schurman SH, Twaddle NC, Churchwell MI, Garantziotis S, Kissling GE, Easterling MR, Bucher JR, Birnbaum LS.

Environ Int. 2015 Oct;83:107-15. doi: 10.1016/j.envint.2015.06.008. Epub 2015 Jun 24.


Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice.

Liu Y, Hilakivi-Clarke L, Zhang Y, Wang X, Pan YX, Xuan J, Fleck SC, Doerge DR, Helferich WG.

Mol Nutr Food Res. 2015 Aug;59(8):1419-30. doi: 10.1002/mnfr.201500028. Epub 2015 Jun 26.


Dietary soy isoflavones increase metastasis to lungs in an experimental model of breast cancer with bone micro-tumors.

Yang X, Belosay A, Hartman JA, Song H, Zhang Y, Wang W, Doerge DR, Helferich WG.

Clin Exp Metastasis. 2015 Apr;32(4):323-33. doi: 10.1007/s10585-015-9709-2. Epub 2015 Mar 8.


Acrylamide-induced carcinogenicity in mouse lung involves mutagenicity: cII gene mutations in the lung of big blue mice exposed to acrylamide and glycidamide for up to 4 weeks.

Manjanatha MG, Guo LW, Shelton SD, Doerge DR.

Environ Mol Mutagen. 2015 Jun;56(5):446-56. doi: 10.1002/em.21939. Epub 2015 Jan 29.


24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup.

Teeguarden JG, Twaddle NC, Churchwell MI, Yang X, Fisher JW, Seryak LM, Doerge DR.

Toxicol Appl Pharmacol. 2015 Oct 15;288(2):131-42. doi: 10.1016/j.taap.2015.01.009. Epub 2015 Jan 22.


Persistence of furan-induced epigenetic aberrations in the livers of F344 rats.

de Conti A, Kobets T, Tryndyak V, Burnett SD, Han T, Fuscoe JC, Beland FA, Doerge DR, Pogribny IP.

Toxicol Sci. 2015 Apr;144(2):217-26. doi: 10.1093/toxsci/kfu313. Epub 2014 Dec 23.


Reaction of dehydropyrrolizidine alkaloids with valine and hemoglobin.

Zhao Y, Wang S, Xia Q, Gamboa da Costa G, Doerge DR, Cai L, Fu PP.

Chem Res Toxicol. 2014 Oct 20;27(10):1720-31. doi: 10.1021/tx5002139. Epub 2014 Sep 11.


Development of a physiologically based model to describe the pharmacokinetics of methylphenidate in juvenile and adult humans and nonhuman primates.

Yang X, Morris SM, Gearhart JM, Ruark CD, Paule MG, Slikker W Jr, Mattison DR, Vitiello B, Twaddle NC, Doerge DR, Young JF, Fisher JW.

PLoS One. 2014 Sep 3;9(9):e106101. doi: 10.1371/journal.pone.0106101. eCollection 2014.


Response to Hunt et al., invalid controls undermine conclusions of FDA studies.

Delclos KB, Doerge DR.

Toxicol Sci. 2014 Sep;141(1):3. No abstract available.


Long-term exposure to dietary sources of genistein induces estrogen-independence in the human breast cancer (MCF-7) xenograft model.

Andrade JE, Ju YH, Baker C, Doerge DR, Helferich WG.

Mol Nutr Food Res. 2015 Mar;59(3):413-23. doi: 10.1002/mnfr.201300780. Epub 2014 Feb 24.


Dose- and time-dependent epigenetic changes in the livers of Fisher 344 rats exposed to furan.

Conti Ad, Kobets T, Escudero-Lourdes C, Montgomery B, Tryndyak V, Beland FA, Doerge DR, Pogribny IP.

Toxicol Sci. 2014 Jun;139(2):371-80. doi: 10.1093/toxsci/kfu044. Epub 2014 Mar 10.


Comparison of life-stage-dependent internal dosimetry for bisphenol A, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats.

Churchwell MI, Camacho L, Vanlandingham MM, Twaddle NC, Sepehr E, Delclos KB, Fisher JW, Doerge DR.

Toxicol Sci. 2014 May;139(1):4-20. doi: 10.1093/toxsci/kfu021. Epub 2014 Feb 4.


Testicular development in male rats is sensitive to a soy-based diet in the neonatal period.

Napier ID, Simon L, Perry D, Cooke PS, Stocco DM, Sepehr E, Doerge DR, Kemppainen BW, Morrison EE, Akingbemi BT.

Biol Reprod. 2014 Feb 27;90(2):40. doi: 10.1095/biolreprod.113.113787. Print 2014 Feb.


The effects of dietary treatment with S-equol on learning and memory processes in middle-aged ovariectomized rats.

Neese SL, Pisani SL, Doerge DR, Helferich WG, Sepehr E, Chittiboyina AG, Rotte SC, Smillie TJ, Khan IA, Korol DL, Schantz SL.

Neurotoxicol Teratol. 2014 Jan-Feb;41:80-8. doi: 10.1016/ Epub 2013 Dec 22.


Exposure conditions and pharmacokinetic principles: interpreting bisphenol a absorption in the canine oral cavity.

Teeguarden JG, Fisher JW, Doerge DR.

Environ Health Perspect. 2013 Nov-Dec;121(11-12):A323. doi: 10.1289/ehp.1307424. No abstract available.


Are typical human serum BPA concentrations measurable and sufficient to be estrogenic in the general population?

Teeguarden J, Hanson-Drury S, Fisher JW, Doerge DR.

Food Chem Toxicol. 2013 Dec;62:949-63. doi: 10.1016/j.fct.2013.08.001. Epub 2013 Aug 17.


Pyrrolizidine alkaloid-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicity.

Xia Q, Zhao Y, Von Tungeln LS, Doerge DR, Lin G, Cai L, Fu PP.

Chem Res Toxicol. 2013 Sep 16;26(9):1384-96. doi: 10.1021/tx400241c. Epub 2013 Aug 26.


Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model.

Yang X, Doerge DR, Fisher JW.

Toxicol Appl Pharmacol. 2013 Jul 1;270(1):45-59. doi: 10.1016/j.taap.2013.03.022. Epub 2013 Apr 6.


Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys.

Patterson TA, Twaddle NC, Roegge CS, Callicott RJ, Fisher JW, Doerge DR.

Toxicol Appl Pharmacol. 2013 Feb 15;267(1):41-8. doi: 10.1016/j.taap.2012.12.006. Epub 2012 Dec 19.


Carcinogenicity of acrylamide in B6C3F(1) mice and F344/N rats from a 2-year drinking water exposure.

Beland FA, Mellick PW, Olson GR, Mendoza MC, Marques MM, Doerge DR.

Food Chem Toxicol. 2013 Jan;51:149-59. doi: 10.1016/j.fct.2012.09.017. Epub 2012 Sep 23.


Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: quantification using UPLC-ES/MS/MS.

Sepehr E, Lebl-Rinnova M, Mann MK, Pisani SL, Churchwell MI, Korol DL, Katzenellenbogen JA, Doerge DR.

J Pharm Biomed Anal. 2012 Dec;71:119-26. doi: 10.1016/j.jpba.2012.08.022. Epub 2012 Aug 24.


Acute genistein treatment mimics the effects of estradiol by enhancing place learning and impairing response learning in young adult female rats.

Pisani SL, Neese SL, Doerge DR, Helferich WG, Schantz SL, Korol DL.

Horm Behav. 2012 Sep;62(4):491-9. doi: 10.1016/j.yhbeh.2012.08.006. Epub 2012 Aug 27.


In vivo genotoxicity of furan in F344 rats at cancer bioassay doses.

Ding W, Petibone DM, Latendresse JR, Pearce MG, Muskhelishvili L, White GA, Chang CW, Mittelstaedt RA, Shaddock JG, McDaniel LP, Doerge DR, Morris SM, Bishop ME, Manjanatha MG, Aidoo A, Heflich RH.

Toxicol Appl Pharmacol. 2012 Jun 1;261(2):164-71. doi: 10.1016/j.taap.2012.03.021. Epub 2012 Apr 5.


Pharmacokinetics of bisphenol A in serum and adipose tissue following intravenous administration to adult female CD-1 mice.

Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW.

Toxicol Lett. 2012 Jun 1;211(2):114-9. doi: 10.1016/j.toxlet.2012.03.008. Epub 2012 Mar 20.


Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats.

Camacho L, Latendresse JR, Muskhelishvili L, Patton R, Bowyer JF, Thomas M, Doerge DR.

Toxicol Lett. 2012 Jun 1;211(2):135-43. doi: 10.1016/j.toxlet.2012.03.007. Epub 2012 Mar 20.


Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.

Von Tungeln LS, Doerge DR, Gamboa da Costa G, Matilde Marques M, Witt WM, Koturbash I, Pogribny IP, Beland FA.

Int J Cancer. 2012 Nov 1;131(9):2008-15. doi: 10.1002/ijc.27493. Epub 2012 Mar 28.


Recent advances in the risk assessment of melamine and cyanuric acid in animal feed.

Dorne JL, Doerge DR, Vandenbroeck M, Fink-Gremmels J, Mennes W, Knutsen HK, Vernazza F, Castle L, Edler L, Benford D.

Toxicol Appl Pharmacol. 2013 Aug 1;270(3):218-29. doi: 10.1016/j.taap.2012.01.012. Epub 2012 Jan 25. Review.


A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague-Dawley rats during the waking (lights off) cycle.

Levi MS, Divine B, Hanig JP, Doerge DR, Vanlandingham MM, George NI, Twaddle NC, Bowyer JF.

Neurotoxicol Teratol. 2012 Mar;34(2):253-62. doi: 10.1016/ Epub 2012 Jan 20.


Low-dose dietary genistein negates the therapeutic effect of tamoxifen in athymic nude mice.

Du M, Yang X, Hartman JA, Cooke PS, Doerge DR, Ju YH, Helferich WG.

Carcinogenesis. 2012 Apr;33(4):895-901. doi: 10.1093/carcin/bgs017. Epub 2012 Jan 20.

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