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Adult farming exposure does not protect against sensitization to the storage mite Lepidoglyphus destructor.

Elholm G, Schlünssen V, Doekes G, Basinas I, Omland Ø, Grønager PM, Sigsgaard T.

Allergy. 2018 Nov;73(11):2234-2237. doi: 10.1111/all.13533. Epub 2018 Jul 26. No abstract available.


Asthmatic farm children show increased CD3+CD8low T-cells compared to non-asthmatic farm children.

Twardziok M, Schröder PC, Krusche J, Casaca VI, Illi S, Böck A, Loss GJ, Kabesch M, Toncheva AA, Roduit C, Depner M, Genuneit J, Renz H, Roponen M, Weber J, Braun-Fahrländer C, Riedler J, Lauener R, Vuitton DA, Dalphin JC, Pekkanen J, von Mutius E, Schaub B; PASTURE Study Group:, Hyvärinen A, Karvonen AM, Kirjavainen PV, Remes S, Kaulek V, Dalphin ML, Ege M, Pfefferle PI, Doekes G.

Clin Immunol. 2017 Oct;183:285-292. doi: 10.1016/j.clim.2017.09.009. Epub 2017 Sep 13. No abstract available.


High exposure to endotoxin in farming is associated with less new-onset pollen sensitisation.

Elholm G, Schlünssen V, Doekes G, Basinas I, Bolund ACS, Hjort C, Grønager PM, Omland Ø, Sigsgaard T.

Occup Environ Med. 2018 Feb;75(2):139-147. doi: 10.1136/oemed-2017-104384. Epub 2017 Aug 23. Erratum in: Occup Environ Med. 2018 Nov;75(11):845-846.


Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis.

Frei R, Ferstl R, Roduit C, Ziegler M, Schiavi E, Barcik W, Rodriguez-Perez N, Wirz OF, Wawrzyniak M, Pugin B, Nehrbass D, Jutel M, Smolinska S, Konieczna P, Bieli C, Loeliger S, Waser M, Pershagen G, Riedler J, Depner M, Schaub B, Genuneit J, Renz H, Pekkanen J, Karvonen AM, Dalphin JC, van Hage M, Doekes G, Akdis M, Braun-Fahrländer C, Akdis CA, von Mutius E, O'Mahony L, Lauener RP; Prevention of Allergy Risk factors for Sensitization in Children Related to Farming and Anthroposophic Lifestyle (PARSIFAL) study group; Protection Against Allergy Study in Rural Environments (PASTURE)/Mechanisms of Early Protective Exposures on Allergy Development (EFRAIM) study group.

J Allergy Clin Immunol. 2018 Jan;141(1):382-390.e7. doi: 10.1016/j.jaci.2017.04.051. Epub 2017 Jun 17.


Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood.

Roduit C, Frei R, Depner M, Karvonen AM, Renz H, Braun-Fahrländer C, Schmausser-Hechfellner E, Pekkanen J, Riedler J, Dalphin JC, von Mutius E, Lauener RP; the PASTURE study group, Hyvärinen A, Kirjavainen P, Remes S, Roponen M, Dalphin ML, Kaulek V, Ege M, Genuneit J, Illi S, Kabesch M, Schaub B, Pfefferle PI, Doekes G.

JAMA Pediatr. 2017 Jul 1;171(7):655-662. doi: 10.1001/jamapediatrics.2017.0556.


Allergy and respiratory health effects of dampness and dampness-related agents in schools and homes: a cross-sectional study in Danish pupils.

Holst GJ, Høst A, Doekes G, Meyer HW, Madsen AM, Plesner KB, Sigsgaard T.

Indoor Air. 2016 Dec;26(6):880-891. doi: 10.1111/ina.12275. Epub 2016 Jan 5.


Predictors of microbial agents in dust and respiratory health in the Ecrhs.

Tischer C, Zock JP, Valkonen M, Doekes G, Guerra S, Heederik D, Jarvis D, Norbäck D, Olivieri M, Sunyer J, Svanes C, Täubel M, Thiering E, Verlato G, Hyvärinen A, Heinrich J.

BMC Pulm Med. 2015 May 2;15:48. doi: 10.1186/s12890-015-0042-y.


Component-resolved diagnosis of baker's allergy based on specific IgE to recombinant wheat flour proteins.

Sander I, Rihs HP, Doekes G, Quirce S, Krop E, Rozynek P, van Kampen V, Merget R, Meurer U, Brüning T, Raulf M.

J Allergy Clin Immunol. 2015 Jun;135(6):1529-37. doi: 10.1016/j.jaci.2014.11.021. Epub 2015 Jan 7.


Early exposure to bio-contaminants and asthma up to 10 years of age: results of the HITEA study.

Tischer C, Casas L, Wouters IM, Doekes G, Garcia-Esteban R, Gehring U, Hyvärinen A, Oldenwening M, Kerkhof M, Sunyer J, Standl M, Thiering E, Torrent M, Heinrich J; HITEA study group.

Eur Respir J. 2015 Feb;45(2):328-37. doi: 10.1183/09031936.00060214. Epub 2014 Sep 3.


Determinants of house dust, endotoxin, and β-(1→3)-D-glucan in homes of Danish children.

Holst G, Høst A, Doekes G, Meyer HW, Madsen AM, Sigsgaard T.

Indoor Air. 2015 Jun;25(3):245-59. doi: 10.1111/ina.12143. Epub 2014 Sep 12.


Dampness, bacterial and fungal components in dust in primary schools and respiratory health in schoolchildren across Europe.

Jacobs J, Borràs-Santos A, Krop E, Täubel M, Leppänen H, Haverinen-Shaughnessy U, Pekkanen J, Hyvärinen A, Doekes G, Zock JP, Heederik D.

Occup Environ Med. 2014 Oct;71(10):704-12. doi: 10.1136/oemed-2014-102246. Epub 2014 Jul 17.


Quantity and diversity of environmental microbial exposure and development of asthma: a birth cohort study.

Karvonen AM, Hyvärinen A, Rintala H, Korppi M, Täubel M, Doekes G, Gehring U, Renz H, Pfefferle PI, Genuneit J, Keski-Nisula L, Remes S, Lampi J, von Mutius E, Pekkanen J.

Allergy. 2014 Aug;69(8):1092-101. doi: 10.1111/all.12439. Epub 2014 Jun 13.


Monitoring of occupational and environmental aeroallergens-- EAACI Position Paper. Concerted action of the EAACI IG Occupational Allergy and Aerobiology & Air Pollution.

Raulf M, Buters J, Chapman M, Cecchi L, de Blay F, Doekes G, Eduard W, Heederik D, Jeebhay MF, Kespohl S, Krop E, Moscato G, Pala G, Quirce S, Sander I, Schlünssen V, Sigsgaard T, Walusiak-Skorupa J, Wiszniewska M, Wouters IM, Annesi-Maesano I; European Academy of Allergy and Clinical Immunology.

Allergy. 2014 Oct;69(10):1280-99. doi: 10.1111/all.12456. Epub 2014 Aug 4.


Daily changes of peak expiratory flow and respiratory symptom occurrence around a soy processing factory.

Heederik D, Doekes G, van Strien R, Brunekreef B.

Ann Agric Environ Med. 2014;21(1):5-10.


Exhaled nitric oxide in spray painters exposed to isocyanates: effect modification by atopy and smoking.

Jonaid BS, Pronk A, Doekes G, Heederik D.

Occup Environ Med. 2014 Jun;71(6):415-22. doi: 10.1136/oemed-2013-101672. Epub 2014 Mar 28.


Expression of genes related to anti-inflammatory pathways are modified among farmers' children.

Frei R, Roduit C, Bieli C, Loeliger S, Waser M, Scheynius A, van Hage M, Pershagen G, Doekes G, Riedler J, von Mutius E, Sennhauser F, Akdis CA, Braun-Fahrländer C, Lauener RP; as part of the PARSIFAL study team.

PLoS One. 2014 Mar 6;9(3):e91097. doi: 10.1371/journal.pone.0091097. eCollection 2014.


Rule-based models of the interplay between genetic and environmental factors in childhood allergy.

Bornelöv S, Sääf A, Melén E, Bergström A, Torabi Moghadam B, Pulkkinen V, Acevedo N, Orsmark Pietras C, Ege M, Braun-Fahrländer C, Riedler J, Doekes G, Kabesch M, van Hage M, Kere J, Scheynius A, Söderhäll C, Pershagen G, Komorowski J.

PLoS One. 2013 Nov 19;8(11):e80080. doi: 10.1371/journal.pone.0080080. eCollection 2013.


Become a farmer and avoid new allergic sensitization: adult farming exposures protect against new-onset atopic sensitization.

Elholm G, Schlünssen V, Doekes G, Basinas I, Bibby BM, Hjort C, Grønager PM, Omland Ø, Sigsgaard T.

J Allergy Clin Immunol. 2013 Nov;132(5):1239-41. doi: 10.1016/j.jaci.2013.07.003. Epub 2013 Aug 26. No abstract available.


Endotoxin levels in settled airborne dust in European schools: the HITEA school study.

Jacobs JH, Krop EJ, Borras-Santos A, Zock JP, Taubel M, Hyvarinnen A, Pekkanen J, Doekes G, Heederik DJ; HITEA schools study consortium.

Indoor Air. 2014 Apr;24(2):148-57. doi: 10.1111/ina.12064. Epub 2013 Sep 23.


Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma.

Acevedo N, Sääf A, Söderhäll C, Melén E, Mandelin J, Pietras CO, Ezer S, Karisola P, Vendelin J, Gennäs GB, Yli-Kauhaluoma J, Alenius H, von Mutius E, Doekes G, Braun-Fahrländer C, Riedler J, van Hage M, D'Amato M, Scheynius A, Pershagen G, Kere J, Pulkkinen V.

PLoS One. 2013;8(4):e60111. doi: 10.1371/journal.pone.0060111. Epub 2013 Apr 2.


Early life exposures to home dampness, pet ownership and farm animal contact and neuropsychological development in 4 year old children: a prospective birth cohort study.

Casas L, Torrent M, Zock JP, Doekes G, Forns J, Guxens M, Täubel M, Heinrich J, Sunyer J.

Int J Hyg Environ Health. 2013 Nov;216(6):690-7. doi: 10.1016/j.ijheh.2012.12.013. Epub 2013 Jan 26.


Health effects of selected microbiological control agents. A 3-year follow-up study.

Baelum J, Larsen P, Doekes G, Sigsgaard T.

Ann Agric Environ Med. 2012;19(4):631-6.


Endotoxin, extracellular polysaccharides, and β(1-3)-glucan concentrations in dust and their determinants in four European birth cohorts: results from the HITEA project.

Casas L, Tischer C, Wouters IM, Valkonen M, Gehring U, Doekes G, Torrent M, Pekkanen J, Garcia-Esteban R, Hyvärinen A, Heinrich J, Sunyer J.

Indoor Air. 2013 Jun;23(3):208-18. doi: 10.1111/ina.12017. Epub 2012 Dec 21.


Exposure to microbial agents in house dust and wheezing, atopic dermatitis and atopic sensitization in early childhood: a birth cohort study in rural areas.

Karvonen AM, Hyvärinen A, Gehring U, Korppi M, Doekes G, Riedler J, Braun-Fahrländer C, Bitter S, Schmid S, Keski-Nisula L, Roponen M, Kaulek V, Dalphin JC, Pfefferle PI, Renz H, Büchele G, von Mutius E, Pekkanen J; PASTURE Study Group.

Clin Exp Allergy. 2012 Aug;42(8):1246-56. doi: 10.1111/j.1365-2222.2012.04002.x.


Comparison of the potency of a variety of β-glucans to induce cytokine production in human whole blood.

Noss I, Doekes G, Thorne PS, Heederik DJ, Wouters IM.

Innate Immun. 2013 Feb;19(1):10-9. doi: 10.1177/1753425912447129. Epub 2012 May 30.


Skin symptoms in bakery and auto body shop workers: associations with exposure and respiratory symptoms.

Arrandale V, Meijster T, Pronk A, Doekes G, Redlich CA, Holness DL, Heederik D.

Int Arch Occup Environ Health. 2013 Feb;86(2):167-75. doi: 10.1007/s00420-012-0760-x. Epub 2012 Mar 13.


IgG to various beta-glucans in a human adult population.

Noss I, Wouters IM, Smit LA, Meijer E, Pronk A, Heederik DJ, Doekes G.

Int Arch Allergy Immunol. 2012;157(1):98-108. doi: 10.1159/000324674. Epub 2011 Sep 7.


Geographical variation and the determinants of domestic endotoxin levels in mattress dust in Europe.

Chen CM, Thiering E, Doekes G, Zock JP, Bakolis I, Norbäck D, Sunyer J, Villani S, Verlato G, Täubel M, Jarvis D, Heinrich J.

Indoor Air. 2012 Feb;22(1):24-32. doi: 10.1111/j.1600-0668.2011.00740.x. Epub 2011 Oct 13.


Respiratory health and endotoxin: associations and modification by CD14/-260 genotype.

Bakolis I, Doekes G, Heinrich J, Zock JP, Heederik D, Kogevinas M, Guerra S, Norbäck D, Ramasamy A, Nevalainen A, Svanes C, Chen CM, Verlato G, Olivieri M, Castro-Giner F, Jarvis D; Indoor Group of the ECRHS; Work Package 10 Group of HITEA.

Eur Respir J. 2012 Mar;39(3):573-81. doi: 10.1183/09031936.00164410. Epub 2011 Sep 1.


Endotoxin exposure, CD14 and wheeze among farmers: a gene--environment interaction.

Smit LA, Heederik D, Doekes G, Koppelman GH, Bottema RW, Postma DS, Wouters IM.

Occup Environ Med. 2011 Nov;68(11):826-31. doi: 10.1136/oem.2010.060038. Epub 2011 Mar 9.


A comprehensive analysis of the COL29A1 gene does not support a role in eczema.

Naumann A, Söderhäll C, Fölster-Holst R, Baurecht H, Harde V, Müller-Wehling K, Rodríguez E, Ruether A, Franke A, Wagenpfeil S, Novak N, Mempel M, Kalali BN, Allgaeuer M, Koch J, Gerhard M, Melén E, Wahlgren CF, Kull I, Stahl C, Pershagen G, Lauener R, Riedler J, Doekes G, Scheynius A, Illig T, von Mutius E, Schreiber S, Kere J, Kabesch M, Weidinger S.

J Allergy Clin Immunol. 2011 May;127(5):1187-94.e7. doi: 10.1016/j.jaci.2010.12.1123. Epub 2011 Feb 25.


IgG4 antibodies against rodents in laboratory animal workers do not protect against allergic sensitization.

Krop EJ, Doekes G, Heederik DJ, Aalberse RC, van der Zee JS.

Allergy. 2011 Apr;66(4):517-22. doi: 10.1111/j.1398-9995.2010.02508.x. Epub 2010 Nov 17.


Passive airborne dust sampling with the electrostatic dustfall collector: optimization of storage and extraction procedures for endotoxin and glucan measurement.

Noss I, Doekes G, Sander I, Heederik DJ, Thorne PS, Wouters IM.

Ann Occup Hyg. 2010 Aug;54(6):651-8. doi: 10.1093/annhyg/meq026. Epub 2010 Mar 30.


Childhood asthma and early life exposure to indoor allergens, endotoxin and beta(1,3)-glucans.

Bertelsen RJ, Carlsen KC, Carlsen KH, Granum B, Doekes G, Håland G, Mowinckel P, Løvik M.

Clin Exp Allergy. 2010 Feb;40(2):307-16. doi: 10.1111/j.1365-2222.2009.03424.x.


beta-(1,3)-Glucan exposure assessment by passive airborne dust sampling and new sensitive immunoassays.

Noss I, Wouters IM, Bezemer G, Metwali N, Sander I, Raulf-Heimsoth M, Heederik DJ, Thorne PS, Doekes G.

Appl Environ Microbiol. 2010 Feb;76(4):1158-67. doi: 10.1128/AEM.01486-09. Epub 2009 Dec 28.


International variations in associations of allergic markers and diseases in children: ISAAC Phase Two.

Weinmayr G, Genuneit J, Nagel G, Björkstén B, van Hage M, Priftanji A, Cooper P, Rijkjärv MA, von Mutius E, Tsanakas J, Forastiere F, Doekes G, Garrido JB, Suarez-Varela MM, Bråbäck L, Strachan DP; ISAAC Phase Two Study Group.

Allergy. 2010 Jun 1;65(6):766-75. doi: 10.1111/j.1398-9995.2009.02283.x. Epub 2009 Dec 21.


Occupational endotoxin exposure reduces the risk of atopic sensitization but increases the risk of bronchial hyperresponsiveness.

Smit LA, Heederik D, Doekes G, Lammers JW, Wouters IM.

Int Arch Allergy Immunol. 2010;152(2):151-8. doi: 10.1159/000265536. Epub 2009 Dec 16.


Ex vivo cytokine release reflects sensitivity to occupational endotoxin exposure.

Smit LA, Heederik D, Doekes G, Krop EJ, Rijkers GT, Wouters IM.

Eur Respir J. 2009 Oct;34(4):795-802. doi: 10.1183/09031936.00161908. Epub 2009 Apr 8.


Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations.

Ekelund E, Bradley M, Weidinger S, Jovanovic DL, Johansson C, Lindgren CM, Todorova A, Jakob T, Illig T, von Mutius E, Braun-Fahrländer C, Doekes G, Riedler J, Scheynius A, Pershagen G, Kockum I, Kere J.

Acta Derm Venereol. 2009;89(2):115-21. doi: 10.2340/00015555-0549.


Different respiratory phenotypes are associated with isocyanate exposure in spray painters.

Pronk A, Preller L, Doekes G, Wouters IM, Rooijackers J, Lammers JW, Heederik D.

Eur Respir J. 2009 Mar;33(3):494-501. doi: 10.1183/09031936.00091408. Epub 2009 Jan 7.


Exhaled nitric oxide in endotoxin-exposed adults: effect modification by smoking and atopy.

Smit LA, Heederik D, Doekes G, Wouters IM.

Occup Environ Med. 2009 Apr;66(4):251-5. doi: 10.1136/oem.2008.042465. Epub 2008 Dec 5.


Asthma and allergic symptoms in relation to house dust endotoxin: Phase Two of the International Study on Asthma and Allergies in Childhood (ISAAC II).

Gehring U, Strikwold M, Schram-Bijkerk D, Weinmayr G, Genuneit J, Nagel G, Wickens K, Siebers R, Crane J, Doekes G, Di Domenicantonio R, Nilsson L, Priftanji A, Sandin A, El-Sharif N, Strachan D, van Hage M, von Mutius E, Brunekreef B; ISAAC Phase Two Study Group.

Clin Exp Allergy. 2008 Dec;38(12):1911-20. doi: 10.1111/j.1365-2222.2008.03087.x.


Evaluation of a low-cost electrostatic dust fall collector for indoor air endotoxin exposure assessment.

Noss I, Wouters IM, Visser M, Heederik DJ, Thorne PS, Brunekreef B, Doekes G.

Appl Environ Microbiol. 2008 Sep;74(18):5621-7. doi: 10.1128/AEM.00619-08. Epub 2008 Aug 1.


Effect of extraction and assay media on analysis of airborne endotoxin.

Spaan S, Doekes G, Heederik D, Thorne PS, Wouters IM.

Appl Environ Microbiol. 2008 Jun;74(12):3804-11. doi: 10.1128/AEM.02537-07. Epub 2008 Apr 25.


Biological and genetic interaction between tenascin C and neuropeptide S receptor 1 in allergic diseases.

Orsmark-Pietras C, Melén E, Vendelin J, Bruce S, Laitinen A, Laitinen LA, Lauener R, Riedler J, von Mutius E, Doekes G, Wickman M, van Hage M, Pershagen G, Scheynius A, Nyberg F, Kere J; PARSIFAL Genetics Study Group.

Hum Mol Genet. 2008 Jun 1;17(11):1673-82. doi: 10.1093/hmg/ddn058. Epub 2008 Feb 27.


The protective effect of farm animal exposure on childhood allergy is modified by NPSR1 polymorphisms.

Bruce S, Nyberg F, Melén E, James A, Pulkkinen V, Orsmark-Pietras C, Bergström A, Dahlén B, Wickman M, von Mutius E, Doekes G, Lauener R, Riedler J, Eder W, van Hage M, Pershagen G, Scheynius A, Kere J.

J Med Genet. 2009 Mar;46(3):159-67. doi: 10.1136/jmg.2007.055137. Epub 2008 Feb 19.


Exposure-response analysis of allergy and respiratory symptoms in endotoxin-exposed adults.

Smit LA, Heederik D, Doekes G, Blom C, van Zweden I, Wouters IM.

Eur Respir J. 2008 Jun;31(6):1241-8. doi: 10.1183/09031936.00090607. Epub 2008 Feb 6.


Assessment of soy aeroallergen levels in different work environments.

Gómez-Ollés S, Cruz MJ, Bogdanovic J, Wouters IM, Doekes G, Sander I, Morell F, Rodrigo MJ.

Clin Exp Allergy. 2007 Dec;37(12):1863-72. Epub 2007 Oct 10.


A polymorphism in CD14 modifies the effect of farm milk consumption on allergic diseases and CD14 gene expression.

Bieli C, Eder W, Frei R, Braun-Fahrländer C, Klimecki W, Waser M, Riedler J, von Mutius E, Scheynius A, Pershagen G, Doekes G, Lauener R, Martinez FD; PARSIFAL study group.

J Allergy Clin Immunol. 2007 Dec;120(6):1308-15. Epub 2007 Oct 24.


Inhalable beta(1->3)glucans as a non-allergenic exposure factor in Dutch bakeries.

Stuurman B, Meijster T, Heederik D, Doekes G.

Occup Environ Med. 2008 Jan;65(1):68-70. Epub 2007 Aug 15.


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