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Pharmacological Profile of AZD8871 (LAS191351), a Novel Inhaled Dual M3 Receptor Antagonist/β 2-Adrenoceptor Agonist Molecule with Long-Lasting Effects and Favorable Safety Profile.

Aparici M, Carcasona C, Ramos I, Montero JL, Otal R, Ortiz JL, Cortijo J, Puig C, Vilella D, De Alba J, Doe C, Gavaldà A, Miralpeix M.

J Pharmacol Exp Ther. 2019 Jul;370(1):127-136. doi: 10.1124/jpet.118.255620. Epub 2019 May 13.


Regulation of subcellular dendritic synapse specificity by axon guidance cues.

Sales EC, Heckman EL, Warren TL, Doe CQ.

Elife. 2019 Apr 23;8. pii: e43478. doi: 10.7554/eLife.43478.


The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting in Drosophila.

Seroka AQ, Doe CQ.

Development. 2019 Apr 5;146(7). pii: dev175570. doi: 10.1242/dev.175570.


Temporal identity establishes columnar neuron morphology, connectivity, and function in a Drosophila navigation circuit.

Sullivan LF, Warren TL, Doe CQ.

Elife. 2019 Feb 6;8. pii: e43482. doi: 10.7554/eLife.43482.


Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci.

Sen SQ, Chanchani S, Southall TD, Doe CQ.

Elife. 2019 Jan 29;8. pii: e44036. doi: 10.7554/eLife.44036.


A repressor-decay timer for robust temporal patterning in embryonic Drosophila neuroblast lineages.

Averbukh I, Lai SL, Doe CQ, Barkai N.

Elife. 2018 Dec 10;7. pii: e38631. doi: 10.7554/eLife.38631.


MDN brain descending neurons coordinately activate backward and inhibit forward locomotion.

Carreira-Rosario A, Zarin AA, Clark MQ, Manning L, Fetter RD, Cardona A, Doe CQ.

Elife. 2018 Aug 2;7. pii: e38554. doi: 10.7554/eLife.38554.


Drosophila nucleostemin 3 is required to maintain larval neuroblast proliferation.

Johnson PW, Doe CQ, Lai SL.

Dev Biol. 2018 Aug 1;440(1):1-12. doi: 10.1016/j.ydbio.2018.04.014. Epub 2018 Apr 19.


Neural circuits driving larval locomotion in Drosophila.

Clark MQ, Zarin AA, Carreira-Rosario A, Doe CQ.

Neural Dev. 2018 Apr 19;13(1):6. doi: 10.1186/s13064-018-0103-z. Review.


Drosophila embryonic type II neuroblasts: origin, temporal patterning, and contribution to the adult central complex.

Walsh KT, Doe CQ.

Development. 2017 Dec 15;144(24):4552-4562. doi: 10.1242/dev.157826. Epub 2017 Nov 20.


TU-Tagging: A Method for Identifying Layer-Enriched Neuronal Genes in Developing Mouse Visual Cortex.

Tomorsky J, DeBlander L, Kentros CG, Doe CQ, Niell CM.

eNeuro. 2017 Oct 4;4(5). pii: ENEURO.0181-17.2017. doi: 10.1523/ENEURO.0181-17.2017. eCollection 2017 Sep-Oct.


Temporal Patterning in the Drosophila CNS.

Doe CQ.

Annu Rev Cell Dev Biol. 2017 Oct 6;33:219-240. doi: 10.1146/annurev-cellbio-111315-125210. Review.


Playing Well with Others: Extrinsic Cues Regulate Neural Progenitor Temporal Identity to Generate Neuronal Diversity.

Syed MH, Mark B, Doe CQ.

Trends Genet. 2017 Dec;33(12):933-942. doi: 10.1016/j.tig.2017.08.005. Epub 2017 Sep 9. Review.


Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /β2-adrenoceptor agonist (MABA) molecule.

Aparici M, Carcasona C, Ramos I, Montero JL, Ortiz JL, Cortijo J, Puig C, Vilella D, Doe C, Gavaldà A, Miralpeix M.

Pulm Pharmacol Ther. 2017 Oct;46:1-10. doi: 10.1016/j.pupt.2017.07.003. Epub 2017 Jul 17.


Opportunities lost and gained: Changes in progenitor competence during nervous system development.

Farnsworth DR, Doe CQ.

Neurogenesis (Austin). 2017 May 26;4(1):e1324260. doi: 10.1080/23262133.2017.1324260. eCollection 2017. Review.


The Hunchback temporal transcription factor establishes, but is not required to maintain, early-born neuronal identity.

Hirono K, Kohwi M, Clark MQ, Heckscher ES, Doe CQ.

Neural Dev. 2017 Jan 31;12(1):1. doi: 10.1186/s13064-017-0078-1.


Immunofluorescent antibody staining of intact Drosophila larvae.

Manning L, Doe CQ.

Nat Protoc. 2017 Jan;12(1):1-14. doi: 10.1038/nprot.2016.162. Epub 2016 Dec 1.


Utilisation and Tolerability of Aliskiren in the Primary Care Setting in England.

Coughtrie AL, Doe C, Layton D, Shakir SA.

J Clin Hypertens (Greenwich). 2016 Dec;18(12):1237-1243. doi: 10.1111/jch.12852. Epub 2016 Jun 3.


Anatomic and Technical Considerations: Inferior Vena Cava Filter Placement.

Doe C, Ryu RK.

Semin Intervent Radiol. 2016 Jun;33(2):88-92. doi: 10.1055/s-0036-1581089. Review.


Functional Genetic Screen to Identify Interneurons Governing Behaviorally Distinct Aspects of Drosophila Larval Motor Programs.

Clark MQ, McCumsey SJ, Lopez-Darwin S, Heckscher ES, Doe CQ.

G3 (Bethesda). 2016 Jul 7;6(7):2023-31. doi: 10.1534/g3.116.028472.


In vitro and in vivo preclinical profile of abediterol (LAS100977), an inhaled long-acting β2-adrenoceptor agonist, compared with indacaterol, olodaterol and vilanterol.

Aparici M, Gavaldà A, Ramos I, Carcasona C, Otal R, Fernández-Blanco JA, Montero JL, García VM, López R, De Alba J, Doe C, Puig C, Vilella D, Miralpeix M.

Eur J Pharmacol. 2016 Jan 5;770:61-9. doi: 10.1016/j.ejphar.2015.11.053. Epub 2015 Dec 4.


Aging Neural Progenitors Lose Competence to Respond to Mitogenic Notch Signaling.

Farnsworth DR, Bayraktar OA, Doe CQ.

Curr Biol. 2015 Dec 7;25(23):3058-68. doi: 10.1016/j.cub.2015.10.027. Epub 2015 Nov 12.


Even-Skipped(+) Interneurons Are Core Components of a Sensorimotor Circuit that Maintains Left-Right Symmetric Muscle Contraction Amplitude.

Heckscher ES, Zarin AA, Faumont S, Clark MQ, Manning L, Fushiki A, Schneider-Mizell CM, Fetter RD, Truman JW, Zwart MF, Landgraf M, Cardona A, Lockery SR, Doe CQ.

Neuron. 2015 Oct 21;88(2):314-29. doi: 10.1016/j.neuron.2015.09.009. Epub 2015 Oct 1.


IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk.

Kaur D, Gomez E, Doe C, Berair R, Woodman L, Saunders R, Hollins F, Rose FR, Amrani Y, May R, Kearley J, Humbles A, Cohen ES, Brightling CE.

Allergy. 2015 May;70(5):556-67. doi: 10.1111/all.12593. Epub 2015 Mar 16.


Transient nuclear Prospero induces neural progenitor quiescence.

Lai SL, Doe CQ.

Elife. 2014 Oct 29;3. doi: 10.7554/eLife.03363.


The RanGEF Bj1 promotes prospero nuclear export and neuroblast self-renewal.

Joy T, Hirono K, Doe CQ.

Dev Neurobiol. 2015 May;75(5):485-93. doi: 10.1002/dneu.22237. Epub 2014 Oct 20.


Atlas-builder software and the eNeuro atlas: resources for developmental biology and neuroscience.

Heckscher ES, Long F, Layden MJ, Chuang CH, Manning L, Richart J, Pearson JC, Crews ST, Peng H, Myers E, Doe CQ.

Development. 2014 Jun;141(12):2524-32. doi: 10.1242/dev.108720.


Applying thiouracil tagging to mouse transcriptome analysis.

Gay L, Karfilis KV, Miller MR, Doe CQ, Stankunas K.

Nat Protoc. 2014 Feb;9(2):410-20. doi: 10.1038/nprot.2014.023. Epub 2014 Jan 23.


Temporal fate specification and neural progenitor competence during development.

Kohwi M, Doe CQ.

Nat Rev Neurosci. 2013 Dec;14(12):823-38. Review.


Live imaging of neuroblast lineages within intact larval brains in Drosophila.

Cabernard C, Doe CQ.

Cold Spring Harb Protoc. 2013 Oct 1;2013(10):970-7. doi: 10.1101/pdb.prot078162.


midlife crisis encodes a conserved zinc-finger protein required to maintain neuronal differentiation in Drosophila.

Carney TD, Struck AJ, Doe CQ.

Development. 2013 Oct;140(20):4155-64. doi: 10.1242/dev.093781. Epub 2013 Sep 11.


Formin-mediated actin polymerization cooperates with Mushroom body defect (Mud)-Dynein during Frizzled-Dishevelled spindle orientation.

Johnston CA, Manning L, Lu MS, Golub O, Doe CQ, Prehoda KE.

J Cell Sci. 2013 Oct 1;126(Pt 19):4436-44. doi: 10.1242/jcs.129544. Epub 2013 Jul 18.


Combinatorial temporal patterning in progenitors expands neural diversity.

Bayraktar OA, Doe CQ.

Nature. 2013 Jun 27;498(7455):449-55. doi: 10.1038/nature12266. Epub 2013 Jun 19.


Developmentally regulated subnuclear genome reorganization restricts neural progenitor competence in Drosophila.

Kohwi M, Lupton JR, Lai SL, Miller MR, Doe CQ.

Cell. 2013 Jan 17;152(1-2):97-108. doi: 10.1016/j.cell.2012.11.049.


Mouse TU tagging: a chemical/genetic intersectional method for purifying cell type-specific nascent RNA.

Gay L, Miller MR, Ventura PB, Devasthali V, Vue Z, Thompson HL, Temple S, Zong H, Cleary MD, Stankunas K, Doe CQ.

Genes Dev. 2013 Jan 1;27(1):98-115. doi: 10.1101/gad.205278.112. Erratum in: Genes Dev. 2014 Dec 1;28(23):2677.


Comparative analysis of state-level concussion legislation and review of current practices in concussion.

Tomei KL, Doe C, Prestigiacomo CJ, Gandhi CD.

Neurosurg Focus. 2012 Dec;33(6):E11: 1-9. doi: 10.3171/2012.9.FOCUS12280. Review.


The Snail family member Worniu is continuously required in neuroblasts to prevent Elav-induced premature differentiation.

Lai SL, Miller MR, Robinson KJ, Doe CQ.

Dev Cell. 2012 Oct 16;23(4):849-57. doi: 10.1016/j.devcel.2012.09.007.


A resource for manipulating gene expression and analyzing cis-regulatory modules in the Drosophila CNS.

Manning L, Heckscher ES, Purice MD, Roberts J, Bennett AL, Kroll JR, Pollard JL, Strader ME, Lupton JR, Dyukareva AV, Doan PN, Bauer DM, Wilbur AN, Tanner S, Kelly JJ, Lai SL, Tran KD, Kohwi M, Laverty TR, Pearson JC, Crews ST, Rubin GM, Doe CQ.

Cell Rep. 2012 Oct 25;2(4):1002-13. doi: 10.1016/j.celrep.2012.09.009. Epub 2012 Oct 11.


Characterization of Drosophila larval crawling at the level of organism, segment, and somatic body wall musculature.

Heckscher ES, Lockery SR, Doe CQ.

J Neurosci. 2012 Sep 5;32(36):12460-71. doi: 10.1523/JNEUROSCI.0222-12.2012. Erratum in: J Neurosci. 2013 Mar 20;33(12):5433.


Structure of an enzyme-derived phosphoprotein recognition domain.

Johnston CA, Doe CQ, Prehoda KE.

PLoS One. 2012;7(4):e36014. doi: 10.1371/journal.pone.0036014. Epub 2012 Apr 24.


Neurophysiological defects and neuronal gene deregulation in Drosophila mir-124 mutants.

Sun K, Westholm JO, Tsurudome K, Hagen JW, Lu Y, Kohwi M, Betel D, Gao FB, Haghighi AP, Doe CQ, Lai EC.

PLoS Genet. 2012 Feb;8(2):e1002515. doi: 10.1371/journal.pgen.1002515. Epub 2012 Feb 9.


Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts.

Andersen RO, Turnbull DW, Johnson EA, Doe CQ.

Dev Biol. 2012 Mar 1;363(1):258-65. doi: 10.1016/j.ydbio.2011.12.047. Epub 2012 Jan 10.


Strategies for asymptomatic carotid artery stenosis.

Doe C, Jethwa PR, Gandhi CD, Prestigiacomo CJ.

Neurosurg Focus. 2011 Dec;31(6):E9. doi: 10.3171/2011.9.FOCUS11206. Review.


Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma.

Sutcliffe A, Hollins F, Gomez E, Saunders R, Doe C, Cooke M, Challiss RA, Brightling CE.

Am J Respir Crit Care Med. 2012 Feb 1;185(3):267-74. doi: 10.1164/rccm.201107-1281OC. Epub 2011 Nov 22.


Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis.

Carney TD, Miller MR, Robinson KJ, Bayraktar OA, Osterhout JA, Doe CQ.

Dev Biol. 2012 Jan 1;361(1):137-46. doi: 10.1016/j.ydbio.2011.10.020. Epub 2011 Oct 25.


Mast cell-airway smooth muscle crosstalk: the role of thymic stromal lymphopoietin.

Kaur D, Doe C, Woodman L, Heidi Wan WY, Sutcliffe A, Hollins F, Brightling C.

Chest. 2012 Jul;142(1):76-85. doi: 10.1378/chest.11-1782.


Identification of hunchback cis-regulatory DNA conferring temporal expression in neuroblasts and neurons.

Hirono K, Margolis JS, Posakony JW, Doe CQ.

Gene Expr Patterns. 2012 Jan-Feb;12(1-2):11-7. doi: 10.1016/j.gep.2011.10.001. Epub 2011 Oct 20.


Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation.

Wee B, Johnston CA, Prehoda KE, Doe CQ.

J Cell Biol. 2011 Oct 31;195(3):369-76. doi: 10.1083/jcb.201102130. Epub 2011 Oct 24.


Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing.

Johnston CA, Whitney DS, Volkman BF, Doe CQ, Prehoda KE.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):E973-8. doi: 10.1073/pnas.1104365108. Epub 2011 Oct 11.

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