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A Peptide Inhibitor of NADPH Oxidase (NOX2) Activation Markedly Decreases Mouse Lung Injury and Mortality Following Administration of Lipopolysaccharide (LPS).

Fisher AB, Dodia C, Chatterjee S, Feinstein SI.

Int J Mol Sci. 2019 May 15;20(10). pii: E2395. doi: 10.3390/ijms20102395. Erratum in: Int J Mol Sci. 2020 Jan 08;21(2):.


Non-Mammalian Prdx6 Enzymes (Proteins with 1-Cys Prdx Mechanism) Display PLA₂ Activity Similar to the Human Orthologue.

Bannitz-Fernandes R, Aleixo-Silva R, Silva JP, Dodia C, Vazquez-Medina JP, Tao JQ, Fisher A, Netto L.

Antioxidants (Basel). 2019 Mar 1;8(3). pii: E52. doi: 10.3390/antiox8030052.


Genetic inactivation of the phospholipase A2 activity of peroxiredoxin 6 in mice protects against LPS-induced acute lung injury.

Vázquez-Medina JP, Tao JQ, Patel P, Bannitz-Fernandes R, Dodia C, Sorokina EM, Feinstein SI, Chatterjee S, Fisher AB.

Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1;316(4):L656-L668. doi: 10.1152/ajplung.00344.2018. Epub 2019 Jan 31.


Oxidation of Peroxiredoxin 6 in the Presence of GSH Increases its Phospholipase A₂ Activity at Cytoplasmic pH.

Zhou S, Dodia C, Feinstein SI, Harper S, Forman HJ, Speicher DW, Fisher AB.

Antioxidants (Basel). 2018 Dec 24;8(1). pii: E4. doi: 10.3390/antiox8010004.


Identification of Small Peptides that Inhibit NADPH Oxidase (Nox2) Activation.

Fisher AB, Dodia C, Feinstein SI.

Antioxidants (Basel). 2018 Dec 5;7(12). pii: E181. doi: 10.3390/antiox7120181.


Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid.

Kuda O, Brezinova M, Silhavy J, Landa V, Zidek V, Dodia C, Kreuchwig F, Vrbacky M, Balas L, Durand T, Hübner N, Fisher AB, Kopecky J, Pravenec M.

Diabetes. 2018 Jun;67(6):1190-1199. doi: 10.2337/db17-1087. Epub 2018 Mar 16.


Deficiency of peroxiredoxin 6 or inhibition of its phospholipase A2 activity impair the in vitro sperm fertilizing competence in mice.

Moawad AR, Fernandez MC, Scarlata E, Dodia C, Feinstein SI, Fisher AB, O'Flaherty C.

Sci Rep. 2017 Oct 11;7(1):12994. doi: 10.1038/s41598-017-13411-2.


Peroxiredoxin 6 phospholipid hydroperoxidase activity in the repair of peroxidized cell membranes.

Fisher AB, Vasquez-Medina JP, Dodia C, Sorokina EM, Tao JQ, Feinstein SI.

Redox Biol. 2018 Apr;14:41-46. doi: 10.1016/j.redox.2017.08.008. Epub 2017 Aug 12.


The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages.

Vázquez-Medina JP, Dodia C, Weng L, Mesaros C, Blair IA, Feinstein SI, Chatterjee S, Fisher AB.

FASEB J. 2016 Aug;30(8):2885-98. doi: 10.1096/fj.201500146R. Epub 2016 May 13.


Mutation of Serine 32 to Threonine in Peroxiredoxin 6 Preserves Its Structure and Enzymatic Function but Abolishes Its Trafficking to Lamellar Bodies.

Sorokina EM, Dodia C, Zhou S, Tao JQ, Gao L, Raabe T, Feinstein SI, Fisher AB.

J Biol Chem. 2016 Apr 22;291(17):9268-80. doi: 10.1074/jbc.M115.698894. Epub 2016 Feb 26.


Peroxiredoxin 6 homodimerization and heterodimerization with glutathione S-transferase pi are required for its peroxidase but not phospholipase A2 activity.

Zhou S, Sorokina EM, Harper S, Li H, Ralat L, Dodia C, Speicher DW, Feinstein SI, Fisher AB.

Free Radic Biol Med. 2016 May;94:145-56. doi: 10.1016/j.freeradbiomed.2016.02.012. Epub 2016 Feb 16.


A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6.

Fisher AB, Dodia C, Sorokina EM, Li H, Zhou S, Raabe T, Feinstein SI.

J Lipid Res. 2016 Apr;57(4):587-96. doi: 10.1194/jlr.M064758. Epub 2016 Feb 1.


Binding sites for interaction of peroxiredoxin 6 with surfactant protein A.

Krishnaiah SY, Dodia C, Sorokina EM, Li H, Feinstein SI, Fisher AB.

Biochim Biophys Acta. 2016 Apr;1864(4):419-25. doi: 10.1016/j.bbapap.2015.12.009. Epub 2015 Dec 23.


Critical role of peroxiredoxin 6 in the repair of peroxidized cell membranes following oxidative stress.

Li H, Benipal B, Zhou S, Dodia C, Chatterjee S, Tao JQ, Sorokina EM, Raabe T, Feinstein SI, Fisher AB.

Free Radic Biol Med. 2015 Oct;87:356-65. doi: 10.1016/j.freeradbiomed.2015.06.009. Epub 2015 Jun 25.


Inhibition of the phospholipase A2 activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia.

Benipal B, Feinstein SI, Chatterjee S, Dodia C, Fisher AB.

Redox Biol. 2015;4:321-7. doi: 10.1016/j.redox.2015.01.011. Epub 2015 Jan 16.


Protection against LPS-induced acute lung injury by a mechanism-based inhibitor of NADPH oxidase (type 2).

Lee I, Dodia C, Chatterjee S, Feinstein SI, Fisher AB.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L635-44. doi: 10.1152/ajplung.00374.2013. Epub 2014 Jan 31.


A novel nontoxic inhibitor of the activation of NADPH oxidase reduces reactive oxygen species production in mouse lung.

Lee I, Dodia C, Chatterjee S, Zagorski J, Mesaros C, Blair IA, Feinstein SI, Jain M, Fisher AB.

J Pharmacol Exp Ther. 2013 May;345(2):284-96. doi: 10.1124/jpet.112.201079. Epub 2013 Mar 8.


p67(phox) terminates the phospholipase A(2)-derived signal for activation of NADPH oxidase (NOX2).

Krishnaiah SY, Dodia C, Feinstein SI, Fisher AB.

FASEB J. 2013 May;27(5):2066-73. doi: 10.1096/fj.12-222133. Epub 2013 Feb 11.


Antioxidant protection by PECAM-targeted delivery of a novel NADPH-oxidase inhibitor to the endothelium in vitro and in vivo.

Hood ED, Greineder CF, Dodia C, Han J, Mesaros C, Shuvaev VV, Blair IA, Fisher AB, Muzykantov VR.

J Control Release. 2012 Oct 28;163(2):161-9. doi: 10.1016/j.jconrel.2012.08.031. Epub 2012 Sep 6.


Increased phospholipase A2 activity with phosphorylation of peroxiredoxin 6 requires a conformational change in the protein.

Rahaman H, Zhou S, Dodia C, Feinstein SI, Huang S, Speicher D, Fisher AB.

Biochemistry. 2012 Jul 10;51(27):5521-30. Epub 2012 Jun 29.


The roles of peroxidase and phospholipase A2 activities of peroxiredoxin 6 in protecting pulmonary microvascular endothelial cells against peroxidative stress.

Lien YC, Feinstein SI, Dodia C, Fisher AB.

Antioxid Redox Signal. 2012 Mar 1;16(5):440-51. doi: 10.1089/ars.2011.3950. Epub 2011 Dec 23.


Peroxiredoxin 6 phosphorylation and subsequent phospholipase A2 activity are required for agonist-mediated activation of NADPH oxidase in mouse pulmonary microvascular endothelium and alveolar macrophages.

Chatterjee S, Feinstein SI, Dodia C, Sorokina E, Lien YC, Nguyen S, Debolt K, Speicher D, Fisher AB.

J Biol Chem. 2011 Apr 1;286(13):11696-706. doi: 10.1074/jbc.M110.206623. Epub 2011 Jan 24.


Comparison of glutathione peroxidase 1 and peroxiredoxin 6 in protection against oxidative stress in the mouse lung.

Liu G, Feinstein SI, Wang Y, Dodia C, Fisher D, Yu K, Ho YS, Fisher AB.

Free Radic Biol Med. 2010 Oct 15;49(7):1172-81. doi: 10.1016/j.freeradbiomed.2010.07.002. Epub 2010 Jul 11.


Pathway to lamellar bodies for surfactant protein A.

Fisher AB, Dodia C, Ruckert P, Tao JQ, Bates SR.

Am J Physiol Lung Cell Mol Physiol. 2010 Jul;299(1):L51-8. doi: 10.1152/ajplung.00066.2010. Epub 2010 Apr 9.


Binding of peroxiredoxin 6 to substrate determines differential phospholipid hydroperoxide peroxidase and phospholipase A(2) activities.

Manevich Y, Shuvaeva T, Dodia C, Kazi A, Feinstein SI, Fisher AB.

Arch Biochem Biophys. 2009 May 15;485(2):139-49. doi: 10.1016/ Epub 2009 Feb 21.


Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A(2) activity.

Wu Y, Feinstein SI, Manevich Y, Chowdhury I, Pak JH, Kazi A, Dodia C, Speicher DW, Fisher AB.

Biochem J. 2009 May 1;419(3):669-79. doi: 10.1042/BJ20082061.


Surfactant protein-A plays an important role in lung surfactant clearance: evidence using the surfactant protein-A gene-targeted mouse.

Bates SR, Dodia C, Tao JQ, Fisher AB.

Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L325-33. Epub 2007 Dec 14.


ABCA3 is critical for lamellar body biogenesis in vivo.

Cheong N, Zhang H, Madesh M, Zhao M, Yu K, Dodia C, Fisher AB, Savani RC, Shuman H.

J Biol Chem. 2007 Aug 17;282(33):23811-7. Epub 2007 May 31.


Lung phospholipid metabolism in transgenic mice overexpressing peroxiredoxin 6.

Fisher AB, Dodia C, Yu K, Manevich Y, Feinstein SI.

Biochim Biophys Acta. 2006 Jul;1761(7):785-92. Epub 2006 May 23.


Interaction of surfactant protein A with peroxiredoxin 6 regulates phospholipase A2 activity.

Wu YZ, Manevich Y, Baldwin JL, Dodia C, Yu K, Feinstein SI, Fisher AB.

J Biol Chem. 2006 Mar 17;281(11):7515-25. Epub 2005 Dec 5.


Pathways for clearance of surfactant protein A from the lung.

Jain D, Dodia C, Fisher AB, Bates SR.

Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L1011-8. Epub 2005 Jul 8.


Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A2.

Fisher AB, Dodia C, Feinstein SI, Ho YS.

J Lipid Res. 2005 Jun;46(6):1248-56. Epub 2005 Mar 16.


SP-A is necessary for increased clearance of alveolar DPPC with hyperventilation or secretagogues.

Jain D, Dodia C, Bates SR, Hawgood S, Poulain FR, Fisher AB.

Am J Physiol Lung Cell Mol Physiol. 2003 May;284(5):L759-65. Epub 2003 Jan 10.


Lysosomal-type PLA2 and turnover of alveolar DPPC.

Fisher AB, Dodia C.

Am J Physiol Lung Cell Mol Physiol. 2001 Apr;280(4):L748-54.


1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities.

Chen JW, Dodia C, Feinstein SI, Jain MK, Fisher AB.

J Biol Chem. 2000 Sep 15;275(37):28421-7.


Simulated ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling.

Wei Z, Costa K, Al-Mehdi AB, Dodia C, Muzykantov V, Fisher AB.

Circ Res. 1999 Oct 15;85(8):682-9.


Phospholipid hydroperoxides are substrates for non-selenium glutathione peroxidase.

Fisher AB, Dodia C, Manevich Y, Chen JW, Feinstein SI.

J Biol Chem. 1999 Jul 23;274(30):21326-34.


Characterization of acidic Ca(2+)-independent phospholipase A2 of bovine lung.

Akiba S, Dodia C, Chen X, Fisher AB.

Comp Biochem Physiol B Biochem Mol Biol. 1998 Jun;120(2):393-404.


Endothelial NADPH oxidase as the source of oxidants in lungs exposed to ischemia or high K+.

Al-Mehdi AB, Zhao G, Dodia C, Tozawa K, Costa K, Muzykantov V, Ross C, Blecha F, Dinauer M, Fisher AB.

Circ Res. 1998 Oct 5;83(7):730-7.


Calcium-triggered selective intermembrane exchange of phospholipids by the lung surfactant protein SP-A.

Cajal Y, Dodia C, Fisher AB, Jain MK.

Biochemistry. 1998 Sep 1;37(35):12178-88.


Cloning and expression of rat lung acidic Ca(2+)-independent PLA2 and its organ distribution.

Kim TS, Dodia C, Chen X, Hennigan BB, Jain M, Feinstein SI, Fisher AB.

Am J Physiol. 1998 May;274(5):L750-61. doi: 10.1152/ajplung.1998.274.5.L750.


Macrophages primed by overnight culture demonstrate a marked stimulation of surfactant protein A degradation.

Bates SR, Xu J, Dodia C, Fisher AB.

Am J Physiol. 1997 Oct;273(4):L831-9. doi: 10.1152/ajplung.1997.273.4.L831.


Identification of a cDNA for Ca++-independent phospholipase A2 of lung lamellar bodies/lysosomes.

Fisher AB, Feinstein SI, Kim TS, Dodia C, Skach W.

Chest. 1997 Jun;111(6 Suppl):88S-89S. No abstract available.


Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein.

Kim TS, Sundaresh CS, Feinstein SI, Dodia C, Skach WR, Jain MK, Nagase T, Seki N, Ishikawa K, Nomura N, Fisher AB.

J Biol Chem. 1997 Jan 24;272(4):2542-50. Erratum in: J Biol Chem 1997 Apr 18;272(16):10981.


Endothelial cells internalize monoclonal antibody to angiotensin-converting enzyme.

Muzykantov VR, Atochina EN, Kuo A, Barnathan ES, Notarfrancesco K, Shuman H, Dodia C, Fisher AB.

Am J Physiol. 1996 May;270(5 Pt 1):L704-13.


Surfactant protein A regulates uptake of pulmonary surfactant by lung type II cells on microporous membranes.

Bates SR, Dodia C, Fisher AB.

Am J Physiol. 1994 Dec;267(6 Pt 1):L753-60.


Purification and characterization of a calcium-independent acidic phospholipase A2 from rat lung.

Wang R, Dodia CR, Jain MK, Fisher AB.

Biochem J. 1994 Nov 15;304 ( Pt 1):131-7.

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