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Items: 33


Lipid Involvement in Neurodegenerative Diseases of the Motor System: Insights from Lysosomal Storage Diseases.

Dodge JC.

Front Mol Neurosci. 2017 Nov 3;10:356. doi: 10.3389/fnmol.2017.00356. eCollection 2017. Review.


Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models.

Sardi SP, Viel C, Clarke J, Treleaven CM, Richards AM, Park H, Olszewski MA, Dodge JC, Marshall J, Makino E, Wang B, Sidman RL, Cheng SH, Shihabuddin LS.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2699-2704. doi: 10.1073/pnas.1616152114. Epub 2017 Feb 21.


Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.

Rockenstein E, Clarke J, Viel C, Panarello N, Treleaven CM, Kim C, Spencer B, Adame A, Park H, Dodge JC, Cheng SH, Shihabuddin LS, Masliah E, Sardi SP.

Hum Mol Genet. 2016 Jul 1;25(13):2645-2660. Epub 2016 Apr 28.


Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis.

Dodge JC, Treleaven CM, Pacheco J, Cooper S, Bao C, Abraham M, Cromwell M, Sardi SP, Chuang WL, Sidman RL, Cheng SH, Shihabuddin LS.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8100-5. doi: 10.1073/pnas.1508767112. Epub 2015 Jun 8.


Systemic administration of a recombinant AAV1 vector encoding IGF-1 improves disease manifestations in SMA mice.

Tsai LK, Chen CL, Ting CH, Lin-Chao S, Hwu WL, Dodge JC, Passini MA, Cheng SH.

Mol Ther. 2014 Aug;22(8):1450-1459. doi: 10.1038/mt.2014.84. Epub 2014 May 12.


Metabolic signatures of amyotrophic lateral sclerosis reveal insights into disease pathogenesis.

Dodge JC, Treleaven CM, Fidler JA, Tamsett TJ, Bao C, Searles M, Taksir TV, Misra K, Sidman RL, Cheng SH, Shihabuddin LS.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10812-7. doi: 10.1073/pnas.1308421110. Epub 2013 Jun 10.


Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies.

Sardi SP, Clarke J, Viel C, Chan M, Tamsett TJ, Treleaven CM, Bu J, Sweet L, Passini MA, Dodge JC, Yu WH, Sidman RL, Cheng SH, Shihabuddin LS.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3537-42. doi: 10.1073/pnas.1220464110. Epub 2013 Jan 7.


Merits of combination cortical, subcortical, and cerebellar injections for the treatment of Niemann-Pick disease type A.

Bu J, Ashe KM, Bringas J, Marshall J, Dodge JC, Cabrera-Salazar MA, Forsayeth J, Schuchman EH, Bankiewicz KS, Cheng SH, Shihabuddin LS, Passini MA.

Mol Ther. 2012 Oct;20(10):1893-901. doi: 10.1038/mt.2012.118. Epub 2012 Jul 24.


Gene transfer to the CNS is efficacious in immune-primed mice harboring physiologically relevant titers of anti-AAV antibodies.

Treleaven CM, Tamsett TJ, Bu J, Fidler JA, Sardi SP, Hurlbut GD, Woodworth LA, Cheng SH, Passini MA, Shihabuddin LS, Dodge JC.

Mol Ther. 2012 Sep;20(9):1713-23. doi: 10.1038/mt.2012.114. Epub 2012 Jun 26.


IGF-1 delivery to CNS attenuates motor neuron cell death but does not improve motor function in type III SMA mice.

Tsai LK, Chen YC, Cheng WC, Ting CH, Dodge JC, Hwu WL, Cheng SH, Passini MA.

Neurobiol Dis. 2012 Jan;45(1):272-9. doi: 10.1016/j.nbd.2011.06.021. Epub 2011 Aug 18.


Disease progression in a mouse model of amyotrophic lateral sclerosis: the influence of chronic stress and corticosterone.

Fidler JA, Treleaven CM, Frakes A, Tamsett TJ, McCrate M, Cheng SH, Shihabuddin LS, Kaspar BK, Dodge JC.

FASEB J. 2011 Dec;25(12):4369-77. doi: 10.1096/fj.11-190819. Epub 2011 Aug 29.


Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion.

Ziegler RJ, Salegio EA, Dodge JC, Bringas J, Treleaven CM, Bercury SD, Tamsett TJ, Shihabuddin L, Hadaczek P, Fiandaca M, Bankiewicz K, Scheule RK.

Exp Neurol. 2011 Oct;231(2):261-71. doi: 10.1016/j.expneurol.2011.06.019. Epub 2011 Jul 14.


Comparative analysis of acid sphingomyelinase distribution in the CNS of rats and mice following intracerebroventricular delivery.

Treleaven CM, Tamsett T, Fidler JA, Taksir TV, Cheng SH, Shihabuddin LS, Dodge JC.

PLoS One. 2011 Jan 25;6(1):e16313. doi: 10.1371/journal.pone.0016313.


Relationship between neuropathology and disease progression in the SOD1(G93A) ALS mouse.

Yang WW, Sidman RL, Taksir TV, Treleaven CM, Fidler JA, Cheng SH, Dodge JC, Shihabuddin LS.

Exp Neurol. 2011 Feb;227(2):287-95. doi: 10.1016/j.expneurol.2010.11.019. Epub 2010 Dec 9.


AAV4-mediated expression of IGF-1 and VEGF within cellular components of the ventricular system improves survival outcome in familial ALS mice.

Dodge JC, Treleaven CM, Fidler JA, Hester M, Haidet A, Handy C, Rao M, Eagle A, Matthews JC, Taksir TV, Cheng SH, Shihabuddin LS, Kaspar BK.

Mol Ther. 2010 Dec;18(12):2075-84. doi: 10.1038/mt.2010.206. Epub 2010 Sep 21.


Intracerebroventricular infusion of acid sphingomyelinase corrects CNS manifestations in a mouse model of Niemann-Pick A disease.

Dodge JC, Clarke J, Treleaven CM, Taksir TV, Griffiths DA, Yang W, Fidler JA, Passini MA, Karey KP, Schuchman EH, Cheng SH, Shihabuddin LS.

Exp Neurol. 2009 Feb;215(2):349-57. doi: 10.1016/j.expneurol.2008.10.021. Epub 2008 Nov 14.


Temporal neuropathologic and behavioral phenotype of 6neo/6neo Pompe disease mice.

Sidman RL, Taksir T, Fidler J, Zhao M, Dodge JC, Passini MA, Raben N, Thurberg BL, Cheng SH, Shihabuddin LS.

J Neuropathol Exp Neurol. 2008 Aug;67(8):803-18. doi: 10.1097/NEN.0b013e3181815994.


Delivery of AAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity.

Dodge JC, Haidet AM, Yang W, Passini MA, Hester M, Clarke J, Roskelley EM, Treleaven CM, Rizo L, Martin H, Kim SH, Kaspar R, Taksir TV, Griffiths DA, Cheng SH, Shihabuddin LS, Kaspar BK.

Mol Ther. 2008 Jun;16(6):1056-64. doi: 10.1038/mt.2008.60. Epub 2008 Apr 1.


Intraventricular enzyme replacement improves disease phenotypes in a mouse model of late infantile neuronal ceroid lipofuscinosis.

Chang M, Cooper JD, Sleat DE, Cheng SH, Dodge JC, Passini MA, Lobel P, Davidson BL.

Mol Ther. 2008 Apr;16(4):649-56. doi: 10.1038/mt.2008.9. Epub 2008 Feb 12.


Intraparenchymal injections of acid sphingomyelinase results in regional correction of lysosomal storage pathology in the Niemann-Pick A mouse.

Yang WW, Dodge JC, Passini MA, Taksir TV, Griffiths D, Schuchman EH, Cheng SH, Shihabuddin LS.

Exp Neurol. 2007 Oct;207(2):258-66. Epub 2007 Jul 10.


Timing of therapeutic intervention determines functional and survival outcomes in a mouse model of late infantile batten disease.

Cabrera-Salazar MA, Roskelley EM, Bu J, Hodges BL, Yew N, Dodge JC, Shihabuddin LS, Sohar I, Sleat DE, Scheule RK, Davidson BL, Cheng SH, Lobel P, Passini MA.

Mol Ther. 2007 Oct;15(10):1782-8. Epub 2007 Jul 17.


Combination brain and systemic injections of AAV provide maximal functional and survival benefits in the Niemann-Pick mouse.

Passini MA, Bu J, Fidler JA, Ziegler RJ, Foley JW, Dodge JC, Yang WW, Clarke J, Taksir TV, Griffiths DA, Zhao MA, O'Riordan CR, Schuchman EH, Shihabuddin LS, Cheng SH.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9505-10. Epub 2007 May 21.


Intracranial delivery of CLN2 reduces brain pathology in a mouse model of classical late infantile neuronal ceroid lipofuscinosis.

Passini MA, Dodge JC, Bu J, Yang W, Zhao Q, Sondhi D, Hackett NR, Kaminsky SM, Mao Q, Shihabuddin LS, Cheng SH, Sleat DE, Stewart GR, Davidson BL, Lobel P, Crystal RG.

J Neurosci. 2006 Feb 1;26(5):1334-42.


Gene transfer of human acid sphingomyelinase corrects neuropathology and motor deficits in a mouse model of Niemann-Pick type A disease.

Dodge JC, Clarke J, Song A, Bu J, Yang W, Taksir TV, Griffiths D, Zhao MA, Schuchman EH, Cheng SH, O'Riordan CR, Shihabuddin LS, Passini MA, Stewart GR.

Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17822-7. Epub 2005 Nov 21.


AAV vector-mediated correction of brain pathology in a mouse model of Niemann-Pick A disease.

Passini MA, Macauley SL, Huff MR, Taksir TV, Bu J, Wu IH, Piepenhagen PA, Dodge JC, Shihabuddin LS, O'Riordan CR, Schuchman EH, Stewart GR.

Mol Ther. 2005 May;11(5):754-62.


Intracerebral transplantation of adult mouse neural progenitor cells into the Niemann-Pick-A mouse leads to a marked decrease in lysosomal storage pathology.

Shihabuddin LS, Numan S, Huff MR, Dodge JC, Clarke J, Macauley SL, Yang W, Taksir TV, Parsons G, Passini MA, Gage FH, Stewart GR.

J Neurosci. 2004 Nov 24;24(47):10642-51.


Male-induced estrus synchronization in the female Siberian hamster (Phodopus sungorus sungorus).

Dodge JC, Kristal MB, Badura LL.

Physiol Behav. 2002 Nov;77(2-3):227-31.


Age, breed, sex and period effects on skin biophysical parameters for dogs fed canned dog food.

Young LA, Dodge JC, Guest KJ, Cline JL, Kerr WW.

J Nutr. 2002 Jun;132(6 Suppl 2):1695S-7S. doi: 10.1093/jn/132.6.1695S. No abstract available.


GABA levels within the medial preoptic area: effects of chronic administration of sodium valproic acid.

Dodge JC, Illig AM, Snyder PJ, Badura LL.

Psychoneuroendocrinology. 2000 Jul;25(5):519-34.


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