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A Decoupled Automation Platform for Hydrogen/Deuterium Exchange Mass Spectrometry Experiments.

Espada A, Haro R, Castañon J, Sayago C, Perez-Cozar F, Cano L, Redero P, Molina-Martin M, Broughton H, Stites RE, Pascal BD, Griffin PR, Dodge JA, Chalmers MJ.

J Am Soc Mass Spectrom. 2019 Dec;30(12):2580-2583. doi: 10.1007/s13361-019-02331-2. Epub 2019 Nov 13.


Deciphering Binding Interactions of IL-23R with HDX-MS: Mapping Protein and Macrocyclic Dodecapeptide Ligands.

Sayago C, Gonzalez Valcarcel IC, Qian Y, Lee J, Alsina-Fernandez J, Fite NC, Carrillo JJ, Zhang FF, Chalmers MJ, Dodge JA, Broughton H, Espada A.

ACS Med Chem Lett. 2018 Aug 1;9(9):912-916. doi: 10.1021/acsmedchemlett.8b00255. eCollection 2018 Sep 13.


Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery.

Ting JP, Tung F, Antonysamy S, Wasserman S, Jones SB, Zhang FF, Espada A, Broughton H, Chalmers MJ, Woodman ME, Bina HA, Dodge JA, Benach J, Zhang A, Groshong C, Manglicmot D, Russell M, Afshar S.

PLoS One. 2018 Jan 12;13(1):e0190850. doi: 10.1371/journal.pone.0190850. eCollection 2018.


HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions.

Zheng J, Chang MR, Stites RE, Wang Y, Bruning JB, Pascal BD, Novick SJ, Garcia-Ordonez RD, Stayrook KR, Chalmers MJ, Dodge JA, Griffin PR.

Nat Commun. 2017 Oct 13;8(1):923. doi: 10.1038/s41467-017-00978-7.


Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG.

Roberts JM, Martin RS, Piyarathna DB, MacKrell JG, Rocha GV, Dodge JA, Coarfa C, Krishnan V, Rowley DR, Weigel NL.

Oncotarget. 2017 Jul 4;8(27):44447-44464. doi: 10.18632/oncotarget.17968.


A Residue-Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen-Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein-Ligand Interactions.

Saltzberg DJ, Broughton HB, Pellarin R, Chalmers MJ, Espada A, Dodge JA, Pascal BD, Griffin PR, Humblet C, Sali A.

J Phys Chem B. 2017 Apr 20;121(15):3493-3501. doi: 10.1021/acs.jpcb.6b09358. Epub 2016 Dec 1.


Corrigendum to "Structural features underlying raloxifene's biophysical interaction with bone matrix" [Bioorg. Med. Chem. 24 (2016) 759-767].

Bivi N, Hu H, Chavali B, Chalmers MJ, Reutter CT, Durst GL, Riley A, Sato M, Allen MR, Burr DB, Dodge JA.

Bioorg Med Chem. 2016 Sep 15;24(18):4516. doi: 10.1016/j.bmc.2016.07.014. Epub 2016 Jul 14. No abstract available.


Two-Site Evaluation of the Repeatability and Precision of an Automated Dual-Column Hydrogen/Deuterium Exchange Mass Spectrometry Platform.

Cummins DJ, Espada A, Novick SJ, Molina-Martin M, Stites RE, Espinosa JF, Broughton H, Goswami D, Pascal BD, Dodge JA, Chalmers MJ, Griffin PR.

Anal Chem. 2016 Jun 21;88(12):6607-14. doi: 10.1021/acs.analchem.6b01650. Epub 2016 Jun 13.


Program Implementation Approaches to Build and Sustain Health Care Coordination for Type 2 Diabetes.

Fitzgerald TM, Williams PA, Dodge JA, Quinn M, Heminger CL, Moultrie R, Taylor O, Nelson BW, Lewis MA.

Health Promot Pract. 2017 Mar;18(2):306-313. doi: 10.1177/1524839916643705. Epub 2016 Jul 9.


A Binding Site on IL-17A for Inhibitory Macrocycles Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry.

Espada A, Broughton H, Jones S, Chalmers MJ, Dodge JA.

J Med Chem. 2016 Mar 10;59(5):2255-60. doi: 10.1021/acs.jmedchem.5b01693. Epub 2016 Feb 18.


Structural features underlying raloxifene's biophysical interaction with bone matrix.

Bivi N, Hu H, Chavali B, Chalmers MJ, Reutter CT, Durst GL, Riley A, Sato M, Allen MR, Burr DB, Dodge JA.

Bioorg Med Chem. 2016 Feb 15;24(4):759-67. doi: 10.1016/j.bmc.2015.12.045. Epub 2015 Dec 29. Erratum in: Bioorg Med Chem. 2016 Sep 15;24(18):4516.


A millennial view of cystic fibrosis.

Dodge JA.

Dev Period Med. 2015 Jan-Mar;19(1):9-13. Review.


Alliance system and policy change: necessary ingredients for improvement in diabetes care and reduction of disparities.

Clark NM, Quinn M, Dodge JA, Nelson BW.

Health Promot Pract. 2014 Nov;15(2 Suppl):11S-22S. doi: 10.1177/1524839914543829.


Heart disease management by women: does intervention format matter?

Clark NM, Janz NK, Dodge JA, Lin X, Trabert BL, Kaciroti N, Mosca L, Wheeler JR, Keteyian S.

Health Educ Behav. 2014 Oct;41(5):518-27. doi: 10.1177/1090198114547516.


Pancreatic enzymes and Fibrosing Colonopathy.

Dodge JA.

J Cyst Fibros. 2015 Jan;14(1):153. doi: 10.1016/j.jcf.2014.09.002. Epub 2014 Sep 18. No abstract available.


HDX reveals unique fragment ligands for the vitamin D receptor.

Carson MW, Zhang J, Chalmers MJ, Bocchinfuso WP, Holifield KD, Masquelin T, Stites RE, Stayrook KR, Griffin PR, Dodge JA.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3459-63. doi: 10.1016/j.bmcl.2014.05.070. Epub 2014 May 29.


Discovery of synthetic Leishmania inhibitors by screening of a 2-arylbenzothiophene library.

Bonano VI, Yokoyama-Yasunaka JK, Miguel DC, Jones SA, Dodge JA, Uliana SR.

Chem Biol Drug Des. 2014 Mar;83(3):289-96. doi: 10.1111/cbdd.12239. Epub 2013 Dec 26.


Hydrophobic Interactions Improve Selectivity to ERα for Ben-zothiophene SERMs.

Chalmers MJ, Wang Y, Novick S, Sato M, Bryant HU, Montrose-Rafizdeh C, Griffin PR, Dodge JA.

ACS Med Chem Lett. 2012 Mar 8;3(3):207-210.


Methods for the Analysis of High Precision Differential Hydrogen Deuterium Exchange Data.

Chalmers MJ, Pascal BD, Willis S, Zhang J, Iturria SJ, Dodge JA, Griffin PR.

Int J Mass Spectrom. 2011 Apr 30;302(1-3):59-68.


DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.

Zhang J, Chalmers MJ, Stayrook KR, Burris LL, Wang Y, Busby SA, Pascal BD, Garcia-Ordonez RD, Bruning JB, Istrate MA, Kojetin DJ, Dodge JA, Burris TP, Griffin PR.

Nat Struct Mol Biol. 2011 May;18(5):556-63. doi: 10.1038/nsmb.2046. Epub 2011 Apr 10.


Novel 3-aryl indoles as progesterone receptor antagonists for uterine fibroids.

Richardson TI, Clarke CA, Yu KL, Yee YK, Bleisch TJ, Lopez JE, Jones SA, Hughes NE, Muehl BS, Lugar CW, Moore TL, Shetler PK, Zink RW, Osborne JJ, Montrose-Rafizadeh C, Patel N, Geiser AG, Galvin RJ, Dodge JA.

ACS Med Chem Lett. 2010 Dec 9;2(2):148-53. doi: 10.1021/ml100220b. eCollection 2011 Feb 10.


Exercise self-regulation among older women participating in a heart disease-management intervention.

Janevic MR, Janz NK, Kaciroti N, Dodge JA, Keteyian SJ, Mosca L, Clark NM.

J Women Aging. 2010;22(4):255-72. doi: 10.1080/08952841.2010.518874.


Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer.

Zhang J, Chalmers MJ, Stayrook KR, Burris LL, Garcia-Ordonez RD, Pascal BD, Burris TP, Dodge JA, Griffin PR.

Structure. 2010 Oct 13;18(10):1332-41. doi: 10.1016/j.str.2010.07.007.


Asthma in 10- to 13-year-olds: challenges at a time of transition.

Clark NM, Dodge JA, Thomas LJ, Andridge RR, Awad D, Paton JY.

Clin Pediatr (Phila). 2010 Oct;49(10):931-7. doi: 10.1177/0009922809357339. Epub 2010 Aug 19. Review.


The importance of rare diseases: from the gene to society.

Dodge JA, Chigladze T, Donadieu J, Grossman Z, Ramos F, Serlicorni A, Siderius L, Stefanidis CJ, Tasic V, Valiulis A, Wierzba J.

Arch Dis Child. 2011 Sep;96(9):791-2. doi: 10.1136/adc.2010.193664. Epub 2010 Aug 12. No abstract available.


An evaluation of asthma interventions for preteen students.

Clark NM, Shah S, Dodge JA, Thomas LJ, Andridge RR, Little RJ.

J Sch Health. 2010 Feb;80(2):80-7. doi: 10.1111/j.1746-1561.2009.00469.x.


A current picture of asthma diagnosis, severity, and control in a low-income minority preteen population.

Clark NM, Dodge JA, Shah S, Thomas LJ, Andridge RR, Awad D.

J Asthma. 2010 Mar;47(2):150-5. doi: 10.3109/02770900903483824.


Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange.

Dai SY, Burris TP, Dodge JA, Montrose-Rafizadeh C, Wang Y, Pascal BD, Chalmers MJ, Griffin PR.

Biochemistry. 2009 Oct 13;48(40):9668-76. doi: 10.1021/bi901149t.


Focusing on outcomes: making the most of COPD interventions.

Clark NM, Dodge JA, Partridge MR, Martinez FJ.

Int J Chron Obstruct Pulmon Dis. 2009;4:61-77. Epub 2009 Apr 15. Review.


Pancreatic enzyme therapy in cystic fibrosis.

Dodge JA.

Expert Rev Respir Med. 2008 Dec;2(6):681-3. doi: 10.1586/17476348.2.6.681. No abstract available.


An international/multicentre report on patients with cystic fibrosis (CF) over the age of 40 years.

Hodson ME, Simmonds NJ, Warwick WJ, Tullis E, Castellani C, Assael B, Dodge JA, Corey M; International Study Of Aging In Cystic Fibrosis.

J Cyst Fibros. 2008 Nov;7(6):537-42. doi: 10.1016/j.jcf.2008.06.003. Epub 2008 Aug 19.


The effect of patient choice of intervention on health outcomes.

Clark NM, Janz NK, Dodge JA, Mosca L, Lin X, Long Q, Little RJ, Wheeler JR, Keteyian S, Liang J.

Contemp Clin Trials. 2008 Sep;29(5):679-86. doi: 10.1016/j.cct.2008.04.002. Epub 2008 Apr 20.


Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.

Dai SY, Chalmers MJ, Bruning J, Bramlett KS, Osborne HE, Montrose-Rafizadeh C, Barr RJ, Wang Y, Wang M, Burris TP, Dodge JA, Griffin PR.

Proc Natl Acad Sci U S A. 2008 May 20;105(20):7171-6. doi: 10.1073/pnas.0710802105. Epub 2008 May 12.


The selective oestrogen receptor modulator, LY362321, is not neuroprotective in a rat model of transient focal ischaemia.

Farr TD, Carswell HV, McCann DJ, Sato M, Bryant HU, Dodge JA, Macrae IM.

J Neuroendocrinol. 2008 Mar;20(3):366-74. doi: 10.1111/j.1365-2826.2008.01648.x. Epub 2008 Jan 15.


Heart disease management by women: does intervention format matter?

Clark NM, Janz NK, Dodge JA, Lin X, Trabert BL, Kaciroti N, Mosca L, Wheeler JR, Keteyian S.

Health Educ Behav. 2009 Apr;36(2):394-409. Epub 2007 Dec 15.


Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 5: Combined A- and C-ring structure-activity relationship studies.

Richardson TI, Dodge JA, Wang Y, Durbin JD, Krishnan V, Norman BH.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5563-6. Epub 2007 Aug 11.


Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 4: functionalization of the benzopyran A-ring.

Norman BH, Richardson TI, Dodge JA, Pfeifer LA, Durst GL, Wang Y, Durbin JD, Krishnan V, Dinn SR, Liu S, Reilly JE, Ryter KT.

Bioorg Med Chem Lett. 2007 Sep 15;17(18):5082-5. Epub 2007 Jul 13.


Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 3: synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification.

Richardson TI, Dodge JA, Durst GL, Pfeifer LA, Shah J, Wang Y, Durbin JD, Krishnan V, Norman BH.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4824-8. Epub 2007 Jun 20.


Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 2: structure-activity relationship studies on the benzopyran scaffold.

Richardson TI, Norman BH, Lugar CW, Jones SA, Wang Y, Durbin JD, Krishnan V, Dodge JA.

Bioorg Med Chem Lett. 2007 Jul 1;17(13):3570-4. Epub 2007 Apr 25.


Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety.

Richardson TI, Frank SA, Wang M, Clarke CA, Jones SA, Ying BP, Kohlman DT, Wallace OB, Shepherd TA, Dally RD, Palkowitz AD, Geiser AG, Bryant HU, Henck JW, Cohen IR, Rudmann DG, McCann DJ, Coutant DE, Oldham SW, Hummel CW, Fong KC, Hinklin R, Lewis G, Tian H, Dodge JA.

Bioorg Med Chem Lett. 2007 Jul 1;17(13):3544-9. Epub 2007 Apr 24.


Cystic fibrosis mortality and survival in the UK: 1947-2003.

Dodge JA, Lewis PA, Stanton M, Wilsher J.

Eur Respir J. 2007 Mar;29(3):522-6. Epub 2006 Dec 20.


Benzopyrans are selective estrogen receptor beta agonists with novel activity in models of benign prostatic hyperplasia.

Norman BH, Dodge JA, Richardson TI, Borromeo PS, Lugar CW, Jones SA, Chen K, Wang Y, Durst GL, Barr RJ, Montrose-Rafizadeh C, Osborne HE, Amos RM, Guo S, Boodhoo A, Krishnan V.

J Med Chem. 2006 Oct 19;49(21):6155-7.


Cystic fibrosis: nutritional consequences and management.

Dodge JA, Turck D.

Best Pract Res Clin Gastroenterol. 2006;20(3):531-46. Review.


Shwachman-Diamond syndrome: UK perspective.

Hall GW, Dale P, Dodge JA.

Arch Dis Child. 2006 Jun;91(6):521-4. Review.


A selective estrogen receptor modulator for the treatment of hot flushes.

Wallace OB, Lauwers KS, Dodge JA, May SA, Calvin JR, Hinklin R, Bryant HU, Shetler PK, Adrian MD, Geiser AG, Sato M, Burris TP.

J Med Chem. 2006 Feb 9;49(3):843-6.


A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats.

Hummel CW, Geiser AG, Bryant HU, Cohen IR, Dally RD, Fong KC, Frank SA, Hinklin R, Jones SA, Lewis G, McCann DJ, Rudmann DG, Shepherd TA, Tian H, Wallace OB, Wang M, Wang Y, Dodge JA.

J Med Chem. 2005 Nov 3;48(22):6772-5.


Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues.

Evers B, Ruehter G, Berg M, Dodge JA, Hankotius D, Hary U, Jungheim LN, Mest HJ, de la Nava EM, Mohr M, Muehl BS, Petersen S, Sommer B, Riedel-Herold G, Tebbe MJ, Thrasher KJ, Voelkers S.

Bioorg Med Chem. 2005 Dec 15;13(24):6748-62. Epub 2005 Oct 10.


Patient-centred cystic fibrosis services.

Dodge JA.

J R Soc Med. 2005;98 Suppl 45:2-6. No abstract available.


A new selective estrogen receptor modulator with potent uterine antagonist activity, agonist activity in bone, and minimal ovarian stimulation.

Geiser AG, Hummel CW, Draper MW, Henck JW, Cohen IR, Rudmann DG, Donnelly KB, Adrian MD, Shepherd TA, Wallace OB, McCann DJ, Oldham SW, Bryant HU, Sato M, Dodge JA.

Endocrinology. 2005 Oct;146(10):4524-35. Epub 2005 Jul 7.


Cystic fibrosis is no longer an important cause of childhood death in the UK.

Dodge JA, Lewis PA.

Arch Dis Child. 2005 May;90(5):547. No abstract available.

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