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A meta-analysis of clinical studies conducted during the West Africa Ebola virus disease outbreak confirms the need for randomized control groups.

Dodd LE, Follmann D, Proschan M, Wang J, Malvy D, van Griensven J, Ciglenecki I, Horby PW, Ansumana R, Jiang JF, Davey RT, Lane HC, Gouel-Cheron A.

Sci Transl Med. 2019 Nov 27;11(520). pii: eaaw1049. doi: 10.1126/scitranslmed.aaw1049.


A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics.

Mulangu S, Dodd LE, Davey RT Jr, Tshiani Mbaya O, Proschan M, Mukadi D, Lusakibanza Manzo M, Nzolo D, Tshomba Oloma A, Ibanda A, Ali R, Coulibaly S, Levine AC, Grais R, Diaz J, Lane HC, Muyembe-Tamfum JJ; PALM Writing Group, Sivahera B, Camara M, Kojan R, Walker R, Dighero-Kemp B, Cao H, Mukumbayi P, Mbala-Kingebeni P, Ahuka S, Albert S, Bonnett T, Crozier I, Duvenhage M, Proffitt C, Teitelbaum M, Moench T, Aboulhab J, Barrett K, Cahill K, Cone K, Eckes R, Hensley L, Herpin B, Higgs E, Ledgerwood J, Pierson J, Smolskis M, Sow Y, Tierney J, Sivapalasingam S, Holman W, Gettinger N, Vallée D, Nordwall J; PALM Consortium Study Team.

N Engl J Med. 2019 Dec 12;381(24):2293-2303. doi: 10.1056/NEJMoa1910993. Epub 2019 Nov 27.


Double-sided slippery liquid-infused porous materials using conformable mesh.

Geraldi NR, Guan JH, Dodd LE, Maiello P, Xu BB, Wood D, Newton MI, Wells GG, McHale G.

Sci Rep. 2019 Sep 16;9(1):13280. doi: 10.1038/s41598-019-49887-3.


Re-randomization tests in clinical trials.

Proschan MA, Dodd LE.

Stat Med. 2019 May 30;38(12):2292-2302. doi: 10.1002/sim.8093. Epub 2019 Jan 22.


Increased Metabolic Activity on 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in Human Immunodeficiency Virus-Associated Immune Reconstitution Inflammatory Syndrome.

Hammoud DA, Boulougoura A, Papadakis GZ, Wang J, Dodd LE, Rupert A, Higgins J, Roby G, Metzger D, Laidlaw E, Mican JM, Pau A, Lage S, Wong CS, Lisco A, Manion M, Sheikh V, Millo C, Sereti I.

Clin Infect Dis. 2019 Jan 7;68(2):229-238. doi: 10.1093/cid/ciy454.


Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial.

Chen RY, Via LE, Dodd LE, Walzl G, Malherbe ST, Loxton AG, Dawson R, Wilkinson RJ, Thienemann F, Tameris M, Hatherill M, Diacon AH, Liu X, Xing J, Jin X, Ma Z, Pan S, Zhang G, Gao Q, Jiang Q, Zhu H, Liang L, Duan H, Song T, Alland D, Tartakovsky M, Rosenthal A, Whalen C, Duvenhage M, Cai Y, Goldfeder LC, Arora K, Smith B, Winter J, Barry Iii CE; Predict TB Study Group.

Gates Open Res. 2017 Nov 6;1:9. doi: 10.12688/gatesopenres.12750.1.


Bioinspired nanoparticle spray-coating for superhydrophobic flexible materials with oil/water separation capabilities.

Geraldi NR, Dodd LE, Xu BB, Wood D, Wells GG, McHale G, Newton MI.

Bioinspir Biomim. 2018 Feb 2;13(2):024001. doi: 10.1088/1748-3190/aaa1c1.


Interferon-gamma response to the treatment of active pulmonary and extra-pulmonary tuberculosis.

Liang L, Shi R, Liu X, Yuan X, Zheng S, Zhang G, Wang W, Wang J, England K, Via LE, Cai Y, Goldfeder LC, Dodd LE, Barry CE, Chen RY.

Int J Tuberc Lung Dis. 2017 Oct 1;21(10):1145-1149. doi: 10.5588/ijtld.16.0880.


Commentary on Tinè et al.

Dodd LE.

Clin Trials. 2017 Oct;14(5):489-490. doi: 10.1177/1740774517715448. Epub 2017 Jul 1. No abstract available.


Controlling the family-wise error rate in multi-arm, multi-stage trials.

Crouch LA, Dodd LE, Proschan MA.

Clin Trials. 2017 Jun;14(3):237-245. doi: 10.1177/1740774517694130. Epub 2017 Mar 19.


Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure.

Malherbe ST, Shenai S, Ronacher K, Loxton AG, Dolganov G, Kriel M, Van T, Chen RY, Warwick J, Via LE, Song T, Lee M, Schoolnik G, Tromp G, Alland D, Barry CE 3rd, Winter J, Walzl G; Catalysis TB–Biomarker Consortium, Lucas L, Spuy GV, Stanley K, Thiart L, Smith B, Du Plessis N, Beltran CG, Maasdorp E, Ellmann A, Choi H, Joh J, Dodd LE, Allwood B, Koegelenberg C, Vorster M, Griffith-Richards S.

Nat Med. 2016 Oct;22(10):1094-1100. doi: 10.1038/nm.4177. Epub 2016 Sep 5. Erratum in: Nat Med. 2017 Apr 7;23 (4):526. Nat Med. 2017 Dec 7;23 (12 ):1499.


Bacterial Loads Measured by the Xpert MTB/RIF Assay as Markers of Culture Conversion and Bacteriological Cure in Pulmonary TB.

Shenai S, Ronacher K, Malherbe S, Stanley K, Kriel M, Winter J, Peppard T, Barry CE, Wang J, Dodd LE, Via LE, Barry CE 3rd, Walzl G, Alland D.

PLoS One. 2016 Aug 10;11(8):e0160062. doi: 10.1371/journal.pone.0160062. eCollection 2016.


Low Friction Droplet Transportation on a Substrate with a Selective Leidenfrost Effect.

Dodd LE, Wood D, Geraldi NR, Wells GG, McHale G, Xu BB, Stuart-Cole S, Martin J, Newton MI.

ACS Appl Mater Interfaces. 2016 Aug 31;8(34):22658-63. doi: 10.1021/acsami.6b06738. Epub 2016 Aug 16.


University of Pennsylvania 8th annual conference on statistical issues in clinical trials: Pragmatic clinical trials (morning panel).

Dodd LE, Lantos JD, Pinheiro J.

Clin Trials. 2016 Oct;13(5):493-503. doi: 10.1177/1740774516657547. Epub 2016 Jul 17. No abstract available.


Pulmonary Manifestations of the Autoimmune Lymphoproliferative Syndrome. A Retrospective Study of a Unique Patient Cohort.

Lau CY, Mihalek AD, Wang J, Dodd LE, Perkins K, Price S, Webster S, Pittaluga S, Folio LR, Rao VK, Olivier KN.

Ann Am Thorac Soc. 2016 Aug;13(8):1279-88. doi: 10.1513/AnnalsATS.201601-079OC.



Proschan MA, Dodd LE.

Clin Trials. 2016 Aug;13(4):454-5. doi: 10.1177/1740774516644906. Epub 2016 May 2. No abstract available.


Design of a Randomized Controlled Trial for Ebola Virus Disease Medical Countermeasures: PREVAIL II, the Ebola MCM Study.

Dodd LE, Proschan MA, Neuhaus J, Koopmeiners JS, Neaton J, Beigel JD, Barrett K, Lane HC, Davey RT Jr.

J Infect Dis. 2016 Jun 15;213(12):1906-13. doi: 10.1093/infdis/jiw061. Epub 2016 Feb 11.


Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis.

Song T, Lee M, Jeon HS, Park Y, Dodd LE, Dartois V, Follman D, Wang J, Cai Y, Goldfeder LC, Olivier KN, Xie Y, Via LE, Cho SN, Barry CE 3rd, Chen RY.

EBioMedicine. 2015 Oct 9;2(11):1627-33. doi: 10.1016/j.ebiom.2015.09.051. eCollection 2015 Nov.


A phase 1 randomized, double-blind, placebo-controlled, crossover trial of DAS181 (Fludase®) in adult subjects with well-controlled asthma.

Colombo RE, Fiorentino C, Dodd LE, Hunsberger S, Haney C, Barrett K, Nabha L, Davey RT Jr, Olivier KN.

BMC Infect Dis. 2016 Feb 1;16:54. doi: 10.1186/s12879-016-1358-9.


Clinical trials during the Ebola crisis.

Dodd LE.

Clin Trials. 2016 Feb;13(1):5. doi: 10.1177/1740774515621509. Epub 2016 Jan 14. No abstract available.


Statistical considerations for a trial of Ebola virus disease therapeutics.

Proschan MA, Dodd LE, Price D.

Clin Trials. 2016 Feb;13(1):39-48. doi: 10.1177/1740774515620145. Epub 2016 Jan 14.


A sterilizing tuberculosis treatment regimen is associated with faster clearance of bacteria in cavitary lesions in marmosets.

Via LE, England K, Weiner DM, Schimel D, Zimmerman MD, Dayao E, Chen RY, Dodd LE, Richardson M, Robbins KK, Cai Y, Hammoud D, Herscovitch P, Dartois V, Flynn JL, Barry CE 3rd.

Antimicrob Agents Chemother. 2015 Jul;59(7):4181-9. doi: 10.1128/AAC.00115-15. Epub 2015 May 4.


PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis.

Coleman MT, Chen RY, Lee M, Lin PL, Dodd LE, Maiello P, Via LE, Kim Y, Marriner G, Dartois V, Scanga C, Janssen C, Wang J, Klein E, Cho SN, Barry CE 3rd, Flynn JL.

Sci Transl Med. 2014 Dec 3;6(265):265ra167. doi: 10.1126/scitranslmed.3009500.


PET/CT imaging correlates with treatment outcome in patients with multidrug-resistant tuberculosis.

Chen RY, Dodd LE, Lee M, Paripati P, Hammoud DA, Mountz JM, Jeon D, Zia N, Zahiri H, Coleman MT, Carroll MW, Lee JD, Jeong YJ, Herscovitch P, Lahouar S, Tartakovsky M, Rosenthal A, Somaiyya S, Lee S, Goldfeder LC, Cai Y, Via LE, Park SK, Cho SN, Barry CE 3rd.

Sci Transl Med. 2014 Dec 3;6(265):265ra166. doi: 10.1126/scitranslmed.3009501.


Predictors of pulmonary tuberculosis treatment outcomes in South Korea: a prospective cohort study, 2005-2012.

Choi H, Lee M, Chen RY, Kim Y, Yoon S, Joh JS, Park SK, Dodd LE, Lee J, Song T, Cai Y, Goldfeder LC, Via LE, Carroll MW, Barry CE 3rd, Cho SN.

BMC Infect Dis. 2014 Jul 2;14:360. doi: 10.1186/1471-2334-14-360.


Matched longitudinal analysis of biomarkers associated with survival.

Dodd LE, Johnson RF, Blaney JE, Follmann D.

Clin Vaccine Immunol. 2014 Aug;21(8):1145-52. doi: 10.1128/CVI.00252-14. Epub 2014 Jun 18.


A modest proposal for dropping poor arms in clinical trials.

Proschan MA, Dodd LE.

Stat Med. 2014 Aug 30;33(19):3241-52. doi: 10.1002/sim.6169. Epub 2014 Apr 22.


An audit strategy for time-to-event outcomes measured with error: application to five randomized controlled trials in oncology.

Dodd LE, Korn EL, Freidlin B, Gu W, Abrams JS, Bushnell WD, Canetta R, Doroshow JH, Gray RJ, Sridhara R.

Clin Trials. 2013 Oct;10(5):754-60. doi: 10.1177/1740774513493973. Epub 2013 Aug 9.


Efficacy and safety of metronidazole for pulmonary multidrug-resistant tuberculosis.

Carroll MW, Jeon D, Mountz JM, Lee JD, Jeong YJ, Zia N, Lee M, Lee J, Via LE, Lee S, Eum SY, Lee SJ, Goldfeder LC, Cai Y, Jin B, Kim Y, Oh T, Chen RY, Dodd LE, Gu W, Dartois V, Park SK, Kim CT, Barry CE 3rd, Cho SN.

Antimicrob Agents Chemother. 2013 Aug;57(8):3903-9. doi: 10.1128/AAC.00753-13. Epub 2013 Jun 3.


Missing data and measurement variability in assessing progression-free survival endpoint in randomized clinical trials.

Sridhara R, Mandrekar SJ, Dodd LE.

Clin Cancer Res. 2013 May 15;19(10):2613-20. doi: 10.1158/1078-0432.CCR-12-2938. Review.


Assessment of audit methodologies for bias evaluation of tumor progression in oncology clinical trials.

Zhang JJ, Zhang L, Chen H, Murgo AJ, Dodd LE, Pazdur R, Sridhara R.

Clin Cancer Res. 2013 May 15;19(10):2637-45. doi: 10.1158/1078-0432.CCR-12-3364. Epub 2013 Mar 26.


Innovative trial designs to improving tuberculosis drug development.

Dodd LE, Proschan MA.

J Infect Dis. 2013 Feb 1;207(3):544. doi: 10.1093/infdis/jis704. Epub 2012 Nov 21. No abstract available.


Elevations in D-dimer and C-reactive protein are associated with the development of osteonecrosis of the hip in HIV-infected adults.

Morse CG, Dodd LE, Nghiem K, Costello R, Csako G, Lane HC, Lozier JN, Kovacs JA.

AIDS. 2013 Feb 20;27(4):591-5. doi: 10.1097/QAD.0b013e32835c206a.


Diagnosis of paediatric tuberculosis: the culture conundrum.

Dodd LE, Wilkinson RJ.

Lancet Infect Dis. 2013 Jan;13(1):3-4. doi: 10.1016/S1473-3099(12)70290-6. Epub 2012 Nov 5. No abstract available.


Frequency, severity, and prediction of tuberculous meningitis immune reconstitution inflammatory syndrome.

Marais S, Meintjes G, Pepper DJ, Dodd LE, Schutz C, Ismail Z, Wilkinson KA, Wilkinson RJ.

Clin Infect Dis. 2013 Feb;56(3):450-60. doi: 10.1093/cid/cis899. Epub 2012 Oct 24.


Using audit information to adjust parameter estimates for data errors in clinical trials.

Shepherd BE, Shaw PA, Dodd LE.

Clin Trials. 2012 Dec;9(6):721-9. doi: 10.1177/1740774512450100. Epub 2012 Jul 30.


Evaluation of tuberculosis diagnostics in children: 2. Methodological issues for conducting and reporting research evaluations of tuberculosis diagnostics for intrathoracic tuberculosis in children. Consensus from an expert panel.

Cuevas LE, Browning R, Bossuyt P, Casenghi M, Cotton MF, Cruz AT, Dodd LE, Drobniewski F, Gale M, Graham SM, Grzemska M, Heinrich N, Hesseling AC, Huebner R, Jean-Philippe P, Kabra SK, Kampmann B, Lewinsohn D, Li M, Lienhardt C, Mandalakas AM, Marais BJ, Menzies HJ, Montepiedra G, Mwansambo C, Oberhelman R, Palumbo P, Russek-Cohen E, Shapiro DE, Smith B, Soto-Castellares G, Starke JR, Swaminathan S, Wingfield C, Worrell C.

J Infect Dis. 2012 May 15;205 Suppl 2:S209-15. doi: 10.1093/infdis/jir879. Epub 2012 Apr 3.


Evaluating imaging and computer-aided detection and diagnosis devices at the FDA.

Gallas BD, Chan HP, D'Orsi CJ, Dodd LE, Giger ML, Gur D, Krupinski EA, Metz CE, Myers KJ, Obuchowski NA, Sahiner B, Toledano AY, Zuley ML.

Acad Radiol. 2012 Apr;19(4):463-77. doi: 10.1016/j.acra.2011.12.016. Epub 2012 Feb 3.


Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone.

Altmann SE, Smith AL, Dyall J, Johnson RF, Dodd LE, Jahrling PB, Paragas J, Blaney JE.

Antiviral Res. 2012 Feb;93(2):305-308. doi: 10.1016/j.antiviral.2011.12.001. Epub 2011 Dec 11.


Evaluation of perceived threat differences posed by filovirus variants.

Kuhn JH, Dodd LE, Wahl-Jensen V, Radoshitzky SR, Bavari S, Jahrling PB.

Biosecur Bioterror. 2011 Dec;9(4):361-71. doi: 10.1089/bsp.2011.0051. Epub 2011 Nov 9.


Simian hemorrhagic fever virus infection of rhesus macaques as a model of viral hemorrhagic fever: clinical characterization and risk factors for severe disease.

Johnson RF, Dodd LE, Yellayi S, Gu W, Cann JA, Jett C, Bernbaum JG, Ragland DR, St Claire M, Byrum R, Paragas J, Blaney JE, Jahrling PB.

Virology. 2011 Dec 20;421(2):129-40. doi: 10.1016/j.virol.2011.09.016. Epub 2011 Oct 19.


Evaluation of the polyclonal ELISA HPV serology assay as a biomarker for human papillomavirus exposure.

Coseo SE, Porras C, Dodd LE, Hildesheim A, Rodriguez AC, Schiffman M, Herrero R, Wacholder S, Gonzalez P, Sherman ME, Jimenez S, Solomon D, Bougelet C, van Doorn LJ, Quint W, Safaeian M; Costa Rica HPV Vaccine Trial (CVT) Group.

Sex Transm Dis. 2011 Oct;38(10):976-82. doi: 10.1097/OLQ.0b013e31822545c0.


Plasma metalloproteinase levels are dysregulated in signal transducer and activator of transcription 3 mutated hyper-IgE syndrome.

Sekhsaria V, Dodd LE, Hsu AP, Heimall JR, Freeman AF, Ding L, Holland SM, Uzel G.

J Allergy Clin Immunol. 2011 Nov;128(5):1124-7. doi: 10.1016/j.jaci.2011.07.046. Epub 2011 Aug 27. No abstract available.


Isoniazid preventive therapy in HIV infection.

Dodd LE, Wilkinson RJ.

Lancet. 2011 May 7;377(9777):1548-50. doi: 10.1016/S0140-6736(11)60434-0. Epub 2011 Apr 12. No abstract available.


The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI): a completed reference database of lung nodules on CT scans.

Armato SG 3rd, McLennan G, Bidaut L, McNitt-Gray MF, Meyer CR, Reeves AP, Zhao B, Aberle DR, Henschke CI, Hoffman EA, Kazerooni EA, MacMahon H, Van Beeke EJ, Yankelevitz D, Biancardi AM, Bland PH, Brown MS, Engelmann RM, Laderach GE, Max D, Pais RC, Qing DP, Roberts RY, Smith AR, Starkey A, Batrah P, Caligiuri P, Farooqi A, Gladish GW, Jude CM, Munden RF, Petkovska I, Quint LE, Schwartz LH, Sundaram B, Dodd LE, Fenimore C, Gur D, Petrick N, Freymann J, Kirby J, Hughes B, Casteele AV, Gupte S, Sallamm M, Heath MD, Kuhn MH, Dharaiya E, Burns R, Fryd DS, Salganicoff M, Anand V, Shreter U, Vastagh S, Croft BY.

Med Phys. 2011 Feb;38(2):915-31.


The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of L-phenylalanine and its derivatives.

Wang YS, Russell WK, Wang Z, Wan W, Dodd LE, Pai PJ, Russell DH, Liu WR.

Mol Biosyst. 2011 Mar;7(3):714-7. doi: 10.1039/c0mb00217h. Epub 2011 Jan 14.


An audit strategy for progression-free survival.

Dodd LE, Korn EL, Freidlin B, Gray R, Bhattacharya S.

Biometrics. 2011 Sep;67(3):1092-9. doi: 10.1111/j.1541-0420.2010.01539.x. Epub 2011 Jan 6.


Measurement error in the timing of events: effect on survival analyses in randomized clinical trials.

Korn EL, Dodd LE, Freidlin B.

Clin Trials. 2010 Dec;7(6):626-33. doi: 10.1177/1740774510382801. Epub 2010 Sep 6.


Second toe proximal phalanx interposition bone graft to correct a failed Keller's arthroplasty. A new technique.

Patel S, Mistry RS, Dodd LE, Shaikh N, Palmer SH.

Foot Ankle Surg. 2009;15(3):149-51. doi: 10.1016/j.fas.2008.08.008. Epub 2008 Nov 13.


Lessons learned from independent central review.

Ford R, Schwartz L, Dancey J, Dodd LE, Eisenhauer EA, Gwyther S, Rubinstein L, Sargent D, Shankar L, Therasse P, Verweij J.

Eur J Cancer. 2009 Jan;45(2):268-74. doi: 10.1016/j.ejca.2008.10.031.


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